mAbs, Volume 15, Issue 1 (2023)

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mAbs, Volume 15, Issue 1 (2023)

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Kinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab
Stefanie Mak, Agnes Marszal, Nena Matscheko & Ulrich Rant
Article: 2149053
Published online: 01 Dec 2022
AbstractforKinetic analysis of ternary and binary binding modes of the bispecific antibody emicizumab | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Report
A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects
Yukari Koya, Hirotsugu Tanaka, Eiji Yoshimi, Nobuaki Takeshita, Shuji Morita, Hiroki Morio, Kanako Mori, Hiroshi Fushiki & Masazumi Kamohara
Article: 2149055
Published online: 02 Dec 2022
AbstractforA novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2369 Views
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A glyco-engineering approach for site-specific conjugation to Fab glycans
Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates & Michel Gilbert
Article: 2149057
Published online: 29 Nov 2022
AbstractforA glyco-engineering approach for site-specific conjugation to Fab glycans | Full Text | References | PDF (8.8 MB) | EPUB | Supplemental
  • 4578 Views
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Report
Restoring the biological activity of crizanlizumab at physiological conditions through a pH-dependent aspartic acid isomerization reaction
Fabian Bickel, François Griaud, Wolfram Kern, Frieder Kroener, Manuela Gritsch, Jérôme Dayer, Samuel Barteau, Blandine Denefeld, Chi-Ya Kao-Scharf, Manuel Lang, Izabela Slupska-Muanza, Carla Schmidt, Matthias Berg, Jürgen Sigg, Lina Boado & Dirk Chelius
Article: 2151075
Published online: 15 Dec 2022
AbstractforRestoring the biological activity of crizanlizumab at physiological conditions through a pH-dependent aspartic acid isomerization reaction | Full Text | References | PDF (2.1 MB) | EPUB
  • 2939 Views
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Report
Developability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies
Andrew Dippel, Austin Gallegos, Vineela Aleti, Arnita Barnes, Xiaoru Chen, Elizabeth Christian, Jared Delmar, Qun Du, Reza Esfandiary, Erika Farmer, Andrew Garcia, Qing Li, Jia Lin, Weiyi Liu, LeeAnn Machiesky, Neil Mody, Arun Parupudi, Meagan Prophet, Keith Rickert, Kim Rosenthal, Song Ren, Harini Shandilya, Reena Varkey, Kevin Wons, Yuling Wu, Yueh-Ming Loo, Mark T. Esser, Nicole L. Kallewaard, Sarav Rajan, Melissa Damschroder, Weichen Xu & Gilad Kaplan
Article: 2152526
Published online: 08 Dec 2022
AbstractforDevelopability profiling of a panel of Fc engineered SARS-CoV-2 neutralizing antibodies | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer
Jiawei Guan, Hongchuan Liu, Yan Chai, Jie Yu, Jian Yao, Jing Wang, Zhiwei Pan, Jing Zhang, Yuehua Zhou, Hui Liu, Sheng Yao, Jianxun Qi, Hui Feng, George F. Gao, Qihui Wang, Yi Shi & Shuguang Tan
Article: 2153409
Published online: 13 Dec 2022
AbstractforCharacterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Perspective

Article Commentary
Antibodies to watch in 2023
Hélène Kaplon, Silvia Crescioli, Alicia Chenoweth, Jyothsna Visweswaraiah & Janice M. Reichert
Article: 2153410
Published online: 06 Dec 2022
AbstractforAntibodies to watch in 2023 | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Receptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study
Dmitry Shchelokov & Oleg Demin Jr
Article: 2156317
Published online: 16 Dec 2022
AbstractforReceptor occupancy assessment and interpretation in terms of quantitative systems pharmacology: nivolumab case study | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 5053 Views
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Report
Correlated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb
Tsega L. Solomon, Frank Delaglio, John P. Giddens, John P. Marino, Yihua Bruce Yu, Marc B. Taraban & Robert G. Brinson
Article: 2160227
Published online: 22 Jan 2023
AbstractforCorrelated analytical and functional evaluation of higher order structure perturbations from oxidation of NISTmAb | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2876 Views
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Report
TRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life
Emma Davé, Oliver Durrant, Neha Dhami, Joanne Compson, Janice Broadbridge, Sophie Archer, Asher Maroof, Kevin Whale, Karelle Menochet, Pierre Bonnaillie, Emily Barry, Gavin Wild, Claude Peerboom, Pallavi Bhatta, Mark Ellis, Matthew Hinchliffe, David P. Humphreys & Sam P. Heywood
Article: 2160229
Published online: 14 Feb 2023
AbstractforTRYBE®: an Fc-free antibody format with three monovalent targeting arms engineered for long in vivo half-life | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 4851 Views
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Report
HDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure
Saw Yen Ow, Eugene A. Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis, Michael J. Wilson, Andrew D. Nash & Matthias Pelzing
Article: 2163459
Published online: 10 Jan 2023
AbstractforHDX-MS study on garadacimab binding to activated FXII reveals potential binding interfaces through differential solvent exposure | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 2234 Views
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Toward generalizable prediction of antibody thermostability using machine learning on sequence and structure features
Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray & Kathy Y. Wei
Article: 2163584
Published online: 22 Jan 2023
AbstractforToward generalizable prediction of antibody thermostability using machine learning on sequence and structure features | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
  • 8102 Views
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Review

Review
Approaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties
Hristo L. Svilenov, Paolo Arosio, Tim Menzen, Peter Tessier & Pietro Sormanni
Article: 2164459
Published online: 11 Jan 2023
AbstractforApproaches to expand the conventional toolbox for discovery and selection of antibodies with drug-like physicochemical properties | Full Text | References | PDF (2.4 MB) | EPUB
  • 9341 Views
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Report

