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mAbs Volume 11, 2019 - Issue 6
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Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease

Robert J. BenschopBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USAORCID Iconhttps://orcid.org/0000-0001-6313-5218
ORCID Icon,
Chi-Kin ChowBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
,
Yu TianBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
,
James NelsonBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USA
,
Barbra BarmettlerBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USAORCID Iconhttps://orcid.org/0000-0002-3333-4846
ORCID Icon,
Shane AtwellBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USAORCID Iconhttps://orcid.org/0000-0002-2578-2462
ORCID Icon,
David ClawsonDiscovery Chemistry Research and Technologies, Eli Lilly and Company Corporate Center, Indianapolis, IN, USAORCID Iconhttps://orcid.org/0000-0002-1593-0214
ORCID Icon,
Qing ChaiBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USAORCID Iconhttps://orcid.org/0000-0002-6273-905X
ORCID Icon,
Bryan JonesBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USAORCID Iconhttps://orcid.org/0000-0003-4764-6290
ORCID Icon,
Jon FitchettBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USA
,
Stacy TorgersonDepartment of Drug Disposition Development/Commercialization; Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
,
Yan Ji
ORCID Icon,
Holly BinaBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
,
Ningjie HuBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USAORCID Iconhttps://orcid.org/0000-0002-2786-4250
ORCID Icon,
Mahmoud Ghanem
ORCID Icon,
Joseph ManettaBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
,
Victor J. WroblewskiDepartment of Drug Disposition Development/Commercialization; Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
,
Jirong LuBiotechnology Discovery Research, Lilly Research Laboratories, Eli Lilly and Company Corporate Center, Indianapolis, IN, USA
&
Barrett W. AllanBiotechnology Discovery Research, Applied Molecular Evolution, Eli Lilly and Company, San Diego, CA, USACorrespondence[email protected]
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Pages 1175-1190 | Received 24 Jan 2019, Accepted 22 May 2019, Published online: 10 Jun 2019

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Soledad Retamozo, Antoni Sisó-Almirall, Alejandra Flores-Chávez, Manuel Ramos-Casals & Pilar Brito-Zerón. (2021) An update of targeted therapeutic options for primary Sjögren syndrome: current status and future development. Expert Opinion on Pharmacotherapy 22:17, pages 2359-2371.
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Adam R. Root, Gurkan Guntas, Madan Katragadda, James R. Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C. King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fang Jin, Nicole Piche-Nicholas, Sinead E. Keating, Fernando Narciandi, Rosemary Lawrence-Henderson, Maya Arai, Wayne R. Stochaj, Kristine Svenson, Lidia Mosyak, Khetemcnee Lam, Christopher Francis, Kimberly Marquette, Liliana Wroblewska, H. Lily Zhu, Alfredo Darmanin Sheehan, Edward R. LaVallie, Aaron M. D’Antona, Alison Betts, Lindsay King, Edward Rosfjord, Orla Cunningham, Laura Lin, Puja Sapra, Lioudmila Tchistiakova, Divya Mathur & Laird Bloom. (2021) Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors. mAbs 13:1.
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Lauren M. Mathias & William Stohl. (2020) Systemic lupus erythematosus (SLE): emerging therapeutic targets. Expert Opinion on Therapeutic Targets 24:12, pages 1283-1302.
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Xuhong Zhao, Qian Ning, Zhongcheng Mo & Shengsong Tang. (2019) A promising cancer diagnosis and treatment strategy: targeted cancer therapy and imaging based on antibody fragment. Artificial Cells, Nanomedicine, and Biotechnology 47:1, pages 3621-3630.
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Gudny Ella Thorlacius, Albin Björk & Marie Wahren-Herlenius. (2023) Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies. Nature Reviews Rheumatology 19:5, pages 288-306.
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E. L. Nasonov, A. S. Avdeeva, T. V. Korotaeva, T. V. Dubinina & Ju. V. Usacheva. (2023) The role of interleukin 17 in the pathogenesis of rheumatoid arthritis. Are there any prospects for the use of IL-17 inhibitors?. Rheumatology Science and Practice 61:2, pages 165-180.
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Clio P. Mavragani & Haralampos M. Moutsopoulos. (2020) Sjögren's syndrome: Old and new therapeutic targets. Journal of Autoimmunity 110, pages 102364.
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Qi Zhao. (2020) Bispecific Antibodies for Autoimmune and Inflammatory Diseases: Clinical Progress to Date. BioDrugs 34:2, pages 111-119.
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Nicole Swope, Wai Keen Chung, Mingyan Cao, Dana Motabar, Dengfeng Liu, Sanjeev Ahuja & Michael Handlogten. (2020) Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation. Biotechnology and Bioengineering 117:4, pages 1063-1071.
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Matthew I J Raybould, Claire Marks, Alan P Lewis, Jiye Shi, Alexander Bujotzek, Bruck Taddese & Charlotte M Deane. (2020) Thera-SAbDab: the Therapeutic Structural Antibody Database. Nucleic Acids Research 48:D1, pages D383-D388.
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Samantha J. Allen & Kevin J. Lumb. 2020. 253 303 .

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