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Original Articles

Monitoring by LC-MS/MS of 48 compounds of sildenafil, tadalafil, vardenafil and their analogues in illicit health food products in the Korean market advertised as enhancing male sexual performance

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Pages 1849-1857 | Received 16 May 2013, Accepted 17 Jul 2013, Published online: 02 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Samin Hamidi. (2023) Assessment of Undeclared Synthetic Drugs in Dietary Supplements in an Analytical View: A Comprehensive Review. Critical Reviews in Analytical Chemistry 53:5, pages 986-996.
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Fan He, Tingting Zou, Jinyi Yang, Hong Wang, Lihua Deng, Yuanxin Tian, Zhenlin Xu, Yuanming Sun, Hongtao Lei, Xuecai Tan & Yudong Shen. (2019) Development of a skeleton-specific antibody and Au nanoparticle-based immunochromatographic sensor for simultaneous detection of various tadalafil adulterants in health food. Food and Agricultural Immunology 30:1, pages 349-368.
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Fatema ElAmrawy, Ghada ElAgouri, Ola Elnoweam, Samar Aboelazayem, ElMohanad Farouk & Mohamed I. Nounou. (2016) Adulterated and Counterfeit Male Enhancement Nutraceuticals and Dietary Supplements Pose a Real Threat to the Management of Erectile Dysfunction: A Global Perspective. Journal of Dietary Supplements 13:6, pages 660-693.
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Ji Hyun Lee, Han Na Park, Bogonda Ganganna, Ji Hye Jeong, Sung-Kwan Park, Jongkook Lee & Sun Young Baek. (2016) Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil. Food Additives & Contaminants: Part A 33:6, pages 945-952.
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So-Hyun Cho, Hyoung Joon Park, Ji Hyun Lee, Hyung Joo Kim, Sooyeul Cho, Chang-Yong Yoon & Woo Seong Kim. (2014) Monitoring of 35 illegally added steroid compounds in foods and dietary supplements. Food Additives & Contaminants: Part A 31:9, pages 1470-1475.
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İlknur Üstündağ & Mustafa Oguzhan Caglayan. (2024) Spectroscopic determination of hydrophobic adulterant tadalafil by aptasensor based ellipsometry. Talanta 266, pages 124940.
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Guowen Li, Qiuli Pan, Chun Zhang, Jun Wang, Chifang Peng & Zhouping Wang. (2023) Fluorescence “turn-on” sensing for five PDE5 inhibitors in functional food based on bimetallic nanoclusters. Analytica Chimica Acta 1280, pages 341883.
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Qing-rui Zeng, Zi-ang Jia, Xu Liu, Bo-wen Xiu & Jin-ping Cheng. (2023) Multi-Interface polarization engineering constructed 1T-2H MoS2 QDs/Y-NaBi(MoO4)2 multiple heterostructure for high-efficient piezoelectric-photoelectrocatalysis PDE-5i degradation. Applied Catalysis B: Environmental 327, pages 122460.
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Sara I Aboras, Mohamed A Korany, Heba H Abdine & Marwa A A Ragab. (2022) HPLC/Fluorescence-Diode Array Detection for Rapid and Reliable Determination of Illegal Synthetic Drugs in Male Sexual Herbal and Honey Remedies: Comparative Study with UFLC–MS. Journal of AOAC INTERNATIONAL 105:5, pages 1288-1298.
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Nurşen Başaran, Duygu Paslı & A. Ahmet Başaran. (2022) Unpredictable adverse effects of herbal products. Food and Chemical Toxicology 159, pages 112762.
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Youngmin Hong, Ingyu Lee, Beomseok Tae, Wonseok Lee, Shu-Yuan Pan, Seth W. Snyder & Hyunook Kim. (2021) Contribution of sewage to occurrence of phosphodiesterase-5 inhibitors in natural water. Scientific Reports 11:1.
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Fan He, Jinyi Yang, Tingting Zou, Zhenlin Xu, Yuanxin Tian, Wenjia Sun, Hong Wang, Yuanming Sun, Hongtao Lei, Zijian Chen, Juewen Liu, Xuecai Tan & Yudong Shen. (2021) A gold nanoparticle-based immunochromatographic assay for simultaneous detection of multiplex sildenafil adulterants in health food by only one antibody. Analytica Chimica Acta 1141, pages 1-12.
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Dan Osei Mensah Bonsu, Constance Afoakwah & Maria de la Paz Aguilar-Caballos. (2021) Counterfeit formulations: analytical perspective on anorectics. Forensic Toxicology 39:1, pages 1-25.
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Dasom Shin, Hui-Seung Kang, Hyungsoo Kim & Guiim Moon. (2020) Multi-Class Determination of 64 Illicit Compounds in Dietary Supplements Using Liquid Chromatography–Tandem Mass Spectrometry. Molecules 25:19, pages 4399.
