mAbs, Volume 8, Issue 3 (2016)

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mAbs, Volume 8, Issue 3 (2016)

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Perspective

Waiving in vivo studies for monoclonal antibody biosimilar development: National and global challenges
Kathryn Chapman, Akosua Adjei, Paul Baldrick, Antonio da Silva, Karen De Smet, Richard DiCicco, Seung Suh Hong, David Jones, Michael W. Leach, James McBlane, Ian Ragan, Praveen Reddy, Donald I. H. Stewart, Amanda Suitters & Jennifer Sims
Pages: 427-435
Published online: 24 Mar 2016
AbstractforWaiving in vivo studies for monoclonal antibody biosimilar development: National and global challenges | Full Text | References | PDF (420.2 KB)
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Reports

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors
Con Panousis, Urmi Dhagat, Kirsten M. Edwards, Veronika Rayzman, Matthew P. Hardy, Hal Braley, Gail M. Gauvreau, Timothy R. Hercus, Steven Smith, Roma Sehmi, Laura McMillan, Mara Dottore, Barbara J. McClure, Louis J. Fabri, Gino Vairo, Angel F Lopez, Michael W. Parker, Andrew D. Nash, Nicholas J. Wilson, Michael J. Wilson & Catherine M. Owczarek
Pages: 436-453
Published online: 28 Jan 2016
AbstractforCSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors | Full Text | References | PDF (1.4 MB) | Supplemental
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Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action
James C. Geoghegan, Gundo Diedrich, Xiaojun Lu, Kim Rosenthal, Kris F. Sachsenmeier, Herren Wu, William F. Dall'Acqua & Melissa M. Damschroder
Pages: 454-467
Published online: 16 Mar 2016
AbstractforInhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action | Full Text | References | PDF (1.5 MB) | Supplemental
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A human monoclonal antibody against small envelope protein of hepatitis B virus with potent neutralization effect
Wei Wang, Lina Sun, Tiansheng Li, Yanchun Ma, Jisu Li, Yang Liu, Meng Li, Lei Wang, Chuan Li, Youhua Xie, Yumei Wen, Mifang Liang, Li Chen & Shuping Tong
Pages: 468-477
Published online: 04 Mar 2016
AbstractforA human monoclonal antibody against small envelope protein of hepatitis B virus with potent neutralization effect | Full Text | References | PDF (1.1 MB) | Supplemental
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Free Access
Immunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells
Maria-Luisa del Rio, Carlos Fernandez-Renedo, Olivier Chaloin, Stefanie Scheu, Klaus Pfeffer, Yasushi Shintani, Jose-Antonio Perez-Simon, Pascal Schneider & Jose-Ignacio Rodriguez-Barbosa
Pages: 478-490
Published online: 08 Feb 2016
AbstractforImmunotherapeutic targeting of LIGHT/LTβR/HVEM pathway fully recapitulates the reduced cytotoxic phenotype of LIGHT-deficient T cells | Full Text | References | PDF (1.2 MB)
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Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies
Aileen Houston, John M. Williams, Tihana Lenac Rovis, Daniel K. Shanley, Ronan T. O'Riordan, Patrick A. Kiely, Melanie Ball, Orla P. Barry, Jacquie Kelly, Aine Fanning, John MacSharry, Ofer Mandelboim, Bernhard B. Singer, Stipan Jonjic & Tom Moore
Pages: 491-500
Published online: 18 Mar 2016
AbstractforPregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies | Full Text | References | PDF (1,001.4 KB)
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Combining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies
Keith W. Rickert, Luba Grinberg, Robert M. Woods, Susan Wilson, Michael A. Bowen & Manuel Baca
Pages: 501-512
Published online: 24 Mar 2016
AbstractforCombining phage display with de novo protein sequencing for reverse engineering of monoclonal antibodies | Full Text | References | PDF (1.2 MB) | Supplemental
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Microscale screening of antibody libraries as maytansinoid antibody-drug conjugates
Kalli C. Catcott, Molly A. McShea, Carl Uli Bialucha, Kathy L. Miller, Stuart W. Hicks, Parmita Saxena, Thomas G. Gesner, Mikias Woldegiorgis, Megan E. Lewis, Chen Bai, Michael S. Fleming, Seth A. Ettenberg, Hans K. Erickson & Nicholas C. Yoder
Pages: 513-523
Published online: 08 Feb 2016
AbstractforMicroscale screening of antibody libraries as maytansinoid antibody-drug conjugates | Full Text | References | PDF (1.3 MB) | Supplemental
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The use of lectin microarray for assessing glycosylation of therapeutic proteins
