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mAbs Volume 13, 2021 - Issue 1
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Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody

Sharon M. Campbella Biomedicine Design, Pfizer, Dublin, Ireland
,
Joseph DeBartolob Biomedicine Design, Pfizer, Cambridge, MA, USA
,
James R. Apgarb Biomedicine Design, Pfizer, Cambridge, MA, USA
,
Lydia Mosyakb Biomedicine Design, Pfizer, Cambridge, MA, USA
,
Virginie McManusa Biomedicine Design, Pfizer, Dublin, Ireland
,
Sonia Beyera Biomedicine Design, Pfizer, Dublin, Ireland
,
Eric M. Bennettb Biomedicine Design, Pfizer, Cambridge, MA, USA
,
Matthew Lamberta Biomedicine Design, Pfizer, Dublin, Ireland
&
Orla Cunninghama Biomedicine Design, Pfizer, Dublin, IrelandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3888-9541
ORCID Icon show all
Article: 1883239 | Received 02 Dec 2020, Accepted 26 Jan 2021, Published online: 09 Feb 2021

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Orla Cunningham, Martin Scott, Zhaohui Sunny Zhou & William J.J. Finlay. (2021) Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns. mAbs 13:1.
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Articles from other publishers (2)

Hannes Ausserwöger, Matthias M. Schneider, Therese W. Herling, Paolo Arosio, Gaetano Invernizzi, Tuomas P. J. Knowles & Nikolai Lorenzen. (2022) Non-specificity as the sticky problem in therapeutic antibody development. Nature Reviews Chemistry 6:12, pages 844-861.
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Jorge Moura-Sampaio, André F. Faustino, Remi Boeuf, Miguel A. Antunes, Stefan Ewert & Ana P. Batista. (2022) Reconstruction of full antibody sequences in NGS datasets and accurate VL:VH coupling by cluster coordinate matching of non-overlapping reads. Computational and Structural Biotechnology Journal 20, pages 2723-2727.
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