mAbs, Volume 12, Issue 1 (2020)

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mAbs, Volume 12, Issue 1 (2020)

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Structure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment
Traian Sulea, Nazanin Rohani, Jason Baardsnes, Christopher R. Corbeil, Christophe Deprez, Yuneivy Cepero-Donates, Alma Robert, Joseph D. Schrag, Marie Parat, Mélanie Duchesne, Maria L. Jaramillo, Enrico O. Purisima & John C. Zwaagstra
Article: 1682866
Published online: 28 Nov 2019
AbstractforStructure-based engineering of pH-dependent antibody binding for selective targeting of solid-tumor microenvironment | Full Text | References | PDF (5 MB) | EPUB | Supplemental
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Open Access
Native size-exclusion chromatography-mass spectrometry: suitability for antibody–drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels
Jay Jones, Laura Pack, Joshua H. Hunter & John F. Valliere-Douglass
Article: 1682895
Published online: 26 Nov 2019
AbstractforNative size-exclusion chromatography-mass spectrometry: suitability for antibody–drug conjugate drug-to-antibody ratio quantitation across a range of chemotypes and drug-loading levels | Full Text | References | PDF (3 MB) | EPUB
  • 6704 Views
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Open Access
Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry
Christoph Gstöttner, Dietmar Reusch, Markus Haberger, Irina Dragan, Peter Van Veelen, David P. A. Kilgour, Yury O. Tsybin, Yuri E. M. van der Burgt, Manfred Wuhrer & Simone Nicolardi
Article: 1682403
Published online: 18 Dec 2019
AbstractforMonitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 5069 Views
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Open Access
In vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model
Iwan P. Williams, Silvia Crescioli, Heng Sheng Sow, Heather J. Bax, Carl Hobbs, Kristina M. Ilieva, Elise French, Giulia Pellizzari, Vivienne Cox, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis & Silvia Mele
Article: 1685349
Published online: 26 Nov 2019
AbstractforIn vivo safety profile of a CSPG4-directed IgE antibody in an immunocompetent rat model | Full Text | References | PDF (9.3 MB) | EPUB | Supplemental
  • 2795 Views
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Open Access
Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis
Thomas E. Kraft, Wolfgang F. Richter, Thomas Emrich, Alexander Knaupp, Michaela Schuster, Andreas Wolfert & Hubert Kettenberger
Article: 1683432
Published online: 26 Nov 2019
AbstractforHeparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 5308 Views
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Open Access
Defining the right diluent for intravenous infusion of therapeutic antibodies
Shen Luo, Keisha Melodi McSweeney, Tao Wang, Silvia M. Bacot, Gerald M. Feldman & Baolin Zhang
Article: 1685814
Published online: 27 Nov 2019
AbstractforDefining the right diluent for intravenous infusion of therapeutic antibodies | Full Text | References | PDF (13.7 MB) | EPUB | Supplemental
  • 6728 Views
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Open Access
Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences
Gargi Roy, Jason Reier, Andrew Garcia, Tom Martin, Megan Rice, Jihong Wang, Meagan Prophet, Ronald Christie, William Dall’Acqua, Sanjeev Ahuja, Michael A Bowen & Marcello Marelli
Article: 1684749
Published online: 27 Nov 2019
AbstractforDevelopment of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 6059 Views
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Open Access

Back Matter

Harnessing MerTK agonism for targeted therapeutics
Vivekananda Kedage, Diego Ellerman, Yongmei Chen, Wei-Ching Liang, Joven Borneo, Yan Wu & Minhong Yan
Article: 1685832
Published online: 18 Dec 2019
AbstractforHarnessing MerTK agonism for targeted therapeutics | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 4217 Views
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Open Access

Report

NHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies
Corinna Lau, Martin Berner McAdam, Grethe Bergseth, Algirdas Grevys, Jack Ansgar Bruun, Judith Krey Ludviksen, Hilde Fure, Terje Espevik, Anders Moen, Jan Terje Andersen & Tom Eirik Mollnes
Article: 1686319
Published online: 27 Nov 2019
AbstractforNHDL, a recombinant VL/VH hybrid antibody control for IgG2/4 antibodies | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 2207 Views
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Open Access
Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies
Cholpon Tilegenova, Saeed Izadi, Jianping Yin, Christine S. Huang, Jiansheng Wu, Diego Ellerman, Sarah G. Hymowitz, Benjamin Walters, Cleo Salisbury & Paul J. Carter
Article: 1692764
Published online: 28 Nov 2019
AbstractforDissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 6357 Views
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Open Access
An engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding
Guangcan Cao, Xinyu Gao, Yancheng Zhan, Qingguang Wang, Zhe Zhang, Dimiter S. Dimitrov & Rui Gong
Article: 1689027
Published online: 03 Dec 2019
AbstractforAn engineered human IgG1 CH2 domain with decreased aggregation and nonspecific binding | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 3407 Views
  • 6 CrossRef citations
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Open Access
Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models
Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal & Pavel Strop
Article: 1685350
Published online: 19 Dec 2019
AbstractforDesign and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 10473 Views
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Open Access
Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen
Bo Wang, Chunning Yang, Xiaofang Jin, Qun Du, Herren Wu, William Dall’Acqua & Yariv Mazor
Article: 1690959
Published online: 12 Dec 2019
AbstractforRegulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 6682 Views
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Open Access
Rapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples
Zachary D. Dunn, Jayesh Desai, Gabriel M. Leme, Dwight R. Stoll & Douglas D. Richardson
Article: 1702263
Published online: 26 Dec 2019
AbstractforRapid two-dimensional Protein-A size exclusion chromatography of monoclonal antibodies for titer and aggregation measurements from harvested cell culture fluid samples | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 5166 Views
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Open Access
Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies
Chunze Li, Cindy Zhang, Zao Li, Divya Samineni, Dan Lu, Bei Wang, Shang-Chiung Chen, Rong Zhang, Priya Agarwal, Bernard M. Fine & Sandhya Girish
Article: 1699768
Published online: 18 Dec 2019
AbstractforClinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 7519 Views
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Open Access
Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model
Aman P. Singh, Xirong Zheng, Xiefan Lin-Schmidt, Wenbo Chen, Thomas J. Carpenter, Alice Zong, Weirong Wang & Donald L. Heald
Article: 1688616
Published online: 18 Dec 2019
AbstractforDevelopment of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 12499 Views
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Open Access
The impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody
Alessandro Masiero, Lechat Nelly, Gentric Marianne, Sourrouille Christophe, Laville Florian, Crépin Ronan, Borel Claire, Ziegler Cornelia, Bisch Grégoire, Leclerc Eric, Laurent Ludovic, Brault Dominique, Alexandre Sylvie, Gagnaire Marie, Duffieux Francis, Soubrier Fabienne, Capdevila Cécile, Arnould Isabelle, Dumas Jacques, Dabin Jérôme, Genet Bruno, Radošević Katarina, Menet Jean-Michel & Prades Catherine
Article: 1698128
Published online: 10 Jan 2020
AbstractforThe impact of proline isomerization on antigen binding and the analytical profile of a trispecific anti-HIV antibody | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 4385 Views
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Open Access
Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly
Mercè Farràs, Joan Miret, Marc Camps, Ramón Román, Óscar Martínez, Xavier Pujol, Stéphane Erb, Anthony Ehkirch, Sarah Cianferani, Antoni Casablancas & Jordi Joan Cairó
Article: 1702262
Published online: 26 Dec 2019
AbstractforHomogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly | Full Text | References | PDF (4.6 MB) | EPUB
  • 4189 Views
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Open Access

