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mAbs Volume 15, 2023 - Issue 1
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Review

Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties

Hristo L. Svilenova Laboratory of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Gent, BelgiumCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-5863-9569View further author information
ORCID Icon,
Paolo Arosiob Department of Chemistry and Applied Biosciences, ETH Zürich, Zürich, SwitzerlandView further author information
,
Tim Menzenc Coriolis Pharma Research GmbH, Martinsried, 82152, GermanyView further author information
,
Peter Tessierd Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA;e Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA;f Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA;g Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USAView further author information
&
Pietro Sormannih Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UKView further author information
Article: 2164459 | Received 15 Nov 2022, Accepted 29 Dec 2022, Published online: 11 Jan 2023

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Caitlin Fawcett, Joseph. R. Tickle & Charlotte. H. Coles. (2024) Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows. mAbs 16:1.
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Carl Mieczkowski, Xuejin Zhang, Dana Lee, Khanh Nguyen, Wei Lv, Yanling Wang, Yue Zhang, Jackie Way & Jean-Michel Gries. (2023) Blueprint for antibody biologics developability. mAbs 15:1.
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Articles from other publishers (9)

Taras Hvozd, Yurij V. Kalyuzhnyi & Vojko Vlachy. (2024) Modelling bi-specific antibodies in aqueous solution. Journal of Molecular Liquids 402, pages 124740.
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Leon F. Willis, Vishal Toprani, Sashini Wijetunge, Annette Sievers, Laura Lin, Jeanine Williams, Tom J. Crowley, Sheena E. Radford, Nikil Kapur & David J. Brockwell. (2024) Exploring a Role for Flow-Induced Aggregation Assays in Platform Formulation Optimisation for Antibody-Based Proteins. Journal of Pharmaceutical Sciences 113:3, pages 625-636.
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Andreas V. Madsen, Lasse E. Pedersen, Peter Kristensen & Steffen Goletz. (2024) Design and engineering of bispecific antibodies: insights and practical considerations. Frontiers in Bioengineering and Biotechnology 12.
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Aubin Ramon, Montader Ali, Misha Atkinson, Alessio Saturnino, Kieran Didi, Cristina Visentin, Stefano Ricagno, Xing Xu, Matthew Greenig & Pietro Sormanni. (2024) Assessing antibody and nanobody nativeness for hit selection and humanization with AbNatiV. Nature Machine Intelligence 6:1, pages 74-91.
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Pankaj Gupta, Alexander M. Horspool, Goral Trivedi, Gina Moretti, Akshita Datar, Zhong-Fu Huang, Jeffrey Chiecko, Cynthia Hess Kenny & Michael S. Marlow. (2024) Matrixed CDR grafting: A neoclassical framework for antibody humanization and developability. Journal of Biological Chemistry 300:1, pages 105555.
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Dominik Zürcher, Severin Caduff, Laetitia Aurand, Umberto Capasso Palmiero, Klaus Wuchner & Paolo Arosio. (2023) Comparison of the Protective Effect of Polysorbates, Poloxamer and Brij on Antibody Stability Against Different Interfaces. Journal of Pharmaceutical Sciences 112:11, pages 2853-2862.
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Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich, Christian Schröter, Jennifer Schanz, Jason Tonillo, Vanessa Siegmund, Achim Doerner, Simon Krah, Enrico Guarnera, Stefan Zielonka & Andreas Evers. (2023) AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study. Frontiers in Molecular Biosciences 10.
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Nicolás F. Gajardo-Parra, Gabriel Rodríguez, Andrés F. Arroyo-Avirama, Astrit Veliju, Thomas Happe, Roberto I. Canales, Gabriele Sadowski & Christoph Held. (2023) Impact of Deep Eutectic Solvents on Kinetics and Folding Stability of Formate Dehydrogenase. Processes 11:10, pages 2815.
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Joschka Bauer, Nandhini Rajagopal, Priyanka Gupta, Pankaj Gupta, Andrew E. Nixon & Sandeep Kumar. (2023) How can we discover developable antibody-based biotherapeutics?. Frontiers in Molecular Biosciences 10.
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