Report
Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency
Baoshan Zhang, Jason Gorman, Young D. Kwon, Amarendra Pegu, Cara W. Chao, Tracy Liu, Mangaiarkarasi Asokan, Michael F. Bender, Tatsiana Bylund, Leland Damron, Deepika Gollapudi, Paula Lei, Yile Li, Cuiping Liu, Mark K. Louder, Krisha McKee, Adam S. Olia, Reda Rawi, Arne Schön, Shuishu Wang, Eun Sung Yang, Yongping Yang, Kevin Carlton, Nicole A. Doria-Rose, Lawrence Shapiro, Michael S. Seaman, John R. Mascola & Peter D. Kwong
Article: 2165390
Published online: 02 Feb 2023
AbstractforBispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
  • 3045 Views
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Review

Review
The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy
Christina Claus, Claudia Ferrara-Koller & Christian Klein
Article: 2167189
Published online: 01 Feb 2023
AbstractforThe emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy | Full Text | References | PDF (8.2 MB) | EPUB | Supplemental
  • 9756 Views
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Report

Report
Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning
Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda & Mitsuo Umetsu
Article: 2168470
Published online: 22 Jan 2023
AbstractforSelection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 5203 Views
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Brief Report

Brief Report
Predictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks
Jonathan Schmitt, Abbas Razvi & Christoph Grapentin
Article: 2169440
Published online: 27 Jan 2023
AbstractforPredictive modeling of concentration-dependent viscosity behavior of monoclonal antibody solutions using artificial neural networks | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 5038 Views
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Review

Review
Assessing developability early in the discovery process for novel biologics
Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty & Andreas H. Laustsen
Article: 2171248
Published online: 23 Feb 2023
AbstractforAssessing developability early in the discovery process for novel biologics | Full Text | References | PDF (1.7 MB) | EPUB
  • 14983 Views
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Report

Report
Deciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold
Tiphanie Pruvost, Magali Mathieu, Steven Dubois, Bernard Maillère, Emmanuelle Vigne & Hervé Nozach
Article: 2175311
Published online: 16 Feb 2023
AbstractforDeciphering cross-species reactivity of LAMP-1 antibodies using deep mutational epitope mapping and AlphaFold | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 2945 Views
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Report
Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
Dario A. T. Cramer, Vojtech Franc, Anna-Katharina Heidenreich, Michaela Hook, Mahdi Adibzadeh, Dietmar Reusch, Albert J. R. Heck & Markus Haberger
Article: 2175312
Published online: 17 Feb 2023
AbstractforCharacterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 3694 Views
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Research Paper

Article
Challenges in antibody structure prediction
Monica L. Fernández-Quintero, Janik Kokot, Franz Waibl, Anna-Lena M. Fischer, Patrick K. Quoika, Charlotte M. Deane & Klaus R. Liedl
Article: 2175319
Published online: 12 Feb 2023
AbstractforChallenges in antibody structure prediction | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 6531 Views
  • 10 CrossRef citations
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Report

Report
SpyDisplay: A versatile phage display selection system using SpyTag/SpyCatcher technology
Sarah-Jane Kellmann, Christian Hentrich, Mateusz Putyrski, Hanh Hanuschka, Manuel Cavada, Achim Knappik & Francisco Ylera
Article: 2177978
Published online: 20 Feb 2023
AbstractforSpyDisplay: A versatile phage display selection system using SpyTag/SpyCatcher technology | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 4786 Views
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Report
Cadonilimab, a tetravalent PD-1/CTLA-4 bispecific antibody with trans-binding and enhanced target binding avidity
Xinghua Pang, Zhaoliang Huang, Tingting Zhong, Peng Zhang, Zhongmin Maxwell Wang, Michelle Xia & Baiyong Li
Article: 2180794
Published online: 05 Mar 2023
AbstractforCadonilimab, a tetravalent PD-1/CTLA-4 bispecific antibody with trans-binding and enhanced target binding avidity | Full Text | References | PDF (2.6 MB) | EPUB
  • 6568 Views
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Review

Review
Strategies for clinical dose optimization of T cell-engaging therapies in oncology
Kathryn Ball, Simon J Dovedi, Pavan Vajjah & Alex Phipps
Article: 2181016
Published online: 23 Feb 2023
AbstractforStrategies for clinical dose optimization of T cell-engaging therapies in oncology | Full Text | References | PDF (1.9 MB) | EPUB
  • 7275 Views
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Report

Report
eIg-based bispecific T-cell engagers targeting EGFR: Format matters
Lennart Kühl, Annelie K. Schäfer, Sebastian Kraft, Nadine Aschmoneit, Roland E. Kontermann & Oliver Seifert
Article: 2183540
Published online: 02 Mar 2023
AbstractforeIg-based bispecific T-cell engagers targeting EGFR: Format matters | Full Text | References | PDF (9.3 MB) | EPUB | Supplemental
  • 2828 Views
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Report
High-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions
André Luiz Lourenço, Shih-Wei Chuo, Markus F. Bohn, Byron Hann, Shireen Khan, Neha Yevalekar, Nitin Patel, Teddy Yang, Lina Xu, Dandan Lv, Robert Drakas, Sarah Lively & Charles S. Craik
Article: 2184197
Published online: 01 Mar 2023
AbstractforHigh-throughput optofluidic screening of single B cells identifies novel cross-reactive antibodies as inhibitors of uPAR with antibody-dependent effector functions | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
  • 2532 Views
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Review

Review Article
Blueprint for antibody biologics developability
Carl Mieczkowski, Xuejin Zhang, Dana Lee, Khanh Nguyen, Wei Lv, Yanling Wang, Yue Zhang, Jackie Way & Jean-Michel Gries
Article: 2185924
Published online: 07 Mar 2023
AbstractforBlueprint for antibody biologics developability | Full Text | References | PDF (2.3 MB) | EPUB
  • 12994 Views
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Report