Perspective

Antibodies to watch in 2020
Hélène Kaplon, Mrinalini Muralidharan, Zita Schneider & Janice M. Reichert
Article: 1703531
Published online: 26 Dec 2019
AbstractforAntibodies to watch in 2020 | Full Text | References | PDF (2.1 MB) | EPUB
  • 35958 Views
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Open Access

Report

T cell epitope mapping of secukinumab and ixekizumab in healthy donors
Sebastian Spindeldreher, Anette Karle, Evelyne Correia, Maxime Tenon, Sascha Gottlieb, Thomas Huber, Bernard Maillere & Frank Kolbinger
Article: 1707418
Published online: 10 Jan 2020
AbstractforT cell epitope mapping of secukinumab and ixekizumab in healthy donors | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 4595 Views
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Open Access
SPLICELECT™: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell level
Christel Aebischer-Gumy, Pierre Moretti, Romain Ollier, Christelle Ries Fecourt, François Rousseau & Martin Bertschinger
Article: 1709333
Published online: 19 Jan 2020
AbstractforSPLICELECT™: an adaptable cell surface display technology based on alternative splicing allowing the qualitative and quantitative prediction of secreted product at a single-cell level | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 3267 Views
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Open Access
VHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis
Sarah Low, Haixia Wu, Kavita Jerath, Annette Tibolla, Birgit Fogal, Rebecca Conrad, Deborah Webb, Margit MacDougall, Steven Kerr, Valentina Berger, Rajvee Dave, Jorge Villalona, Lynn Pantages, Jennifer Ahlberg, Hua Li, Diane Van Hoorick, Cedric Ververken, John Broadwater, Alisa Waterman, Sanjaya Singh & Rachel Kroe-Barrett
Article: 1709322
Published online: 10 Jan 2020
AbstractforVHH antibody targeting the chemokine receptor CX3CR1 inhibits progression of atherosclerosis | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 5936 Views
  • 21 CrossRef citations
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Open Access
Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor
Xiaoshan Min, Junming Yie, Jinghong Wang, Ben C. Chung, Ching-Shin Huang, Haoda Xu, Jie Yang, Liying Deng, Joanne Lin, Qing Chen, Christina M. Abbott, Caroline Gundel, Stephen A. Thibault, Tina Meng, Darren L. Bates, David J. Lloyd, Murielle M. Véniant & Zhulun Wang
Article: 1710047
Published online: 12 Jan 2020
AbstractforMolecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3472 Views
  • 7 CrossRef citations
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Open Access
Discovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics
Bharathikumar Vellalore Maruthachalam, Adam Zwolak, Xiefan Lin-Schmidt, Edward Keough, Ninkka Tamot, Sathya Venkataramani, Brian Geist, Sanjaya Singh & Rajkumar Ganesan
Article: 1708030
Published online: 13 Jan 2020
AbstractforDiscovery and characterization of single-domain antibodies for polymeric Ig receptor-mediated mucosal delivery of biologics | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 4060 Views
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Open Access
Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site
Karl J. M. Hanf, Joseph W. Arndt, YuTing Liu, Bang Jian Gong, Mia Rushe, Richelle Sopko, Ramiro Massol, Benjamin Smith, Yan Gao, Isin Dalkilic-Liddle, Xinhua Lee, Shanell Mojta, Zhaohui Shao, Sha Mi & R. Blake Pepinsky
Article: 1713648
Published online: 17 Jan 2020
AbstractforFunctional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 3608 Views
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Open Access
In situ antibody phage display yields optimal inhibitors of integrin α11/β1
Eugenio Gallo, Abdellali Kelil, Peter E. Bayliss, Ajitha Jeganathan, Olga Egorova, Lynda Ploder, Jarrett J. Adams, Patricia Giblin & Sachdev S. Sidhu
Article: 1717265
Published online: 24 Jan 2020
AbstractforIn situ antibody phage display yields optimal inhibitors of integrin α11/β1 | Full Text | References | PDF (6.9 MB) | EPUB | Supplemental
  • 3315 Views
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Open Access
Investigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies
Serene W. Chen, Darryl Tan, Yuan Sheng Yang & Wei Zhang
Article: 1718440
Published online: 25 Jan 2020
AbstractforInvestigation of the effect of salt additives in Protein L affinity chromatography for the purification of tandem single-chain variable fragment bispecific antibodies | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 6475 Views
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Open Access
Improved translation of stability for conjugated antibodies using an in vitro whole blood assay
Aimee Fourie-O’Donohue, Phillip Y. Chu, Josefa dela Cruz Chuh, Robert Tchelepi, Siao Ping Tsai, John C. Tran, William S. Sawyer, Dian Su, Carl Ng, Keyang Xu, Shang-Fan Yu, Thomas H. Pillow, Jack Sadowsky, Peter S. Dragovich, Yichin Liu & Katherine R. Kozak
Article: 1715705
Published online: 30 Jan 2020
AbstractforImproved translation of stability for conjugated antibodies using an in vitro whole blood assay | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 3938 Views
  • 9 CrossRef citations
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Open Access
Exploiting next-generation sequencing in antibody selections – a simple PCR method to recover binders
Fortunato Ferrara, Andre A. Teixeira, Leslie Naranjo, M. Frank Erasmus, Sara D’Angelo & Andrew R.M. Bradbury
Article: 1701792
Published online: 05 Feb 2020
AbstractforExploiting next-generation sequencing in antibody selections – a simple PCR method to recover binders | Full Text | References | PDF (4.6 MB) | EPUB
  • 5935 Views
  • 4 CrossRef citations
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Open Access
A novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis
Patrizia Murer, Louis Plüss & Dario Neri
Article: 1714371
Published online: 03 Feb 2020
AbstractforA novel human monoclonal antibody specific to the A33 glycoprotein recognizes colorectal cancer and inhibits metastasis | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 3628 Views
  • 7 CrossRef citations
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Open Access
Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires
Yi-Chun Hsiao, Ying-Jiun J. Chen, Leonard D. Goldstein, Jia Wu, Zhonghua Lin, Kellen Schneider, Subhra Chaudhuri, Aju Antony, Kanika Bajaj Pahuja, Zora Modrusan, Dhaya Seshasayee, Somasekar Seshagiri & Isidro Hötzel
Article: 1722541
Published online: 10 Feb 2020
AbstractforRestricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
  • 2748 Views
  • 4 CrossRef citations
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Open Access

