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mAbs Volume 15, 2023 - Issue 1
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Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies

Marissa Mocka Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0009-0009-0659-988XView further author information
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Alex W. Jacobitzb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Christopher James Langmeada Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Athena Sudomc Structural Biology, Amgen Research, South San Francisco, CA, USAView further author information
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Daniel Yooa Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Sara C. Humphreysd Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USAView further author information
,
Mai Aldaya Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Larysa Alekseychykb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
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Nicolas Angellb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
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Vivian Bia Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Hannah Catteralla Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Chen-Chun Chena Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Hui-Ting Chouc Structural Biology, Amgen Research, South San Francisco, CA, USAView further author information
,
Kip P. Connerd Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USAView further author information
,
Kevin D. Cookd Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USAView further author information
,
Ana R. Correiaa Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Andrew Dykstrab Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
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Sudipa Ghimire-Rijale Structural Biology, Amgen Research, Thousand Oaks, CA, USAView further author information
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Kevin Grahama Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
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Peter Grandsarda Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Joon Huhb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
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John O. Huia Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Mani Jaina Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Victoria Janna Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Lei Jiaa Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Sheree Johnstonec Structural Biology, Amgen Research, South San Francisco, CA, USAView further author information
,
Neelam Khanalb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Carl Kolvenbacha Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Linda Narhib Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Rupa Padakib Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Emma M. Pelegri-O’Daya Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Wei Qib Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Vladimir Razinkovb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Austin J. Ricea Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Richard Smithd Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USAView further author information
,
Christopher Spahra Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Jennitte Stevensb Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Yax Suna Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Veena A. Thomasd Pharmacokinetics & Drug Metabolism, Amgen Research, South San Francisco, CA, USAView further author information
,
Sarah van Drieschea Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Robert Vernona Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Victoria Wagnera Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Kenneth W. Walkera Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Yangjie Weib Process Development, Amgen Operations, Thousand Oaks, CA, USAView further author information
,
Dwight Wintersa Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
,
Melissa Yanga Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USAView further author information
&
Iain D. G. Campuzanoa Biologic Therapeutic Discovery, Amgen Research, Thousand Oaks, CA, USACorrespondence[email protected]
View further author information
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Article: 2256745 | Received 29 May 2023, Accepted 05 Sep 2023, Published online: 12 Sep 2023

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Emily K. Makowski, Hsin-Ting Chen, Tiexin Wang, Lina Wu, Jie Huang, Marissa Mock, Patrick Underhill, Emma Pelegri-O’Day, Erick Maglalang, Dwight Winters & Peter M. Tessier. (2024) Reduction of monoclonal antibody viscosity using interpretable machine learning. mAbs 16:1.
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Shufang Liu, Sara C. Humphreys, Kevin D. Cook, Kip P. Conner, Ana R. Correia, Alex W. Jacobitz, Melissa Yang, Ronya Primack, Marcus Soto, Rupa Padaki, Mariusz Lubomirski, Richard Smith, Marissa Mock & Veena A. Thomas. (2023) Utility of physiologically based pharmacokinetic modeling to predict inter-antibody variability in monoclonal antibody pharmacokinetics in mice. mAbs 15:1.
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Articles from other publishers (2)

Marissa Mock, Christopher James Langmead, Peter Grandsard, Suzanne Edavettal & Alan Russell. (2024) Recent advances in generative biology for biotherapeutic discovery. Trends in Pharmacological Sciences 45:3, pages 255-267.
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Kamal Bhandari, Yangjie Wei, Brendan R. Amer, Emma M. Pelegri-O’Day, Joon Huh & Jeremy D. Schmit. (2023) Prediction of Antibody Viscosity from Dilute Solution Measurements. Antibodies 12:4, pages 78.
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