mAbs, Volume 10, Issue 7 (2018)

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mAbs, Volume 10, Issue 7 (2018)

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Multi-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control
Bhumit A. Patel, Adrian Gospodarek, Michael Larkin, Sophia A. Kenrick, Mark A. Haverick, Nihal Tugcu, Mark A. Brower & Douglas D. Richardson
Pages: 945-950
Published online: 19 Sep 2018
AbstractforMulti-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control | Full Text | References | PDF (1.4 MB)
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Antibody characterization using novel ERLIC-MS/MS-based peptide mapping
Jing Zhen, John Kim, Ying Zhou, Ervinas Gaidamauskas, Shyamsundar Subramanian & Ping Feng
Pages: 951-959
Published online: 11 Sep 2018
AbstractforAntibody characterization using novel ERLIC-MS/MS-based peptide mapping | Full Text | References | PDF (1.6 MB) | Supplemental
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Characterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry
Jintang He, Shang-Fan Yu, Sharon Yee, Surinder Kaur & Keyang Xu
Pages: 960-967
Published online: 26 Jul 2018
AbstractforCharacterization of in vivo biotransformations for trastuzumab emtansine by high-resolution accurate-mass mass spectrometry | Full Text | References | PDF (3.5 MB) | Supplemental
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Data-independent oxonium ion profiling of multi-glycosylated biotherapeutics
James A. Madsen, Victor Farutin, Yin Yin Lin, Stephen Smith & Ishan Capila
Pages: 968-978
Published online: 01 Aug 2018
AbstractforData-independent oxonium ion profiling of multi-glycosylated biotherapeutics | Full Text | References | PDF (2.4 MB) | Supplemental
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Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid
Rina Fong, Kimberly Kajihara, Matthew Chen, Isidro Hotzel, Sanjeev Mariathasan, Wouter L.W. Hazenbos & Patrick J. Lupardus
Pages: 979-991
Published online: 23 Aug 2018
AbstractforStructural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid | Full Text | References | PDF (6.6 MB)
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Platform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli
Prasad T. Reddy, Robert G. Brinson, J. Todd Hoopes, Colleen McClung, Na Ke, Lila Kashi, Mehmet Berkmen & Zvi Kelman
Pages: 992-1002
Published online: 30 Jul 2018
AbstractforPlatform development for expression and purification of stable isotope labeled monoclonal antibodies in Escherichia coli | Full Text | References | PDF (1.7 MB) | Supplemental
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T-DM1-resistant cells gain high invasive activity via EGFR and integrin cooperated pathways
Yukinori Endo, Yi Shen, Lamis Abou Youssef, Nishant Mohan & Wen Jin Wu
Pages: 1003-1017
Published online: 11 Sep 2018
AbstractforT-DM1-resistant cells gain high invasive activity via EGFR and integrin cooperated pathways | Full Text | References | PDF (7.9 MB)
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The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities
Urmi Dhagat, Timothy R. Hercus, Sophie E. Broughton, Tracy L. Nero, Karen S. Cheung Tung Shing, Emma F. Barry, Christy A. Thomson, Steve Bryson, Emil F. Pai, Barbara J. McClure, John W. Schrader, Angel F. Lopez & Michael W. Parker
Pages: 1018-1029
Published online: 12 Sep 2018
AbstractforThe mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities | Full Text | References | PDF (2.2 MB) | Supplemental
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Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation
J.I. Rodriguez-Barbosa, M.C. Ferreras, L. Buhler, N.D. Jones, P. Schneider, J.A. Perez-Simon & M.L. del Rio
Pages: 1030-1044
Published online: 05 Sep 2018
AbstractforTherapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation | Full Text | References | PDF (3.6 MB) | Supplemental
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Intracellular displacement of p53 using transactivation domain (p53 TAD) specific nanobodies