Review Article

Review Article
Anti-ErbB2 immunotherapeutics: struggling to make better antibodies for cancer therapy
Rita De Santis
Article: 1725346
Published online: 13 Feb 2020
AbstractforAnti-ErbB2 immunotherapeutics: struggling to make better antibodies for cancer therapy | Full Text | References | PDF (929.6 KB) | EPUB
  • 4330 Views
  • 12 CrossRef citations
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Open Access

Report

A functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope
Dong Li, Jing Li, Huanyu Chu & Zhuozhi Wang
Article: 1725365
Published online: 13 Feb 2020
AbstractforA functional antibody cross-reactive to both human and murine cytotoxic T-lymphocyte-associated protein 4 via binding to an N-glycosylation epitope | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 3274 Views
  • 7 CrossRef citations
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Open Access
10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals
S. Tourdot, A. Abdolzade-Bavil, J. Bessa, P. Broët, A. Fogdell-Hahn, M. Giorgi, V. Jawa, K. Kuranda, N. Legrand, S. Pattijn, J. A. Pedras-Vasconcelos, A. Rudy, P. Salmikangas, D. W. Scott, V. Snoeck, N. Smith, S. Spindeldreher & D. Kramer
Article: 1725369
Published online: 16 Feb 2020
Abstractfor10th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals | Full Text | References | PDF (872.2 KB) | EPUB
  • 3012 Views
  • 9 CrossRef citations
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Open Access

Review

Understanding the human antibody repertoire
Anthony R Rees
Article: 1729683
Published online: 25 Feb 2020
AbstractforUnderstanding the human antibody repertoire | Full Text | References | PDF (1.9 MB) | EPUB
  • 11889 Views
  • 41 CrossRef citations
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Open Access

Report

HX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties
Jibin Zhang, Ying Huang, Gan Xi & Faming Zhang
Article: 1724751
Published online: 27 Feb 2020
AbstractforHX008: a humanized PD-1 blocking antibody with potent antitumor activity and superior pharmacologic properties | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 4968 Views
  • 21 CrossRef citations
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Open Access
Intein mediated high throughput screening for bispecific antibodies
Tim Hofmann, Johannes Schmidt, Elke Ciesielski, Stefan Becker, Thomas Rysiok, Mark Schütte, Lars Toleikis, Harald Kolmar & Achim Doerner
Article: 1731938
Published online: 09 Mar 2020
AbstractforIntein mediated high throughput screening for bispecific antibodies | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 5733 Views
  • 14 CrossRef citations
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Open Access
Interaction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach
Joanna Hajduk, Cyrill Brunner, Sebastian Malik, Jana Bangerter, Gisbert Schneider, Marco Thomann, Dietmar Reusch & Renato Zenobi
Article: 1736975
Published online: 13 Mar 2020
AbstractforInteraction analysis of glycoengineered antibodies with CD16a: a native mass spectrometry approach | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2887 Views
  • 7 CrossRef citations
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Open Access
Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors
Eric Hatterer, Xavier Chauchet, Françoise Richard, Leticia Barba, Valéry Moine, Laurence Chatel, Lucile Broyer, Guillemette Pontini, Tereza Bautzova, Flora Juan, Sebastien Calloud, Nicolas Bosson, Maud Charreton, Krzysztof Masternak, Vanessa Buatois & Limin Shang
Article: 1739408
Published online: 19 Mar 2020
AbstractforTargeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 4450 Views
  • 18 CrossRef citations
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Open Access
Analytical characterization of coformulated antibodies as combination therapy
Jun Kim, Yoen Joo Kim, Mingyan Cao, Niluka De Mel, Kenneth Miller, Jared S. Bee, Jihong Wang, Xiangyang Wang & Methal Albarghouthi
Article: 1738691
Published online: 21 Mar 2020
AbstractforAnalytical characterization of coformulated antibodies as combination therapy | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 4349 Views
  • 18 CrossRef citations
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Open Access
Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
Pengfei Fan, Xiangyang Chi, Guodong Liu, Guanying Zhang, Zhengshan Chen, Yujiao Liu, Ting Fang, Jianmin Li, Logan Banadyga, Shihua He, Changming Yu, Xiangguo Qiu & Wei Chen
Article: 1742457
Published online: 26 Mar 2020
AbstractforPotent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 3749 Views
  • 14 CrossRef citations
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Open Access
Predicting Antibody Developability Profiles Through Early Stage Discovery Screening
Marc Bailly, Carl Mieczkowski, Veronica Juan, Essam Metwally, Daniela Tomazela, Jeanne Baker, Makiko Uchida, Ester Kofman, Fahimeh Raoufi, Soha Motlagh, Yao Yu, Jihea Park, Smita Raghava, John Welsh, Michael Rauscher, Gopalan Raghunathan, Mark Hsieh, Yi-Ling Chen, Hang Thu Nguyen, Nhung Nguyen, Dan Cipriano & Laurence Fayadat-Dilman
Article: 1743053
Published online: 05 Apr 2020
AbstractforPredicting Antibody Developability Profiles Through Early Stage Discovery Screening | Full Text | References | PDF (7.2 MB) | EPUB | Supplemental
  • 31913 Views
  • 94 CrossRef citations
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Open Access
Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures
Monica L. Fernández-Quintero, Martin C. Heiss, Nancy D. Pomarici, Barbara A. Math & Klaus R. Liedl
Article: 1744328
Published online: 07 Apr 2020
AbstractforAntibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2855 Views
  • 25 CrossRef citations
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Open Access

