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mAbs Volume 9, 2017 - Issue 5
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Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic

Haruki HasegawaDepartment of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USACorrespondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-3464-4715
ORCID Icon,
Ann HsuDepartment of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, USA
,
Christine E. TinbergDepartment of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USAORCID Iconhttp://orcid.org/0000-0002-6179-0435
ORCID Icon,
Karen E. SieglerDepartment of Cardiometabolic Disorders, Amgen Inc., South San Francisco, CA, USA
,
Aaron A. NazarianDepartment of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, USAORCID Iconhttp://orcid.org/0000-0001-7531-6040
ORCID Icon &
Mei-Mei TsaiDepartment of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA, USAORCID Iconhttp://orcid.org/0000-0002-3052-7853
ORCID Icon
Pages 854-873 | Received 21 Feb 2017, Accepted 30 Mar 2017, Published online: 12 May 2017

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Baoshan Cai, Jian Zhao, Yuling Zhang, Yaxing Liu, Chunhong Ma, Fan Yi, Yi Zheng, Lei Zhang, Tian Chen, Huiqing Liu, Bingyu Liu & Chengjiang Gao. (2022) USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3. Autophagy 18:5, pages 990-1004.
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Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer & Anne R Karow-Zwick. (2020) Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain. mAbs 12:1.
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Haruki Hasegawa, Mei Geng, Randal R. Ketchem, Ling Liu, Kevin Graham & Frederick Jacobsen. (2017) Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum. Cellular Logistics 7:3.
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Articles from other publishers (7)

Alana C. SzkodnyKelvin H. Lee. (2022) Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions. Annual Review of Chemical and Biomolecular Engineering 13:1, pages 141-165.
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Haruki Hasegawa, Kathy Y. Wei, Melissa Thomas, Peng Li, Francis Kinderman, Heather Franey, Ling Liu & Frederick Jacobsen. (2021) Light chain subunit of a poorly soluble human IgG2λ crystallizes in physiological pH environment both in cellulo and in vitro. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:9, pages 119078.
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Sven Mathias, Anna Wippermann, Nadja Raab, Nikolas Zeh, René Handrick, Ingo Gorr, Patrick Schulz, Simon Fischer, Martin Gamer & Kerstin Otte. (2019) Unraveling what makes a monoclonal antibody difficult‐to‐express: From intracellular accumulation to incomplete folding and degradation via ERAD. Biotechnology and Bioengineering 117:1, pages 5-16.
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Elsa Arcalis, Verena Ibl, Julia Hilscher, Thomas Rademacher, Linda Avesani, Francesca Morandini, Luisa Bortesi, Mario Pezzotti, Alessandro Vitale, Dietmar Pum, Thomas De Meyer, Ann Depicker & Eva Stoger. (2019) Russell-Like Bodies in Plant Seeds Share Common Features With Prolamin Bodies and Occur Upon Recombinant Protein Production. Frontiers in Plant Science 10.
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Haruki Hasegawa. (2019) Simultaneous induction of distinct protein phase separation events in multiple subcellular compartments of a single cell. Experimental Cell Research 379:1, pages 92-109.
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Kohei Kaneyoshi, Kouki Kuroda, Keiji Uchiyama, Masayoshi Onitsuka, Noriko Yamano-Adachi, Yuichi Koga & Takeshi Omasa. (2019) Secretion analysis of intracellular “difficult-to-express” immunoglobulin G (IgG) in Chinese hamster ovary (CHO) cells. Cytotechnology 71:1, pages 305-316.
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Sven Mathias, Simon Fischer, René Handrick, Jürgen Fieder, Patrick Schulz, Harald Bradl, Ingo Gorr, Martin Gamer & Kerstin Otte. (2018) Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy. Journal of Biotechnology 271, pages 47-55.
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