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Nam Sook Kim, Sun Hee Moon, Hwan Seong Choi, Ji Hyun Lee, Seongsoo Park & Hoil Kang. (2020) Simultaneous separation and determination of 20 potential adulterant antigout and antiosteoporosis pharmaceutical compounds in herbal food products using LC with electrospray ionization MS/MS and LC with quadrupole‐time‐of‐flight MS. Journal of Separation Science 43:14, pages 2750-2765.
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Dayoung Heo, Jae Seon Kang, Sanggil Choe, Sooyeun Lee, Kang Min Kim & Jaesung Pyo. (2020) Metabolic study of vardenafil analogues: Pseudovardenafil and hydroxyvardenafil. Journal of Chromatography B 1139, pages 121940.
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Elif Öztürk Er, Erhan Akkaya, Belma Özbek & Sezgin Bakırdere. (2019) Development of an analytical method based on citric acid coated magnetite nanoparticles assisted dispersive magnetic solid-phase extraction for the enrichment and extraction of sildenafil, tadalafil, vardenafil and avanafil in human plasma and urine prior to determination by LC-MS/MS. Microchemical Journal 147, pages 269-276.
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Ji Hyun Lee, Han Na Park, Ok Rim Park, Nam Sook Kim, Sung-Kwan Park & Hoil Kang. (2019) Screening of illegal sexual enhancement supplements and counterfeit drugs sold in the online and offline markets between 2014 and 2017. Forensic Science International 298, pages 10-19.
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František Králík, Patrik Jirmásek, Martin Kuchař & Vladimír Setnička. (2018) Chiroptical and vibrational spectroscopic study of genuine and counterfeit medicines containing tadalafil. Chirality 30:5, pages 560-567.
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Krystyna Skalicka-Woźniak, Milen I. Georgiev & Ilkay Erdogan Orhan. (2017) Adulteration of herbal sexual enhancers and slimmers: The wish for better sexual well-being and perfect body can be risky. Food and Chemical Toxicology 108, pages 355-364.
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Jing Li, Si Hun Roh, Jia Shaodong, Ji Yeon Hong, Dong-Kyu Lee, Byong-kyu Shin, Jeong Hill Park, Jeongmi Lee & Sung Won Kwon. (2017) Solid-phase extraction assisted dispersive liquid-liquid microextraction based on solidification of floating organic droplet to determine sildenafil and its analogues in dietary supplements. Journal of Separation Science 40:15, pages 3120-3129.
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Jacqueline Wiesner. 2017. Toxicology of Herbal Products. Toxicology of Herbal Products 237 269 .
Tiago Rocha, Joana S. Amaral & Maria Beatriz P.P. Oliveira. (2016) Adulteration of Dietary Supplements by the Illegal Addition of Synthetic Drugs: A Review. Comprehensive Reviews in Food Science and Food Safety 15:1, pages 43-62.
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Monica Mazzarino, Lorenzo Cesarei, Xavier de la Torre, Ilaria Fiacco, Paul Robach & Francesco Botrè. (2016) A multi-targeted liquid chromatography–mass spectrometry screening procedure for the detection in human urine of drugs non-prohibited in sport commonly used by the athletes. Journal of Pharmaceutical and Biomedical Analysis 117, pages 47-60.
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N. Satheeshkumar, David Paul & A. Lingesh. 2016. Medicinal Plants - Recent Advances in Research and Development. Medicinal Plants - Recent Advances in Research and Development 73 95 .
Hongxia Liu, Xusheng Zhao, Mingxin Guo, Hui Liu & Zhiming Zheng. (2015) Growth and metabolism of Beauveria bassiana spores and mycelia. BMC Microbiology 15:1.
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Sooyeun Lee, Dajeong Ji, Meejung Park & Kyu Hyuck Chung. (2015) Development of a comprehensive spectral library of sildenafil and related active analogues using LC–QTOF–MS and its application for screening counterfeit pharmaceuticals. Forensic Science International 257, pages 182-188.
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Claudio Bortolini, Antonio Pivato, Sara Bogialli & Paolo Pastore. (2015) “One-shot” analysis of PDE-5 inhibitors and analogues in counterfeit herbal natural products using an LC-DAD-QTOF system. Analytical and Bioanalytical Chemistry 407:20, pages 6207-6216.
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Zhe Wang, Caisheng Wu, Gangli Wang, Qingsheng Zhang & Jinlan Zhang. (2015) Novel strategy for the determination of illegal adulterants in health foods and herbal medicines using high-performance liquid chromatography with high-resolution mass spectrometry. Journal of Separation Science 38:6, pages 925-935.
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Ji Hyun Lee, Hyung Joo Kim, Eunyoung Noh, Jung Yeon Kim, So Hyun Cho, Jung-Ah Do, Chang-Yong Yoon, Sooyeul Cho & Woo Seong Kim. (2015) Identification and screening of a tadalafil analogue found in adulterated herbal products. Journal of Pharmaceutical and Biomedical Analysis 103, pages 80-84.
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