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mAbs Volume 15, 2023 - Issue 1
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Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition

Britta Lipinskia Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, Germany;b Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyView further author information
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Laura Unmuthc Early Protein Supply and Characterization (EPSC), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Paul Arrasa Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Stefan Beckerc Early Protein Supply and Characterization (EPSC), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Christina Bauera Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Lars Toleikisc Early Protein Supply and Characterization (EPSC), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Simon Kraha Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Achim Doernera Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Desislava Yanakievaa Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Ammelie Svea Bojed Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, GermanyView further author information
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Katja Klauszd Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, GermanyView further author information
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Matthias Peippd Division of Antibody-Based Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Kiel, GermanyView further author information
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Vanessa Siegmundc Early Protein Supply and Characterization (EPSC), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Andreas Eversa Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyView further author information
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Harald Kolmarb Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyView further author information
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Lukas Pekara Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, GermanyORCID Iconhttps://orcid.org/0000-0001-9259-0965View further author information
ORCID Icon &
Stefan Zielonkaa Antibody Discovery and Protein Engineering (ADPE), Merck Healthcare KGaA, Darmstadt, Germany;b Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, GermanyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4649-2843View further author information
ORCID Icon show all
Article: 2236265 | Received 02 Apr 2023, Accepted 10 Jul 2023, Published online: 19 Jul 2023

Citations (6)

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Lukas Pekar, Simon Krah & Stefan Zielonka. (2024) Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics. Expert Opinion on Biological Therapy 24:3, pages 115-118.
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Paul Arras, Han Byul Yoo, Lukas Pekar, Christian Schröter, Thomas Clarke, Simon Krah, Daniel Klewinghaus, Vanessa Siegmund, Andreas Evers & Stefan Zielonka. (2023) A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization. mAbs 15:1.
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Articles from other publishers (4)

Christian Klein, Ulrich Brinkmann, Janice M. Reichert & Roland E. Kontermann. (2024) The present and future of bispecific antibodies for cancer therapy. Nature Reviews Drug Discovery 23:4, pages 301-319.
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Yasaman MortazaviRobert HerreraMatthieu MasureelTimurs MaculinsIsabelle LehouxJonathan SockoloskyNathan WestBeyza BulutogluYue Zhao. (2024) Activation of the Interleukin-18 Signaling Pathway via Direct Receptor Dimerization in the Absence of Interleukin-18. Journal of Interferon & Cytokine Research 44:1, pages 37-42.
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Paul Arras, Han Byul Yoo, Lukas Pekar, Thomas Clarke, Lukas Friedrich, Christian Schröter, Jennifer Schanz, Jason Tonillo, Vanessa Siegmund, Achim Doerner, Simon Krah, Enrico Guarnera, Stefan Zielonka & Andreas Evers. (2023) AI/ML combined with next-generation sequencing of VHH immune repertoires enables the rapid identification of de novo humanized and sequence-optimized single domain antibodies: a prospective case study. Frontiers in Molecular Biosciences 10.
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Fatemeh Heidari, Soheil Madadi, Neda Alizadeh, Mohammad Hossein Alimardani, Armin Safari, Mohammad Hossein Armand, Elahe Pishgahzadeh & Meysam Soleimani. (2023) The potential of monoclonal antibodies for colorectal cancer therapy. Medical Oncology 40:9.
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