mAbs, Volume 9, Issue 6 (2017)

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mAbs, Volume 9, Issue 6 (2017)

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Book Review

Book Review
Safety of biologics therapy: Monoclonal antibodies, cytokines, fusion proteins, hormones, enzymes, coagulation proteins, vaccines, botulinum toxins
Stephen Mahler
Pages: 885-888
Published online: 19 Jul 2017
First Page PreviewforSafety of biologics therapy: Monoclonal antibodies, cytokines, fusion proteins, hormones, enzymes, coagulation proteins, vaccines, botulinum toxins | Full Text | PDF (313.8 KB)
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Short Communication

Rapid Communication
Impact of S-sulfocysteine on fragments and trisulfide bond linkages in monoclonal antibodies
Ronja Seibel, Sandra Maier, Alisa Schnellbaecher, Susanne Bohl, Maria Wehsling, Anne Zeck & Aline Zimmer
Pages: 889-897
Published online: 25 Jul 2017
AbstractforImpact of S-sulfocysteine on fragments and trisulfide bond linkages in monoclonal antibodies | Full Text | References | PDF (869.3 KB) | Supplemental
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Perspective

Article Commentary
Changes to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more
Paul W. H. I. Parren, Paul J. Carter & Andreas Plückthun
Pages: 898-906
Published online: 12 Jul 2017
AbstractforChanges to International Nonproprietary Names for antibody therapeutics 2017 and beyond: of mice, men and more | Full Text | References | PDF (731.4 KB)
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Report

Report
Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins
Jared L. Spidel, Earl F. Albone, Xin Cheng, Benjamin Vaessen, Sara Jacob, Andrew Z. Milinichik, Arielle Verdi, J. Bradford Kline & Luigi Grasso
Pages: 907-915
Published online: 29 Jun 2017
AbstractforEngineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins | Full Text | References | PDF (1.1 MB) | Supplemental
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Report
Evidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody
Yin Luo, Stephen W. Raso, Judith Gallant, Colleen Steinmeyer, Yasuko Mabuchi, Zhaojiang Lu, Clifford Entrican & Jason C. Rouse
Pages: 916-926
Published online: 05 Jul 2017
AbstractforEvidence for intermolecular domain exchange in the Fab domains of dimer and oligomers of an IgG1 monoclonal antibody | Full Text | References | PDF (1.3 MB)
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Report
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis
Alain P. Vicari, Alain M. Schoepfer, Bertrand Meresse, Laurence Goffin, Olivier Léger, Soheila Josserand, Nicolas Guégan, Shida Yousefi, Alex Straumann, Nadine Cerf-Bensussan, Hans-Uwe Simon & Yolande Chvatchko
Pages: 927-944
Published online: 05 Jul 2017
AbstractforDiscovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis | Full Text | References | PDF (1.3 MB) | Supplemental
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Report
Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks
Kristell Lebozec, Martine Jandrot-Perrus, Gilles Avenard, Olivier Favre-Bulle & Philippe Billiald
Pages: 945-958
Published online: 12 Jul 2017
AbstractforDesign, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks | Full Text | References | PDF (1.5 MB)
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Report
Tuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning
Patrick Koenig, Sarah Sanowar, Chingwei V. Lee & Germaine Fuh
Pages: 959-967
Published online: 07 Jul 2017
AbstractforTuning the specificity of a Two-in-One Fab against three angiogenic antigens by fully utilizing the information of deep mutational scanning | Full Text | References | PDF (1 MB)
  • 2006 Views
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Report
Glycosylation profile and biological activity of Remicade® compared with Flixabi® and Remsima®
Changsoo Lee, Min Jeong, JongAh Joanne Lee, Saebom Seo, Sung Chun Cho, Wei Zhang & Orlando Jaquez
Pages: 968-977
Published online: 12 Jul 2017
AbstractforGlycosylation profile and biological activity of Remicade® compared with Flixabi® and Remsima® | Full Text | References | PDF (1.1 MB)
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Report
Improved sequence variant analysis strategy by automated false positive removal
Wenzhou Li, Jette Wypych & Robert J. Duff
Pages: 978-984
Published online: 19 Jul 2017
AbstractforImproved sequence variant analysis strategy by automated false positive removal | Full Text | References | PDF (982.7 KB)
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Report
Characterization of a novel modification of a CHO-produced mAb: Evidence for the presence of tyrosine sulfation
Jia Zhao, Jason Saunders, Svetlana Dukleska Schussler, Sandra Rios, Francis Kobina Insaidoo, Aleksandr L. Fridman, Huijuan Li & Yan-Hui Liu
Pages: 985-995
Published online: 02 Aug 2017
AbstractforCharacterization of a novel modification of a CHO-produced mAb: Evidence for the presence of tyrosine sulfation | Full Text | References | PDF (1.4 MB)
  • 2016 Views
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Report
A high-throughput platform for population reformatting and mammalian expression of phage display libraries to enable functional screening as full-length IgG
Xiaodong Xiao, Julie A. Douthwaite, Yan Chen, Ben Kemp, Sara Kidd, Jennifer Percival-Alwyn, Alison Smith, Kate Goode, Bonnie Swerdlow, David Lowe, Herren Wu, William F. Dall'Acqua & Partha S. Chowdhury
Pages: 996-1006
Published online: 31 Jul 2017
AbstractforA high-throughput platform for population reformatting and mammalian expression of phage display libraries to enable functional screening as full-length IgG | Full Text | References | PDF (1 MB)
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Report
Quantification of IgG monoclonal antibody clearance in tissues
Miro J. Eigenmann, Ludivine Fronton, Hans Peter Grimm, Michael B. Otteneder & Ben-Fillippo Krippendorff
Pages: 1007-1015
Published online: 27 Jul 2017
AbstractforQuantification of IgG monoclonal antibody clearance in tissues | Full Text | References | PDF (927.1 KB) | Supplemental
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Report
Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease
Matthias Vandesquille, Tengfei Li, Chrystelle Po, Christelle Ganneau, Pascal Lenormand, Clémence Dudeffant, Christian Czech, Fiona Grueninger, Charles Duyckaerts, Benoît Delatour, Marc Dhenain, Pierre Lafaye & Sylvie Bay
Pages: 1016-1027
Published online: 31 Jul 2017
AbstractforChemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease | Full Text | References | PDF (1.4 MB) | Supplemental
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