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mAbs Volume 15, 2023 - Issue 1
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Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody

Dario A. T. Cramera Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;b Netherlands Proteomics Center, Utrecht, The NetherlandsView further author information
,
Vojtech Franca Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;b Netherlands Proteomics Center, Utrecht, The NetherlandsView further author information
,
Anna-Katharina Heidenreichc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyView further author information
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Michaela Hookc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyView further author information
,
Mahdi Adibzadehd Pharma Technical Development, F. Hoffmann-La Roche AG, Basel, SwitzerlandView further author information
,
Dietmar Reuschc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyView further author information
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Albert J. R. Hecka Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands;b Netherlands Proteomics Center, Utrecht, The NetherlandsView further author information
&
Markus Habergerc Pharma Technical Development, Roche Diagnostics GmbH, Penzberg, GermanyCorrespondence[email protected]
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Article: 2175312 | Received 10 Oct 2022, Accepted 29 Jan 2023, Published online: 17 Feb 2023

Citations (3)

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Read on this site (1)

Caitlin Fawcett, Joseph. R. Tickle & Charlotte. H. Coles. (2024) Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows. mAbs 16:1.
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Articles from other publishers (2)

Andreas V. Madsen, Lasse E. Pedersen, Peter Kristensen & Steffen Goletz. (2024) Design and engineering of bispecific antibodies: insights and practical considerations. Frontiers in Bioengineering and Biotechnology 12.
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Jake T. Kline, Rafael D. Melani & Luca Fornelli. (2023) Mass spectrometry characterization of antibodies at the intact and subunit levels: From targeted to large-scale analysis. International Journal of Mass Spectrometry 492, pages 117117.
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