Lei Zhang, Shen Luo & Baolin Zhang
Pages: 524-535
Published online: 11 Mar 2016
AbstractforThe use of lectin microarray for assessing glycosylation of therapeutic proteins | Full Text | References | PDF (1.5 MB) | Supplemental
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Open Access
Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity
Anette Karle, Sebastian Spindeldreher & Frank Kolbinger
Pages: 536-550
Published online: 04 Mar 2016
AbstractforSecukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity | Full Text | References | PDF (1 MB) | Supplemental
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Open Access
Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody
Songmao Zheng, Sheri Moores, Stephen Jarantow, Jose Pardinas, Mark Chiu, Honghui Zhou & Weirong Wang
Pages: 551-561
Published online: 21 Feb 2016
AbstractforCross-arm binding efficiency of an EGFR x c-Met bispecific antibody | Full Text | References | PDF (1.1 MB)
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Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2
Werner Scheuer, Markus Thomas, Petra Hanke, Johannes Sam, Franz Osl, Diana Weininger, Monika Baehner, Stefan Seeber, Hubert Kettenberger, Jürgen Schanzer, Ulrich Brinkmann, K. Michael Weidner, Jörg Regula & Christian Klein
Pages: 562-573
Published online: 24 Mar 2016
AbstractforAnti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2 | Full Text | References | PDF (972.5 KB)
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Open Access
A bispecific antibody effectively neutralizes all four serotypes of dengue virus by simultaneous blocking virus attachment and fusion
Xin Shi, Yongqiang Deng, Huajing Wang, Guanghui Ji, Wenlong Tan, Tao Jiang, Xiaofeng Li, Hui Zhao, Tian Xia, Yanchun Meng, Chao Wang, Xiaojie Yu, Yang Yang, Bohua Li, E-De Qin, Jianxin Dai, Cheng-Feng Qin & Yajun Guo
Pages: 574-584
Published online: 10 Mar 2016
AbstractforA bispecific antibody effectively neutralizes all four serotypes of dengue virus by simultaneous blocking virus attachment and fusion | Full Text | References | PDF (983.5 KB)
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The application of mathematical modelling to the design of bispecific monoclonal antibodies
Tamara J. van Steeg, Kirsten Riber Bergmann, Nazzareno Dimasi, Kris F. Sachsenmeier & Balaji Agoram
Pages: 585-592
Published online: 04 Mar 2016
AbstractforThe application of mathematical modelling to the design of bispecific monoclonal antibodies | Full Text | References | PDF (859.4 KB) | Supplemental
  • 3475 Views
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Open Access
Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor
Rong Deng, Daniela Bumbaca, Cinthia V. Pastuskovas, C. Andrew Boswell, David West, Kyra J. Cowan, Henry Chiu, Jacqueline McBride, Clarissa Johnson, Yan Xin, Hartmut Koeppen, Maya Leabman & Suhasini Iyer
Pages: 593-603
Published online: 26 Feb 2016
AbstractforPreclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor | Full Text | References | PDF (1.3 MB) | Supplemental
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Pharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2
Nikolai Siebert, Christin Eger, Diana Seidel, Madlen Jüttner, Maxi Zumpe, Danilo Wegner, Silke Kietz, Karoline Ehlert, Gareth J. Veal, Werner Siegmund, Michael Weiss, Hans Loibner, Ruth Ladenstein & Holger N. Lode
Pages: 604-616
Published online: 08 Feb 2016
AbstractforPharmacokinetics and pharmacodynamics of ch14.18/CHO in relapsed/refractory high-risk neuroblastoma patients treated by long-term infusion in combination with IL-2 | Full Text | References | PDF (801.5 KB)
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Meeting Report

Meeting Report
Antibody engineering & therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA
Matthias Pauthner, Jenny Yeung, Chris Ullman, Joost Bakker, Thierry Wurch, Janice M. Reichert, Fridtjof Lund-Johansen, Andrew R.M. Bradbury, Paul J. Carter & Joost P.M. Melis
Pages: 617-652
Published online: 24 Feb 2016
AbstractforAntibody engineering & therapeutics, the annual meeting of the antibody society December 7–10, 2015, San Diego, CA, USA | Full Text | References | PDF (716.2 KB)
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Editor's Corner

Editorial
Note of appreciation to reviewers
Janice M. Reichert (Editor-in-Chief)
Pages: 653-657
Published online: 01 Mar 2016
First Page PreviewforNote of appreciation to reviewers | Full Text | PDF (186.9 KB)
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