Research Article

Article
Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues
Kip P. Conner, Cinthia V. Pastuskovas, Marcus Soto, Veena A. Thomas, Mylo Wagner & Dan A. Rock
Article: 1746520
Published online: 20 Apr 2020
AbstractforPreclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 3383 Views
  • 4 CrossRef citations
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Open Access

Report

Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody
Yan Wang, Donghui Pan, Chenrong Huang, Bingliang Chen, Mingzhu Li, Shuaixiang Zhou, Lizhen Wang, Min Wu, Xinyu Wang, Yicong Bian, Junjie Yan, Junjian Liu, Min Yang & Liyan Miao
Article: 1748322
Published online: 10 Apr 2020
AbstractforDose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 3132 Views
  • 20 CrossRef citations
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Open Access
Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Margaret S. Ricci & Pavel V. Bondarenko
Article: 1739825
Published online: 15 Apr 2020
AbstractforCharacterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 6909 Views
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Open Access
An overview of patents on therapeutic monoclonal antibodies in Europe: are they a hurdle to biosimilar market entry?
Evelien Moorkens, Arnold G. Vulto & Isabelle Huys
Article: 1743517
Published online: 19 Apr 2020
AbstractforAn overview of patents on therapeutic monoclonal antibodies in Europe: are they a hurdle to biosimilar market entry? | Full Text | References | PDF (1.4 MB) | EPUB
  • 8743 Views
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Open Access
A rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development
Zaneer Segu, Todd Stone, Claudia Berdugo, Anthony Roberts, Emma Doud & Yunsong Li
Article: 1750794
Published online: 19 Apr 2020
AbstractforA rapid method for relative quantification of N-glycans from a therapeutic monoclonal antibody during trastuzumab biosimilar development | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 4942 Views
  • 16 CrossRef citations
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Open Access
Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats
Ami Miller, Stephen Carr, Terry Rabbitts & Hanif Ali
Article: 1752529
Published online: 22 Apr 2020
AbstractforMultimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 4414 Views
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Open Access
In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo
Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Gareth Young, Kim Marquette, Sadhana Jain, Kerry Kelleher, Ting Chen, Qingcong Lin, Laird Bloom, Laura Lin, William Finlay, Rie Suzuki & Orla Cunningham
Article: 1755000
Published online: 24 Apr 2020
AbstractforIn vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 2921 Views
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Open Access
Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies
Martin J. Scott, Amanda Jowett, Martin Orecchia, Peter Ertl, Larissa Ouro-Gnao, Julia Ticehurst, David Gower, John Yates, Katie Poulton, Carol Harris, Michael J. Mullin, Kathrine J. Smith, Alan P. Lewis, Nick Barton, Michael L. Washburn & Ruud de Wildt
Article: 1755069
Published online: 28 Apr 2020
AbstractforRapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Open Access
Benchmarking biopharmaceutical process development and manufacturing cost contributions to R&D
Suzanne S. Farid, Max Baron, Christos Stamatis, Wenhao Nie & Jon Coffman
Article: 1754999
Published online: 23 May 2020
AbstractforBenchmarking biopharmaceutical process development and manufacturing cost contributions to R&D | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 22364 Views
  • 39 CrossRef citations
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Open Access
Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires
Samuel Schmitz, Cinque Soto, James E. Crowe Jr. & Jens Meiler
Article: 1758291
Published online: 13 May 2020
AbstractforHuman-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires | Full Text | References | PDF (6.3 MB) | EPUB | Supplemental
  • 3265 Views
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Open Access
Enabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies
Parimala Bolisetty, Gabi Tremml, Sen Xu & Anurag Khetan
Article: 1763727
Published online: 25 May 2020
AbstractforEnabling speed to clinic for monoclonal antibody programs using a pool of clones for IND-enabling toxicity studies | Full Text | References | PDF (1.5 MB) | EPUB
  • 7330 Views
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Open Access
Post-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms
Robin E. Walsh, Megan Lannan, Yi Wen, Xiaoli Wang, Christopher A. Moreland, Jill Willency, Michael D. Knierman, Laura Spindler, Ling Liu, Wei Zeng, Guilherme V. Rocha, Victor Obungu, Jirong Lu, Arunan Kaliyaperumal, Andrea Ferrante, Robert Siegel & Laurent P. Malherbe
Article: 1764829
Published online: 18 May 2020
AbstractforPost-hoc assessment of the immunogenicity of three antibodies reveals distinct immune stimulatory mechanisms | Full Text | References | PDF (2.5 MB) | EPUB
  • 6040 Views
  • 20 CrossRef citations
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Open Access
Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb
Wenkui Lan, Joseph J. Valente, Andrew Ilott, Naresh Chennamsetty, Zhihua Liu, Joseph M. Rizzo, Aaron P. Yamniuk, Difei Qiu, Holly M. Shackman & Mark S. Bolgar
Article: 1763138
Published online: 20 May 2020
AbstractforInvestigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2994 Views
  • 6 CrossRef citations
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Open Access
Hyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies
Fengfei Ma, Fahimeh Raoufi, Marc Andre Bailly, Laurence Fayadat-Dilman & Daniela Tomazela
Article: 1763762
Published online: 20 May 2020
AbstractforHyphenation of strong cation exchange chromatography to native mass spectrometry for high throughput online characterization of charge heterogeneity of therapeutic monoclonal antibodies | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 4642 Views
  • 20 CrossRef citations
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Open Access
Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies
Amita Datta-Mannan, Selina Estwick, Chen Zhou, Hiuwan Choi, Nicole E. Douglass, Derrick R. Witcher, Jirong Lu, Catherine Beidler & Rohn Millican
Article: 1770028
Published online: 03 Jun 2020
AbstractforInfluence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 6536 Views
  • 24 CrossRef citations
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Open Access
Biomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study
Jianlin Xu, Xuankuo Xu, Chao Huang, James Angelo, Christopher L. Oliveira, Mengmeng Xu, Xia Xu, Deniz Temel, Julia Ding, Sanchayita Ghose, Michael C. Borys & Zheng Jian Li
Article: 1770669
Published online: 08 Jun 2020
AbstractforBiomanufacturing evolution from conventional to intensified processes for productivity improvement: a case study | Full Text | References | PDF (2.9 MB) | EPUB
  • 9034 Views
  • 47 CrossRef citations
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Open Access

Short communication

Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold
Zehua Sun, Chuan Chen, Wei Li, David R. Martinez, Aleksandra Drelich, Du-San Baek, Xianglei Liu, John W. Mellors, Chien-Te Tseng, Ralph S. Baric & Dimiter S. Dimitrov
Article: 1778435
Published online: 16 Jun 2020
AbstractforPotent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 4510 Views
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Open Access

