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Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties

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Article: 2056944 | Received 14 Jan 2022, Accepted 20 Mar 2022, Published online: 01 May 2022

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Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel & Srinath Kasturirangan. (2024) Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies. mAbs 16:1.
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Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock & Veena A. Thomas. (2023) Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice. mAbs 15:1.
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Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang & Iain D. G. Campuzano. (2023) Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies. mAbs 15:1.
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Shufang Liu & Dhaval K. Shah. (2023) Physiologically Based Pharmacokinetic Modeling to Characterize the Effect of Molecular Charge on Whole-Body Disposition of Monoclonal Antibodies. The AAPS Journal 25:3.
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Hannes Ausserwöger, Georg Krainer, Timothy J. Welsh, Nels Thorsteinson, Ella de Csilléry, Tomas Sneideris, Matthias M. Schneider, Thomas Egebjerg, Gaetano Invernizzi, Therese W. Herling, Nikolai Lorenzen & Tuomas P. J. Knowles. (2023) Surface patches induce nonspecific binding and phase separation of antibodies. Proceedings of the National Academy of Sciences 120:15.
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Pradeep Sharma, Felix Stader, Vijender Panduga, Jin Dong & David W. Boulton. 2023. The Quintessence of Basic and Clinical Research and Scientific Publishing. The Quintessence of Basic and Clinical Research and Scientific Publishing 267 290 .
Shihao Hu, Amita Datta-Mannan & David Z. D’Argenio. (2022) Monoclonal Antibody Pharmacokinetics in Cynomolgus Monkeys Following Subcutaneous Administration: Physiologically Based Model Predictions from Physiochemical Properties. The AAPS Journal 25:1.
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Hannes Ausserwöger, Matthias M. Schneider, Therese W. Herling, Paolo Arosio, Gaetano Invernizzi, Tuomas P. J. Knowles & Nikolai Lorenzen. (2022) Non-specificity as the sticky problem in therapeutic antibody development. Nature Reviews Chemistry 6:12, pages 844-861.
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