mAbs, Volume 14, Issue 1 (2022)

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mAbs, Volume 14, Issue 1 (2022)

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Development of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors
Richard Graveline, Morad Haida, Carolyne Dumont, Dominic Poulin, Florence Poitout-Belissent, Rana Samadfam, Sven Kronenberg, Franziska Regenass-Lechner, Rodney Prell & Marie-Soleil Piche
Article: 1979447
Published online: 20 Dec 2021
AbstractforDevelopment of a nonhuman primate challenge model to evaluate CD8+ T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors | Full Text | References | PDF (3.1 MB) | EPUB
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Reviews

Review Article
Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays
Axel Ducret, Chloé Ackaert, Juliana Bessa, Campbell Bunce, Timothy Hickling, Vibha Jawa, Mark A. Kroenke, Kasper Lamberth, Anaïs Manin, Hweixian L. Penny, Noel Smith, Grzegorz Terszowski, Sophie Tourdot & Sebastian Spindeldreher
Article: 1993522
Published online: 20 Dec 2021
AbstractforAssay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays | Full Text | References | PDF (826 KB) | EPUB
  • 7673 Views
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Rapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries
Tom Z. Yuan, Pankaj Garg, Linya Wang, Jordan R. Willis, Eric Kwan, Ana G Lujan Hernandez, Emily Tuscano, Emily N. Sever, Erica Keane, Cinque Soto, Eric M. Mucker, Mallorie E. Fouch, Edgar Davidson, Benjamin J. Doranz, Shweta Kailasan, M. Javad Aman, Haoyang Li, Jay W. Hooper, Erica Ollmann Saphire, James E. Crowe, Qiang Liu, Fumiko Axelrod & Aaron K. Sato
Article: 2002236
Published online: 30 Dec 2021
AbstractforRapid discovery of diverse neutralizing SARS-CoV-2 antibodies from large-scale synthetic phage libraries | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
  • 6796 Views
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Non-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromatography-mass spectrometry
Daniel W. Woodall, Thomas M. Dillon, Kevin Kalenian, Rupa Padaki, Scott Kuhns, David J. Semin & Pavel V. Bondarenko
Article: 2004982
Published online: 03 Jan 2022
AbstractforNon-targeted characterization of attributes affecting antibody-FcγRIIIa V158 (CD16a) binding via online affinity chromatography-mass spectrometry | Full Text | References | PDF (2.8 MB) | EPUB
  • 3921 Views
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Quality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells
Gangling Xu, Chuanfei Yu, Wenbo Wang, Cexiong Fu, Hongchuan Liu, Yanping Zhu, Yuan Li, Chunyu Liu, Zhihao Fu, Gang Wu, Meng Li, Sha Guo, Xiaojuan Yu, Jialiang Du, Yalan Yang, Maoqin Duan, Yongfei Cui, Hui Feng & Lan Wang
Article: 2005507
Published online: 20 Dec 2021
AbstractforQuality comparability assessment of a SARS-CoV-2-neutralizing antibody across transient, mini-pool-derived and single-clone CHO cells | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 3636 Views
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Phenotypic whole-cell screening identifies a protective carbohydrate epitope on Klebsiella pneumoniae
Sophia K. Berry, Steven Rust, Carolina Caceres, Lorraine Irving, Josefin Bartholdson Scott, David E. Tabor, Gordon Dougan, Graham Christie, Paul Warrener, Ralph Minter & Andrew J. Grant
Article: 2006123
Published online: 20 Dec 2021
AbstractforPhenotypic whole-cell screening identifies a protective carbohydrate epitope on Klebsiella pneumoniae | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2725 Views
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Correction

Correction
Correction
Article: 2006471
Published online: 13 Jan 2022
CitationforCorrection | Full Text | PDF (135.4 KB) | EPUB
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Report

Report
Multi-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics
Bingchuan Wei, Nicholas Woon, Lu Dai, Raphael Fish, Michelle Tai, Winode Handagama, Ashley Yin, Jia Sun, Andrew Maier, Dana McDaniel, Elvira Kadaub, Jessica Yang, Miguel Saggu, Ann Woys, Oxana Pester, Danny Lambert, Alex Pell, Zhiqi Hao, Gordon Magill, Jack Yim, Jefferson Chan, Lindsay Yang, Frank Macchi, Christian Bell, Galahad Deperalta & Yan Chen
Article: 2007564
Published online: 29 Dec 2021
AbstractforMulti-attribute Raman spectroscopy (MARS) for monitoring product quality attributes in formulated monoclonal antibody therapeutics | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 7086 Views
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Review

Review
Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies
Rahmad Akbar, Habib Bashour, Puneet Rawat, Philippe A. Robert, Eva Smorodina, Tudor-Stefan Cotet, Karine Flem-Karlsen, Robert Frank, Brij Bhushan Mehta, Mai Ha Vu, Talip Zengin, Jose Gutierrez-Marcos, Fridtjof Lund-Johansen, Jan Terje Andersen & Victor Greiff
Article: 2008790
Published online: 16 Mar 2022
AbstractforProgress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies | Full Text | References | PDF (3.5 MB) | EPUB
  • 21922 Views
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Article
Harnessing the potential of machine learning for advancing “Quality by Design” in biomanufacturing
Ian Walsh, Matthew Myint, Terry Nguyen-Khuong, Ying Swan Ho, Say Kong Ng & Meiyappan Lakshmanan
Article: 2013593
Published online: 09 Jan 2022
AbstractforHarnessing the potential of machine learning for advancing “Quality by Design” in biomanufacturing | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 9297 Views
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Report

