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Original Articles

The ecological context of pyrrolizidine alkaloids in food, feed and forage: an overview

Pages 260-281 | Received 09 Jul 2010, Accepted 22 Dec 2010, Published online: 25 Feb 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Fenja Klevenhusen, Anja These, Julian Taenzer, Kirsten Weiß & Robert Pieper. (2022) Effects of ensiling conditions on pyrrolizidine alkaloid degradation in silages mixed with two different Senecio spp.. Archives of Animal Nutrition 76:2, pages 93-111.
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Maria G. Campos, Ofélia Anjos, Manuel Chica, Pascual Campoy, Janka Nozkova, Norma Almaraz-Abarca, Lidia M. R. C. Barreto, João Carlos Nordi, Leticia M. Estevinho, Ananias Pascoal, Vanessa Branco Paula, Altino Chopina, Luis G. Dias, Živoslav L. j. Tešić, Mirjana D. Mosić, Aleksandar Ž. Kostić, Mirjana B. Pešić, Dušanka M. Milojković-Opsenica, Wiebke Sickel, Markus J. Ankenbrand, Gudrun Grimmer, Ingolf Steffan-Dewenter, Alexander Keller, Frank Förster, Chrysoula H. Tananaki, Vasilios Liolios, Dimitrios Kanelis, Maria-Anna Rodopoulou, Andreas Thrasyvoulou, Luísa Paulo, Christina Kast, Matteo A. Lucchetti, Gaëtan Glauser, Olena Lokutova, Ligia Bicudo de Almeida-Muradian, Teresa Szczęsna & Norman L. Carreck. (2021) Standard methods for pollen research. Journal of Apicultural Research 60:4, pages 1-109.
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F.J. Orantes-Bermejo, J. Serra Bonvehí, A. Gómez-Pajuelo, M. Megías & C. Torres. (2013) Pyrrolizidine alkaloids: their occurrence in Spanish honey collected from purple viper’s bugloss (Echium spp.). Food Additives & Contaminants: Part A 30:10, pages 1799-1806.
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A. Dübecke, G. Beckh & C. Lüllmann. (2011) Pyrrolizidine alkaloids in honey and bee pollen. Food Additives & Contaminants: Part A 28:3, pages 348-358.
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Articles from other publishers (56)

Weiting Jiao, Lei Zhu, Tingting Shen, Luyao Wang, Qing X. Li, Chen Wang, Xiangwei Wu, Hongping Chen & Rimao Hua. (2024) Simultaneous determination of 15 pyrrolizidine alkaloids and their N-oxides in weeds, soil, fresh tea leaves, and tea: Exploring the pollution source of pyrrolizidine alkaloids in tea. Food Chemistry 434, pages 137305.
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Fawzy Eissa & El-Kazafy A. Taha. (2023) Contaminants in honey: an analysis of EU RASFF notifications from 2002 to 2022. Journal of Consumer Protection and Food Safety 18:4, pages 393-402.
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Emmanuel Letsyo, John Dzikunoo, Courage Sedem Dzah, Zeenatu Suglo Adams & David Asante-Donyinah. (2023) Hepatic phytotoxins in herbal medicines: A review of Africa's pyrrolizidine alkaloid-containing plants, their traditional uses, contamination pathways and associated health risks. South African Journal of Botany 161, pages 78-89.
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M. Barberis, G. Bogo, L. Bortolotti, M. Guarnieri, M. Nepi, A. Felicioli & M. Galloni. (2023) Nectar tyramine decreases the duration of bumblebee visits on flowers. Arthropod-Plant Interactions 17:5, pages 563-569.
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Michael Boppré & Julio Monzón. (2023) Baiting Insects with Pyrrolizidine Alkaloids (PAs): A Fieldwork-Oriented Review and Guide to PA-Pharmacophagy. Neotropical Entomology.
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Adriana L. Silva, Joana L. Oliveira, Ravena P. do Nascimento, Letícia O. Santos, Fillipe M. de Araújo, Balbino L. dos Santos, Rejane C. Santana, Eduardo Luiz T. Moreira, Maria José M. Batatinha, Iura M. Alves, Eudes S. Velozo, Mauricio M. Victor, Adriano M. Assis, Roberto F. Almeida, Diogo O.G. de Souza, Victor Diógenes A. Silva & Silvia L. Costa. (2023) Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: A model of vascular damage in perspective. NeuroToxicology 94, pages 59-70.
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Lisa Monika Klein, Angelika Miriam Gabler, Michael Rychlik, Christoph Gottschalk & Florian Kaltner. (2022) A sensitive LC–MS/MS method for isomer separation and quantitative determination of 51 pyrrolizidine alkaloids and two tropane alkaloids in cow’s milk. Analytical and Bioanalytical Chemistry 414:28, pages 8107-8124.
