mAbs, Volume 11, Issue 6 (2019)

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mAbs, Volume 11, Issue 6 (2019)

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Antibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan
David M. Goldenberg & Robert M. Sharkey
Pages: 987-995
Published online: 18 Jul 2019
AbstractforAntibody-drug conjugates targeting TROP-2 and incorporating SN-38: A case study of anti-TROP-2 sacituzumab govitecan | Full Text | References | PDF (2 MB) | EPUB
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Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members
Yanli Yang, Sherry H. Yeh, Shravan Madireddi, Wadim L. Matochko, Chen Gu, Patricia Pacheco Sanchez, Mark Ultsch, Gladys De Leon Boenig, Seth F. Harris, Brandon Leonard, Suzie J. Scales, Jing W. Zhu, Erin Christensen, Julie Q. Hang, Randall J. Brezski, Scot Marsters, Avi Ashkenazi, Siddharth Sukumaran, Henry Chiu, Rafael Cubas, Jeong M. Kim & Greg A. Lazar
Pages: 996-1011
Published online: 20 Jun 2019
AbstractforTetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Influence of the bispecific antibody IgG subclass on T cell redirection
Stephanie Kapelski, Erna Cleiren, Ricardo M. Attar, Ulrike Philippar, Julien Häsler & Mark L. Chiu
Pages: 1012-1024
Published online: 26 Jun 2019
AbstractforInfluence of the bispecific antibody IgG subclass on T cell redirection | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Rapid single B cell antibody discovery using nanopens and structured light
Aaron Winters, Karyn McFadden, John Bergen, Julius Landas, Kelly A. Berry, Anthony Gonzalez, Hossein Salimi-Moosavi, Christopher M. Murawsky, Philip Tagari & Chadwick T. King
Pages: 1025-1035
Published online: 11 Jun 2019
AbstractforRapid single B cell antibody discovery using nanopens and structured light | Full Text | References | PDF (2.9 MB) | EPUB
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Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα
Janet Sim, Jonathan T. Sockolosky, Emma Sangalang, Shelley Izquierdo, Darlene Pedersen, William Harriman, Ardian S. Wibowo, Josh Carter, Anup Madan, Laura Doyle, Ons Harrabi, Steven E. Kauder, Amy Chen, Tracy C. Kuo, Hong Wan & Jaume Pons
Pages: 1036-1052
Published online: 01 Jul 2019
AbstractforDiscovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRPα | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
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Site-specific N- and O-glycosylation analysis of atacicept
Kathrin Stavenhagen, Rabah Gahoual, Elena Dominguez Vega, Angelo Palmese, Agnes L. Hipgrave Ederveen, Francesca Cutillo, Wolf Palinsky, Horst Bierau & Manfred Wuhrer
Pages: 1053-1063
Published online: 26 Jul 2019
AbstractforSite-specific N- and O-glycosylation analysis of atacicept | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis
Mingyan Cao, Niluka De Mel, Yang Jiao, James Howard, Conner Parthemore, Samuel Korman, Christopher Thompson, Michaela Wendeler & Dengfeng Liu
Pages: 1064-1076
Published online: 14 Jun 2019
AbstractforSite-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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CDR-H3 loop ensemble in solution – conformational selection upon antibody binding
Monica L. Fernández-Quintero, Johannes Kraml, Guy Georges & Klaus R. Liedl
Pages: 1077-1088
Published online: 09 Jun 2019
AbstractforCDR-H3 loop ensemble in solution – conformational selection upon antibody binding | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Rapid global characterization of immunoglobulin G1 following oxidative stress
Yao Chen, Emma Doud, Todd Stone, Lun Xin, Wei Hong & Yunsong Li
Pages: 1089-1100
Published online: 04 Jul 2019
AbstractforRapid global characterization of immunoglobulin G1 following oxidative stress | Full Text | References | PDF (11.2 MB) | EPUB | Supplemental