Report
Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats
Andreas V. Madsen, Peter Kristensen, Alexander K. Buell & Steffen Goletz
Article: 2189432
Published online: 20 Mar 2023
AbstractforGeneration of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 6664 Views
  • 5 CrossRef citations
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Report
Structure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity
Catherine Y Liu, Cory L Ahonen, Michael E Brown, Ling Zhou, Martin Welin, Eric M Krauland, Robert Pejchal, Paul F Widboom & Michael B Battles
Article: 2189974
Published online: 29 Mar 2023
AbstractforStructure-based engineering of a novel CD3ε-targeting antibody for reduced polyreactivity | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
  • 8224 Views
  • 4 CrossRef citations
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Review

Review Article
Trends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics
Kyle P. Martin, Christine Grimaldi, Rolf Grempler, Steven Hansel & Sandeep Kumar
Article: 2191301
Published online: 30 Mar 2023
AbstractforTrends in industrialization of biotherapeutics: a survey of product characteristics of 89 antibody-based biotherapeutics | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 9816 Views
  • 16 CrossRef citations
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Report

Report
Impact of IgG subclass on monoclonal antibody developability
Paul Cain, Lihua Huang, Yu Tang, Victor Anguiano & Yiqing Feng
Article: 2191302
Published online: 21 Mar 2023
AbstractforImpact of IgG subclass on monoclonal antibody developability | Full Text | References | PDF (1.6 MB) | EPUB
  • 7098 Views
  • 2 CrossRef citations
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Review

Review
Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions
Joshuaine Grant, Fei Hua, Joshua F. Apgar, John M. Burke & Diana H. Marcantonio
Article: 2192251
Published online: 23 Mar 2023
AbstractforMechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions | Full Text | References | PDF (2.6 MB) | EPUB
  • 4663 Views
  • 1 CrossRef citations
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Report

Report
“Stapling” scFv for multispecific biotherapeutics of superior properties
Lauren E. Boucher, Elisabeth Geyer Prinslow, Michael Feldkamp, Fang Yi, Rupesh Nanjunda, Sheng-Jiun Wu, Tun Liu, Eilyn R. Lacy, Steven Jacobs, Natalia Kozlyuk, Brian Del Rosario, Bingyuan Wu, Patricia Aquino, Robert C. Davidson, Samantha Heyne, Nicholas Mazzanti, James Testa, Michael D. Diem, Elsa Gorre, Andrew Mahan, Hirsh Nanda, Harsha P. Gunawardena, Alexis Gervais, Anthony A. Armstrong, Alexey Teplyakov, Chichi Huang, Adam Zwolak, Partha Chowdhury, Wan Cheung Cheung & Jinquan Luo
Article: 2195517
Published online: 19 Apr 2023
Abstractfor“Stapling” scFv for multispecific biotherapeutics of superior properties | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 11197 Views
  • 5 CrossRef citations
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Review

Review
Mass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control
Feng Yang, Jennifer Zhang, Alexander Buettner, Eva Vosika, Monica Sadek, Zhiqi Hao, Dietmar Reusch, Maximiliane Koenig, Wayman Chan, Anja Bathke, Hilary Pallat, Victor Lundin, Jochen Felix Kepert, Patrick Bulau, Galahad Deperalta, Christopher Yu, Richard Beardsley, Tura Camilli, Reed Harris & John Stults
Article: 2197668
Published online: 14 Apr 2023
AbstractforMass spectrometry-based multi-attribute method in protein therapeutics product quality monitoring and quality control | Full Text | References | PDF (1.5 MB) | EPUB
  • 5931 Views
  • 9 CrossRef citations
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Report

Report
Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS
Laurence Whitty-Léveillé, Zachary L. VanAernum, Jorge Alexander Pavon, Christa Murphy, Katie Neal, William Forest, Xinliu Gao, Wendy Zhong, Douglas D. Richardson & Hillary A. Schuessler
Article: 2199466
Published online: 09 Apr 2023
AbstractforDetermination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS | Full Text | References | PDF (993.1 KB) | EPUB | Supplemental
  • 2447 Views
  • 1 CrossRef citations
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Review

Review
Identifying developability risks for clinical progression of antibodies using high-throughput in vitro and in silico approaches
Tushar Jain, Todd Boland & Maximiliano Vásquez
Article: 2200540
Published online: 18 Apr 2023
AbstractforIdentifying developability risks for clinical progression of antibodies using high-throughput in vitro and in silico approaches | Full Text | References | PDF (7.3 MB) | EPUB | Supplemental
  • 10469 Views
  • 9 CrossRef citations
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Review
A systematic review of commercial high concentration antibody drug products approved in the US: formulation composition, dosage form design and primary packaging considerations
Indrajit Ghosh, Hiten Gutka, Mary E. Krause, Ryan Clemens & Ramesh S. Kashi
Article: 2205540
Published online: 27 May 2023
AbstractforA systematic review of commercial high concentration antibody drug products approved in the US: formulation composition, dosage form design and primary packaging considerations | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 8469 Views
  • 15 CrossRef citations
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Rapid Communication

Rapid Communication
VERITAS: Harnessing the power of nomenclature in biologic discovery
Riti Biswas, Ed Belouski, Kevin Graham, Michelle Hortter, Marissa Mock, Christine E. Tinberg & Alan J. Russell
Article: 2207232
Published online: 10 May 2023
AbstractforVERITAS: Harnessing the power of nomenclature in biologic discovery | Full Text | References | PDF (7.1 MB) | EPUB
  • 2826 Views
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Review

Review
Engaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors
Kerry A. Whalen, Kavya Rakhra, Naveen K. Mehta, Alexander Steinle, Jennifer S. Michaelson & Patrick A. Baeuerle
Article: 2208697
Published online: 10 May 2023
AbstractforEngaging natural killer cells for cancer therapy via NKG2D, CD16A and other receptors | Full Text | References | PDF (1.7 MB) | EPUB
  • 4523 Views
  • 9 CrossRef citations
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Report