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Haolei Han, Changling Jiang, Chen Wang, Yuting Lu, Ziqi Wang, Yunfeng Chai, Xiangchun Zhang, Xin Liu, Chengyin Lu & Hongping Chen. (2022) Dissipation pattern and conversion of pyrrolizidine alkaloids (PAs) and pyrrolizidine alkaloid N-oxides (PANOs) during tea manufacturing and brewing. Food Chemistry 390, pages 133183.
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Jochem Louisse, Patrick P. J. Mulder, Arjen Gerssen, Geert Stoopen, Deborah Rijkers, Milou G. M. van de Schans & Ad A. C. M. Peijnenburg. (2022) Bioassay-directed analysis-based identification of relevant pyrrolizidine alkaloids. Archives of Toxicology 96:8, pages 2299-2317.
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Seda Dicle KORKMAZ & Özlem KÜPLÜLÜ. (2022) Denizli ilinde üretilen kekiklerde (Origanum onites) pirolizidin alkaloidlerinin LC-MS Q-TOF yöntemi ile belirlenmesiDetermination of pyrrolizidine alkoloids in oregano (Origanum onites) produced in Denizli by LC-MS Q-TOF method. Veteriner Hekimler Derneği Dergisi 93:2, pages 115-123.
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K. Schwarz, T.W. Donath, E. Kaltenegger & T. Diekötter. (2021) Environmental preferences of Longitarsus jacobaeae, a biocontrol agent of Jacobaea vulgaris, in northern Germany. Biological Control 164, pages 104740.
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Nancy LawsonRichard I. Vane‐Wright & Michael Boppré. (2021) The puzzle of monarch butterflies ( Danaus plexippus ) and their association with plants containing pyrrolizidine alkaloids . Ecological Entomology 46:5, pages 999-1005.
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Luis O. Tedeschi, James P. Muir, Harley D. Naumann, Aaron B. Norris, Carlos A. Ramírez-Restrepo & Susanne U. Mertens-Talcott. (2021) Nutritional Aspects of Ecologically Relevant Phytochemicals in Ruminant Production. Frontiers in Veterinary Science 8.
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Jawameer R. Hama & Bjarne W. Strobel. (2021) Occurrence of pyrrolizidine alkaloids in ragwort plants, soils and surface waters at the field scale in grassland. Science of The Total Environment 755, pages 142822.
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Barbara F. Günthardt, Felix E. Wettstein, Juliane Hollender, Heinz Singer, Jana Härri, Martin Scheringer, Konrad Hungerbühler & Thomas D. Bucheli. (2020) Retrospective HRMS Screening and Dedicated Target Analysis Reveal a Wide Exposure to Pyrrolizidine Alkaloids in Small Streams. Environmental Science & Technology 55:2, pages 1036-1044.
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Michael Boppré, Juan Grados, Michel Laguerre & Julio Monzón. (2020) Vanewrightia gen. nov.—A Highly Variable Taxon of Neotropical Ctenuchina (Lepidoptera: Erebidae: Arctiinae: Arctiini) Revealed by Behavioral Traits. Insect Systematics and Diversity 4:5.
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Florian Kaltner, Verena Kukula & Christoph Gottschalk. (2020) Screening of food supplements for toxic pyrrolizidine alkaloids. Journal of Consumer Protection and Food Safety 15:3, pages 237-243.
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Piotr Kaczyński & Bożena Łozowicka. (2020) A novel approach for fast and simple determination pyrrolizidine alkaloids in herbs by ultrasound-assisted dispersive solid phase extraction method coupled to liquid chromatography–tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 187, pages 113351.
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Florian Kaltner, Michael Rychlik, Manfred Gareis & Christoph Gottschalk. (2020) Occurrence and Risk Assessment of Pyrrolizidine Alkaloids in Spices and Culinary Herbs from Various Geographical Origins. Toxins 12:3, pages 155.
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Florian Kaltner, Michael Rychlik, Manfred Gareis & Christoph Gottschalk. (2020) Vorkommen und Risikobewertung von Pyrrolizidinalkaloiden in Kräutern und Gewürzen. Lebensmittelchemie 74:S1.
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Thiago Bousquet Bandini, Antonio Carlos Siani & Bernardete Ferraz Spisso. (2020) A botanical census on pyrrolizidine alkaloid-producing species in Brazilian herbaria: data set for a potential health risk indication. Rodriguésia 71.
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Juan A. García, Juan E. Rosas, Carmen García y Santos, Nicolas Streitenberger, Matías Feijoo & Fernando Dutra. (2020) Senecio spp. transboundary introduction and expansion affecting cattle in Uruguay: Clinico-pathological, epidemiological and genetic survey, and experimental intoxication with Senecio oxyphyllus. Toxicon 173, pages 68-74.
