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Eva M Soriano Jerez, Jonathan M Gibbins & Craig E Hughes. (2021) Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B. Platelets 32:6, pages 761-769.
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Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam & Steve P. Watson. (2021) Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2. Platelets 32:6, pages 744-752.
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Hari Hara Sudhan Lakshmanan, Alexander R. Melrose, Anna-Liisa I. Sepp, Annachiara Mitrugno, Anh T. P. Ngo, Ayesha Khader, Rachel Thompson, Daniel Sallee, Jiaqing Pang, Pierre H. Mangin, Martine Jandrot-Perrus, Joseph E. Aslan & Owen J.T. McCarty. (2021) The basement membrane protein nidogen-1 supports platelet adhesion and activation. Platelets 32:3, pages 424-428.
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Maan H. Harbi, Christopher W. Smith, Phillip L. R. Nicolson, Steve P. Watson & Mark R. Thomas. (2021) Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases. Platelets 32:1, pages 29-41.
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Fawaz O. Alenazy & Mark R. Thomas. (2021) Novel antiplatelet targets in the treatment of acute coronary syndromes. Platelets 32:1, pages 15-28.
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Articles from other publishers (47)
Yujia Ye, Lihong Yang, Min Leng, Qian Wang, Jiankui Wu, Wen Wan, Huawei Wang, Longjun Li, Yunzhu Peng, Shengjie Chai & Zhaohui Meng. (2023) Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis. Frontiers in Pharmacology 14.
Crossref
Crossref
Martha M. S. Sim, Semekidus Shiferawe & Jeremy P. Wood. (2023) Novel strategies in antithrombotic therapy: targeting thrombosis while preserving hemostasis. Frontiers in Cardiovascular Medicine 10.
Crossref
Crossref
Meinrad Gawaz, Tobias Geisler & Oliver Borst. (2023) Current concepts and novel targets for antiplatelet therapy. Nature Reviews Cardiology 20:9, pages 583-599.
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Crossref
Camila Alves-Mondini, Martina Beltramino, Isabella Gizzi Jiacomini, Sabrina Karim-Silva, Nicolle dos Santos Antunes, Juliana de Moura, Nicolas Aubrey, Philippe Billiald, Ricardo Andrez Machado-de-Ávila, Larissa M. Alvarenga & Alessandra Becker-Finco. (2023) Identification of a common epitope in knottins and phospholipases D present in Loxosceles sp venom by a monoclonal antibody. International Journal of Biological Macromolecules 246, pages 125588.
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Pierre H. Mangin, Elizabeth E. Gardiner, Robert A.S. Ariëns & Martine Jandrot-Perrus. (2023) Glycoprotein VI interplay with fibrin(ogen) in thrombosis. Journal of Thrombosis and Haemostasis 21:7, pages 1703-1713.
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Philippe Billiald, Alexandre Slater, Martin Welin, Joanne C. Clark, Stéphane Loyau, Martine Pugnière, Isabella G. Jiacomini, Nadia Rose, Kristell Lebozec, Elie Toledano, Déborah François, Steve P. Watson & Martine Jandrot-Perrus. (2023) Targeting platelet GPVI with glenzocimab: a novel mechanism for inhibition. Blood Advances 7:7, pages 1258-1268.
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Sanghwan Ko, Man-Seok Ju, Hye-Mi Ahn, Jung-Hyun Na, Woo Hyung Ko, Migyeong Jo, Munsu Kyung, Chung Su Lim, Byoung Joon Ko, Won-Kyu Lee, Youn-Jae Kim & Sang Taek Jung. (2022) Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity, Developability, and Serum Persistence Exhibits Excellent Antitumor Potency. Molecular Pharmaceutics 20:2, pages 1247-1255.
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Foteini-Nafsika Damaskinaki, Natalie J. Jooss, Eleyna M. Martin, Joanne C. Clark, Mark R. Thomas, Natalie S. Poulter, Jonas Emsley, Barrie Kellam, Steve P. Watson & Alexandre Slater. (2023) Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization. Journal of Thrombosis and Haemostasis 21:2, pages 317-328.