Report
Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis
Susanne Klint, Joachim Feldwisch, Lindvi Gudmundsdotter, Karin Dillner Bergstedt, Elin Gunneriusson, Ingmarie Höidén Guthenberg, Anders Wennborg, Andrew C. Nyborg, Amol P. Kamboj, Paul M. Peloso, David Bejker & Fredrik Y. Frejd
Article: 2209920
Published online: 15 May 2023
AbstractforIzokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 4287 Views
  • 14 CrossRef citations
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Report
GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery
Loes van Schie, Wander Van Breedam, Charlotte Roels, Bert Schepens, Martin Frank, Ahmad Reza Mehdipour, Bram Laukens, Wim Nerinckx, Francis Santens, Simon Devos, Iebe Rossey, Karel Thooft, Sandrine Vanmarcke, Annelies Van Hecke, Xavier Saelens & Nico Callewaert
Article: 2210709
Published online: 21 May 2023
AbstractforGlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery | Full Text | References | PDF (6.1 MB) | EPUB | Supplemental
  • 2493 Views
  • 1 CrossRef citations
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Review

Review Article
High concentration formulation developability approaches and considerations
Jonathan Zarzar, Tarik Khan, Maniraj Bhagawati, Benjamin Weiche, Jasmin Sydow-Andersen & Alavattam Sreedhara
Article: 2211185
Published online: 16 May 2023
AbstractforHigh concentration formulation developability approaches and considerations | Full Text | References | PDF (384.4 KB) | EPUB
  • 7860 Views
  • 6 CrossRef citations
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Meeting Report

Meeting Report
10th antibody industrial symposium: new developments in antibody and adoptive cell therapies
Ana Antunes, Luis Alvarez-Vallina, Federico Bertoglio, Nicolas Bouquin, Stéphanie Cornen, Francis Duffieux, Pierre Ferré, Raphaëlle Gillet, Christian Jorgensen, Mark B Leick, Bernard Maillère, Hélène Negre, Mireia Pelegrin, Nicolas Poirier, Dietmar Reusch, Bruno Robert, Guy Serre, Alain Vicari, Martin Villalba, Christoph Volpers, Gavin Vuddamalay, Hervé Watier, Thierry Wurch, Lennart Zabeau, Stefan Zielonka, Baolin Zhang, Alain Beck & Pierre Martineau
Article: 2211692
Published online: 15 May 2023
Abstractfor10th antibody industrial symposium: new developments in antibody and adoptive cell therapies | Full Text | References | PDF (363.1 KB) | EPUB
  • 3370 Views
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Report

Report
Multivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2
Meghan M. Verstraete, Florian Heinkel, Janessa Li, Siran Cao, Anh Tran, Elizabeth C. Halverson, Robert Gene, Elizabeth Stangle, Begonia Silva-Moreno, Sifa Arrafi, Jegarubee Bavananthasivam, Madeline Fung, Mariam Eji-Lasisi, Stephanie Masterman, Steve Xanthoudakis, Surjit Dixit, John Babcook, Brandon Clavette, Mark Fogg & Eric Escobar-Cabrera
Article: 2212415
Published online: 25 May 2023
AbstractforMultivalent IgM scaffold enhances the therapeutic potential of variant-agnostic ACE2 decoys against SARS-CoV-2 | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1907 Views
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Report
Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches
Chunting Zhang, Steven T. Gossert, Jonathan Williams, Michael Little, Marilia Barros, Barton Dear, Bradley Falk, Ankit D. Kanthe, Robert Garmise, Luciano Mueller, Andrew Ilott & Anuji Abraham
Article: 2212416
Published online: 22 May 2023
AbstractforRanking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2917 Views
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Report
IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation
John P. Dowling, Pavel A. Nikitin, Fang Shen, Halley Shukla, James P. Finn, Nirja Patel, Cezary Swider, Jamie L. Bingaman-Steele, Chris Nicolescu, Eden L Sikorski, Evan J. Greenawalt, Michael J. Morin, Matthew K. Robinson, Karen Lundgren & Benjamin C. Harman
Article: 2212673
Published online: 22 May 2023
AbstractforIL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 2063 Views
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Review

Review Article
Technical advancement and practical considerations of LC-MS/MS-based methods for host cell protein identification and quantitation to support process development
Jia Guo, Regina Kufer, Delia Li, Stefanie Wohlrab, Midori Greenwood-Goodwin & Feng Yang
Article: 2213365
Published online: 22 May 2023
AbstractforTechnical advancement and practical considerations of LC-MS/MS-based methods for host cell protein identification and quantitation to support process development | Full Text | References | PDF (710.8 KB) | EPUB
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Review Article
Evolution of phage display libraries for therapeutic antibody discovery
Yang Zhang
Article: 2213793
Published online: 24 May 2023
AbstractforEvolution of phage display libraries for therapeutic antibody discovery | Full Text | References | PDF (1.4 MB) | EPUB
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Report

