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mAbs Volume 10, 2018 - Issue 8
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EFab domain substitution as a solution to the light-chain pairing problem of bispecific antibodies

Heather A. CookeDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USACorrespondence[email protected]
,
Joe ArndtDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA
,
Chao QuanDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA
,
Renée I. ShapiroDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USAORCID Iconhttp://orcid.org/0000-0003-2448-2545
ORCID Icon,
Dingyi WenDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA
,
Susan FoleyDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA
,
Malgorzata M. VecchiDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA
&
Martin PreyerDepartment of Biotherapeutic and Medicinal Sciences, Biogen, Cambridge, MA, USA
 show all
Pages 1248-1259 | Received 07 Feb 2018, Accepted 30 Aug 2018, Published online: 20 Sep 2018

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Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann & Oliver Seifert. (2022) The eIg technology to generate Ig-like bispecific antibodies. mAbs 14:1.
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Kamal Kishore Joshi, Wilson Phung, Guanghui Han, Yiyuan Yin, Ingrid Kim, Wendy Sandoval & Paul J. Carter. (2019) Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells. mAbs 11:7, pages 1254-1265.
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Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter & Roland E. Kontermann. (2019) Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules. mAbs 11:5, pages 919-929.
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Articles from other publishers (6)

Yan He, Haili Ma, Cong Wang, Zhilong Ai, Qiao Wu, Hongyan Chen & Daru Lu. (2023) A novel brick for bispecific antibody construction. Proteins: Structure, Function, and Bioinformatics 91:8, pages 1065-1076.
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Alina Chrzastek, Ioanna A. Thanasi, James A. Irving, Vijay Chudasama & James R. Baker. (2022) Dual reactivity disulfide bridging reagents; enabling new approaches to antibody fragment bioconjugation. Chemical Science 13:39, pages 11533-11539.
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Natasa Vukovic, Samer Halabi, Joan Salvador Russo-Cabrera, Bart Blokhuis, Pedro Berraondo, Frank A.M. Redegeld & Dietmar M.W. Zaiss. (2022) A human IgE bispecific antibody shows potent cytotoxic capacity mediated by monocytes. Journal of Biological Chemistry 298:8, pages 102153.
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Guanghui Xu, Yuting Luo, Hanbing Wang, Yue Wang, Baorui Liu & Jia Wei. (2022) Therapeutic bispecific antibodies against intracellular tumor antigens. Cancer Letters 538, pages 215699.
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Yifeng Li, Ying Wang, Peter (Keqiang) Shen & Weichang Zhou. 2020. Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics. Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics 167 179 .
Aran F. Labrijn, Maarten L. Janmaat, Janice M. Reichert & Paul W. H. I. Parren. (2019) Bispecific antibodies: a mechanistic review of the pipeline. Nature Reviews Drug Discovery 18:8, pages 585-608.
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