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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

Josefa Dela Cruz Chuha Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA
,
MaryAnn Gob Research biology, Genentech Inc, South San Francisco, CA, USA
,
Yvonne Chenc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Jun Guob Research biology, Genentech Inc, South San Francisco, CA, USA
,
Hanine Rafidid Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, South San Francisco, CA, USA
,
Danielle Mandikiand Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, South San Francisco, CA, USA
,
Yonglian Sunc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Zhonghua Linc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Kellen Schneiderc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Pamela Zhangc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Rajesh Vijc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Danielle Sharpnacka Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA
,
Pamela Chana Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA
,
Cecile de la Cruzb Research biology, Genentech Inc, South San Francisco, CA, USA
,
Jack Sadowskye Protein Chemistry, Genentech Inc, South San Francisco, CA, USA
,
Dhaya Seshasayeec Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
James T. Koerberc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA
,
Thomas H. Pillowf Discovery Chemistry, Genentech Inc, South San Francisco, CA, USAORCID Iconhttps://orcid.org/0000-0001-7300-1002
ORCID Icon,
Gail D. Phillipsb Research biology, Genentech Inc, South San Francisco, CA, USA
,
Rebecca K Rowntreeb Research biology, Genentech Inc, South San Francisco, CA, USA
,
C. Andrew Boswelld Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, South San Francisco, CA, USA
,
Katherine R. Kozaka Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA
,
Andrew G. Polsonb Research biology, Genentech Inc, South San Francisco, CA, USA
,
Paul Polakisb Research biology, Genentech Inc, South San Francisco, CA, USA
,
Shang-Fan Yub Research biology, Genentech Inc, South San Francisco, CA, USA
,
Peter S. Dragovichf Discovery Chemistry, Genentech Inc, South San Francisco, CA, USA
&
Nicholas J. Agardc Antibody Engineering, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
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Article: 1862452 | Received 05 Oct 2020, Accepted 07 Dec 2020, Published online: 31 Dec 2020

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Danielle M. Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Bill Forrest, Chen Gu, Steven R. Leong, Genee Lee, Shang-Fan Yu, Andrew G. Polson & Nicholas J. Agard. (2022) Development of T-cell engagers selective for cells co-expressing two antigens. mAbs 14:1.
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Dipankar Pramanik. (2023) Development of Antibody-Drug Conjugates: Future Perspective Towards Solid Tumor Treatment. Anti-Cancer Agents in Medicinal Chemistry 23:6, pages 642-657.
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Yujie Zhang, Zhichao Xing, Li Mi, Zhihui Li, Jingqiang Zhu, Tao Wei & Wenshuang Wu. (2022) Novel Agents For Relapsed and Refractory Classical Hodgkin Lymphoma: A Review. Frontiers in Oncology 12.
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Qian Zhang, Ying Jia, Pan Pan, Xiuping Zhang, Yanfei Jia, Ping Zhu, Xiaowei Chen, Yang Jiao, Guiyu Kang, Lulu Zhang & Xiaoli Ma. (2022) α5-nAChR associated with Ly6E modulates cell migration via TGF-β1/Smad signaling in non-small cell lung cancer. Carcinogenesis 43:4, pages 393-404.
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Ting Li, Weidong Liu, Chun Wang, Man Wang, Wenjia Hui, Jiajie Lu & Feng Gao. (2022) Multidimension Analysis of the Prognostic Value, Immune Regulatory Function, and ceRNA Network of LY6E in Individuals with Colorectal Cancer. Journal of Immunology Research 2022, pages 1-19.
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