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mAbs Volume 14, 2022 - Issue 1
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Deep mutational engineering of broadly-neutralizing nanobodies accommodating SARS-CoV-1 and 2 antigenic drift

Adrien Larochea CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
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Maria Lucia Orsini Delgadob CEA, INRAE, Medicines and Healthcare Technologies Department, SPI, Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
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Benjamin Chalopina CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
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Philippe Cuniassec CNRS, CEA, Institute for Integrative Biology of the Cell (I2BC), Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
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Steven Duboisa CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
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Raphaël Sierockia CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Université Paris-Saclay, Gif-sur-Yvette, France;d Deeptope SAS, Massy, FranceView further author information
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Fabrice Gallaise CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Université Paris Saclay, Bagnols-sur-Cèze, FranceView further author information
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Stéphanie Debroase CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Université Paris Saclay, Bagnols-sur-Cèze, FranceView further author information
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Laurent Bellangere CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SPI, Université Paris Saclay, Bagnols-sur-Cèze, FranceView further author information
,
Stéphanie Simonb CEA, INRAE, Medicines and Healthcare Technologies Department, SPI, Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
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Bernard Maillèrea CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Université Paris-Saclay, Gif-sur-Yvette, FranceView further author information
&
Hervé Nozacha CEA, INRAE, Medicines and Healthcare Technologies Department, SIMoS, Université Paris-Saclay, Gif-sur-Yvette, FranceCorrespondence[email protected]
View further author information
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Article: 2076775 | Received 16 Jan 2022, Accepted 09 May 2022, Published online: 20 May 2022

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Read on this site (1)

Tiphanie Pruvost, Magali Mathieu, Steven Dubois, Bernard Maillère, Emmanuelle Vigne & Hervé Nozach. (2023) Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold. mAbs 15:1.
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Articles from other publishers (5)

Yang Yang, Fang Li & Lanying Du. (2024) Therapeutic nanobodies against SARS-CoV-2 and other pathogenic human coronaviruses. Journal of Nanobiotechnology 22:1.
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Stefanie Maes, Nick Deploey, Frank Peelman & Sven Eyckerman. (2023) Deep mutational scanning of proteins in mammalian cells. Cell Reports Methods 3:11, pages 100641.
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Coline Sivelle, Raphael Sierocki, Youen Lesparre, Aurore Lomet, Wagner Quintilio, Steven Dubois, Evelyne Correia, Ana Maria Moro, Bernard Maillère & Hervé Nozach. (2023) Combining deep mutational scanning to heatmap of HLA class II binding of immunogenic sequences to preserve functionality and mitigate predicted immunogenicity. Frontiers in Immunology 14.
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Qianling Su, Wei Shi, Xianing Huang, Yakun Wan, Guanghui Li, Bengang Xing, Zhi Ping Xu, Hongbo Liu, Bruce D. Hammock, Xiaomei Yang, Shihua Yin & Xiaoling Lu. (2022) Screening, Expression, and Identification of Nanobody against SARS-CoV-2 Spike Protein. Cells 11:21, pages 3355.
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Zichang Xu, Hendra S. Ismanto, Hao Zhou, Dianita S. Saputri, Fuminori Sugihara & Daron M. Standley. (2022) Advances in antibody discovery from human BCR repertoires. Frontiers in Bioinformatics 2.
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