Crossref
Crossref
Paolo Gresele & Stefania Momi. (2022) Novel approaches to antiplatelet therapy. Biochemical Pharmacology 206, pages 115297.
Crossref
Crossref
Ignacio Barriuso, Fernando Worner & Gemma Vilahur. (2022) Novel Antithrombotic Agents in Ischemic Cardiovascular Disease: Progress in the Search for the Optimal Treatment. Journal of Cardiovascular Development and Disease 9:11, pages 397.
Crossref
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Surasak Wichaiyo, Warisara Parichatikanond & Wipharak Rattanavipanon. (2022) Glenzocimab: A GPVI (Glycoprotein VI)-Targeted Potential Antiplatelet Agent for the Treatment of Acute Ischemic Stroke. Stroke 53:11, pages 3506-3513.
Crossref
Crossref
Natalie J. Jooss, Christopher W. Smith, Alexandre Slater, Samantha J. Montague, Ying Di, Christopher O'Shea, Mark R. Thomas, Yvonne M.C. Henskens, Johan W.M. Heemskerk, Steve P. Watson & Natalie S. Poulter. (2022) Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation. Journal of Thrombosis and Haemostasis 20:11, pages 2617-2631.
Crossref
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María Fernanda Aguilar, A. Sergio Garay, Carolina Attallah, Daniel E. Rodrigues & Marcos Oggero. (2022) Changes in antibody binding and functionality after humanizing a murine scFv anti-IFN-α2: From in silico studies to experimental analysis. Molecular Immunology 151, pages 193-203.
Crossref
Crossref
Isabella Gizzi Jiacomini, Martina Beltramino, Fanny Boursin, João Carlos Minozzo, Juliana Ferreira de Moura, Philippe Billiald, Larissa Magalhães Alvarenga & Nicolas Aubrey. (2022) An effective strategy for the humanization of antibody fragments under an accelerated timeline. International Journal of Biological Macromolecules 216, pages 465-474.
Crossref
Crossref
Wan-Jung Lu, Chung-Hsin Tsai, Ray-Jade Chen, Li-Ting Huang, Ting-Yu Chen, Lih-Chyang Chen, Hsueh-Hsiao Wang, Hsien-Yu Peng, Yu-Yo Sun & Kuan-Hung Lin. (2022) Artesunate as a glycoprotein VI antagonist for preventing platelet activation and thrombus formation. Biomedicine & Pharmacotherapy 153, pages 113531.
Crossref
Crossref
Eduardo Fuentes. (2022) Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target. International Journal of Molecular Sciences 23:17, pages 9882.
Crossref
Crossref
Joanna Shu Ting Liu, Yiran Ding, Simone Schoenwaelder & Xuyu Liu. (2022) Improving treatment for acute ischemic stroke—Clot busting innovation in the pipeline. Frontiers in Medical Technology 4.
Crossref
Crossref
Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Konstantinos Tsioufis & Dimitris Tousoulis. (2022) Factors Associated with Platelet Activation-Recent Pharmaceutical Approaches. International Journal of Molecular Sciences 23:6, pages 3301.
Crossref
Crossref
Holly Foster, Clare WilsonJulia S. GauerRui-Gang XuMark J. HowardIain W. ManfieldRobert AriënsKhalid NaseemLewis R. VidlerHelen PhilippouRichard Foster. (2022) A Comparative Assessment Study of Known Small-molecule GPVI Modulators. ACS Medicinal Chemistry Letters 13:2, pages 171-181.
Crossref
Crossref
Georges Jourdi, Marie Lordkipanidzé, Aurélien Philippe, Christilla Bachelot-Loza & Pascale Gaussem. (2021) Current and Novel Antiplatelet Therapies for the Treatment of Cardiovascular Diseases. International Journal of Molecular Sciences 22:23, pages 13079.
Crossref
Crossref
Tzenge‐Lien Shih, Kuan‐Hung Lin, Ray‐Jade Chen, Ting‐Yu Chen, Wei‐Ting Kao, Jen‐Wei Liu, Hsueh‐Hsiao Wang, Hsien‐Yu Peng, Yu‐Yo Sun & Wan‐Jung Lu. (2021) A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI. Journal of Cellular and Molecular Medicine 25:19, pages 9434-9446.