Report
Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana
Kelsi Swope, Josh Morton, Gregory P. Pogue, Leigh Burden, Nicholas Partain, Steve Hume, John Shepherd, Carrie A. Simpson, Miles B. Brennan, Thomas C. Furman, Sheila Kingrey-Gebe, Theresa Martinez, Jim McDonough, Michael H. Pauly, Kevin J. Whaley, Larry Zeitlin, Barry Bratcher & Hugh Haydon
Article: 2013594
Published online: 09 Jan 2022
AbstractforReproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana | Full Text | References | PDF (1.9 MB) | EPUB
  • 3689 Views
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Report
Structural and functional characterization of a monoclonal antibody blocking TIGIT
Bo-Seong Jeong, Hyemi Nam, Jeewon Lee, Hye-Young Park, Ki Joon Cho, Joong Hyuk Sheen, Eunjung Song, Meesook Oh, Sunggeun Lee, Hyemin Choi, Jung-Eun Yang, Munkyung Kim & Byung-Ha Oh
Article: 2013750
Published online: 28 Jan 2022
AbstractforStructural and functional characterization of a monoclonal antibody blocking TIGIT | Full Text | References | PDF (2 MB) | EPUB
  • 5748 Views
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Perspective

Article Commentary
Antibodies to watch in 2022
Hélène Kaplon, Alicia Chenoweth, Silvia Crescioli & Janice M. Reichert
Article: 2014296
Published online: 14 Jan 2022
AbstractforAntibodies to watch in 2022 | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 39619 Views
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Report

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Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities
Desislava Yanakieva, Lukas Pekar, Andreas Evers, Markus Fleischer, Stephan Keller, Dirk Mueller-Pompalla, Lars Toleikis, Harald Kolmar, Stefan Zielonka & Simon Krah
Article: 2018960
Published online: 11 Jan 2022
AbstractforBeyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 6953 Views
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Mitochondrial membrane potential-enriched CHO host: a novel and powerful tool for improving biomanufacturing capability
Lina Chakrabarti, Raghothama Chaerkady, Junmin Wang, Shao Huan Samuel Weng, Chunlei Wang, Chen Qian, Lisa Cazares, Sonja Hess, Peter Amaya, Jie Zhu & Diane Hatton
Article: 2020081
Published online: 14 Jan 2022
AbstractforMitochondrial membrane potential-enriched CHO host: a novel and powerful tool for improving biomanufacturing capability | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 5866 Views
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Review

Review Article
Current advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics
Rahul Khetan, Robin Curtis, Charlotte M. Deane, Johannes Thorling Hadsund, Uddipan Kar, Konrad Krawczyk, Daisuke Kuroda, Sarah A. Robinson, Pietro Sormanni, Kouhei Tsumoto, Jim Warwicker & Andrew C.R. Martin
Article: 2020082
Published online: 01 Feb 2022
AbstractforCurrent advances in biopharmaceutical informatics: guidelines, impact and challenges in the computational developability assessment of antibody therapeutics | Full Text | References | PDF (1 MB) | EPUB
  • 15731 Views
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Report

Report
BioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan, Laurence Fayadat-Dilman, Daniel Svozil & Danny A. Bitton
Article: 2020203
Published online: 08 Feb 2022
AbstractforBioPhi: A platform for antibody design, humanization, and humanness evaluation based on natural antibody repertoires and deep learning | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 19461 Views
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Report
Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants
Bo-Seong Jeong, Jeong Seok Cha, Insu Hwang, Uijin Kim, Jared Adolf-Bryfogle, Brian Coventry, Hyun-Soo Cho, Kyun-Do Kim & Byung-Ha Oh
Article: 2021601
Published online: 14 Jan 2022
AbstractforComputational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 5544 Views
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Review

Review Article
In silico prediction of post-translational modifications in therapeutic antibodies
Shabdita Vatsa
Article: 2023938
Published online: 18 Jan 2022
AbstractforIn silico prediction of post-translational modifications in therapeutic antibodies | Full Text | References | PDF (1.5 MB) | EPUB
  • 9826 Views
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Report

Report
CDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies
Monica L. Fernández-Quintero, Katharina B. Kroell, Lukas J. Grunewald, Anna-Lena M. Fischer, Jakob R. Riccabona & Klaus R. Liedl
Article: 2024118
Published online: 28 Jan 2022
AbstractforCDR loop interactions can determine heavy and light chain pairing preferences in bispecific antibodies | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 6113 Views
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Report
Improved therapeutic index of an acidic pH-selective antibody
Peter S. Lee, Katherine G. MacDonald, Evan Massi, Pamela V. Chew, Christine Bee, Padma Perkins, Bryant Chau, Kent Thudium, Jack Lohre, Pradyot Nandi, Ekaterina G. Deyanova, Ishita Barman, Olafur Gudmundsson, Gavin Dollinger, Tim Sproul, John J. Engelhardt, Pavel Strop & Arvind Rajpal
Article: 2024642
Published online: 22 Feb 2022
AbstractforImproved therapeutic index of an acidic pH-selective antibody | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 12990 Views
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Report
Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics
Pin-Kuang Lai, Austin Gallegos, Neil Mody, Hasige A. Sathish & Bernhardt L. Trout
Article: 2026208
Published online: 25 Jan 2022
AbstractforMachine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics | Full Text | References | PDF (912.9 KB) | EPUB | Supplemental
  • 13207 Views
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Short Communication

