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Research Paper/Report

Intestinal bacteria are necessary for doxorubicin-induced intestinal damage but not for doxorubicin-induced apoptosis

, , , , & , Ph.D
Pages 414-423 | Received 02 May 2016, Accepted 13 Jul 2016, Published online: 11 Aug 2016

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Crossref
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Crossref
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Rihui Wu, Xueting Mei, Jiasheng Wang, Wenjia Sun, Ting Xue, Caixia Lin & Donghui Xu. (2019) Zn( ii )-Curcumin supplementation alleviates gut dysbiosis and zinc dyshomeostasis during doxorubicin-induced cardiotoxicity in rats . Food & Function 10:9, pages 5587-5604.
Crossref
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Clodagh L. Murphy, Paul W. O'Toole & Fergus Shanahan. (2019) The Gut Microbiota in Causation, Detection, and Treatment of Cancer. American Journal of Gastroenterology 114:7, pages 1036-1042.
Crossref
Weidong Ma, Qixing Mao, Wenjie Xia, Gaochao Dong, Changhua Yu & Feng Jiang. (2019) Gut Microbiota Shapes the Efficiency of Cancer Therapy. Frontiers in Microbiology 10.
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Hannah R. Wardill, Wim J.E. Tissing, Hannelouise Kissow & Andrea M. Stringer. (2019) Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets. Current Opinion in Supportive & Palliative Care 13:2, pages 119-133.
Crossref
Kate R. Secombe, Janet K. Coller, Rachel J. Gibson, Hannah R. Wardill & Joanne M. Bowen. (2018) The bidirectional interaction of the gut microbiome and the innate immune system: Implications for chemotherapy‐induced gastrointestinal toxicity. International Journal of Cancer 144:10, pages 2365-2376.
Crossref
Sheetal Parida & Dipali Sharma. (2019) The power of small changes: Comprehensive analyses of microbial dysbiosis in breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:2, pages 392-405.
Crossref
J.L. Alexander, D. Kohoutova & N. Powell. (2019) Science in Focus: The Microbiome and Cancer Therapy. Clinical Oncology 31:1, pages 1-4.
Crossref
Kelley R. Jordan, Brett R. Loman, Michael T. Bailey & Leah M. Pyter. (2018) Gut microbiota‐immune‐brain interactions in chemotherapy‐associated behavioral comorbidities. Cancer 124:20, pages 3990-3999.
Crossref
Per T. Sangild, René Liang Shen, Peter Pontoppidan & Mathias Rathe. (2018) Animal models of chemotherapy-induced mucositis: translational relevance and challenges. American Journal of Physiology-Gastrointestinal and Liver Physiology 314:2, pages G231-G246.
Crossref
Austin Yan, Elizabeth Culp, Julie Perry, Jennifer T. Lau, Lesley T. MacNeil, Michael G. Surette & Gerard D. Wright. (2017) Transformation of the Anticancer Drug Doxorubicin in the Human Gut Microbiome. ACS Infectious Diseases 4:1, pages 68-76.
Crossref
Aadra P. Bhatt, Matthew R. Redinbo & Scott J. Bultman. (2017) The role of the microbiome in cancer development and therapy. CA: A Cancer Journal for Clinicians 67:4, pages 326-344.
Crossref
Hannah R. Wardill & Wim J.E. Tissing. (2017) Determining risk of severe gastrointestinal toxicity based on pretreatment gut microbial community in patients receiving cancer treatment: a new predictive strategy in the quest for personalized cancer medicine. Current Opinion in Supportive & Palliative Care 11:2, pages 125-132.
Crossref
Soumen Roy & Giorgio Trinchieri. (2017) Microbiota: a key orchestrator of cancer therapy. Nature Reviews Cancer 17:5, pages 271-285.
Crossref
Jacquelyn S. Carr, Stephanie King & Christopher M. Dekaney. (2017) Depletion of enteric bacteria diminishes leukocyte infiltration following doxorubicin-induced small intestinal damage in mice. PLOS ONE 12:3, pages e0173429.
Crossref

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