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mAbs Volume 14, 2022 - Issue 1
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Development of T-cell engagers selective for cells co-expressing two antigens

Danielle M. DicaraGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Sunil BhaktaGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Mary Ann GoGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
James ZiaiGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Ron FiresteinGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Bill ForrestGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Chen GuGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Steven R. LeongGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Genee LeeGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Shang-Fan YuGenentech Research and Early Development, South San Francisco, California, USAView further author information
,
Andrew G. PolsonGenentech Research and Early Development, South San Francisco, California, USAView further author information
&
Nicholas J. AgardGenentech Research and Early Development, South San Francisco, California, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4916-2484View further author information
ORCID Icon show all
Article: 2115213 | Received 27 Apr 2022, Accepted 16 Aug 2022, Published online: 07 Oct 2022

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Read on this site (3)

Michael Mullin, James McClory, Winston Haynes, Justin Grace, Nathan Robertson & Gino van Heeke. (2024) Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions. mAbs 16:1.
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Caitlin Fawcett, Joseph. R. Tickle & Charlotte. H. Coles. (2024) Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows. mAbs 16:1.
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Kathryn Ball, Simon J Dovedi, Pavan Vajjah & Alex Phipps. (2023) Strategies for clinical dose optimization of T cell-engaging therapies in oncology. mAbs 15:1.
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Articles from other publishers (5)

Youwei Lu, Yu Sun, Jie Zhang, Miao Kong, Zhiming Zhao, Boshu Sun, Yuan Wang, Ying Jiang, Shaomu Chen, Chao Wang, Yin Tong, Liangzhu Wen, Moli Huang, Fengying Wu & Liang Zhang. (2024) The deubiquitinase USP2a promotes tumor immunosuppression by stabilizing immune checkpoint B7-H4 in lung adenocarcinoma harboring EGFR-activating mutants. Cancer Letters, pages 217020.
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Christian Klein, Ulrich Brinkmann, Janice M. Reichert & Roland E. Kontermann. (2024) The present and future of bispecific antibodies for cancer therapy. Nature Reviews Drug Discovery 23:4, pages 301-319.
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Yin Yao, Yiyin Hu & Fei Wang. (2023) Trispecific antibodies for cancer immunotherapy. Immunology 169:4, pages 389-399.
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Ying Shen, Shi-jie Jin, Yi-chang Chen, Wen-hui Liu, Yi-ming Li, Wen-yi Zhao, Ying-chun Xu, Shu-qing Chen & Wen-bin Zhao. (2023) Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting. Pharmacological Research 192, pages 106781.
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Li Yin, Gui-lai Chen, Zhuo Xiang, Yu-lin Liu, Xing-yu Li, Jing-wang Bi & Qiang Wang. (2023) Current progress in chimeric antigen receptor-modified T cells for the treatment of metastatic breast cancer. Biomedicine & Pharmacotherapy 162, pages 114648.
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