Report
Epitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody
Arthur J. Schick III, Victor Lundin, Justin Low, Kun Peng, Richard Vandlen & Aaron T. Wecksler
Article: 2028337
Published online: 24 Jan 2022
AbstractforEpitope mapping of anti-drug antibodies to a clinical candidate bispecific antibody | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 4052 Views
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Report

Report
Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα /gp130 hexameric signaling complex formation
Chun-Chi Chou, Kuo-Tai Hua, Min-Wei Chen, Chin-Jui Wu, Chun-Hua Hsu, Jann-Tay Wang, Michael Hsiao & Lin-Hung Wei
Article: 2029675
Published online: 08 Feb 2022
AbstractforDiscovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα /gp130 hexameric signaling complex formation | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 3526 Views
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Report
In silico proof of principle of machine learning-based antibody design at unconstrained scale
Rahmad Akbar, Philippe A. Robert, Cédric R. Weber, Michael Widrich, Robert Frank, Milena Pavlović, Lonneke Scheffer, Maria Chernigovskaya, Igor Snapkov, Andrei Slabodkin, Brij Bhushan Mehta, Enkelejda Miho, Fridtjof Lund-Johansen, Jan Terje Andersen, Sepp Hochreiter, Ingrid Hobæk Haff, Günter Klambauer, Geir Kjetil Sandve & Victor Greiff
Article: 2031482
Published online: 04 Apr 2022
AbstractforIn silico proof of principle of machine learning-based antibody design at unconstrained scale | Full Text | References | PDF (29.3 MB) | EPUB | Supplemental
  • 13182 Views
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Review

Review Article
Therapeutic antibodies for COVID-19: is a new age of IgM, IgA and bispecific antibodies coming?
Jingjing Zhang, Han Zhang & Litao Sun
Article: 2031483
Published online: 27 Feb 2022
AbstractforTherapeutic antibodies for COVID-19: is a new age of IgM, IgA and bispecific antibodies coming? | Full Text | References | PDF (1.4 MB) | EPUB
  • 5441 Views
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Report

Report
The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa
Yuki Yamaguchi, Natsumi Wakaizumi, Mine Irisa, Takahiro Maruno, Mari Shimada, Koya Shintani, Haruka Nishiumi, Rina Yogo, Saeko Yanaka, Daisuke Higo, Tetsuo Torisu, Koichi Kato & Susumu Uchiyama
Article: 2038531
Published online: 16 Mar 2022
AbstractforThe Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 4941 Views
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Report
CLEC5a-directed bispecific antibody for effective cellular phagocytosis
Vivekananda Kedage, Diego Ellerman, Mingjian Fei, Wei-Ching Liang, Gu Zhang, Eric Cheng, Juan Zhang, Yongmei Chen, Haochu Huang, Wyne P. Lee, Yan Wu & Minhong Yan
Article: 2040083
Published online: 16 Mar 2022
AbstractforCLEC5a-directed bispecific antibody for effective cellular phagocytosis | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 4425 Views
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Report
Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants
Taichi Kuramochi, Siok Wan Gan, Adrian W.S. Ho, Bei Wang, Nagisa Kageji, Takeru Nambu, Sayaka Iida, Momoko Okuda-Miura, Wei Shan Chia, Chiew Ying Yeo, Dan Chen, Wen-Hsin Lee, Eve Zi Xian Ngoh, Siti Nazihah Mohd Salleh, Cheng-I Wang, Tomoyuki Igawa & Hideaki Shimada
Article: 2040350
Published online: 16 Mar 2022
AbstractforComprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 3060 Views
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Report article

Report
A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties
Jie Zhao, Liangfeng Jiang, Haodong Yang, Lan Deng, Xiaoqing Meng, Jian Ding, Sixing Yang, Le Zhao, Wei Xu, Xiaolong Wang, Zhenping Zhu & Haomin Huang
Article: 2044435
Published online: 03 Mar 2022
AbstractforA strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 4484 Views
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Review

Review Article
Computational models for studying physical instabilities in high concentration biotherapeutic formulations
Marco A. Blanco
Article: 2044744
Published online: 14 Mar 2022
AbstractforComputational models for studying physical instabilities in high concentration biotherapeutic formulations | Full Text | References | PDF (1.4 MB) | EPUB
  • 4470 Views
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Report

Report
In silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies
Xin Yu, Merlinda Conyne, Marc R. Lake, Karl A. Walter & Jing Min
Article: 2044977
Published online: 11 Mar 2022
AbstractforIn silico high throughput mutagenesis and screening of signal peptides to mitigate N-terminal heterogeneity of recombinant monoclonal antibodies | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 3841 Views
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Reports

