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Estimands and Missing Data

Estimands in a Chronic Pain Trial: Challenges and Opportunities

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Pages 39-44 | Received 24 May 2018, Accepted 02 Jun 2019, Published online: 22 Jul 2019

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Robert H. Dworkin, Scott R. Evans, Omar Mbowe & Michael P. McDermott. (2021) Essential statistical principles of clinical trials of pain treatments. PAIN Reports 6:1, pages e863.
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Rachael Lawrance, Evgeny Degtyarev, Philip Griffiths, Peter Trask, Helen Lau, Denise D’Alessio, Ingolf Griebsch, Gudrun Wallenstein, Kim Cocks & Kaspar Rufibach. (2020) What is an estimand & how does it relate to quantifying the effect of treatment on patient-reported quality of life outcomes in clinical trials?. Journal of Patient-Reported Outcomes 4:1.
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Shannon M. Smith, Maurizio Fava, Mark P. Jensen, Omar B. Mbowe, Michael P. McDermott, Dennis C. Turk & Robert H. Dworkin. (2020) John D. Loeser Award Lecture: Size does matter, but it isn't everything: the challenge of modest treatment effects in chronic pain clinical trials. Pain 161:Supplement 1, pages S3-S13.
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Man Jin & Guanghan Liu. (2020) Estimand framework: Delineating what to be estimated with clinical questions of interest in clinical trials. Contemporary Clinical Trials 96, pages 106093.
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