Report
Molecular recognition requires dimerization of a VHH antibody
Christopher A. Smith, Gregory J. Sonneson, Robert J. Hoey, Jennifer M. Hinerman, Kimberly Sheehy, Richard Walter, Andrew B. Herr & James R. Horn
Article: 2215363
Published online: 27 May 2023
AbstractforMolecular recognition requires dimerization of a VHH antibody | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Identification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity
Meiqi Yi, Jian Sun, Hanzi Sun, Yifei Wang, Shan Hou, Beibei Jiang, Yuanyuan Xie, Ruyue Ji, Liu Xue, Xiao Ding, Xiaomin Song, April Xu, Chichi Huang, Quan Quan & Jing Song
Article: 2215364
Published online: 25 May 2023
AbstractforIdentification and characterization of an unexpected isomerization motif in CDRH2 that affects antibody activity | Full Text | References | PDF (2.9 MB) | EPUB
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Report
Design of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies
Maria U. Johansson, Christopher Weinert, Dietrich Alexander Reichardt, Dana Mahler, Dania Diem, Christian Hess, Diana Feusi, Simon Carnal, Julia Tietz, Noreen Giezendanner, Fabio Mario Spiga, David Urech & Stefan Warmuth
Article: 2215887
Published online: 13 Jun 2023
AbstractforDesign of antibody variable fragments with reduced reactivity to preexisting anti-drug antibodies | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Report
Generation and in vivo characterization of a novel high-affinity human antibody targeting carcinoembryonic antigen
Louis Plüss, Frederik Peissert, Abdullah Elsayed, Giulia Rotta, Jonas Römer, Sheila Dakhel Plaza, Alessandra Villa, Emanuele Puca, Roberto De Luca, Annette Oxenius & Dario Neri
Article: 2217964
Published online: 27 May 2023
AbstractforGeneration and in vivo characterization of a novel high-affinity human antibody targeting carcinoembryonic antigen | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
  • 1964 Views
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Report
Affinity-controlled capture and release of engineered monoclonal antibodies by macroporous dextran hydrogels using coiled-coil interactions
Seyed Farzad Baniahmad, Romane Oliverio, Ines Obregon-Gomez, Alma Robert, Anne E.G. Lenferink, Elena Pazos, Nick Virgilio, Xavier Banquy, Gregory De Crescenzo & Yves Durocher
Article: 2218951
Published online: 10 Jun 2023
AbstractforAffinity-controlled capture and release of engineered monoclonal antibodies by macroporous dextran hydrogels using coiled-coil interactions | Full Text | References | PDF (8.6 MB) | EPUB | Supplemental
  • 1335 Views
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Report
In-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy
Jiarui Wang, Jingyi Chen, Joey Studts & Gang Wang
Article: 2220149
Published online: 08 Jun 2023
AbstractforIn-line product quality monitoring during biopharmaceutical manufacturing using computational Raman spectroscopy | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Review

Review Article
Effects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins
Hervé Broly, Jonathan Souquet & Alain Beck
Article: 2220150
Published online: 06 Jun 2023
AbstractforEffects of the COVID-19 pandemic: new approaches for accelerated delivery of gene to first-in-human CMC data for recombinant proteins | Full Text | References | PDF (1.5 MB) | EPUB
  • 1961 Views
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Report

Report
A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells
Xiaoding Tan, Peng Fang, Kaiying Li, Meng You, Yuxia Cao, Hui Xu, Xiaohong Zhu, Lu Wang, Xin Wei, Haiying Wen, Wendi Li, Lei Shi, Xiaowei Sun, Dongan Yu, Huikai Zhu, Zhenzhen Wang, Datao Liu, Hui Shen, Wei Zhou & Maomao An
Article: 2220466
Published online: 14 Jun 2023
AbstractforA HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells | Full Text | References | PDF (10.3 MB) | EPUB | Supplemental
  • 3081 Views
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Report
Generation of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties
Abdullah Elsayed, Christian Pellegrino, Louis Plüss, Frederik Peissert, Ramon Benz, Franziska Ulrich, Gudrun Thorhallsdottir, Sheila Dakhel Plaza, Alessandra Villa, Jacqueline Mock, Emanuele Puca, Roberto De Luca, Markus G. Manz, Cornelia Halin & Dario Neri
Article: 2220839
Published online: 08 Jun 2023
AbstractforGeneration of a novel fully human non-superagonistic anti-CD28 antibody with efficient and safe T-cell co-stimulation properties | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 3511 Views
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Report
Efficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A
Hikaru Koga, Takashi Yamano, Juan Betancur, Satoko Nagatomo, Yousuke Ikeda, Kazuki Yamaguchi, Yoshiaki Nabuchi, Kazuki Sato, Yuri Teranishi-Ikawa, Motohiko Sato, Hiroyuki Hirayama, Akira Hayasaka, Takuya Torizawa, Kenta Haraya, Zenjiro Sampei, Hirotake Shiraiwa, Takehisa Kitazawa, Tomoyuki Igawa & Taichi Kuramochi
Article: 2222441
Published online: 20 Jun 2023
AbstractforEfficient production of bispecific antibody by FAST-IgTM and its application to NXT007 for the treatment of hemophilia A | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
  • 5385 Views
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Report
Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex
Minoru Tada, Michihiko Aoyama & Akiko Ishii-Watabe
Article: 2222874
Published online: 12 Jun 2023
AbstractforCharacterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 1121 Views
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Report
Improved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain
Young D. Kwon, Amarendra Pegu, Eun Sung Yang, Baoshan Zhang, Michael F. Bender, Mangaiarkarasi Asokan, Qingbo Liu, Krisha McKee, Bob C. Lin, Tracy Liu, Mark K. Louder, Reda Rawi, Mateo Reveiz, Andrew J. Schaub, Chen-Hsiang Shen, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola & Peter D. Kwong
Article: 2223350
Published online: 21 Jun 2023
AbstractforImproved pharmacokinetics of HIV-neutralizing VRC01-class antibodies achieved by reduction of net positive charge on variable domain | Full Text | References | PDF (7.1 MB) | EPUB | Supplemental
  • 1993 Views
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Report
A PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation
Alessandro Mega, Aman Mebrahtu, Gustav Aniander, Eva Ryer, Annette Sköld, Anna Sandegren, Eva Backström Rydin, Johan Rockberg, Arne Östman & Fredrik Y. Frejd
Article: 2223750
Published online: 18 Jun 2023
AbstractforA PDGFRB- and CD40-targeting bispecific AffiMab induces stroma-targeted immune cell activation | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
  • 1807 Views
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Report
Understanding the structure–property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions
Bo Zhao, Yunlong Zhao, Stephanie Adaniya, Yue Fu, Youmi Moon, Justin Heftel, Shuzhen Chen, Hui Xiao & Ning Li
Article: 2228006
Published online: 25 Jun 2023
AbstractforUnderstanding the structure–property relationship of bispecific monoclonal antibodies with Fc site-specific substitutions | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Report
Modifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier
Jason Tien, Dmitri Leonoudakis, Ralitsa Petrova, Vivian Trinh, Tetsuya Taura, Debapriya Sengupta, Lisa Jo, Angela Sho, Yong Yun, Eric Doan, Anita Jamin, Hussein Hallak, David S. Wilson & Jennifer R. Stratton
Article: 2229098
Published online: 28 Jun 2023
AbstractforModifying antibody-FcRn interactions to increase the transport of antibodies through the blood-brain barrier | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Review