Report
Nebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19
Thomas J. Esparza, Yaozong Chen, Negin P. Martin, Helle Bielefeldt-Ohmann, Richard A. Bowen, William D. Tolbert, Marzena Pazgier & David L. Brody
Article: 2047144
Published online: 15 Mar 2022
AbstractforNebulized delivery of a broadly neutralizing SARS-CoV-2 RBD-specific nanobody prevents clinical, virological, and pathological disease in a Syrian hamster model of COVID-19 | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 2972 Views
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Suitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales
Sara Rodriguez-Conde, Sophie Inman, Viv Lindo, Leanne Amery, Alison Tang, Uche Okorji-Obike, Wenjuan Du, Berend-Jan Bosch, Paul J. Wichgers Schreur, Jeroen Kortekaas, Isabel Sola, Luis Enjuanes, Laura Kerry, Katharina Mahal, Martyn Hulley & Olalekan Daramola
Article: 2052228
Published online: 24 Mar 2022
AbstractforSuitability of transiently expressed antibodies for clinical studies: product quality consistency at different production scales | Full Text | References | PDF (1.8 MB) | EPUB
  • 4273 Views
  • 3 CrossRef citations
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Report

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Physiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties
Shihao Hu, Amita Datta-Mannan & David Z. D’Argenio
Article: 2056944
Published online: 01 May 2022
AbstractforPhysiologically Based Modeling to Predict Monoclonal Antibody Pharmacokinetics in Humans from in vitro Physiochemical Properties | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 4592 Views
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Reports

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Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model
Peng Zhao, Yasuaki Anami, Peng Gao, Xuejun Fan, Leike Li, Kyoji Tsuchikama, Ningyan Zhang & Zhiqiang an
Article: 2057269
Published online: 07 Apr 2022
AbstractforEnhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model | Full Text | References | PDF (8.3 MB) | EPUB
  • 3694 Views
  • 8 CrossRef citations
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Review

Review
David versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors
Mohamed A. Alfaleh, Ayat Zawawi, Sawsan S. Al-Amri & Anwar M. Hashem
Article: 2057832
Published online: 05 Apr 2022
AbstractforDavid versus goliath: ACE2-Fc receptor traps as potential SARS-CoV-2 inhibitors | Full Text | References | PDF (1.5 MB) | EPUB
  • 3635 Views
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Report

Report
Upstream cell culture process characterization and in-process control strategy development at pandemic speed
Jianlin Xu, Jianfa Ou, Kyle P. McHugh, Michael C. Borys & Anurag Khetan
Article: 2060724
Published online: 05 Apr 2022
AbstractforUpstream cell culture process characterization and in-process control strategy development at pandemic speed | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 13623 Views
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Development of QSAR models for in silico screening of antibody solubility
Xuan Han, James Shih, Yuhao Lin, Qing Chai & Steven M. Cramer
Article: 2062807
Published online: 20 Apr 2022
AbstractforDevelopment of QSAR models for in silico screening of antibody solubility | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 3620 Views
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The eIg technology to generate Ig-like bispecific antibodies
Lennart Kühl, Nadine Aschmoneit, Roland E. Kontermann & Oliver Seifert
Article: 2063043
Published online: 15 Apr 2022
AbstractforThe eIg technology to generate Ig-like bispecific antibodies | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 4105 Views
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The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta
Samuel Schmitz, Emily A. Schmitz, James E. Crowe Jr & Jens Meiler
Article: 2068212
Published online: 11 May 2022
AbstractforThe human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 3846 Views
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Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering
Yuji Hori, Ken Ohmine, Hitoshi Katada, Yuki Noguchi, Kazuki Sato, Takeru Nambu, Lam Runyi Adeline, Gan Siok Wan, Kenta Haraya, Kazuhisa Ozeki, Masahiko Nanami, Tatsuhiko Tachibana, Zenjiro Sampei, Taichi Kuramochi, Junichi Nezu, Kunihiro Hattori & Tomoyuki Igawa
Article: 2068213
Published online: 28 Apr 2022
AbstractforElimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 4070 Views
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Predicting antibody binders and generating synthetic antibodies using deep learning
Yoong Wearn Lim, Adam S. Adler & David S. Johnson
Article: 2069075
Published online: 28 Apr 2022
AbstractforPredicting antibody binders and generating synthetic antibodies using deep learning | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 10862 Views
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Report
Novel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants
Tatsuhiko Ozawa, Hideki Tani, Yuki Anraku, Shunsuke Kita, Emiko Igarashi, Yumiko Saga, Noriko Inasaki, Hitoshi Kawasuji, Hiroshi Yamada, so-Ichiro Sasaki, Mayu Somekawa, Jiei Sasaki, Yoshihiro Hayakawa, Yoshihiro Yamamoto, Yoshitomo Morinaga, Nobuyuki Kurosawa, Masaharu Isobe, Hideo Fukuhara, Katsumi Maenaka, Takao Hashiguchi, Hiroyuki Kishi, Isao Kitajima, Shigeru Saito & Hideki Niimi
Article: 2072455
Published online: 11 May 2022
AbstractforNovel super-neutralizing antibody UT28K is capable of protecting against infection from a wide variety of SARS-CoV-2 variants | Full Text | References | PDF (3.3 MB) | EPUB
  • 4056 Views
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An adapted consensus protein design strategy for identifying globally optimal biotherapeutics
Yanyun Liu, Kenny Tsang, Michelle Mays, Gale Hansen, Jeffrey Chiecko, Maureen Crames, Yangjie Wei, Weijie Zhou, Chase Fredrick, James Hu, Dongmei Liu, Douglas Gebhard, Zhong-Fu Huang, Akshita Datar, Anthony Kronkaitis, Kristina Gueneva-Boucheva, Daniel Seeliger, Fei Han, Saurabh Sen, Srinath Kasturirangan, Justin M. Scheer, Andrew E. Nixon, Tadas Panavas, Michael S. Marlow & Sandeep Kumar
Article: 2073632
Published online: 25 May 2022
AbstractforAn adapted consensus protein design strategy for identifying globally optimal biotherapeutics | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 4722 Views
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International nonproprietary names for monoclonal antibodies: an evolving nomenclature system
Sofia S. Guimaraes Koch, Robin Thorpe, Nana Kawasaki, Marie-Paule Lefranc, Sarel Malan, Andrew C.R. Martin, Gilles Mignot, Andreas Plückthun, Menico Rizzi, Stephanie Shubat, Karin Weisser & Raffaella Balocco
Article: 2075078
Published online: 18 May 2022
AbstractforInternational nonproprietary names for monoclonal antibodies: an evolving nomenclature system | Full Text | References | PDF (3.3 MB) | EPUB
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The proximity of the N- and C- termini of bovine knob domains enable engineering of target specificity into polypeptide chains
Alice Hawkins, Callum Joyce, Kevin Brady, Adam Hold, Alan Smith, Michael Knight, Conor Howard, Jean van den Elsen, Alastair D.G. Lawson & Alex Macpherson
Article: 2076295
Published online: 29 May 2022
AbstractforThe proximity of the N- and C- termini of bovine knob domains enable engineering of target specificity into polypeptide chains | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 2333 Views
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Reports

