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mAbs Volume 11, 2019 - Issue 4
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Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform

Torben GjettingAntibody Discovery, Antibody Discovery, Ballerup, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1720-474X
ORCID Icon,
Monika GadCancer Biology and Immunology, Symphogen A/S, Ballerup, Denmark
,
Camilla FröhlichAntibody Pharmacology, Symphogen A/S, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0001-8391-2416
ORCID Icon,
Trine LindstedCancer Biology and Immunology, Symphogen A/S, Ballerup, Denmark
,
Maria C MelanderAntibody Pharmacology, Symphogen A/S, Ballerup, Denmark
,
Vikram K BhatiaAntibody Discovery, Antibody Discovery, Ballerup, Denmark
,
Michael M GrandalCancer Biology and Immunology, Symphogen A/S, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0001-5434-9978
ORCID Icon,
Nikolaj DietrichAntibody Discovery, Antibody Discovery, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0002-3477-0922
ORCID Icon,
Franziska UhlenbrockCancer Biology and Immunology, Symphogen A/S, Ballerup, Denmark
,
Gunther R GallerAntibody Discovery, Antibody Discovery, Ballerup, Denmark
,
Magnus StrandhAntibody Discovery, Antibody Discovery, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0002-6878-1566
ORCID Icon,
Johan LanttoGlobal Research and Development, Symphogen A/S, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0002-8650-7157
ORCID Icon,
Thomas BouquinAntibody Discovery, Antibody Discovery, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0002-9597-8137
ORCID Icon,
Ivan D HorakGlobal Research and Development, Symphogen A/S, Ballerup, Denmark
,
Michael KraghAntibody Pharmacology, Symphogen A/S, Ballerup, Denmark
,
Mikkel W PedersenCancer Biology and Immunology, Symphogen A/S, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0001-5711-9051
ORCID Icon &
Klaus KoefoedAntibody Discovery, Antibody Discovery, Ballerup, DenmarkORCID Iconhttps://orcid.org/0000-0001-8945-3791
ORCID Icon show all
Pages 666-680 | Received 23 Jan 2019, Accepted 12 Mar 2019, Published online: 03 May 2019

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Ponraj Prabakaran, Sambasiva P Rao & Maria Wendt. (2021) Animal immunization merges with innovative technologies: A new paradigm shift in antibody discovery. mAbs 13:1.
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Kevin E. Knockenhauer & Robert A. Copeland. (2023) The importance of binding kinetics and drug–target residence time in pharmacology. British Journal of Pharmacology.
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Sherif A. El-Kafrawy, Aymn T. Abbas, Christopher Oelkrug, Marwa Tahoon, Sameera Ezzat, Alimuddin Zumla & Esam I. Azhar. (2023) IgY antibodies: The promising potential to overcome antibiotic resistance. Frontiers in Immunology 14.
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Karuppiah Chockalingam, Anil Kumar, Jianxun Song & Zhilei Chen. (2022) Chicken‐derived CD20 antibodies with potent B‐cell depletion activity . British Journal of Haematology 199:4, pages 560-571.
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Saeed Yakhkeshi, Rao Wu, Brindha Chelliappan & Xiaoying Zhang. (2022) Trends in industrialization and commercialization of IgY technology. Frontiers in Immunology 13.
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Adrian Elter, Jan P. Bogen, Jan Habermann & Harald Kolmar. (2021) Vom Huhn abgeleitete Antikörper für Diagnostik und Immuntherapie. BIOspektrum 27:5, pages 500-504.
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Jan P. Bogen, Juliana Storka, Desislava Yanakieva, David Fiebig, Julius Grzeschik, Björn Hock & Harald Kolmar. (2020) Isolation of Common Light Chain Antibodies from Immunized Chickens Using Yeast Biopanning and Fluorescence‐Activated Cell Sorting. Biotechnology Journal 16:3.
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Adrian Elter, Jan P. Bogen, Steffen C. Hinz, David Fiebig, Arturo Macarrón Palacios, Julius Grzeschik, Björn Hock & Harald Kolmar. (2020) Humanization of Chicken‐Derived scFv Using Yeast Surface Display and NGS Data Mining. Biotechnology Journal 16:3.
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Chenyi An, Wei Hu, Jie Gao, Bing-Feng Ju, Peyman Obeidy, Yunduo Charles Zhao, Xiaoxuan Tu, Weijia Fang, Lining Arnold Ju & Wei Chen. (2020) Ultra-stable Biomembrane Force Probe for Accurately Determining Slow Dissociation Kinetics of PD-1 Blockade Antibodies on Single Living Cells. Nano Letters 20:7, pages 5133-5140.
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Ponraj Prabakaran & Partha S. Chowdhury. (2020) Landscape of Non-canonical Cysteines in Human VH Repertoire Revealed by Immunogenetic Analysis. Cell Reports 31:13, pages 107831.
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Michael E. Brown, Daniel Bedinger, Asparouh Lilov, Palaniswami Rathanaswami, Maximiliano Vásquez, Stéphanie Durand, Ian Wallace-Moyer, Lihui Zhong, Juergen H. Nett, Irina Burnina, Isabelle Caffry, Heather Lynaugh, Melanie Sinclair, Tingwan Sun, John Bukowski, Yingda Xu & Yasmina Noubia Abdiche. (2020) Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors. PLOS ONE 15:3, pages e0229206.
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Karuppiah Chockalingam, Zeyu Peng, Christine N. Vuong, Luc R. Berghman & Zhilei Chen. (2020) Golden Gate assembly with a bi-directional promoter (GBid): A simple, scalable method for phage display Fab library creation. Scientific Reports 10:1.
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Eden Kleiman, Wushouer Ouerkaxi, Marc Delcommenne, Geoffrey W. Stone, Paolo Serafini, Mayra Cruz Tleugabulova & Pirouz M. Daftarian. 2020. Immuno-Oncology. Immuno-Oncology 73 88 .
Vishwanatha R. A. P. Reddy, William Mwangi, Yashar Sadigh & Venugopal Nair. (2019) In vitro Interactions of Chicken Programmed Cell Death 1 (PD-1) and PD-1 Ligand-1 (PD-L1). Frontiers in Cellular and Infection Microbiology 9.
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