Review Article
Exploration of the antibody–drug conjugate clinical landscape
Heather Maecker, Vidya Jonnalagadda, Sunil Bhakta, Vasu Jammalamadaka & Jagath R. Junutula
Article: 2229101
Published online: 28 Aug 2023
AbstractforExploration of the antibody–drug conjugate clinical landscape | Full Text | References | PDF (3.7 MB) | EPUB
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Interrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry
Tian Xu, Fan Zhang, Daoyang Chen, Liangliang Sun, Daniela Tomazela & Laurence Fayadat-Dilman
Article: 2229102
Published online: 28 Jun 2023
AbstractforInterrogating heterogeneity of cysteine-engineered antibody-drug conjugates and antibody-oligonucleotide conjugates by capillary zone electrophoresis-mass spectrometry | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 3147 Views
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Comment
Therapeutic index improvement of antibody-drug conjugates
Hans-Peter Gerber, Sanjeev Gangwar & Alison Betts
Article: 2230618
Published online: 05 Jul 2023
AbstractforTherapeutic index improvement of antibody-drug conjugates | Full Text | References | PDF (504.9 KB) | EPUB
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Report
Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG
Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis & Margaret E. Ackerman
Article: 2231128
Published online: 05 Jul 2023
AbstractforEvidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Report
Manufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies
Han Ping Loh, Farouq Bin Mahfut, Serene W Chen, Yuhan Huang, Jianxin Huo, Wei Zhang, Kong Peng Lam, Shengli Xu & Yuansheng Yang
Article: 2231129
Published online: 04 Jul 2023
AbstractforManufacturability and functionality assessment of different formats of T-cell engaging bispecific antibodies | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 4491 Views
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Report
Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework
Romain Ollier, Aline Fuchs, Florence Gauye, Katarzyna Piorkowska, Sébastien Menant, Monisha Ratnam, Paolo Montanari, Florence Guilhot, Didier Phillipe, Mickael Audrain, Anne-Laure Egesipe, Damien Névoltris, Tamara Seredenina, Andrea Pfeifer, Marie Kosco-Vilbois & Tariq Afroz
Article: 2232087
Published online: 05 Jul 2023
AbstractforImproved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 2972 Views
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Report
Prediction of long-term polysorbate degradation according to short-term degradation kinetics
Sisi Zhang, Caterina Riccardi, Dane Carlson, Douglas Kamen, Kenneth S. Graham, Mohammed Shameem, Hanne Bak, Hui Xiao & Ning Li
Article: 2232486
Published online: 06 Jul 2023
AbstractforPrediction of long-term polysorbate degradation according to short-term degradation kinetics | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2598 Views
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Report
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition
Britta Lipinski, Laura Unmuth, Paul Arras, Stefan Becker, Christina Bauer, Lars Toleikis, Simon Krah, Achim Doerner, Desislava Yanakieva, Ammelie Svea Boje, Katja Klausz, Matthias Peipp, Vanessa Siegmund, Andreas Evers, Harald Kolmar, Lukas Pekar & Stefan Zielonka
Article: 2236265
Published online: 19 Jul 2023
AbstractforGeneration and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Review

