mAbs, Volume 11, Issue 4 (2019)

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mAbs, Volume 11, Issue 4 (2019)

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Review

Review
Combining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells
Diana Darowski, Sebastian Kobold, Christian Jost & Christian Klein
Pages: 621-631
Published online: 17 Apr 2019
AbstractforCombining the best of two worlds: highly flexible chimeric antigen receptor adaptor molecules (CAR-adaptors) for the recruitment of chimeric antigen receptor T cells | Full Text | References | PDF (1.7 MB) | EPUB
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Brief Report

Brief Report
Controlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency
Chen Chen, Tetsuya Wakabayashi, Masaru Muraoka, Feng Shu, Chia Wei Shan, Chong Chor Kun, Ching Tim Jang, Ishin Soehano, Yuichiro Shimizu, Tomoyuki Igawa & Jun-Ichi Nezu
Pages: 632-638
Published online: 21 Mar 2019
AbstractforControlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 3049 Views
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Report

Report
Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies
Nathan D. Trinklein, Duy Pham, Ute Schellenberger, Ben Buelow, Andrew Boudreau, Priya Choudhry, Starlynn C. Clarke, Kevin Dang, Katherine E. Harris, Suhasini Iyer, Brett Jorgensen, Payal P. Pratap, Udaya S. Rangaswamy, Harshad S. Ugamraj, Omid Vafa, Arun P. Wiita, Wim van Schooten, Roland Buelow & Shelley Force Aldred
Pages: 639-652
Published online: 20 Feb 2019
AbstractforEfficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 16763 Views
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Report
Improved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc
Fabian Richter, Oliver Seifert, Andreas Herrmann, Klaus Pfizenmaier & Roland E. Kontermann
Pages: 653-665
Published online: 31 Mar 2019
AbstractforImproved monovalent TNF receptor 1-selective inhibitor with novel heterodimerizing Fc | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 2227 Views
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Report
Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform
Torben Gjetting, Monika Gad, Camilla Fröhlich, Trine Lindsted, Maria C Melander, Vikram K Bhatia, Michael M Grandal, Nikolaj Dietrich, Franziska Uhlenbrock, Gunther R Galler, Magnus Strandh, Johan Lantto, Thomas Bouquin, Ivan D Horak, Michael Kragh, Mikkel W Pedersen & Klaus Koefoed
Pages: 666-680
Published online: 03 May 2019
AbstractforSym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 6510 Views
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Report
Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy
Hongchuan Liu, Lijing Guo, Jing Zhang, Yuehua Zhou, Jinwei Zhou, Jian Yao, Hai Wu, Sheng Yao, Bo Chen, Yan Chai, Jianxun Qi, George F. Gao, Shuguang Tan, Hui Feng & Jinghua Yan
Pages: 681-690
Published online: 19 Apr 2019
AbstractforGlycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Report
Integrin α-3 ß-1’s central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity
Daniel F. Lusche, Michael R. Klemme, Benjamin A. Soll, Ryan J. Reis, Cristopher C. Forrest, Tiffany S. Nop, Deborah J. Wessels, Brian Berger, Rebecca Glover & David R. Soll
Pages: 691-708
Published online: 16 Apr 2019
AbstractforIntegrin α-3 ß-1’s central role in breast cancer, melanoma and glioblastoma cell aggregation revealed by antibodies with blocking activity | Full Text | References | PDF (8.1 MB) | EPUB | Supplemental
  • 1903 Views
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Report
From Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses
William David Tolbert, Ganesh Prasad Subedi, Neelakshi Gohain, George Kenneth Lewis, Kashyap Rajesh Patel, Adam Wesley Barb & Marzena Pazgier
Pages: 709-724
Published online: 02 Apr 2019
AbstractforFrom Rhesus macaque to human: structural evolutionary pathways for immunoglobulin G subclasses | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 1590 Views
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Report
Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold
Adem C. Koksal, Meghan E. Pennini, Marcello Marelli, Xiaodong Xiao & William F. Dall’Acqua
Pages: 725-734
Published online: 16 Apr 2019
AbstractforFunctional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 1456 Views
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Report
Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies
Yi-Chun Hsiao, Yonglei Shang, Danielle M. DiCara, Angie Yee, Joyce Lai, Si Hyun Kim, Diego Ellerman, Racquel Corpuz, Yongmei Chen, Sharmila Rajan, Hao Cai, Yan Wu, Dhaya Seshasayee & Isidro Hötzel
Pages: 735-746
Published online: 22 Mar 2019
AbstractforImmune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2849 Views
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Report
Development of a high-throughput solubility screening assay for use in antibody discovery
Qing Chai, James Shih, Caroline Weldon, Samantha Phan & Bryan E. Jones
Pages: 747-756
Published online: 26 Mar 2019
AbstractforDevelopment of a high-throughput solubility screening assay for use in antibody discovery | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 5431 Views
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Report
Detection and quantification of free sulfhydryls in monoclonal antibodies using maleimide labeling and mass spectrometry
Anna C. Robotham & John F. Kelly
Pages: 757-766
Published online: 16 Apr 2019
AbstractforDetection and quantification of free sulfhydryls in monoclonal antibodies using maleimide labeling and mass spectrometry | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 10850 Views
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Report
Fast protein sequencing of monoclonal antibody by real-time digestion on emitter during nanoelectrospray
Yuan Mao, Lichao Zhang, Andrew Kleinberg, Qiangwei Xia, Thomas J. Daly & Ning Li
Pages: 767-778
Published online: 07 May 2019
AbstractforFast protein sequencing of monoclonal antibody by real-time digestion on emitter during nanoelectrospray | Full Text | References | PDF (6.9 MB) | EPUB | Supplemental
  • 2769 Views
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Report
Hydrogen/deuterium exchange-mass spectrometry analysis of high concentration biotherapeutics: application to phase-separated antibody formulations
Yuwei Tian, Lihua Huang, Brandon T. Ruotolo & Ning Wang
Pages: 779-788
Published online: 19 Mar 2019
AbstractforHydrogen/deuterium exchange-mass spectrometry analysis of high concentration biotherapeutics: application to phase-separated antibody formulations | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 3311 Views
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Report
Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions
Qun Du, Melissa Damschroder, Timothy M. Pabst, Alan K. Hunter, William K. Wang & Haibin Luo
Pages: 789-802
Published online: 14 Apr 2019
AbstractforProcess optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions | Full Text | References | PDF (4.2 MB) | EPUB
  • 2546 Views
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