Advanced search
Publication Cover
mAbs Volume 12, 2020 - Issue 1
Submit an article Journal homepage
6,548
Views
12
CrossRef citations to date
0
Altmetric
Report

Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models

Delphine Valentea DMPK, Sanofi, Vitry-Alfortville, FranceORCID Iconhttps://orcid.org/0000-0003-1790-2548View further author information
ORCID Icon,
Christine Mauriaca DMPK, Sanofi, Vitry-Alfortville, FranceORCID Iconhttps://orcid.org/0000-0002-8445-9761View further author information
ORCID Icon,
Thorsten Schmidtb Biologics Research, Sanofi, Frankfurt, GermanyORCID Iconhttps://orcid.org/0000-0001-9952-8881View further author information
ORCID Icon,
Ingo Fockenb Biologics Research, Sanofi, Frankfurt, GermanyORCID Iconhttps://orcid.org/0000-0002-9604-0538View further author information
ORCID Icon,
Jochen Beningab Biologics Research, Sanofi, Frankfurt, GermanyORCID Iconhttps://orcid.org/0000-0003-3209-004XView further author information
ORCID Icon,
Brian Macknessc Translational In vivo Models (TIM), Sanofi, Frankfurt, GermanyORCID Iconhttps://orcid.org/0000-0002-3587-5603View further author information
ORCID Icon,
Huawei Qiud Biologics, Xilio Therapeutics, Inc. Cambridge, USView further author information
,
Pascale Vicata DMPK, Sanofi, Vitry-Alfortville, FranceORCID Iconhttps://orcid.org/0000-0002-7590-7729View further author information
ORCID Icon,
Abdullah Kandirac Translational In vivo Models (TIM), Sanofi, Frankfurt, GermanyORCID Iconhttps://orcid.org/0000-0001-9822-6136View further author information
ORCID Icon,
Katarina Radoševiće Bio R&D, Lonza, St. Beauzire, FranceORCID Iconhttps://orcid.org/0000-0002-6769-8402View further author information
ORCID Icon,
Srini Raof Translational In vivo Models (TIM), Sanofi, Cambridge, USView further author information
,
John Darbyshireg DMPK, Sanofi, Frankfurt, GermanyView further author information
&
Mostafa Kabiric Translational In vivo Models (TIM), Sanofi, Frankfurt, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3576-4540View further author information
ORCID Icon show all
Article: 1829337 | Received 21 Jun 2020, Accepted 22 Sep 2020, Published online: 20 Oct 2020

Citations (12)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Karelle Ménochet, Hongbin Yu, Bonnie Wang, Jay Tibbitts, Cheng-Pang Hsu, Amrita V. Kamath, Wolfgang F. Richter & Andreas Baumann. (2022) Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper. mAbs 14:1.
Read now

Articles from other publishers (11)

Daniel Keri, Matt Walker, Isha Singh, Kyle Nishikawa & Fernando Garces. (2023) Next generation of multispecific antibody engineering. Antibody Therapeutics.
Crossref
Olga V. Britanova, Kseniia R. Lupyr, Dmitry B. Staroverov, Irina A. Shagina, Alexey A. Aleksandrov, Yakov Y. Ustyugov, Dmitry V. Somov, Alesia Klimenko, Nadejda A. Shostak, Ivan V. Zvyagin, Alexey V. Stepanov, Ekaterina M. Merzlyak, Alexey N. Davydov, Mark Izraelson, Evgeniy S. Egorov, Ekaterina A. Bogdanova, Anna K. Vladimirova, Pavel A. Iakovlev, Denis A. Fedorenko, Roman A. Ivanov, Veronika I. Skvortsova, Sergey Lukyanov & Dmitry M. Chudakov. (2023) Targeted depletion of TRBV9+ T cells as immunotherapy in a patient with ankylosing spondylitis. Nature Medicine 29:11, pages 2731-2736.
Crossref
Hao Cai, Xun Tao, Jeongsup Shim, Rebecca N. Bauer, Meire Bremer, Wei Bu, Jason LaMar, Rachel Basile, Edward Dere, Tien Nguyen, Steven Laing, Pamela Chan, Tangsheng Yi, James T. Koerber, Gizette Sperinde & Eric Stefanich. (2023) Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys. The AAPS Journal 25:4.
Crossref
Wilhelmus E. A. de Witte, Lindsay B. Avery, Brian C. Mackness, Tom Van Bogaert, Anna Park & Maria Laura Sargentini-Maier. (2023) Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules. Journal of Pharmacokinetics and Pharmacodynamics 50:3, pages 229-241.
Crossref
Christopher M. Conner, Don van Fossan, Kristen Read, Dale O. Cowley, Oscar Alvarez, Shannon Xiang-Ru Xu, David R. Webb & Kurt Jarnagin. (2023) A precisely humanized FCRN transgenic mouse for preclinical pharmacokinetics studies. Biochemical Pharmacology 210, pages 115470.
Crossref
Melanie Grandits, Clemens Grünwald-Gruber, Silke Gastine, Joseph F. Standing, Rajko Reljic, Audrey Y-H. Teh & Julian K-C. Ma. (2023) Improving the efficacy of plant-made anti-HIV monoclonal antibodies for clinical use. Frontiers in Plant Science 14.
Crossref
Michael Y.T. Chow, Harry W. Pan, Han Cong Seow & Jenny K.W. Lam. (2023) Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections. Trends in Pharmacological Sciences 44:2, pages 85-97.
Crossref
Blaise Pasquiers, Salih Benamara, Mathieu Felices, Laurent Nguyen & Xavier Declèves. (2022) Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection. International Journal of Molecular Sciences 23:21, pages 12754.
Crossref
Iftekhar Mahmood. (2021) A Single Animal Species-Based Prediction of Human Clearance and First-in-Human Dose of Monoclonal Antibodies: Beyond Monkey. Antibodies 10:3, pages 35.
Crossref
Maxime Fieux, Sandra Le Quellec, Sophie Bartier, André Coste, Bruno Louis, Caroline Giroudon, Mikail Nourredine & Emilie Bequignon. (2021) FcRn as a Transporter for Nasal Delivery of Biologics: A Systematic Review. International Journal of Molecular Sciences 22:12, pages 6475.
Crossref
Timothy Qi & Yanguang Cao. (2021) In Translation: FcRn across the Therapeutic Spectrum. International Journal of Molecular Sciences 22:6, pages 3048.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.