Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response

Josefa Dela Cruz Chuha Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA

MaryAnn Gob Research biology, Genentech Inc, South San Francisco, CA, USA

Yvonne Chenc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Jun Guob Research biology, Genentech Inc, South San Francisco, CA, USA

Hanine Rafidid Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, South San Francisco, CA, USA

Danielle Mandikiand Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, South San Francisco, CA, USA

Yonglian Sunc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Zhonghua Linc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Kellen Schneiderc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Pamela Zhangc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Rajesh Vijc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Danielle Sharpnacka Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA

Pamela Chana Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA

Cecile de la Cruzb Research biology, Genentech Inc, South San Francisco, CA, USA

Jack Sadowskye Protein Chemistry, Genentech Inc, South San Francisco, CA, USA

Dhaya Seshasayeec Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

James T. Koerberc Antibody Engineering, Genentech Inc, South San Francisco, CA, USA

Thomas H. Pillowf Discovery Chemistry, Genentech Inc, South San Francisco, CA, USA

Gail D. Phillipsb Research biology, Genentech Inc, South San Francisco, CA, USA

Rebecca K Rowntreeb Research biology, Genentech Inc, South San Francisco, CA, USA

C. Andrew Boswelld Preclinical & Translational Pharmacokinetics and Pharmacodynamics, Genentech Inc, South San Francisco, CA, USA

Katherine R. Kozaka Departments of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA

Andrew G. Polsonb Research biology, Genentech Inc, South San Francisco, CA, USA

Paul Polakisb Research biology, Genentech Inc, South San Francisco, CA, USA

Shang-Fan Yub Research biology, Genentech Inc, South San Francisco, CA, USA

Peter S. Dragovichf Discovery Chemistry, Genentech Inc, South San Francisco, CA, USA

Nicholas J. Agardc Antibody Engineering, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]

Your download is now in progress and you may close this window