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Gut Microbes Volume 12, 2020 - Issue 1
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Research paper/Report

Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic Escherichia coli infection

Jennifer Foulke-Abela Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3882-5625View further author information
ORCID Icon,
Huimin Yua Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
,
Laxmi Sunuwara Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
,
Ruxian Lina Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
,
James M. Fleckensteinb Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USAORCID Iconhttps://orcid.org/0000-0002-1148-697XView further author information
ORCID Icon,
James B. Kaperc Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USAView further author information
&
Mark Donowitza Division of Gastroenterology & Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USAView further author information
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Article: 1752125 | Received 16 Dec 2019, Accepted 27 Mar 2020, Published online: 07 May 2020

Citations (14)

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Read on this site (2)

Yucheng Zhang, Peng Tan, Ying Zhao & Xi Ma. (2022) Enterotoxigenic Escherichia coli: intestinal pathogenesis mechanisms and colonization resistance by gut microbiota. Gut Microbes 14:1.
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Sridevi Ranganathan, Emily M. Smith, Jennifer D. Foulke-Abel & Eileen M. Barry. (2020) Research in a time of enteroids and organoids: how the human gut model has transformed the study of enteric bacterial pathogens. Gut Microbes 12:1.
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Sheila Gonzalez-Ramos, Jing Wang, Jae Min Cho, Enbo Zhu, Seul-Ki Park, Julie G. In, Srinivasa T. Reddy, Eliseo F. Castillo, Matthew J. Campen & Tzung K. Hsiai. (2023) Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity. Science of The Total Environment 902, pages 165947.
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Emily M. Smith, Antonia Papadimas, Caitlin Gabor, Ceanna Cooney, Tao Wu, David Rasko & Eileen M. Barry. (2023) The role of the minor colonization factor CS14 in adherence to intestinal cell models by geographically diverse ETEC isolates. mSphere 8:5.
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Nicholas C. Zachos, Hannah Vaughan, Ruxian Lin, Rafiquel Sarker, Savannah Est-Witte, Molee Chakraborty, Nicholas W. Baetz, Hongzhe Yu, Vladimir Yarov-Yarovoy, George McNamara, Jordan J. Green, Chung-Ming Tse & Mark Donowitz. (2023) A Novel Peptide Prevents Enterotoxin- and Inflammation-Induced Intestinal Fluid Secretion by Stimulating Sodium-Hydrogen Exchanger 3 Activity. Gastroenterology 165:4, pages 986-998.e11.
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Ji-Su Ahn, Min-Jung Kang, Yoojin Seo & Hyung-Sik Kim. (2022) Intestinal organoids as advanced modeling platforms to study the role of host-microbiome interaction in homeostasis and disease. BMB Reports 56:1, pages 15-23.
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Xueqin Hou, Cuiping Rong, Qiwei Zhang, Shuangshuang Song, Yifan Cong & Han-Ting Zhang. (2023) Cyclic Nucleotide Phosphodiesterases in Alcohol Use Disorders: Involving Gut Microbiota. International Journal of Neuropsychopharmacology 26:1, pages 70-79.
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Emily M. Smith, Christen L. Grassel, Antonia Papadimas, Jennifer Foulke-Abel & Eileen M. Barry. (2022) The role of CFA/I in adherence and toxin delivery by ETEC expressing multiple colonization factors in the human enteroid model. PLOS Neglected Tropical Diseases 16:7, pages e0010638.
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Lu-lu Ren, Jia-yi Zhou, Shao-jie Liang & Xiu-qi Wang. (2022) Impaired intestinal stem cell activity in ETEC infection: enterotoxins, cyclic nucleotides, and Wnt signaling. Archives of Toxicology 96:5, pages 1213-1225.
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Natalya I. Motyka, Sydney R. Stewart, Constance P. Porretta, Ian E. Hollifield, David L. Bauer & Jacob P. Bitoun. (2022) Enterotoxigenic Escherichia coli Enterotoxins Regulate Epithelial to Immune Relay of IL-33 and IL-1Ra Cytokines . Infection and Immunity 90:3.
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Varsha Singh, Kelli Johnson, Jianyi Yin, Sun Lee, Ruxian Lin, Huimin Yu, Julie In, Jennifer Foulke-Abel, Nicholas C. Zachos, Mark Donowitz & Yan Rong. (2022) Chronic Inflammation in Ulcerative Colitis Causes Long-Term Changes in Goblet Cell Function. Cellular and Molecular Gastroenterology and Hepatology 13:1, pages 219-232.
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Xi-Zhang, Xiao-qiang Yuan & Xu-ming Zhang. (2021) Melatonin reduces inflammation in intestinal cells, organoids and intestinal explants. Inflammopharmacology 29:5, pages 1555-1564.
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Natalya I. Motyka, Sydney R. Stewart, Ian E. Hollifield, Thomas R. Kyllo, Joshua A. Mansfield, Elizabeth B. Norton, John D. Clements & Jacob P. Bitoun. (2021) Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity. Infection and Immunity 89:4.
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Kristen A. Clarkson, Chad K. Porter, Kawsar R. Talaat, Melissa C. Kapulu, Wilbur H. Chen, Robert W. FrenckJr.Jr., A. Louis Bourgeois, Robert W. Kaminski & Laura B. Martin. 2021.

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