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mAbs Volume 15, 2023 - Issue 1
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Review

Assessing developability early in the discovery process for novel biologics

Monica L. Fernández-Quinteroa Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, AustriaORCID Iconhttps://orcid.org/0000-0002-6811-6283View further author information
ORCID Icon,
Anne Ljungarsb Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DenmarkORCID Iconhttps://orcid.org/0000-0002-2158-0601View further author information
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Franz Waibla Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, AustriaORCID Iconhttps://orcid.org/0000-0003-0527-0803View further author information
ORCID Icon,
Victor Greiffc Department of Immunology, University of Oslo, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0003-2622-5032View further author information
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Jan Terje Andersend Department of Immunology, University of Oslo, Oslo University Hospital Rikshospitalet, Oslo, Norway;e Institute of Clinical Medicine and Department of Pharmacology, University of Oslo, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0003-1710-1628View further author information
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Torleif T. Gjølbergf Authera AS, Oslo Science Park, Oslo, NorwayORCID Iconhttps://orcid.org/0000-0002-1719-7677View further author information
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Timothy P. Jenkinsb Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DenmarkORCID Iconhttps://orcid.org/0000-0003-2979-5663View further author information
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Bjørn Gunnar Voldborgg National Biologics Facility, Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DenmarkORCID Iconhttps://orcid.org/0000-0002-7005-1642View further author information
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Lise Marie Gravb Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DenmarkORCID Iconhttps://orcid.org/0000-0001-8042-7108View further author information
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Sandeep Kumarh Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, USAORCID Iconhttps://orcid.org/0000-0003-2840-6398View further author information
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Guy Georgesi Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, GermanyORCID Iconhttps://orcid.org/0000-0001-5737-006XView further author information
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Hubert Kettenbergeri Roche Pharma Research and Early Development, Large Molecule Research, Roche Innovation Center Munich, Penzberg, GermanyORCID Iconhttps://orcid.org/0000-0001-7130-1917View further author information
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Klaus R. Liedla Center for Molecular Biosciences Innsbruck (CMBI), Department of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innsbruck, AustriaORCID Iconhttps://orcid.org/0000-0002-0985-2299View further author information
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Peter M. Tessierj Department of Chemical Engineering, Pharmaceutical Sciences and Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan, USAORCID Iconhttps://orcid.org/0000-0002-3220-007XView further author information
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John McCaffertyk Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK;l Maxion Therapeutics, Babraham Research Campus, Cambridge, UKORCID Iconhttps://orcid.org/0000-0003-2195-0972View further author information
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Andreas H. Laustsenb Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6918-5574View further author information
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Article: 2171248 | Received 27 Oct 2022, Accepted 18 Jan 2023, Published online: 23 Feb 2023

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Kristina M.J. Aertker, Minu Ravindra Pilvankar, Tobias M. Prass, Michaela Blech, Fabian Higel & Srinath Kasturirangan. (2024) Exploring molecular determinants and pharmacokinetic properties of IgG1-scFv bispecific antibodies. mAbs 16:1.
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Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters & Peter M. Tessier. (2024) Reduction of monoclonal antibody viscosity using interpretable machine learning. mAbs 16:1.
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Tushar Jain, Todd Boland & Maximiliano Vásquez. (2023) Identifying developability risks for clinical progression of antibodies using high-throughput in vitro and in silico approaches. mAbs 15:1.
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