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mAbs Volume 12, 2020 - Issue 1
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Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism

Bradley N. Spatolaa Antibody Development, Tizona Therapeutics, South San Francisco, CA, USACorrespondence[email protected]
,
Alana G. Lernerb Immunology, Tizona Therapeutics, South San Francisco, CA, USA
,
Clifford Wonga Antibody Development, Tizona Therapeutics, South San Francisco, CA, USA
,
Tracy dela Cruzb Immunology, Tizona Therapeutics, South San Francisco, CA, USA;c Immunology, Trishula Therapeutics, South San Francisco, CA, USA
,
Megan Welchb Immunology, Tizona Therapeutics, South San Francisco, CA, USA
,
Wanchi Funga Antibody Development, Tizona Therapeutics, South San Francisco, CA, USA
,
Maria Kovalenkod Clinical Biomarkers, AbbVie, Redwood City, CA, USA
,
Karolina Losenkovae MediCity Research Laboratory, University of Turku, Turku, Finland
,
Gennady G. Yegutkine MediCity Research Laboratory, University of Turku, Turku, Finland
,
Courtney Beersb Immunology, Tizona Therapeutics, South San Francisco, CA, USA
,
John Corbina Antibody Development, Tizona Therapeutics, South San Francisco, CA, USA
&
Vanessa B. Sorosa Antibody Development, Tizona Therapeutics, South San Francisco, CA, USA
 show all
Article: 1838036 | Received 17 Jun 2020, Accepted 13 Oct 2020, Published online: 04 Nov 2020

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Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris & Maurice Zauderer. (2023) Use of poxvirus display to select antibodies specific for complex membrane antigens. mAbs 15:1.
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Articles from other publishers (17)

Cuicui Li, Litian Zhang, Qiqi Jin, Haoyun Jiang & Chongyang Wu. (2023) CD39 (ENTPD1) in tumors: a potential therapeutic target and prognostic biomarker. Biomarkers in Medicine.
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Yao Liu, Zhongliang Li, Xiaoguang Zhao, Jing Xiao, Jiacheng Bi, Xian-Yang Li, Guokai Chen & Ligong Lu. (2023) Review immune response of targeting CD39 in cancer. Biomarker Research 11:1.
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Venkat M. K. Vadlamani, Kavinda K. J. Gunasinghe, Xavier W. Chee, Taufiq Rahman & Matthew T. Harper. (2023) Human soluble CD39 displays substrate inhibition in a substrate-specific manner. Scientific Reports 13:1.
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Shumin Xu, Chenyang Wang, Lingge Yang, Jiaji Wu, Mengshu Li, Peng Xiao, Zhiyong Xu, Yun Xu & Kai Wang. (2023) Targeting immune checkpoints on tumor-associated macrophages in tumor immunotherapy. Frontiers in Immunology 14.
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Ryan R. Kowash & Esra A. Akbay. (2023) Tumor intrinsic and extrinsic functions of CD73 and the adenosine pathway in lung cancer. Frontiers in Immunology 14.
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Mika Casey, Kane Segawa, Soi Cheng Law, Muhamamed Bilal Sabdia, Bianca Nowlan, Basit Salik, Carol Lee, Clay Winterford, Sally Pearson, Jason Madore, William C. Dougall, Maher K. Gandhi & Kyohei Nakamura. (2022) Inhibition of CD39 unleashes macrophage antibody-dependent cellular phagocytosis against B-cell lymphoma. Leukemia 37:2, pages 379-387.
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Yuchen Wang, Hao Zhang, Chao Liu, Zeyu Wang, Wantao Wu, Nan Zhang, Longbo Zhang, Jason Hu, Peng Luo, Jian Zhang, Zaoqu Liu, Yun Peng, Zhixiong Liu, Lanhua Tang & Quan Cheng. (2022) Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts. Journal of Hematology & Oncology 15:1.
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Haohai Zhang, Lili Feng, Paola de Andrade Mello, Changchuin Mao, Richard Near, Eva Csizmadia, Leo Li-Ying Chan, Keiichi Enjyoji, Wenda Gao, Haitao Zhao & Simon C. Robson. (2022) Glycoengineered anti-CD39 promotes anticancer responses by depleting suppressive cells and inhibiting angiogenesis in tumor models. Journal of Clinical Investigation 132:13.
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Gennady G. Yegutkin & Detlev Boison. (2022) ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain. Pharmacological Reviews 74:3, pages 799-824.
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Xianglei Fu, Yanbin Shi, Hengchang Zang, Qingjie Wang, Yongjun Wang, Hang Wu, Shengnan Qiu, Hua Shen, Fanyang Mo, Yankun Zhang & Guimei Lin. (2022) Combination of oxaliplatin and POM-1 by nanoliposomes to reprogram the tumor immune microenvironment. Journal of Controlled Release 347, pages 1-13.
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Jasmine M. Manouchehri, Jharna Datta, Natalie Willingham, Robert Wesolowski, Daniel Stover, Ramesh K. Ganju, William E. Carson, Bhuvaneswari Ramaswamy & Mathew A. Cherian. (2022) Augmentation of Extracellular ATP Synergizes With Chemotherapy in Triple Negative Breast Cancer. Frontiers in Oncology 12.
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Laura Schäkel, Salahuddin Mirza, Markus Pietsch, Sang‐Yong Lee, Tim Keuler, Katharina Sylvester, Julie Pelletier, Jean Sévigny, Thanigaimalai Pillaiyar, Vigneshwaran Namasivayam, Michael Gütschow & Christa E. Müller. (2021) 2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors. Archiv der Pharmazie 354:12.
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Anna M. Chiarella, Yun K. Ryu, Gulam A. Manji & Anil K. Rustgi. (2021) Extracellular ATP and Adenosine in Cancer Pathogenesis and Treatment. Trends in Cancer 7:8, pages 731-750.
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Gennady G. Yegutkin. (2021) Adenosine metabolism in the vascular system. Biochemical Pharmacology 187, pages 114373.
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Arne Christian Rufer. (2021) Drug discovery for enzymes. Drug Discovery Today 26:4, pages 875-886.
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Alberto Cruz-Bermúdez, Raquel Laza-Briviesca, Marta Casarrubios, Belén Sierra-Rodero & Mariano Provencio. (2021) The Role of Metabolism in Tumor Immune Evasion: Novel Approaches to Improve Immunotherapy. Biomedicines 9:4, pages 361.
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José Manuel Pérez de la Lastra, Victoria Baca-González, Sergio González-Acosta, Patricia Asensio-Calavia, Andrea Otazo-Pérez & Antonio Morales-delaNuez. (2021) Antibodies targeting enzyme inhibition as potential tools for research and drug development. Biomolecular Concepts 12:1, pages 215-232.
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