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Using bispecific antibodies in forced degradation studies to analyze the structure–function relationships of symmetrically and asymmetrically modified antibodies
Adam R. Evans, Michael T. Capaldi, Geetha Goparaju, David Colter, Frank F. Shi, Sarah Aubert, Lian-Chao Li, Jingjie Mo, Michael J. Lewis, Ping Hu, Pedro Alfonso & Promod Mehndiratta
Pages: 1101-1112
Published online: 04 Jun 2019
AbstractforUsing bispecific antibodies in forced degradation studies to analyze the structure–function relationships of symmetrically and asymmetrically modified antibodies | Full Text | References | PDF (3.7 MB) | EPUB
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Impact of linker-drug on ion exchange chromatography separation of antibody-drug conjugates
Zhaorui Zhang, Shiyue Zhou, Linjie Han, Qunying Zhang & Wayne A. Pritts
Pages: 1113-1121
Published online: 25 Jun 2019
AbstractforImpact of linker-drug on ion exchange chromatography separation of antibody-drug conjugates | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
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Production, characterization, and in vivo half-life extension of polymeric IgA molecules in mice
T. Noelle Lombana, Sharmila Rajan, Julie A. Zorn, Danielle Mandikian, Eugene C. Chen, Alberto Estevez, Victor Yip, Daniel D. Bravo, Wilson Phung, Farzam Farahi, Sharon Viajar, Sophia Lee, Avinash Gill, Wendy Sandoval, Jianyong Wang, Claudio Ciferri, C. Andrew Boswell, Marissa L. Matsumoto & Christoph Spiess
Pages: 1122-1138
Published online: 09 Jun 2019
AbstractforProduction, characterization, and in vivo half-life extension of polymeric IgA molecules in mice | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Characterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy
Xiaojie Yu, Xiao Huang, Xiuxiu Chen, Jianfei Liu, Chenglin Wu, Qian Pu, Yuxiao Wang, Xiaoqiang Kang & Lijun Zhou
Pages: 1139-1148
Published online: 26 Jun 2019
AbstractforCharacterization of a novel anti-human lymphocyte activation gene 3 (LAG-3) antibody for cancer immunotherapy | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Conjugation of DM1 to anti-CD30 antibody has potential antitumor activity in CD30-positive hematological malignancies with lower systemic toxicity
Yijun Shen, Tong Yang, Xuemei Cao, Yifan Zhang, Li Zhao, Hua Li, Teng Zhao, Jun Xu, Hengbin Zhang, Qingsong Guo, Junli Cai, Bei Gao, Helin Yu, Sicheng Yin, Ruiwen Song, Jingsong Wu, Lingyu Guan, Guanghao Wu, Li Jin, Yong Su & Yanjun Liu
Pages: 1149-1161
Published online: 04 Jun 2019
AbstractforConjugation of DM1 to anti-CD30 antibody has potential antitumor activity in CD30-positive hematological malignancies with lower systemic toxicity | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus
Rong Deng, Chenguang Zhou, Dongwei Li, Hao Cai, Siddharth Sukumaran, Montserrat Carrasco-Triguero, Ola Saad, Denise Nazzal, Christopher Lowe, Saroja Ramanujan & Amrita V. Kamath
Pages: 1162-1174
Published online: 20 Jun 2019
AbstractforPreclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureus | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Development of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease
Robert J. Benschop, Chi-Kin Chow, Yu Tian, James Nelson, Barbra Barmettler, Shane Atwell, David Clawson, Qing Chai, Bryan Jones, Jon Fitchett, Stacy Torgerson, Yan Ji, Holly Bina, Ningjie Hu, Mahmoud Ghanem, Joseph Manetta, Victor J. Wroblewski, Jirong Lu & Barrett W. Allan
Pages: 1175-1190
Published online: 10 Jun 2019
AbstractforDevelopment of tibulizumab, a tetravalent bispecific antibody targeting BAFF and IL-17A for the treatment of autoimmune disease | Full Text | References | PDF (4.6 MB) | EPUB
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