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mAbs Volume 10, 2018 - Issue 7
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Short Communication

Multi-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control

Bhumit A. PatelBiologics Process Development and Clinical Manufacturing, Merck & Co., Inc., Kenilworth, NJ, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-7970-7759
ORCID Icon,
Adrian GospodarekBiologics Process Development and Clinical Manufacturing, Merck & Co., Inc., Kenilworth, NJ, USA
,
Michael LarkinWyatt Technology Corporation, Santa Barbara, CA, USA
,
Sophia A. KenrickWyatt Technology Corporation, Santa Barbara, CA, USA
,
Mark A. HaverickBiologics Process Development and Clinical Manufacturing, Merck & Co., Inc., Kenilworth, NJ, USA
,
Nihal TugcuBiologics Process Development and Clinical Manufacturing, Merck & Co., Inc., Kenilworth, NJ, USA
,
Mark A. BrowerBiologics Process Development and Clinical Manufacturing, Merck & Co., Inc., Kenilworth, NJ, USA
&
Douglas D. RichardsonBiologics Process Development and Clinical Manufacturing, Merck & Co., Inc., Kenilworth, NJ, USAORCID Iconhttps://orcid.org/0000-0001-8488-6758
ORCID Icon show all
Pages 945-950 | Received 16 May 2018, Accepted 24 Jul 2018, Published online: 19 Sep 2018

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Jiarui Wang, Jingyi Chen, Joey Studts & Gang Wang. (2023) In-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy. mAbs 15:1.
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Mariana N. São Pedro, Madelène Isaksson, Joaquín Gomis‐Fons, Michel H. M. Eppink, Bernt Nilsson & Marcel Ottens. (2023) Real‐time detection of mAb aggregates in an integrated downstream process. Biotechnology and Bioengineering 120:10, pages 2989-3000.
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Astrid Dürauer, Alois Jungbauer & Theresa Scharl. (2023) Sensors and chemometrics in downstream processing. Biotechnology and Bioengineering.
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Jorge João & Duarte Miguel F. Prazeres. (2023) Manufacturing of non-viral protein nanocages for biotechnological and biomedical applications. Frontiers in Bioengineering and Biotechnology 11.
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Ashutosh Sharma, Jason Beirne, Dikshitkumar Khamar, Ciaran Maguire, Ambrose Hayden & Helen Hughes. (2023) Evaluation and Screening of Biopharmaceuticals using Multi-Angle Dynamic Light Scattering. AAPS PharmSciTech 24:4.
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Samadhi Nawalage, Pathum Wathudura, Ankai Wang, Max Wamsley, Shengli Zou & Dongmao Zhang. (2023) Effects of Cascading Optical Processes: Part I: Impacts on Quantification of Sample Scattering Extinction, Intensity, and Depolarization. Analytical Chemistry 95:3, pages 1899-1907.
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Matthias Schad, Saurabh Gautam, Tanja A. Grein & Friedrich Käß. 2023. Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs). Bioprocess and Analytics Development for Virus-based Advanced Therapeutics and Medicinal Products (ATMPs) 295 328 .
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Christina Wagner, Bernd Innthaler, Martin Lemmerer, Robert Pletzenauer & Ruth Birner-Gruenberger. (2022) Biophysical Characterization of Adeno-Associated Virus Vectors Using Ion-Exchange Chromatography Coupled to Light Scattering Detectors. International Journal of Molecular Sciences 23:21, pages 12715.
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Alexander Armstrong, Kieran Horry, Tingting Cui, Martyn Hulley, Richard Turner, Suzanne S. Farid, Stephen Goldrick & Daniel G. Bracewell. (2021) Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products. Journal of Chromatography A 1639, pages 461914.
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