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mAbs Volume 12, 2020 - Issue 1
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Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity

Raul C. Camachoa Janssen R&D, Spring House, PA, USACorrespondence[email protected]
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Seohee Youa Janssen R&D, Spring House, PA, USAView further author information
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Katharine E. D’Aquinoa Janssen R&D, Spring House, PA, USAView further author information
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Wenyu Lia Janssen R&D, Spring House, PA, USAView further author information
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Yuanping Wanga Janssen R&D, Spring House, PA, USAView further author information
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Joseph Gunneta Janssen R&D, Spring House, PA, USAView further author information
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James Littrella Janssen R&D, Spring House, PA, USAView further author information
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Jian Shen Qia Janssen R&D, Spring House, PA, USAView further author information
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Lijuan Kangb Pharmacokinetics, Dynamics, and Metabolism, Janssen R&D, Spring House, PA, USAView further author information
,
Wenying Jianb Pharmacokinetics, Dynamics, and Metabolism, Janssen R&D, Spring House, PA, USAView further author information
,
Mary MacDonaldc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Timothy Tatc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
,
Derek Steinerc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Yue-Mei Zhanga Janssen R&D, Spring House, PA, USAView further author information
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James Lantera Janssen R&D, Spring House, PA, USAView further author information
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Raymond Patcha Janssen R&D, Spring House, PA, USAView further author information
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Rui Zhanga Janssen R&D, Spring House, PA, USAView further author information
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Jiali Lic Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Suzanne Edavettalc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Wilson Edwardsc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Thai Dinhc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Li Ying Wangc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Judy Connorc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Michael Hunterc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Ellen Chic Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Ronald V. Swansonc Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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James N. Leonarda Janssen R&D, Spring House, PA, USAView further author information
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Martin A. Casec Janssen Biotherapeutics, Janssen R&D, San Diego, La Jolla, CA, USAView further author information
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Article: 1794687 | Received 16 Apr 2020, Accepted 23 Jun 2020, Published online: 02 Aug 2020

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Qiang Liu, Pankaj Garg, Burcu Hasdemir, Linya Wang, Emily Tuscano, Emily Sever, Erica Keane, Ana G Lujan Hernandez, Tom Z. Yuan, Eric Kwan, Joyce Lai, Greg Szot, Sreenivasan Paruthiyil, Fumiko Axelrod & Aaron K. Sato. (2021) Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control. mAbs 13:1.
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Articles from other publishers (6)

Biagio Todaro, Elisa Ottalagana, Stefano Luin & Melissa Santi. (2023) Targeting Peptides: The New Generation of Targeted Drug Delivery Systems. Pharmaceutics 15:6, pages 1648.
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Yao Zhihong, Wang Chen, Zhu Qianqian, Sun Lidan, Zhou Qiang, Han Jing, Wang Wenxi & Ruchika Bhawal. (2023) Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity. Peptides 162, pages 170955.
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Junli Wang, Cen Liu, Hongliu Yang, Tao Ma, Yonggang Liu & Fener Chen. (2023) Intramolecularly lactam stapled oxyntomodulin analogues inhibit cancer cell proliferation in vitro. Chinese Chemical Letters 34:4, pages 107920.
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Markus Walles, Michael Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C. Tran, Cong Wei, Keyang Xu & Xiaochun Zhu. (2022) A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation. Drug Metabolism and Disposition 50:6, pages 846-857.
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Raymond J. Patch, Rui Zhang, Suzanne Edavettal, Mark J. Macielag, Annette J. Eckardt, Jiali Li, Marie-Laure Rives, Wilson Edwards, Simon A. Hinke, Xi Qiu, Wenying Jian, Ondrej Libiger, Songmao Zheng, Jey Jeyaseelan, Yin Liang, Shamina M. Rangwala, James N. Leonard & Pamela Hornby. (2022) Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists. European Journal of Medicinal Chemistry 236, pages 114330.
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Wenyu Li, Thomas Kirchner, George Ho, Fany Bonilla, Katharine D'Aquino, James Littrell, Rui Zhang, Wenying Jian, Xi Qiu, Songmao Zheng, Bin Gao, Peggy Wong, James N. Leonard & Raul C. Camacho. (2020) Amino acids are sensitive glucagon receptor‐specific biomarkers for glucagon‐like peptide‐1 receptor/glucagon receptor dual agonists. Diabetes, Obesity and Metabolism 22:12, pages 2437-2450.
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