Review Article
Advances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1
Mengzhen Jiang, Man Liu, Guodi Liu, Jiawen Ma, Lixin Zhang & Shenlin Wang
Article: 2236740
Published online: 02 Aug 2023
AbstractforAdvances in the structural characterization of complexes of therapeutic antibodies with PD-1 or PD-L1 | Full Text | References | PDF (4 MB) | EPUB
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Report
Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies
Grayson Hatfield, Lioudmila Tepliakova, Jessica Tran, Huixin Lu, Michel Gilbert & Roger Y. Tam
Article: 2239405
Published online: 27 Jul 2023
AbstractforBivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
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Report
Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells
Emma Kelsall, Claire Harris, Titash Sen, Diane Hatton, Sarah Dunn & Suzanne Gibson
Article: 2242548
Published online: 09 Aug 2023
AbstractforInterplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Monte Carlo Thompson sampling-guided design for antibody engineering
Taro Kakuzaki, Hikaru Koga, Shuuki Takizawa, Shoichi Metsugi, Hirotake Shiraiwa, Zenjiro Sampei, Kenji Yoshida, Hiroyuki Tsunoda & Reiji Teramoto
Article: 2244214
Published online: 21 Aug 2023
AbstractforMonte Carlo Thompson sampling-guided design for antibody engineering | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 1987 Views
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Targeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy
Vedran Vasic, Can Buldun, Manfred Ritz, Steffen Dickopf, Guy J. Georges, Christian Spick, Alessa Peuker, Thomas Meier, Klaus Mayer & Ulrich Brinkmann
Article: 2245111
Published online: 22 Aug 2023
AbstractforTargeted chain-exchange-mediated reconstitution of a split type-I cytokine for conditional immunotherapy | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 2836 Views
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Selection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method
Thomas Müller, Carolin Tasser, Michael Tesar, Ivica Fucek, Ute Schniegler-Mattox, Joachim Koch & Kristina Ellwanger
Article: 2245519
Published online: 20 Aug 2023
AbstractforSelection of bispecific antibodies with optimal developability using FcRn‑pH‑HPLC as an optimized FcRn affinity chromatography method | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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A machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties
Andrew B. Waight, David Prihoda, Rojan Shrestha, Kevin Metcalf, Marc Bailly, Marco Ancona, Talal Widatalla, Zachary Rollins, Alan C Cheng, Danny A. Bitton & Laurence Fayadat-Dilman
Article: 2248671
Published online: 23 Aug 2023
AbstractforA machine learning strategy for the identification of key in silico descriptors and prediction models for IgG monoclonal antibody developability properties | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
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Report
Unique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display
Feng Ni, Cunle Wu, Ping Xu, Ping Wang, Yves Fortin, Melanie Arbour, Luke Masson, Denis L’Abbé, Andrea Acel, Mylene Gosselin & Anne E.G. Lenferink
Article: 2248672
Published online: 25 Aug 2023
AbstractforUnique epitope–antibody interactions in the intrinsically disordered proteoglycan-like domain of human carbonic anhydrase IX defined by high-resolution NMR combined with yeast surface display | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
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Report
Use of poxvirus display to select antibodies specific for complex membrane antigens
Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris & Maurice Zauderer
Article: 2249947
Published online: 27 Aug 2023
AbstractforUse of poxvirus display to select antibodies specific for complex membrane antigens | Full Text | References | PDF (2.6 MB) | EPUB
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Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening
Ramona Gaa, Hannah Melina Mayer, Daniela Noack, Kavita Kumari, Ralf Guenther, Shang-Pu Tsai, Qingyong Ji & Achim Doerner
Article: 2251190
Published online: 30 Aug 2023
AbstractforMammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Rapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion
Yoshiyuki Arata, Shigeki Motoyama, Mariko Yano, Tatsuya Ikuno, Shunsuke Ito, Tomochika Matsushita, Akira Takeiri, Yukari Nishito, Nami Yabuki, Hideaki Mizuno, Zenjiro Sampei, Masayuki Mishima, Masaki Honda, Jumpei Kiyokawa, Hiromi Suzuki, Shuichi Chiba, Mitsuyasu Tabo & Chiyomi Kubo
Article: 2253570
Published online: 08 Sep 2023
AbstractforRapid in vitro assessment of the immunogenicity potential of engineered antibody therapeutics through detection of CD4+ T cell interleukin-2 secretion | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT
SJ J. Diong, Aarti Jashnani, Andrew W. Drake, Christine Bee, Felix Findeisen, Gavin Dollinger, Feng Wang, Arvind Rajpal, Pavel Strop & Peter S. Lee
Article: 2253788
Published online: 07 Sep 2023
AbstractforBiophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 2454 Views
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Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders
Stephanie Maciuba, Gregory D. Bowden, Harrison J. Stratton, Kazimierz Wisniewski, Claudio D. Schteingart, Juan C. Almagro, Philippe Valadon, Joshua Lowitz, Scott M. Glaser, Grace Lee, Mahdi Dolatyari, Edita Navratilova, Frank Porreca & Pierre J.M. Rivière
Article: 2254676
Published online: 12 Sep 2023
AbstractforDiscovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates
Inga Petersen, Muhammad Ilyas Ali, Alex Petrovic, Anders Jimmy Ytterberg, Karin Staxäng, Monika Hodik, Fadi Rofo, Sina Bondza & Greta Hultqvist
Article: 2256668
Published online: 22 Sep 2023
AbstractforMultivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang & Iain D. G. Campuzano
Article: 2256745
Published online: 12 Sep 2023
AbstractforDevelopment of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Identification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity
Christopher B. Lietz, Ekaterina Deyanova, Younhee Cho, Jon Cordia, Sarah Franc, Sally Kabro, Steven Wang, David Mikolon & Douglas D. Banks
Article: 2259289
Published online: 24 Sep 2023
AbstractforIdentification of tyrosine sulfation in the variable region of a bispecific antibody and its effect on stability and biological activity | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 2368 Views
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A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization
Paul Arras, Han Byul Yoo, Lukas Pekar, Christian Schröter, Thomas Clarke, Simon Krah, Daniel Klewinghaus, Vanessa Siegmund, Andreas Evers & Stefan Zielonka
Article: 2261149
Published online: 27 Sep 2023
AbstractforA library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization | Full Text | References | PDF (8 MB) | EPUB | Supplemental
  • 7176 Views
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Delivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans
Hans Peter Grimm, Vanessa Schumacher, Martin Schäfer, Sabine Imhof-Jung, Per-Ola Freskgård, Kevin Brady, Carsten Hofmann, Petra Rüger, Tilman Schlothauer, Ulrich Göpfert, Maximilian Hartl, Sylvia Rottach, Adrian Zwick, Shanon Seger, Rachel Neff, Jens Niewoehner & Niels Janssen
Article: 2261509
Published online: 12 Oct 2023
AbstractforDelivery of the Brainshuttle™ amyloid-beta antibody fusion trontinemab to non-human primate brain and projected efficacious dose regimens in humans | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 8617 Views
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Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice
Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock & Veena A. Thomas
Article: 2263926
Published online: 12 Oct 2023
AbstractforUtility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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A window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies
Oscar Mejias-Gomez, Andreas V. Madsen, Kerstin Skovgaard, Lasse E. Pedersen, J. Preben Morth, Timothy P. Jenkins, Peter Kristensen & Steffen Goletz
Article: 2268255
Published online: 24 Oct 2023
AbstractforA window into the human immune system: comprehensive characterization of the complexity of antibody complementary-determining regions in functional antibodies | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 3206 Views
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Review