Report
Deep mutational engineering of broadly-neutralizing nanobodies accommodating SARS-CoV-1 and 2 antigenic drift
Adrien Laroche, Maria Lucia Orsini Delgado, Benjamin Chalopin, Philippe Cuniasse, Steven Dubois, Raphaël Sierocki, Fabrice Gallais, Stéphanie Debroas, Laurent Bellanger, Stéphanie Simon, Bernard Maillère & Hervé Nozach
Article: 2076775
Published online: 20 May 2022
AbstractforDeep mutational engineering of broadly-neutralizing nanobodies accommodating SARS-CoV-1 and 2 antigenic drift | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 3113 Views
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Open Access

Short Communications

Rapid Communication
Enzymatic glycan remodeling–metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering
Marloes A. Wijdeven, Remon van Geel, Jorin H. Hoogenboom, Jorge M. M. Verkade, Brian M. G. Janssen, Inge Hurkmans, Laureen de Bever, Sander S. van Berkel & Floris L. van Delft
Article: 2078466
Published online: 29 May 2022
AbstractforEnzymatic glycan remodeling–metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
  • 6603 Views
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Open Access

Review

Review
A perspective toward mass spectrometry-based de novo sequencing of endogenous antibodies
Sebastiaan C. de Graaf, Max Hoek, Sem Tamara & Albert J. R. Heck
Article: 2079449
Published online: 14 Jun 2022
AbstractforA perspective toward mass spectrometry-based de novo sequencing of endogenous antibodies | Full Text | References | PDF (5.1 MB) | EPUB
  • 6415 Views
  • 17 CrossRef citations
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Report

Report
Separating clinical antibodies from repertoire antibodies, a path to in silico developability assessment
Christopher Negron, Joyce Fang, Michael J. McPherson, W. Blaine Stine Jr & Andrew J. McCluskey
Article: 2080628
Published online: 30 Jun 2022
AbstractforSeparating clinical antibodies from repertoire antibodies, a path to in silico developability assessment | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 4520 Views
  • 10 CrossRef citations
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Report
Engineering death resistance in CHO cells for improved perfusion culture
Michael A. MacDonald, Matthias Nöbel, Verónica S. Martínez, Kym Baker, Evan Shave, Peter P. Gray, Stephen Mahler, Trent Munro, Lars K. Nielsen & Esteban Marcellin
Article: 2083465
Published online: 23 Jun 2022
AbstractforEngineering death resistance in CHO cells for improved perfusion culture | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 4020 Views
  • 6 CrossRef citations
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Report
Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics
Melissa L. Geddie, Dmitri B. Kirpotin, Neeraj Kohli, Tad Kornaga, Bjoern Boll, Maja Razlog, Daryl C. Drummond & Alexey A. Lugovskoy
Article: 2083466
Published online: 16 Jun 2022
AbstractforDevelopment of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 4125 Views
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Report
Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization
Shweta Kailasan, Ravi Kant, Madeleine Noonan-Shueh, Tulasikumari Kanipakala, Grant Liao, Sergey Shulenin, Daisy W. Leung, Richard A. Alm, Rajan P. Adhikari, Gaya K. Amarasinghe, Michael L. Gross & M. Javad Aman
Article: 2083467
Published online: 22 Jun 2022
AbstractforAntigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization | Full Text | References | PDF (12.3 MB) | EPUB | Supplemental
  • 1930 Views
  • 3 CrossRef citations
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Report
Effect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies
Hanine Rafidi, Sharmila Rajan, Konnie Urban, Whitney Shatz-Binder, Keliana Hui, Gregory Z. Ferl, Amrita V. Kamath & C. Andrew Boswell
Article: 2085535
Published online: 22 Jul 2022
AbstractforEffect of molecular size on interstitial pharmacokinetics and tissue catabolism of antibodies | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
  • 5671 Views
  • 7 CrossRef citations
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Open Access