Crossref
Crossref
Alexandre Slater, Ying Di, Joanne C. Clark, Natalie J. JoossEleyna M. Martin, Fawaz Alenazy, Mark R. Thomas, Robert A. S. Ariëns, Andrew B. Herr, Natalie S. Poulter, Jonas Emsley & Steve P. Watson. (2021) Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. Blood 137:24, pages 3443-3453.
Crossref
Crossref
Oliver Borst & Meinrad Gawaz. (2021) Glycoprotein VI - novel target in antiplatelet medication. Pharmacology & Therapeutics 217, pages 107630.
Crossref
Crossref
Soumaya Jadoui, Ophélie Le Chapelain, Véronique Ollivier, Ali Mostefa-Kara, Lucas Di Meglio, Sébastien Dupont, Angèle Gros, Mialitiana Solo Nomenjanahary, Jean-Philippe Desilles, Mikaël Mazighi, Bernhard Nieswandt, Stéphane Loyau, Martine Jandrot-Perrus, Pierre H Mangin & Benoit Ho-Tin-Noé. (2020) Glenzocimab does not impact glycoprotein VI-dependent inflammatory hemostasis. Haematologica 106:7, pages 2000-2003.
Crossref
Crossref
Holly FosterClare WilsonHelen PhilippouRichard Foster. (2020) Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis. Journal of Medicinal Chemistry 63:21, pages 12213-12242.
Crossref
Crossref
Paquita Nurden, Simon Stritt, Remi Favier & Alan T. Nurden. (2020) Inherited platelet diseases with normal platelet count: phenotypes, genotypes and diagnostic strategy. Haematologica 106:2, pages 337-350.
Crossref
Crossref
Ivan Peyron, Claire Kizlik‐Masson, Marie‐Daniéla Dubois, Sénadé Atsou, Stephen Ferrière, Cécile V. Denis, Peter J. Lenting, Caterina Casari & Olivier D. Christophe. (2020) Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications. Research and Practice in Thrombosis and Haemostasis 4:7, pages 1087-1100.
Crossref
Crossref
Shuchi GuptaLawrence F. Brass. (2020) Glycoprotein VI Blockade. Arteriosclerosis, Thrombosis, and Vascular Biology 40:9, pages 1964-1966.
Crossref
Crossref
Muhammad Usman AhmedValeria KanevaStéphane Loyau, Dmitry NechipurenkoNicolas Receveur, Marion Le BrisEmily Janus-BellMélusine DidelotAntoine Rauch, Sophie SusenNabil ChakféFrançois Lanza, Elizabeth E. Gardiner, Robert K. Andrews, Mikhail PanteleevChristian Gachet, Martine Jandrot-PerrusPierre H. Mangin. (2020) Pharmacological Blockade of Glycoprotein VI Promotes Thrombus Disaggregation in the Absence of Thrombin. Arteriosclerosis, Thrombosis, and Vascular Biology 40:9, pages 2127-2142.
Crossref
Crossref
Lionel Renaud, Kristell Lebozec, Christine Voors‐Pette, Peter Dogterom, Philippe Billiald, Martine Jandrot Perrus, Yannick Pletan & Matthias Machacek. (2020) Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen‐Induced Platelet Aggregation. The Journal of Clinical Pharmacology 60:9, pages 1198-1208.
Crossref
Crossref
Annamaria Sandomenico, Jwala P. Sivaccumar & Menotti Ruvo. (2020) Evolution of Escherichia coli Expression System in Producing Antibody Recombinant Fragments. International Journal of Molecular Sciences 21:17, pages 6324.
Crossref
Crossref
Bastiaan Zwart, William A. E. Parker & Robert F. Storey. (2020) New Antithrombotic Drugs in Acute Coronary Syndrome. Journal of Clinical Medicine 9:7, pages 2059.
Crossref
Crossref
Nigel Mackman, Wolfgang Bergmeier, George A. Stouffer & Jeffrey I. Weitz. (2020) Therapeutic strategies for thrombosis: new targets and approaches. Nature Reviews Drug Discovery 19:5, pages 333-352.