Report

Characterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A
Songmao Zheng, Fang Shen, Brian Jones, Damien Fink, Brian Geist, Ivo Nnane, Zhao Zhou, Jeff Hall, Ravi Malaviya, Tatiana Ort & Weirong Wang
Article: 1770018
Published online: 16 Jun 2020
AbstractforCharacterization of concurrent target suppression by JNJ-61178104, a bispecific antibody against human tumor necrosis factor and interleukin-17A | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 4040 Views
  • 8 CrossRef citations
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Open Access
Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region
Michael W. Handlogten, Li Peng, Elizabeth A. Christian, Weichen Xu, Shihua Lin, Raghavan Venkat, William Dall’Acqua & Sanjeev Ahuja
Article: 1779974
Published online: 07 Jul 2020
AbstractforPrevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
  • 7054 Views
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Open Access
A Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors
Michael W. Bishop, Paul R. Hutson, Jacquelyn A. Hank, Paul M. Sondel, Wayne L. Furman, Michael M. Meagher, Fariba Navid & Victor M. Santana
Article: 1773751
Published online: 09 Jul 2020
AbstractforA Phase 1 and pharmacokinetic study evaluating daily or weekly schedules of the humanized anti-GD2 antibody hu14.18K322A in recurrent/refractory solid tumors | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 1569 Views
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Open Access
An evaluation of instrument types for mass spectrometry-based multi-attribute analysis of biotherapeutics
Zhongqi Zhang, Pik K. Chan, Jason Richardson & Bhavana Shah
Article: 1783062
Published online: 09 Jul 2020
AbstractforAn evaluation of instrument types for mass spectrometry-based multi-attribute analysis of biotherapeutics | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2965 Views
  • 22 CrossRef citations
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Open Access

Perspective

Ig-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic
Kewen Qian & Shi Hu
Article: 1782600
Published online: 07 Jul 2020
AbstractforIg-like ACE2 protein therapeutics: A revival in development during the COVID-19 pandemic | Full Text | References | PDF (598.9 KB) | EPUB
  • 3515 Views
  • 5 CrossRef citations
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Open Access

Report

Investigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry
G. Rouby, N. T. Tran, Y. Leblanc, M. Taverna & N. Bihoreau
Article: 1781743
Published online: 07 Jul 2020
AbstractforInvestigation of monoclonal antibody dimers in a final formulated drug by separation techniques coupled to native mass spectrometry | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 4388 Views
  • 17 CrossRef citations
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Open Access
Rational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain
Joschka Bauer, Sven Mathias, Sebastian Kube, Kerstin Otte, Patrick Garidel, Martin Gamer, Michaela Blech, Simon Fischer & Anne R Karow-Zwick
Article: 1787121
Published online: 13 Jul 2020
AbstractforRational optimization of a monoclonal antibody improves the aggregation propensity and enhances the CMC properties along the entire pharmaceutical process chain | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 7063 Views
  • 13 CrossRef citations
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Open Access
COBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors
Anand Panchal, Pui Seto, Russell Wall, Brian J. Hillier, Ying Zhu, Jessica Krakow, Aakash Datt, Elizabeth Pongo, Andisheh Bagheri, Tseng-Hui T. Chen, Jeremiah D. Degenhardt, Patricia A. Culp, Danielle E. Dettling, Maia V. Vinogradova, Chad May & Robert B. DuBridge
Article: 1792130
Published online: 19 Jul 2020
AbstractforCOBRA™: a highly potent conditionally active T cell engager engineered for the treatment of solid tumors | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 9887 Views
  • 25 CrossRef citations
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Open Access
Bivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent
Sina Bondza, Toine ten Broeke, Marika Nestor, Jeanette H. W. Leusen & Jos Buijs
Article: 1792673
Published online: 02 Aug 2020
AbstractforBivalent binding on cells varies between anti-CD20 antibodies and is dose-dependent | Full Text | References | PDF (6.2 MB) | EPUB
  • 2399 Views
  • 14 CrossRef citations
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Open Access
A general evidence-based sequence variant control limit for recombinant therapeutic protein development
Aming Zhang, Zhengwei Chen, Meinuo Li, Haibo Qiu, Shawn Lawrence, Hanne Bak & Ning Li
Article: 1791399
Published online: 02 Aug 2020
AbstractforA general evidence-based sequence variant control limit for recombinant therapeutic protein development | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 3749 Views
  • 11 CrossRef citations
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Open Access
Novel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies
Mitchell Evers, Toine Ten Broeke, J.H. Marco Jansen, Maaike Nederend, Firas Hamdan, Karli R. Reiding, Saskia Meyer, Petra Moerer, Iris Brinkman, Thies Rösner, Robert Jan Lebbink, Thomas Valerius & Jeanette H.W. Leusen
Article: 1795505
Published online: 02 Aug 2020
AbstractforNovel chimerized IgA CD20 antibodies: Improving neutrophil activation against CD20-positive malignancies | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 2122 Views
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Open Access

Perspective

The Antibody Society’s antibody validation webinar series
Jan L.A. Voskuil, Anita Bandrowski, C. Glenn Begley, Andrew R.M. Bradbury, Andrew D. Chalmers, Aldrin V. Gomes, Travis Hardcastle, Fridtjof Lund-Johansen, Andreas Plückthun, Giovanna Roncador, Alejandra Solache, Michael J. Taussig, James S. Trimmer, Cecilia Williams & Simon L. Goodman
Article: 1794421
Published online: 04 Aug 2020
AbstractforThe Antibody Society’s antibody validation webinar series | Full Text | References | PDF (441.8 KB) | EPUB
  • 5313 Views
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Open Access