Research Paper

Article
In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom
Line Ledsgaard, Andreas H. Laustsen, Urska Pus, Jack Wade, Pedro Villar, Kim Boddum, Peter Slavny, Edward W. Masters, Ana S. Arias, Saioa Oscoz, Daniel T. Griffiths, Alice M. Luther, Majken Lindholm, Rachael A. Leah, Marie Sofie Møller, Hanif Ali, John McCafferty, Bruno Lomonte, José M. Gutiérrez & Aneesh Karatt-Vellatt
Article: 2085536
Published online: 14 Jun 2022
AbstractforIn vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 4926 Views
  • 20 CrossRef citations
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Article
An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy
Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman & K. Dane Wittrup
Article: 2088454
Published online: 04 Aug 2022
AbstractforAn affinity threshold for maximum efficacy in anti-PD-1 immunotherapy | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 5876 Views
  • 7 CrossRef citations
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Report

Report
High-throughput profiling of antibody self-association in multiple formulation conditions by PEG stabilized self-interaction nanoparticle spectroscopy
Samantha Phan, Auralee Walmer, Eudean W. Shaw & Qing Chai
Article: 2094750
Published online: 13 Jul 2022
AbstractforHigh-throughput profiling of antibody self-association in multiple formulation conditions by PEG stabilized self-interaction nanoparticle spectroscopy | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 3844 Views
  • 8 CrossRef citations
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Report
Mechanistic insights into the rational design of masked antibodies
Carolina T. Orozco, Manuela Bersellini, Lorraine M. Irving, Wesley W. Howard, David Hargreaves, Paul W. A. Devine, Elise Siouve, Gareth J. Browne, Nicholas J. Bond, Jonathan J. Phillips, Peter Ravn & Sophie E. Jackson
Article: 2095701
Published online: 07 Jul 2022
AbstractforMechanistic insights into the rational design of masked antibodies | Full Text | References | PDF (12.4 MB) | EPUB | Supplemental
  • 5470 Views
  • 4 CrossRef citations
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Report
A versatile design platform for glycoengineering therapeutic antibodies
Seth D. Ludwig, Zachary J. Bernstein, Christian Agatemor, Kris Dammen-Brower, Jeffrey Ruffolo, Jonah M. Rosas, Jeremy D. Post, Robert N. Cole, Kevin J. Yarema & Jamie B. Spangler
Article: 2095704
Published online: 09 Jul 2022
AbstractforA versatile design platform for glycoengineering therapeutic antibodies | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3943 Views
  • 1 CrossRef citations
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Open Access
Report
TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity
Harshad S. Ugamraj, Kevin Dang, Laure-Hélène Ouisse, Benjamin Buelow, Eduardo N. Chini, Giulia Castello, James Allison, Starlynn C Clarke, Laura M. Davison, Roland Buelow, Rong Deng, Suhasini Iyer, Ute Schellenberger, Sankar N. Manika, Shipra Bijpuria, Astrid Musnier, Anne Poupon, Maria Cristina Cuturi, Wim van Schooten & Pranjali Dalvi
Article: 2095949
Published online: 22 Jul 2022
AbstractforTNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 6576 Views
  • 9 CrossRef citations
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Report
Antibody markup language (AbML) — a notation language for antibody-based drug formats and software for creating and rendering AbML (abYdraw)
James Sweet-Jones, Maham Ahmad & Andrew C.R. Martin
Article: 2101183
Published online: 15 Jul 2022
AbstractforAntibody markup language (AbML) — a notation language for antibody-based drug formats and software for creating and rendering AbML (abYdraw) | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 3304 Views
  • 4 CrossRef citations
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Report
Extending the capabilities of intact-mass analyses to monoclonal immunoglobulins of the E-isotype (IgE)
Wenhua Yang, Daniil G. Ivanov & Igor A. Kaltashov
Article: 2103906
Published online: 27 Jul 2022
AbstractforExtending the capabilities of intact-mass analyses to monoclonal immunoglobulins of the E-isotype (IgE) | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1698 Views
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Report
Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic
Maria Myzithras, Siqi Lin, Legairre Radden, Cynthia Hess Kenny, Zheng Cai, Angus MacDonald, Ralph Binetti, Michael Marlow, Paul Fracasso, Glenn Gibson, Christina Bartlett, Julie Hawkins & Steven Hansel
Article: 2104153
Published online: 02 Aug 2022
AbstractforDevelopment of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 3592 Views
  • 2 CrossRef citations
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Report
NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells
Hema Preethi Subas Satish, Kathleen Zeglinski, Rachel T. Uren, Stephen L. Nutt, Matthew E. Ritchie, Quentin Gouil & Ruth M. Kluck
Article: 2106621
Published online: 13 Aug 2022
AbstractforNAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
  • 6572 Views
  • 4 CrossRef citations
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Report
Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice
Peng Zhao, Yuanzhong Xu, Xuejun Fan, Leike Li, Xin Li, Hisashi Arase, Qingchun Tong, Ningyan Zhang & Zhiqiang An
Article: 2107971
Published online: 03 Aug 2022
AbstractforDiscovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice | Full Text | References | PDF (15.4 MB) | EPUB | Supplemental
  • 7963 Views
  • 7 CrossRef citations
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Open Access