Crossref
Crossref
Sabrina Karim-Silva, Alessandra Becker-Finco, Isabella Gizzi Jiacomini, Fanny Boursin, Arnaud Leroy, Magali Noiray, Juliana de Moura, Nicolas Aubrey, Philippe Billiald & Larissa M. Alvarenga. (2020) Loxoscelism: Advances and Challenges in the Design of Antibody Fragments with Therapeutic Potential. Toxins 12:4, pages 256.
Crossref
Crossref
Thomas Cnudde, Zineb Lakhrif, Justine Bourgoin, Fanny Boursin, Catherine Horiot, Corinne Henriquet, Anne di Tommaso, Matthieu Olivier Juste, Isabella Gizzi Jiacomini, Isabelle Dimier-Poisson, Martine Pugnière, Marie-Nöelle Mévélec & Nicolas Aubrey. (2020) Exploration and Modulation of Antibody Fragment Biophysical Properties by Replacing the Framework Region Sequences. Antibodies 9:2, pages 9.
Crossref
Crossref
Samantha J. Montague, Yean J. Lim, Woei M. Lee & Elizabeth E. Gardiner. (2020) Imaging Platelet Processes and Function—Current and Emerging Approaches for Imaging in vitro and in vivo. Frontiers in Immunology 11.
Crossref
Crossref
Mark L. Chiu, Dennis R. Goulet, Alexey Teplyakov & Gary L. Gilliland. (2019) Antibody Structure and Function: The Basis for Engineering Therapeutics. Antibodies 8:4, pages 55.
Crossref
Crossref
Yves Gruel, Claire Kizlik-Masson & Peter Lenting. (2020) Les anticorps thérapeutiques en hémostase. médecine/sciences 35:12, pages 1022-1025.
Crossref
Crossref
David Stegner, Vanessa Klaus & Bernhard Nieswandt. (2019) Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury. Frontiers in Immunology 10.
Crossref
Crossref
Christine Voors-PetteKristell LebozecPeter DogteromLaurie JullienPhilippe BillialdPauline FerlanLionel RenaudOlivier Favre-BulleGilles AvenardMatthias MachacekYannick PlétanMartine Jandrot-Perrus. (2019) Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab. Arteriosclerosis, Thrombosis, and Vascular Biology 39:5, pages 956-964.
Crossref
Crossref
Arjun MajithiaDeepak L. Bhatt. (2019) Novel Antiplatelet Therapies for Atherothrombotic Diseases. Arteriosclerosis, Thrombosis, and Vascular Biology 39:4, pages 546-557.
Crossref
Crossref
Kumaran Kolandaivelu & Deepak L. Bhatt. 2019. Platelets. Platelets
991
1015
.
Elizabeth J. Haining, Phillip L.R. Nicolson, Marie-Blanche Onselaer, Natalie S. Poulter, Julie Rayes, Mark R. Thomas & Steve P. Watson. 2019. Platelets. Platelets
213
226
.
Nicolas Aubrey & Philippe Billiald. 2019. Human Monoclonal Antibodies. Human Monoclonal Antibodies
231
252
.
Kristell Lebozec, Martine Jandrot-Perrus, Gilles Avenard, Olivier Favre-Bulle & Philippe Billiald. (2018) Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development. New Biotechnology 44, pages 31-40.
Crossref
Crossref
Marcus LehmannRogier M. SchoemanPatrick J. KrohlAlison M. WallbankJoseph R. SamaniukMartine Jandrot-PerrusKeith B. Neeves. (2018) Platelets Drive Thrombus Propagation in a Hematocrit and Glycoprotein VI–Dependent Manner in an In Vitro Venous Thrombosis Model. Arteriosclerosis, Thrombosis, and Vascular Biology 38:5, pages 1052-1062.
Crossref
Crossref
Yacine Boulaftali, Marie‐Anne Mawhin, Martine Jandrot‐Perrus & Benoît Ho‐Tin‐Noé. (2018) Glycoprotein VI in securing vascular integrity in inflamed vessels. Research and Practice in Thrombosis and Haemostasis 2:2, pages 228-239.
Crossref
Crossref