Report

Malignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness
Dominik Brücher, Vojtech Franc, Sheena N. Smith, Albert J. R. Heck & Andreas Plückthun
Article: 1792084
Published online: 04 Aug 2020
AbstractforMalignant tissues produce divergent antibody glycosylation of relevance for cancer gene therapy effectiveness | Full Text | References | PDF (6 MB) | EPUB | Supplemental
  • 2738 Views
  • 7 CrossRef citations
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Open Access
Development and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab
Sandor Schokker, Fabrizia Fusetti, Francesco Bonardi, Remco J. Molenaar, Ron A.A. Mathôt & Hanneke W.M. van Laarhoven
Article: 1795492
Published online: 02 Aug 2020
AbstractforDevelopment and validation of an LC-MS/MS method for simultaneous quantification of co-administered trastuzumab and pertuzumab | Full Text | References | PDF (802.2 KB) | EPUB | Supplemental
  • 4723 Views
  • 10 CrossRef citations
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Open Access
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity
Raul C. Camacho, Seohee You, Katharine E. D’Aquino, Wenyu Li, Yuanping Wang, Joseph Gunnet, James Littrell, Jian Shen Qi, Lijuan Kang, Wenying Jian, Mary MacDonald, Timothy Tat, Derek Steiner, Yue-Mei Zhang, James Lanter, Raymond Patch, Rui Zhang, Jiali Li, Suzanne Edavettal, Wilson Edwards, Thai Dinh, Li Ying Wang, Judy Connor, Michael Hunter, Ellen Chi, Ronald V. Swanson, James N. Leonard & Martin A. Case
Article: 1794687
Published online: 02 Aug 2020
AbstractforConjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3942 Views
  • 7 CrossRef citations
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Open Access
Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR
Jan Fredrik Simons, Yoong Wearn Lim, Kyle P. Carter, Ellen K. Wagner, Nicholas Wayham, Adam S. Adler & David S. Johnson
Article: 1803646
Published online: 11 Aug 2020
AbstractforAffinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCR | Full Text | References | PDF (8.9 MB) | EPUB | Supplemental
  • 9179 Views
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Open Access
Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity
Yue Sun, Alberto Estevez, Tilman Schlothauer & Aaron T. Wecksler
Article: 1802135
Published online: 14 Aug 2020
AbstractforAntigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 2998 Views
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Open Access

Brief report

Brief Report
A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
Xiaoniu Miao, Yi Luo, Xi Huang, Suki M. Y. Lee, Zhijun Yuan, Yongzhou Tang, Liandi Chen, Chao Wang, Fan Wu, Yifeng Xu, Wenchao Jiang, Wei Gao, Xuedong Song, Yao Yan, Tuling Pang, Cheng Chen, Yuefeng Zou, Weihui Fu, Liping Wan, Javier Gilbert-Jaramillo, Michael Knight, Tiong Kit Tan, Pramila Rijal, Alain Townsend, Joanne Sun, Xiaolin Liu, William James, Andy Tsun & Yingda Xu
Article: 1804241
Published online: 17 Aug 2020
AbstractforA novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 3720 Views
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Open Access

Report

Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action
Mark Austin, Daniel Burschowsky, Denice T.Y. Chan, Lesley Jenkinson, Stuart Haynes, Agata Diamandakis, Chitra Seewooruthun, Alexandra Addyman, Sebastian Fiedler, Stephanie Ryman, Jessica Whitehouse, Louise H. Slater, Andreas V. Hadjinicolaou, Uzi Gileadi, Ellen Gowans, Yoko Shibata, Michelle Barnard, Teresa Kaserer, Pooja Sharma, Nadia M. Luheshi, Robert W. Wilkinson, Tristan J. Vaughan, Sarah V. Holt, Vincenzo Cerundolo, Mark D. Carr & Maria A. T. Groves
Article: 1801230
Published online: 03 Sep 2020
AbstractforStructural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action | Full Text | References | PDF (9.1 MB) | EPUB | Supplemental
  • 3437 Views
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Open Access
AlbuCORE: an albumin-based molecular scaffold for multivalent biologics design
Mario Sanches, Igor D’Angelo, Maria Jaramillo, Jason Baardsnes, John Zwaagstra, Joe Schrag, Ian Schoenhofen, Mauro Acchione, Sam Lawn, Grant Wickman, Nina Weisser, David K. Y. Poon, Gordon Ng & Surjit Dixit
Article: 1802188
Published online: 20 Aug 2020
AbstractforAlbuCORE: an albumin-based molecular scaffold for multivalent biologics design | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 3414 Views
  • 3 CrossRef citations
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Open Access
Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates
Allyson Kwiatkowski, Carl Co, Sei Kameoka, An Zhang, John Coughlin, Tom Cameron, Eric Chiao, Svetlana Bergelson & Cullen Schmid Mason
Article: 1803645
Published online: 19 Aug 2020
AbstractforAssessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates | Full Text | References | PDF (1.9 MB) | EPUB
  • 2845 Views
  • 1 CrossRef citations
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Open Access
Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5
Sebastian Molnar, Lindsay Wieczorek, Michelle Zemil, Bianca Schulte, Elizabeth Martinez, Syna Gift, Lan Tang, Hendrik Streeck, Robert A. Gramzinski, Nelson L. Michael, Gordon Joyce & Victoria R. Polonis
Article: 1802187
Published online: 23 Aug 2020
AbstractforNovel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5 | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 1809 Views
  • 2 CrossRef citations
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Open Access
CD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism
Johannes Nelke, Juliane Medler, Daniela Weisenberger, Andreas Beilhack & Harald Wajant
Article: 1807721
Published online: 25 Aug 2020