Anneleen Steels, Adriaan Verhelle, Olivier Zwaenepoel & Jan Gettemans
Pages: 1045-1059
Published online: 11 Sep 2018
AbstractforIntracellular displacement of p53 using transactivation domain (p53 TAD) specific nanobodies | Full Text | References | PDF (2.6 MB) | Supplemental
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Massive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies
Emanuele Sasso, Chiara D’Avino, Margherita Passariello, Anna Morena D’Alise, Daniela Siciliano, Maria Luisa Esposito, Guendalina Froechlich, Riccardo Cortese, Elisa Scarselli, Nicola Zambrano, Alfredo Nicosia & Claudia De Lorenzo
Pages: 1060-1072
Published online: 01 Aug 2018
AbstractforMassive parallel screening of phage libraries for the generation of repertoires of human immunomodulatory monoclonal antibodies | Full Text | References | PDF (3.3 MB) | Supplemental
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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants
Danielle M. DiCara, Nisana Andersen, Ruby Chan, James A. Ernst, Gai Ayalon, Greg A. Lazar, Nicholas J. Agard, Amy Hilderbrand & Isidro Hötzel
Pages: 1073-1083
Published online: 11 Sep 2018
AbstractforHigh-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants | Full Text | References | PDF (2.5 MB) | Supplemental
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Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells
Alessandro Satta, Delia Mezzanzanica, Francesco Caroli, Barbara Frigerio, Massimo Di Nicola, Roland E. Kontermann, Federico Iacovelli, Alessandro Desideri, Andrea Anichini, Silvana Canevari, Alessandro Massimo Gianni & Mariangela Figini
Pages: 1084-1097
Published online: 06 Aug 2018
AbstractforDesign, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells | Full Text | References | PDF (4.4 MB) | Supplemental
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Extending human IgG half-life using structure-guided design
Brian J. Booth, Boopathy Ramakrishnan, Kristin Narayan, Andrew M. Wollacott, Gregory J. Babcock, Zachary Shriver & Karthik Viswanathan
Pages: 1098-1110
Published online: 26 Jul 2018
AbstractforExtending human IgG half-life using structure-guided design | Full Text | References | PDF (3.2 MB) | Supplemental
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Generation and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration
Bryan Smith, Andrea Kiessling, Rocio Lledo-Garcia, Kate L. Dixon, Louis Christodoulou, Matthew C. Catley, Paul Atherfold, Lena E. D’Hooghe, Helene Finney, Kevin Greenslade, Hanna Hailu, Lara Kevorkian, Daniel Lightwood, Christoph Meier, Rebecca Munro, Omar Qureshi, Kaushik Sarkar, Sophie P. Shaw, Roohi Tewari, Alison Turner, Kerry Tyson, Shauna West, Stevan Shaw & Frank R. Brennan
Pages: 1111-1130
Published online: 12 Sep 2018
AbstractforGeneration and characterization of a high affinity anti-human FcRn antibody, rozanolixizumab, and the effects of different molecular formats on the reduction of plasma IgG concentration | Full Text | References | PDF (3.9 MB) | Supplemental
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Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model
Shun xin Wang-Lin, Chenguang Zhou, Amrita V. Kamath, Kyu Hong, Neelima Koppada, Ola M. Saad, Montserrat Carrasco-Triguero, Cyrus Khojasteh & Rong Deng
Pages: 1131-1143
Published online: 06 Aug 2018
AbstractforMinimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model | Full Text | References | PDF (3.2 MB) | Supplemental
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Effects of the FcRn developmental pharmacology on the pharmacokinetics of therapeutic monoclonal IgG antibody in pediatric subjects using minimal physiologically-based pharmacokinetic modelling
Deni Hardiansyah & Chee Meng Ng
Pages: 1144-1156
Published online: 30 Jul 2018
AbstractforEffects of the FcRn developmental pharmacology on the pharmacokinetics of therapeutic monoclonal IgG antibody in pediatric subjects using minimal physiologically-based pharmacokinetic modelling | Full Text | References | PDF (2 MB) | Supplemental
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