mAbs, Volume 9, Issue 5 (2017)

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mAbs, Volume 9, Issue 5 (2017)

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Meeting Report

Meeting Report
Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges
Mohammed Akli Ayoub, Pascale Crépieux, Markus Koglin, Marc Parmentier, Jean-Philippe Pin, Anne Poupon, Eric Reiter, Martine Smit, Jan Steyaert, Hervé Watier & Trevor Wilkinson
Pages: 735-741
Published online: 06 Jun 2017
AbstractforAntibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges | Full Text | References | PDF (410.6 KB)
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Meeting Report
Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use
Fiona Sewell, Kathryn Chapman, Jessica Couch, Maggie Dempster, Shawn Heidel, Lise Loberg, Curtis Maier, Timothy K. Maclachlan, Marque Todd & Jan Willem van der Laan
Pages: 742-755
Published online: 26 Jun 2017
AbstractforChallenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use | Full Text | References | PDF (668.2 KB)
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Review

Review
Pharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates
Miroslav Dostalek, Thomayant Prueksaritanont & Robert F. Kelley
Pages: 756-766
Published online: 08 Jun 2017
AbstractforPharmacokinetic de-risking tools for selection of monoclonal antibody lead candidates | Full Text | References | PDF (606.7 KB)
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Short Communication

Rapid Communication
Affinity of human IgG subclasses to mouse Fc gamma receptors
Gillian Dekkers, Arthur E. H. Bentlage, Tamara C. Stegmann, Heather L. Howie, Suzanne Lissenberg-Thunnissen, James Zimring, Theo Rispens & Gestur Vidarsson
Pages: 767-773
Published online: 07 Jun 2017
AbstractforAffinity of human IgG subclasses to mouse Fc gamma receptors | Full Text | References | PDF (697.7 KB) | Supplemental
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Perspective

Article Commentary
Contribution of physiologists to the identification of the humoral component of immunity in the 19th century
Yves-Marie Lahaie & Hervé Watier
Pages: 774-780
Published online: 22 Jun 2017
AbstractforContribution of physiologists to the identification of the humoral component of immunity in the 19th century | Full Text | References | PDF (838.5 KB)
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Report

Report
Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms
Claudia A. Castro Jaramillo, Sara Belli, Anne-Christine Cascais, Sherri Dudal, Martin R. Edelmann, Markus Haak, Marie-Elise Brun, Michael B. Otteneder, Mohammed Ullah, Christoph Funk, Franz Schuler & Silke Simon
Pages: 781-791
Published online: 25 May 2017
AbstractforToward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms | Full Text | References | PDF (749.1 KB) | Supplemental
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Report
Population pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults
Yunda Huang, Lily Zhang, Julie Ledgerwood, Nicole Grunenberg, Robert Bailer, Abby Isaacs, Kelly Seaton, Kenneth H. Mayer, Edmund Capparelli, Larry Corey & Peter B. Gilbert
Pages: 792-800
Published online: 19 May 2017
AbstractforPopulation pharmacokinetics analysis of VRC01, an HIV-1 broadly neutralizing monoclonal antibody, in healthy adults | Full Text | References | PDF (1.1 MB) | Supplemental
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Report
Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates
Thomas Botzanowski, Stéphane Erb, Oscar Hernandez-Alba, Anthony Ehkirch, Olivier Colas, Elsa Wagner-Rousset, David Rabuka, Alain Beck, Penelope M. Drake & Sarah Cianférani
Pages: 801-811
Published online: 25 May 2017
AbstractforInsights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates | Full Text | References | PDF (1 MB) | Supplemental
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Report
High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein
Chris Spahr, Kannan Gunasekaran, Kenneth W. Walker & Stone D.-H. Shi
Pages: 812-819
Published online: 14 Jun 2017
AbstractforHigh-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein | Full Text | References | PDF (1.2 MB)
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Report
Unbiased in-depth characterization of CEX fractions from a stressed monoclonal antibody by mass spectrometry
François Griaud, Blandine Denefeld, Manuel Lang, Héloïse Hensinger, Peter Haberl & Matthias Berg
Pages: 820-830
Published online: 19 May 2017
AbstractforUnbiased in-depth characterization of CEX fractions from a stressed monoclonal antibody by mass spectrometry | Full Text | References | PDF (1.4 MB) | Supplemental
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Report
Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV
Lisa C. Schmitt, Alexander Rau, Oliver Seifert, Jonas Honer, Meike Hutt, Simone Schmid, Jonas Zantow, Michael Hust, Stefan Dübel, Monilola A. Olayioye & Roland E. Kontermann
Pages: 831-843
Published online: 06 Jun 2017
AbstractforInhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1929 Views
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Report
Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody
Atsuhiko Maeda, Yuki Iwayanagi, Kenta Haraya, Tatsuhiko Tachibana, Genki Nakamura, Takeru Nambu, Keiko Esaki, Kunihiro Hattori & Tomoyuki Igawa
Pages: 844-853
Published online: 04 May 2017
AbstractforIdentification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody | Full Text | References | PDF (1 MB) | Supplemental
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Report
Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic
Haruki Hasegawa, Ann Hsu, Christine E. Tinberg, Karen E. Siegler, Aaron A. Nazarian & Mei-Mei Tsai
Pages: 854-873
Published online: 12 May 2017
AbstractforSingle amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic | Full Text | References | PDF (2.9 MB) | Supplemental
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Report
Infliximab crystal structures reveal insights into self-association
Thomas F. Lerch, Penelope Sharpe, Stephen J. Mayclin, Thomas E. Edwards, Eunhee Lee, Hugh D. Conlon, Sharon Polleck, Jason C. Rouse, Yin Luo & Qin Zou
Pages: 874-883
Published online: 25 May 2017
AbstractforInfliximab crystal structures reveal insights into self-association | Full Text | References | PDF (1.7 MB)
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