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Florian Kaltner, Benedikt Stiglbauer, Michael Rychlik, Manfred Gareis & Christoph Gottschalk. (2019) Development of a sensitive analytical method for determining 44 pyrrolizidine alkaloids in teas and herbal teas via LC-ESI-MS/MS. Analytical and Bioanalytical Chemistry 411:27, pages 7233-7249.
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Jawameer R. Hama & Bjarne W. Strobel. (2019) Pyrrolizidine alkaloids quantified in soil and water using UPLC-MS/MS. RSC Advances 9:52, pages 30350-30357.
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Michael Boppré, Ottmar W Fischer, Hannes Freitag & Anita Kiesel. (2019) ‘Crystal Macrosetae’: Novel Scales and Bristles in Male Arctiine Moths (Lepidoptera: Erebidae: Arctiinae) Filled with Crystallizing Material. Journal of Insect Science 19:5.
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Tingting Wang, Henrik Lauritz Frandsen, Natasha Roed Christiansson, Sofie Elisabeth Rosendal, Mikael Pedersen & Jørn Smedsgaard. (2019) Pyrrolizidine alkaloids in honey: Quantification with and without standards. Food Control 98, pages 227-237.
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Jens Flade, Heidrun Beschow, Monika Wensch-Dorendorf, Andreas Plescher & Wim Wätjen. (2019) Occurrence of Nine Pyrrolizidine Alkaloids in Senecio vulgaris L. Depending on Developmental Stage and Season. Plants 8:3, pages 54.
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Florian Kaltner, Michael Rychlik, Manfred Gareis & Christoph Gottschalk. (2018) Influence of Storage on the Stability of Toxic Pyrrolizidine Alkaloids and Their N -Oxides in Peppermint Tea, Hay, and Honey . Journal of Agricultural and Food Chemistry 66:20, pages 5221-5228.
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Ewelina Kowalczyk, Zbigniew Sieradzki & Krzysztof Kwiatek. (2017) Determination of Pyrrolizidine Alkaloids in Honey with Sensitive Gas Chromatography-Mass Spectrometry Method. Food Analytical Methods 11:5, pages 1345-1355.
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Juan Agustín García, Carmen García y Santos, Juan Rosas, Fernando Dutra & Dale Gardner. (2018) A survey of Senecio spp. affecting livestock in Uruguay and their associated pyrrolizidine alkaloid content. Ciência Rural 48:2.
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Steven M. Colegate, Dale R. Gardner, Joseph M. Betz, Ottmar W. Fischer, Sigrid Liede-Schumann & Michael Boppré. (2016) Pro-toxic 1,2-Dehydropyrrolizidine Alkaloid Esters, Including Unprecedented 10-Membered Macrocyclic Diesters, in the Medicinally-used Alafia cf. caudata and Amphineurion marginatum (Apocynaceae: Apocynoideae: Nerieae and Apocyneae) . Phytochemical Analysis 27:5, pages 257-276.
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Matteo A. Lucchetti, Gaetan Glauser, Verena Kilchenmann, Arne Dübecke, Gudrun Beckh, Christophe Praz & Christina Kast. (2016) Pyrrolizidine Alkaloids from Echium vulgare in Honey Originate Primarily from Floral Nectar . Journal of Agricultural and Food Chemistry 64:25, pages 5267-5273.
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Lucatello Lorena, Merlanti Roberta, Rossi Alessandra, Montesissa Clara & Capolongo Francesca. (2015) Evaluation of Some Pyrrolizidine Alkaloids in Honey Samples from the Veneto Region (Italy) by LC-MS/MS. Food Analytical Methods 9:6, pages 1825-1836.
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Helge Neumann & Aiko Huckauf. (2015) Jakobs-Kreuzkraut (Senecio jacobaea): eine Ursache für Pyrrolizidin-Alkaloide im Sommerhonig?Tansy ragwort (Senecio jacobaea): a source of pyrrolizidine alkaloids in summer honey?. Journal für Verbraucherschutz und Lebensmittelsicherheit 11:2, pages 105-115.
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Steven M. Colegate, Michael Boppré, Julio Monzón & Joseph M. Betz. (2015) Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean herbal medicine “asmachilca”. Journal of Ethnopharmacology 172, pages 179-194.
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Michael Boppré & Steven M. Colegate. (2015) Recognition of Pyrrolizidine Alkaloid Esters in the Invasive Aquatic Plant Gymnocoronis spilanthoides (Asteraceae) . Phytochemical Analysis 26:3, pages 215-225.
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Elizabeth A. Burzynski, Kevin P.C. Minbiole & Tatyana Livshultz. (2015) New sources of lycopsamine-type pyrrolizidine alkaloids and their distribution in Apocynaceae. Biochemical Systematics and Ecology 59, pages 331-339.
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Martina Bolechová, Josef Čáslavský, Markéta Pospíchalová & Petra Kosubová. (2015) UPLC–MS/MS method for determination of selected pyrrolizidine alkaloids in feed. Food Chemistry 170, pages 265-270.
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