Review Article
Breaking barriers in antibody discovery: harnessing divergent species for accessing difficult and conserved drug targets
Soma S.R. Banik, Natasha Kushnir, Benjamin J. Doranz & Ross Chambers
Article: 2273018
Published online: 05 Dec 2023
AbstractforBreaking barriers in antibody discovery: harnessing divergent species for accessing difficult and conserved drug targets | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 2802 Views
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Report

Report
Robust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface
John D. Bagert, Vaheh Oganesyan, Chi-I Chiang, Mike Iannotti, Jia Lin, Chunning Yang, Sterling Payne, Will McMahon, Samuel Edwards, Andrew Dippel, Mark Hutchinson, Fengying Huang, Vineela Aleti, Chendi Niu, Chen Qian, Jessica Denham, Sofia Ferreira, Pallab Pradhan, Mark Penney, Chunlei Wang, Wenhai Liu, Even Walseng & Yariv Mazor
Article: 2273449
Published online: 06 Nov 2023
AbstractforRobust production of monovalent bispecific IgG antibodies through novel electrostatic steering mutations at the CH1-Cλ interface | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Report
Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases
Maarten van der Linden, Sangeeta Kumari, Daphne Montizaan, Stephanie van Dalen, Annemarie Kip, Martyn Foster, Inge Reinieren-Beeren, Elsa Neubert, Luise Erpenbeck, Kelsy Waaijenberg, Tirza Bruurmijn, Rezie te Poele, Peter van Zandvoort, Paul Vink, Eric Meldrum, Helmuth van Es & Renato G.S. Chirivi
Article: 2281763
Published online: 29 Nov 2023
AbstractforAnti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
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Review

Review Article
Monoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume
M. Desai, A. Kundu, M. Hageman, H. Lou & D. Boisvert
Article: 2285277
Published online: 27 Nov 2023
AbstractforMonoclonal antibody and protein therapeutic formulations for subcutaneous delivery: high-concentration, low-volume vs. low-concentration, high-volume | Full Text | References | PDF (885.4 KB) | EPUB
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Report

Report
Epitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies
Xibei Dang, Lars Guelen, David Lutje Hulsik, Grigori Ermakov, Edward J. Hsieh, Joost Kreijtz, Judith Stammen-Vogelzangs, Imke Lodewijks, Astrid Bertens, Arne Bramer, Marco Guadagnoli, Alexis Nazabal, Andrea van Elsas, Thierry Fischmann, Veronica Juan, Amy Beebe, Maribel Beaumont & Hans van Eenennaam
Article: 2285285
Published online: 27 Nov 2023
AbstractforEpitope mapping of monoclonal antibodies: a comprehensive comparison of different technologies | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 5387 Views
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Correction

Correction
Correction
Article: 2285575
Published online: 27 Nov 2023
CitationforCorrection | Full Text | PDF (154.6 KB) | EPUB
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Report

Report
BERT2DAb: a pre-trained model for antibody representation based on amino acid sequences and 2D-structure
Xiaowei Luo, Fan Tong, Wenbin Zhao, Xiangwen Zheng, Jiangyu Li, Jing Li & Dongsheng Zhao
Article: 2285904
Published online: 27 Nov 2023
AbstractforBERT2DAb: a pre-trained model for antibody representation based on amino acid sequences and 2D-structure | Full Text | References | PDF (18.5 MB) | EPUB | Supplemental
  • 1283 Views
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Development and pharmacokinetic assessment of a fully canine anti-PD-1 monoclonal antibody for comparative translational research in dogs with spontaneous tumors
Sho Yoshimoto, Nicholas Chester, Ailian Xiong, Enrico Radaelli, Hong Wang, Marc Brillantes, Gayathri Gulendran, Patrick Glassman, Don L. Siegel & Nicola J. Mason
Article: 2287250
Published online: 04 Dec 2023
AbstractforDevelopment and pharmacokinetic assessment of a fully canine anti-PD-1 monoclonal antibody for comparative translational research in dogs with spontaneous tumors | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2421 Views
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Report
Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer
Gareth C. G. Davies, Neesha Dedi, Paul S. Jones, Lara Kevorkian, David McMillan, Cristina Ottone, Monika-Sarah E. D. Schulze, Anthony Scott-Tucker, Roohi Tewari, Shauna West, Michael Wright & Tania F. Rowley
Article: 2289681
Published online: 12 Dec 2023
AbstractforDiscovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2269 Views
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Report
Determining the affinities of high-affinity antibodies using KinExA and surface plasmon resonance
M. Frank Erasmus, Molly Dovner, Fortunato Ferrara, Sara D’Angelo, André A. Teixeira, Camila Leal-Lopes, Laura Spector, Elizabeth Hopkins & Andrew R. M. Bradbury
Article: 2291209
Published online: 13 Dec 2023
AbstractforDetermining the affinities of high-affinity antibodies using KinExA and surface plasmon resonance | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 2564 Views
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Report
Accelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies
Yuqi Wang, Quan Quan, Camille Gleason, Helin Yu, Lujia Peng, Yanshen Kang, Ling Jiang, Kailun Wu, Jie Pan, Moxiyele Bao, Qing Zhu, Meiqi Yi, Ming Fang, Yue Zheng, Ling Qiu, Bin Xu, Xiang Li, Jinfeng Song, Jiamu Sun, Zheng Zhang, Zijun Su, Jara Lin, Yuanyuan Xie, April Xu, Xiling Song, Chichi Huang, Zhirong Shen, Lai Wang & Jing Song
Article: 2292305
Published online: 14 Dec 2023
AbstractforAccelerating the speed of innovative anti-tumor drugs to first-in-human trials incorporating key de-risk strategies | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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