Review

Review Article
Full-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation
Md Harunur Rashid
Article: 2111748
Published online: 26 Aug 2022
AbstractforFull-length recombinant antibodies from Escherichia coli: production, characterization, effector function (Fc) engineering, and clinical evaluation | Full Text | References | PDF (1.7 MB) | EPUB
  • 21828 Views
  • 11 CrossRef citations
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Report

Report
Simultaneous affinity maturation and developability enhancement using natural liability-free CDRs
Andre A. R. Teixeira, Sara D’Angelo, M. Frank Erasmus, Camila Leal-Lopes, Fortunato Ferrara, Laura P. Spector, Leslie Naranjo, Esteban Molina, Tamara Max, Ashley DeAguero, Katherine Perea, Shaun Stewart, Rebecca A. Buonpane, Horacio G. Nastri & Andrew R. M. Bradbury
Article: 2115200
Published online: 06 Sep 2022
AbstractforSimultaneous affinity maturation and developability enhancement using natural liability-free CDRs | Full Text | References | PDF (13.3 MB) | EPUB | Supplemental
  • 7201 Views
  • 6 CrossRef citations
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Report
Liposomal T cell engager and re-director for tumor cell eradication in cancer immunotherapy
Fang Xie, Luchen Zhang, Sanyuan Shi, Anjie Zheng, Jiaxing Di, Shanshan Jin, Xuguang Miao, Fenglan Wu, Xiaolong Chen, Yanhong Zhang, Xiaohui Wei & Yuhong Xu
Article: 2115205
Published online: 30 Aug 2022
AbstractforLiposomal T cell engager and re-director for tumor cell eradication in cancer immunotherapy | Full Text | References | PDF (3.6 MB) | EPUB
  • 2678 Views
  • 4 CrossRef citations
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Report
Development of T-cell engagers selective for cells co-expressing two antigens
Danielle M. Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Bill Forrest, Chen Gu, Steven R. Leong, Genee Lee, Shang-Fan Yu, Andrew G. Polson & Nicholas J. Agard
Article: 2115213
Published online: 07 Oct 2022
AbstractforDevelopment of T-cell engagers selective for cells co-expressing two antigens | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 6432 Views
  • 8 CrossRef citations
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Report
Fast-tracking antibody maturation using a B cell-based display system
Hitomi Masuda, Atsushi Sawada, Shu-ichi Hashimoto, Kanako Tamai, Ke-Yi Lin, Naoto Harigai, Kohei Kurosawa, Kunihiro Ohta, Hidetaka Seo & Hiroshi Itou
Article: 2122275
Published online: 06 Oct 2022
AbstractforFast-tracking antibody maturation using a B cell-based display system | Full Text | References | PDF (7.4 MB) | EPUB | Supplemental
  • 3315 Views
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Report
Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species
Zephania Kwong Glover, Aaron Wecksler, Baikuntha Aryal, Shrenik Mehta, Melissa Pegues, Wayman Chan, Mari Lehtimaki, Allen Luo, Alavattam Sreedhara & V. Ashutosh Rao
Article: 2122957
Published online: 24 Sep 2022
AbstractforPhysicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species | Full Text | References | PDF (7 MB) | EPUB | Supplemental
  • 3695 Views
  • 9 CrossRef citations
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Report
Systematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names
Ian Wilkinson & Geoff Hale
Article: 2123299
Published online: 15 Sep 2022
AbstractforSystematic analysis of the varied designs of 819 therapeutic antibodies and Fc fusion proteins assigned international nonproprietary names | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 13676 Views
  • 9 CrossRef citations
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Report
Investigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy
Jainik Panchal, Bradley T. Falk, Valentyn Antochshuk & Mark A. McCoy
Article: 2124902
Published online: 27 Sep 2022
AbstractforInvestigating protein–excipient interactions of a multivalent VHH therapeutic protein using NMR spectroscopy | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2884 Views
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Report
The impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity
Michael J. Knight, Léontine Floret, Nisha Patel, John O’Hara & Elizabeth Rodriguez
Article: 2127172
Published online: 05 Oct 2022
AbstractforThe impact of forced degradation conditions on mAb dimer formation and subsequent influence on aggregation propensity | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 3128 Views
  • 2 CrossRef citations
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Report
Unambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy
Arthur Hinterholzer, Jennifer Moises, Christof Regl, Sebastian Schwap, Erdmann Rapp, Christian G. Huber & Mario Schubert
Article: 2132977
Published online: 14 Oct 2022
AbstractforUnambiguous identification of α-Gal epitopes in intact monoclonal antibodies by NMR spectroscopy | Full Text | References | PDF (7.3 MB) | EPUB | Supplemental
  • 2397 Views
  • 4 CrossRef citations
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Open Access