AbstractforCD40- and CD95-specific antibody single chain-Baff fusion proteins display BaffR-, TACI- and BCMA-restricted agonism | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 1914 Views
  • 5 CrossRef citations
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Open Access
Measuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions
Sumit K. Chaturvedi, Arun Parupudi, Kristian Juul-Madsen, Ai Nguyen, Thomas Vorup-Jensen, Sonia Dragulin-Otto, Huaying Zhao, Reza Esfandiary & Peter Schuck
Article: 1810488
Published online: 04 Sep 2020
AbstractforMeasuring aggregates, self-association, and weak interactions in concentrated therapeutic antibody solutions | Full Text | References | PDF (2.8 MB) | EPUB
  • 3696 Views
  • 12 CrossRef citations
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Open Access
Biophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform
Lukas Pekar, Michael Busch, Bernhard Valldorf, Steffen C. Hinz, Lars Toleikis, Simon Krah & Stefan Zielonka
Article: 1812210
Published online: 04 Sep 2020
AbstractforBiophysical and biochemical characterization of a VHH-based IgG-like bi- and trispecific antibody platform | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 7552 Views
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Open Access
Biased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics
Christina Großerichter-Wagener, Dorien Kos, Astrid van Leeuwen, Lisanne Dijk, Jorn Jeremiasse, Floris C. Loeff & Theo Rispens
Article: 1814661
Published online: 04 Sep 2020
AbstractforBiased anti-idiotype response in rabbits leads to high-affinity monoclonal antibodies to biologics | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 1660 Views
  • 6 CrossRef citations
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Open Access
Engineered Fc-glycosylation switch to eliminate antibody effector function
Qun Zhou, Julie Jaworski, Yanfeng Zhou, Delphine Valente, Joanne Cotton, Denise Honey, Ekaterina Boudanova, Jochen Beninga, Ercole Rao, Ronnie Wei, Christine Mauriac, Clark Pan, Anna Park & Huawei Qiu
Article: 1814583
Published online: 06 Sep 2020
AbstractforEngineered Fc-glycosylation switch to eliminate antibody effector function | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 6858 Views
  • 5 CrossRef citations
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Open Access
Targeted IgMs agonize ocular targets with extended vitreal exposure
Yvonne Chen, Maciej Paluch, Julie A. Zorn, Sharmila Rajan, Brandon Leonard, Alberto Estevez, John Brady, Henry Chiu, Wilson Phung, Amin Famili, Minhong Yan, Claudio Ciferri, Marissa L. Matsumoto, Greg A. Lazar, Susan Crowell, Phil Hass & Nicholas J. Agard
Article: 1818436
Published online: 16 Sep 2020
AbstractforTargeted IgMs agonize ocular targets with extended vitreal exposure | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2330 Views
  • 3 CrossRef citations
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Open Access
An accelerated surface-mediated stress assay of antibody instability for developability studies
Marie R.G. Kopp, Adriana-Michelle Wolf Pérez, Marta Virginia Zucca, Umberto Capasso Palmiero, Brigitte Friedrichsen, Nikolai Lorenzen & Paolo Arosio
Article: 1815995
Published online: 20 Sep 2020
AbstractforAn accelerated surface-mediated stress assay of antibody instability for developability studies | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 4678 Views
  • 23 CrossRef citations
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Open Access
Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity
Theresa K. Cloutier, Chaitanya Sudrik, Neil Mody, Sathish A. Hasige & Bernhardt L. Trout
Article: 1816312
Published online: 17 Sep 2020
AbstractforMolecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 3743 Views
  • 16 CrossRef citations
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Open Access
A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model
Songmao Zheng, Jin Niu, Brian Geist, Damien Fink, Zhenhua Xu, Honghui Zhou & Weirong Wang
Article: 1813962
Published online: 24 Sep 2020
AbstractforA minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model | Full Text | References | PDF (3.8 MB) | EPUB
  • 2208 Views
  • 4 CrossRef citations
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Open Access
On-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies
Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li & Shijie Liu
Article: 1829333
Published online: 04 Oct 2020
AbstractforOn-column disulfide bond formation of monoclonal antibodies during Protein A chromatography eliminates low molecular weight species and rescues reduced antibodies | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 4767 Views
  • 3 CrossRef citations
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Open Access
Functional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice
Benjamin E. Low, Gregory J. Christianson, Emily Lowell, Wenning Qin & Michael V. Wiles
Article: 1829334
Published online: 07 Oct 2020
AbstractforFunctional humanization of immunoglobulin heavy constant gamma 1 Fc domain human FCGRT transgenic mice | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 2644 Views
  • 7 CrossRef citations
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Open Access
Optimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses
Peifeng Tang, Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Laurel Hoffman, Cheng Du, Yuanli Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li & Shijie Liu
Article: 1829336
Published online: 08 Oct 2020
AbstractforOptimization and kinetic modeling of interchain disulfide bond reoxidation of monoclonal antibodies in bioprocesses | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 5210 Views
  • 8 CrossRef citations
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Open Access

