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mAbs Volume 12, 2020 - Issue 1
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Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent

Sina Bondzaa Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;b Ridgeview Instruments AB, Uppsala, SwedenCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2420-8626View further author information
ORCID Icon,
Toine ten Broekec Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands;d Current: Department of Pathology, University Medical Center Utrecht, Utrecht, The NetherlandsView further author information
,
Marika Nestora Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, SwedenView further author information
,
Jeanette H. W. Leusenc Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-4982-6914View further author information
ORCID Icon &
Jos Buijsa Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden;b Ridgeview Instruments AB, Uppsala, SwedenView further author information
Article: 1792673 | Received 27 Mar 2020, Accepted 01 Jul 2020, Published online: 02 Aug 2020

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Inga Petersen, Muhammad Ilyas Ali, Alex Petrovic, Anders Jimmy Ytterberg, Karin Staxäng, Monika Hodik, Fadi Rofo, Sina Bondza & Greta Hultqvist. (2023) Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates. mAbs 15:1.
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Dawei Sun, Yonglian Sun, Eric Janezic, Tricia Zhou, Matthew Johnson, Caleigh Azumaya, Sigrid Noreng, Cecilia Chiu, Akiko Seki, Teresita L. Arenzana, John M. Nicoludis, Yongchang Shi, Baomei Wang, Hoangdung Ho, Prajakta Joshi, Christine Tam, Jian Payandeh, Laëtitia Comps-Agrar, Jianyong Wang, Sascha Rutz, James T. Koerber & Matthieu Masureel. (2023) Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nature Communications 14:1.
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Eric M. Janezic, Alexander Doan, Elaine Mai, Daniel D. Bravo, Jianyong Wang, Hok Seon Kim, Christoph Spiess, Kathryn Bewley, Adel ElSohly, Wei‐Ching Liang, James T. Koerber, Pascale Richalet, Marc Vanhove & Laetitia Comps‐Agrar. (2023) A novel, label‐free, pre‐equilibrium assay to determine the association and dissociation rate constants of therapeutic antibodies on living cells. British Journal of Pharmacology.
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Kyle Nguyen, Kan Li, Kevin Flores, Georgia D. Tomaras, S. Moses Dennison & Janice M. McCarthy. (2023) Parameter estimation and identifiability analysis for a bivalent analyte model of monoclonal antibody-antigen binding. Analytical Biochemistry 679, pages 115263.
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Le Deng & Gaosi Xu. (2023) Update on the Application of Monoclonal Antibody Therapy in Primary Membranous Nephropathy. Drugs 83:6, pages 507-530.
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Anke Schilhabel, Peter Jonas Walter, Paula Cramer, Julia von Tresckow, Saskia Kohlscheen, Monika Szczepanowski, Anna Laqua, Kirsten Fischer, Barbara Eichhorst, Sebastian Böttcher, Christof Schneider, Eugen Tausch, Monika Brüggemann, Michael Kneba, Michael Hallek & Matthias Ritgen. (2022) CD20 Expression as a Possible Novel Prognostic Marker in CLL: Application of EuroFlow Standardization Technique and Normalization Procedures in Flow Cytometric Expression Analysis. Cancers 14:19, pages 4917.
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Xiangdan Wang, Minh Michael Phan, Yonglian Sun, James T. Koerber, Hoangdung Ho, Yongmei Chen & Jihong Yang. (2022) Development of an SPR-based binding assay for characterization of anti-CD20 antibodies to CD20 expressed on extracellular vesicles. Analytical Biochemistry 646, pages 114635.
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Tyler Dunlap & Yanguang Cao. (2022) Physiological Considerations for Modeling in vivo Antibody-Target Interactions. Frontiers in Pharmacology 13.
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Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri, Yuji Kuge & Hiromichi Akizawa. (2021) Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin α v β 3 . Journal of Medicinal Chemistry 64:21, pages 16008-16019.
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Mitchell EversThies RösnerAnna DünkelJ. H. Marco JansenNiklas BaumannToine ten BroekeMaaike NederendKlara EichholzKatja KlauszKarli ReidingDenis M. Schewe, Christian Kellner, Matthias PeippJeanette H. W. Leusen & Thomas Valerius. (2021) The selection of variable regions affects effector mechanisms of IgA antibodies against CD20. Blood Advances 5:19, pages 3807-3820.
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Diana Spiegelberg, Jonas Stenberg, Pascale Richalet & Marc Vanhove. (2021) KD determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements. European Biophysics Journal 50:7, pages 979-991.
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Sina Bondza, Anita Marosan, Sibel Kara, Josephine Lösing, Matthias Peipp, Falk Nimmerjahn, Jos Buijs & Anja Lux. (2021) Complement-Dependent Activity of CD20-Specific IgG Correlates With Bivalent Antigen Binding and C1q Binding Strength. Frontiers in Immunology 11.
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Jonas Graf, Jan MaresMichael BarnettOrhan Aktas, Philipp Albrecht, Scott S. ZamvilHans-Peter Hartung. (2021) Targeting B Cells to Modify MS, NMOSD, and MOGAD. Neurology Neuroimmunology & Neuroinflammation 8:1.
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Clive S. Zent, Jonathan J. Pinney, Charles C. Chu & Michael R. Elliott. (2020) Complement Activation in the Treatment of B-Cell Malignancies. Antibodies 9:4, pages 68.
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