Perspective

Article
Pandemic’s silver lining
Fortunato Ferrara, Sara D’Angelo, M. Frank Erasmus, André A. Teixeira, Camila Leal-Lopes, Laura P. Spector, Tom Pohl, Adeline Fanni, Simon Cocklin & Andrew R. M. Bradbury
Article: 2133666
Published online: 17 Oct 2022
AbstractforPandemic’s silver lining | Full Text | References | PDF (550.7 KB) | EPUB
  • 1421 Views
  • 1 CrossRef citations
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Open Access

Report

Report
A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies
Zhengqi Zhang, Yuetian Yan, Shunhai Wang & Ning Li
Article: 2133674
Published online: 12 Oct 2022
AbstractforA competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2753 Views
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Report
Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms
Elizabeth Sara Hecht, Shrenik Mehta, Aaron T. Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W. Henry Benner, Devin Tesar, Robert F. Kelley, Wendy Sandoval & Alavattam Sreedhara
Article: 2135183
Published online: 25 Oct 2022
AbstractforInsights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms | Full Text | References | PDF (6.5 MB) | EPUB | Supplemental
  • 3218 Views
  • 8 CrossRef citations
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Report
A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers
James T. Heads, Sebastian Kelm, Kerry Tyson & Alastair D. G. Lawson
Article: 2138092
Published online: 23 Nov 2022
AbstractforA computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3023 Views
  • 6 CrossRef citations
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Open Access

Rapid Communication

Rapid Communication
A mouse pancreatic organoid model to compare PD-L1 blocking antibodies
Guangyuan Li, Susmita Ghosh, JuMe Park, Hyunsu Shin, Mamatha Garige, Gregory Reaman & Carole Sourbier
Article: 2139886
Published online: 05 Nov 2022
AbstractforA mouse pancreatic organoid model to compare PD-L1 blocking antibodies | Full Text | References | PDF (2.8 MB) | EPUB
  • 1625 Views
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Open Access

Report

Report
Engineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics
Florian Heinkel, Meghan M. Verstraete, Siran Cao, Janessa Li, Patrick Farber, Elizabeth Stangle, Begonia Silva-Moreno, Fangni Peng, Surjit Dixit, Martin J. Boulanger, Thomas Spreter Von Kreudenstein & Eric Escobar-Cabrera
Article: 2141637
Published online: 07 Nov 2022
AbstractforEngineering a pure and stable heterodimeric IgA for the development of multispecific therapeutics | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2950 Views
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Report
Deciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue
Flaviyan Jerome Irudayanathan, Jonathan Zarzar, Jasper Lin & Saeed Izadi
Article: 2143006
Published online: 14 Nov 2022
AbstractforDeciphering deamidation and isomerization in therapeutic proteins: Effect of neighboring residue | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 3950 Views
  • 8 CrossRef citations
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Report
Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice
Jerome Egli, Stefan Heiler, Felix Weber, Guido Steiner, Timo Schwandt, Katharine Bray-French, Christian Klein, Sebastian Fenn, Gregor P. Lotz, Eugenia Opolka-Hoffmann, Thomas E. Kraft, Laetitia Petersen, Rebecca Moser, Jonathan DeGeer, Michel Siegel, Daniela Finke, Juliana Bessa & Antonio Iglesias
Article: 2143009
Published online: 17 Nov 2022
AbstractforEnhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice | Full Text | References | PDF (10 MB) | EPUB | Supplemental
  • 3922 Views
  • 2 CrossRef citations
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Report
Clearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model
David Falck, Martin Lechmann, Ana Momčilović, Marco Thomann, Carolien A. M. Koeleman, Cordula Jany, Sebastian Malik, Manfred Wuhrer & Dietmar Reusch
Article: 2145929
Published online: 16 Nov 2022
AbstractforClearance of therapeutic antibody glycoforms after subcutaneous and intravenous injection in a porcine model | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 2153 Views
  • 3 CrossRef citations
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Review

Review Article
Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper
Karelle Ménochet, Hongbin Yu, Bonnie Wang, Jay Tibbitts, Cheng-Pang Hsu, Amrita V. Kamath, Wolfgang F. Richter & Andreas Baumann
Article: 2145997
Published online: 23 Nov 2022
AbstractforNon-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White Paper | Full Text | References | PDF (522.8 KB) | EPUB
  • 6026 Views
  • 3 CrossRef citations
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Report

Report
Reduction of therapeutic antibody self-association using yeast-display selections and machine learning
Emily K. Makowski, Hongwei Chen, Matthew Lambert, Eric M. Bennett, Nicole S. Eschmann, Yulei Zhang, Jennifer M. Zupancic, Alec A. Desai, Matthew D. Smith, Wenjia Lou, Amendra Fernando, Timothy Tully, Christopher J. Gallo, Laura Lin & Peter M. Tessier
Article: 2146629
Published online: 26 Nov 2022
AbstractforReduction of therapeutic antibody self-association using yeast-display selections and machine learning | Full Text | References | PDF (12.8 MB) | EPUB | Supplemental
  • 5272 Views
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