Short Communication

Design of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics
Zhiqiang Chen, Yueming Qian, Yuanli Song, Xuankuo Xu, Li Tao, Nesredin Mussa, Sanchayita Ghose & Zheng Jian Li
Article: 1829338
Published online: 12 Oct 2020
AbstractforDesign of next-generation therapeutic IgG4 with improved manufacturability and bioanalytical characteristics | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3358 Views
  • 3 CrossRef citations
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Open Access

Report

Beyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries
Michael R. Dyson, Edward Masters, Deividas Pazeraitis, Rajika L. Perera, Johanna L. Syrjanen, Sachin Surade, Nels Thorsteinson, Kothai Parthiban, Philip C. Jones, Maheen Sattar, Gordana Wozniak-Knopp, Florian Rueker, Rachael Leah & John McCafferty
Article: 1829335
Published online: 25 Oct 2020
AbstractforBeyond affinity: selection of antibody variants with optimal biophysical properties and reduced immunogenicity from mammalian display libraries | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 10733 Views
  • 31 CrossRef citations
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Open Access
Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models
Delphine Valente, Christine Mauriac, Thorsten Schmidt, Ingo Focken, Jochen Beninga, Brian Mackness, Huawei Qiu, Pascale Vicat, Abdullah Kandira, Katarina Radošević, Srini Rao, John Darbyshire & Mostafa Kabiri
Article: 1829337
Published online: 20 Oct 2020
AbstractforPharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 6518 Views
  • 12 CrossRef citations
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Open Access
Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans
Armin Sepp, Mats Bergström & Marie Davies
Article: 1832861
Published online: 19 Oct 2020
AbstractforCross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1904 Views
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Open Access
Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies
Gwo-Yu Chuang, Mangaiarkarasi Asokan, Vera B. Ivleva, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Rajoshi Chaudhuri, Hui Geng, Bob C. Lin, Mark K. Louder, Krisha McKee, Sijy O’Dell, Hairong Wang, Tongqing Zhou, Nicole A. Doria-Rose, Lisa A. Kueltzo, Q. Paula Lei, John R. Mascola & Peter D. Kwong
Article: 1836719
Published online: 30 Oct 2020
AbstractforRemoval of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
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Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody
Jeffrey S. Boyles, Catherine B. Beidler, Beth A. Strifler, Daniel S. Girard, Zhanna Druzina, Jim D. Durbin, Michelle L. Swearingen, Linda N. Lee, Kristine Kikly, Sudhakar Chintharlapalli & Derrick R. Witcher
Article: 1831880
Published online: 13 Nov 2020
AbstractforDiscovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 2730 Views
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Vaccine-induced CD8 T cells are redirected with peptide-MHC class I-IgG antibody fusion proteins to eliminate tumor cells in vivo
Cornelia Fischer, Michael W. Munks, Ann B. Hill, Richard A. Kroczek, Stefan Bissinger, Verena Brand, Martina Schmittnaegel, Sabine Imhof-Jung, Eike Hoffmann, Frank Herting, Christian Klein & Hendrik Knoetgen
Article: 1834818
Published online: 05 Nov 2020
AbstractforVaccine-induced CD8 T cells are redirected with peptide-MHC class I-IgG antibody fusion proteins to eliminate tumor cells in vivo | Full Text | References | PDF (18.4 MB) | EPUB | Supplemental
  • 2620 Views
  • 6 CrossRef citations
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A monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice
Joseph Ray Cepeda, Nitin S Sekhar, Junying Han, Wei Xiong, Ningyan Zhang, Liping Yu, Shaodong Dai, Howard W. Davidson, John W. Kappler, Zhiqiang An & Li Zhang
Article: 1836714
Published online: 05 Nov 2020
AbstractforA monoclonal antibody with broad specificity for the ligands of insulin B:9-23 reactive T cells prevents spontaneous type 1 diabetes in mice | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 1839 Views
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Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants
Luke Burman, Yeeting E. Chong, Sherie Duncan, Anders Klaus, Kaitlyn Rauch, Kristina Hamel, Karine Hervé, Stephanie Pfaffen, David W. Collins, Kevin Heyries, Leslie Nangle, Carl Hansen & David J. King
Article: 1836718
Published online: 01 Nov 2020
AbstractforIsolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2113 Views
  • 6 CrossRef citations
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Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism
Bradley N. Spatola, Alana G. Lerner, Clifford Wong, Tracy dela Cruz, Megan Welch, Wanchi Fung, Maria Kovalenko, Karolina Losenkova, Gennady G. Yegutkin, Courtney Beers, John Corbin & Vanessa B. Soros
Article: 1838036
Published online: 04 Nov 2020
AbstractforFully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 4750 Views
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Novel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo
Lisa Nadal, Riccardo Corbellari, Alessandra Villa, Tobias Weiss, Michael Weller, Dario Neri & Roberto De Luca
Article: 1836713
Published online: 02 Nov 2020
AbstractforNovel human monoclonal antibodies specific to the alternatively spliced domain D of Tenascin C efficiently target tumors in vivo | Full Text | References | PDF (15 MB) | EPUB | Supplemental
  • 2219 Views
  • 10 CrossRef citations
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CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins
Christian Jost, Diana Darowski, John Challier, Vesna Pulko, Lydia J Hanisch, Wei Xu, Ekkehard Mössner, Alexander Bujotzek, Stefan Klostermann, Pablo Umana, Roland E. Kontermann & Christian Klein
Article: 1840709
Published online: 02 Nov 2020
AbstractforCAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 4004 Views
  • 1 CrossRef citations
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Hiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen binding
Simon P. Kelow, Jared Adolf-Bryfogle & Roland L. Dunbrack
Article: 1840005
Published online: 12 Nov 2020
AbstractforHiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen binding | Full Text | References | PDF (16.9 MB) | EPUB | Supplemental
  • 3347 Views
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Selection and verification of antibodies against the cytoplasmic domain of M2 of influenza, a transmembrane protein
Nileena Velappan, Sofiya Micheva-Viteva, Samantha H. Adikari, Geoffrey S. Waldo, Antonietta M. Lillo & Andrew R.M. Bradbury
Article: 1843754
Published online: 18 Nov 2020
AbstractforSelection and verification of antibodies against the cytoplasmic domain of M2 of influenza, a transmembrane protein | Full Text | References | PDF (4.8 MB) | EPUB
  • 1196 Views
  • 5 CrossRef citations
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Impact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line
Jun Kim, Haibin Luo, Wendy White, William Rees, Raghavan Venkat & Methal Albarghouthi
Article: 1844928
Published online: 10 Nov 2020
AbstractforImpact of Fc N-linked glycans on in vivo clearance of an immunoglobulin G1 antibody produced by NS0 cell line | Full Text | References | PDF (3.4 MB) | EPUB
  • 2161 Views
  • 5 CrossRef citations
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Short Communication

Diverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice
Yme U. van der Velden, Julien Villaudy, Esther Siteur - van Rijnstra, Cynthia A. van der Linden, Monique A. Vink, Edith E. Schermer, Kees Weijer, Ben Berkhout, Rogier W. Sanders & Marit J. van Gils
Article: 1845908
Published online: 20 Nov 2020
AbstractforDiverse HIV-1 escape pathways from broadly neutralizing antibody PGDM1400 in humanized mice | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1321 Views
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Report

Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity
Francesca Ros, Sonja Offner, Stefan Klostermann, Irmgard Thorey, Helmut Niersbach, Sebastian Breuer, Grit Zarnt, Stefan Lorenz, Juergen Puels, Basile Siewe, Nicole Schueler, Tajana Dragicevic, Dominique Ostler, Imke Hansen-Wester, Valeria Lifke, Brigitte Kaluza, Klaus Kaluza, Wim van Schooten, Roland Buelow, Alain C Tissot & Josef Platzer
Article: 1846900
Published online: 24 Nov 2020
AbstractforRabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
  • 3663 Views
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Review

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline
Marco Tuccori, Sara Ferraro, Irma Convertino, Emiliano Cappello, Giulia Valdiserra, Corrado Blandizzi, Fabrizio Maggi & Daniele Focosi
Article: 1854149
Published online: 15 Dec 2020
AbstractforAnti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline | Full Text | References | PDF (1.3 MB) | EPUB
  • 12404 Views
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Report

Identification and quantitation of hinge cysteinylation on endogenous IgG2 antibodies from human serum
Luladey Ayalew, Alicia D. D’Souza, Yan Chen & Michael T. Kim
Article: 1854923
Published online: 15 Dec 2020
AbstractforIdentification and quantitation of hinge cysteinylation on endogenous IgG2 antibodies from human serum | Full Text | References | PDF (2.1 MB) | EPUB
  • 2998 Views
  • 1 CrossRef citations
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Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies
Md Jahangir Alam, Liang Xie, Caroline Ang, Farnaz Fahimi, Stephen B. Willingham, Andrew J. Kueh, Marco J. Herold, Charles R. Mackay & Remy Robert
Article: 1856460
Published online: 21 Dec 2020
AbstractforTherapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies | Full Text | References | PDF (10.5 MB) | EPUB | Supplemental
  • 3157 Views
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Monoclonal antibody 2C5 specifically targets neutrophil extracellular traps
Livia P. Mendes, Kobra Rostamizadeh, Kandace Gollomp, Jacob W. Myerson, Oscar A. Marcos-Contreras, Marco Zamora, Ed Luther, Jacob S. Brenner, Nina Filipczak, Xiang Li & Vladimir P. Torchilin
Article: 1850394
Published online: 15 Dec 2020
AbstractforMonoclonal antibody 2C5 specifically targets neutrophil extracellular traps | Full Text | References | PDF (6 MB) | EPUB | Supplemental
  • 2714 Views
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