Advanced search
Publication Cover
Journal of Oral Microbiology Volume 9, 2017 - Issue 1
Submit an article Journal homepage
3,139
Views
46
CrossRef citations to date
0
Altmetric
Original Articles

Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE–/– mice brains

Sim K. SinghraoDementia and Neurodegeneration Research Group, College of Clinical and Biomedical Sciences, University of Central Lancashire, Preston, UKCorrespondence[email protected]
View further author information
,
Sasanka ChukkapalliDepartment of Periodontology, University of Florida, Gainesville, FL, USAView further author information
,
Sophie PooleDementia and Neurodegeneration Research Group, College of Clinical and Biomedical Sciences, University of Central Lancashire, Preston, UKView further author information
,
Irina VelskoDepartment of Periodontology, University of Florida, Gainesville, FL, USAView further author information
,
St John CreanDementia and Neurodegeneration Research Group, College of Clinical and Biomedical Sciences, University of Central Lancashire, Preston, UKView further author information
&
Lakshmyya KesavaluDepartment of Periodontology, University of Florida, Gainesville, FL, USA;Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, FL, USAView further author information
Article: 1270602 | Received 26 Jul 2016, Accepted 15 Nov 2016, Published online: 17 Jan 2017

Citations (46)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Ingar Olsen & Sim K. Singhrao. (2020) Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer’s disease. Journal of Oral Microbiology 12:1.
Read now
Sim K. Singhrao & Ingar Olsen. (2019) Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease. Journal of Oral Microbiology 11:1.
Read now
Ingar Olsen, Sim K. Singhrao & Jan Potempa. (2018) Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer’s disease. Journal of Oral Microbiology 10:1.
Read now

Articles from other publishers (43)

Leila Salhi, Yaman Al Taep, Eric Salmon, Dorien Van Hede & France Lambert. (2023) How Periodontitis or Periodontal Bacteria Can Influence Alzheimer’s Disease Features? A Systematic Review of Pre-Clinical Studies. Journal of Alzheimer's Disease 96:3, pages 979-1010.
Crossref
Dan Tang, Chang Sun, Jumei Yang, Lili Fan & Yonggang Wang. (2023) Advances in the Study of the Pathology and Treatment of Alzheimer’s Disease and Its Association with Periodontitis. Life 13:11, pages 2203.
Crossref
Chuanjiang Zhao, Ryutaro Kuraji, Changchang Ye, Li Gao, Allan Radaic, Pachiyappan Kamarajan, Yoshimasa Taketani & Yvonne L. Kapila. (2023) Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer’s disease-like neuroinflammation triggered by periodontal disease. Journal of Neuroinflammation 20:1.
Crossref
Eri Ishida, Hisako Furusho, Ting-Yi Renn, Fumie Shiba, Hung-Ming Chang, Hiroshi Oue, Ryuji Terayama, Yukio Ago, Kazuhiro Tsuga & Mutsumi Miyauchi. (2023) Mouse maternal odontogenic infection with Porphyromonas gingivalis induces cognitive decline in offspring. Frontiers in Pediatrics 11.
Crossref
Imke Schamarek, Lars Anders, Rima M. Chakaroun, Peter Kovacs & Kerstin Rohde-Zimmermann. (2023) The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception. Nutrition Journal 22:1.
Crossref
David T. Wu, Ye Won Cho, Matthew D. Spalti, Mark Bishara & Thomas T. Nguyen. (2023) The link between periodontitis and Alzheimer's disease – emerging clinical evidence. Dentistry Review 3:1, pages 100062.
Crossref
Sixin Liu, Stuart G. Dashper & Rui Zhao. (2023) Association Between Oral Bacteria and Alzheimer’s Disease: A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease 91:1, pages 129-150.
Crossref
Beyza OLUKPINAR GENÇ & Tanju KADİR. (2022) ALZHEİMER HASTALIĞI İLE PERİODONTAL HASTALIKLAR ARASINDA BİR İLİŞKİ OLABİLİR Mİ?. Selcuk Dental Journal 9:2, pages 675-684.
Crossref
Connor M. Wander, Tamy Harumy Moraes Tsujimoto, John F. Ervin, Chanung Wang, Spencer M. Maranto, Vanya Bhat, Julian D. Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K. Scott, David M. Holtzman & Todd J. Cohen. (2022) Corpora amylacea are associated with tau burden and cognitive status in Alzheimer’s disease. Acta Neuropathologica Communications 10:1.
Crossref
Van Thi Ai Tran, Luke P. Lee & Hansang Cho. (2022) Neuroinflammation in neurodegeneration via microbial infections. Frontiers in Immunology 13.
Crossref
Gert Jungbauer, Alexandra Stähli, Xilei Zhu, Lavinia Auber Alberi, Anton Sculean & Sigrun Eick. (2022) Periodontal microorganisms and Alzheimer disease – A causative relationship?. Periodontology 2000 89:1, pages 59-82.
Crossref
Remi L. Landry & Monica E. Embers. (2022) Does Dementia Have a Microbial Cause?. NeuroSci 3:2, pages 262-283.
Crossref
Yael-Natalie H. Escobar, Devin O’Piela, Loren E. Wold & Amy R. Mackos. (2022) Influence of the Microbiota-Gut-Brain Axis on Cognition in Alzheimer’s Disease. Journal of Alzheimer's Disease 87:1, pages 17-31.
Crossref
Mona Sohrabi, Bijayani Sahu, Harpreet Kaur, Wendie A. Hasler, Atish Prakash & Colin K. Combs. (2022) Gastrointestinal Changes and Alzheimer's Disease. Current Alzheimer Research 19:5, pages 335-350.
Crossref
Xiaoxiao Hao, Zhaofei Li, Wei Li, Jannet Katz, Suzanne M. Michalek, Scott R. Barnum, Lucas Pozzo-Miller, Takashi Saito, Takaomi C. Saido, Qin Wang, Erik D. Roberson & Ping Zhang. (2022) Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice. Frontiers in Immunology 13.
Crossref
Luis Daniel Sansores-España, Samanta Melgar-Rodríguez, Katherine Olivares-Sagredo, Emilio A. Cafferata, Víctor Manuel Martínez-Aguilar, Rolando Vernal, Andrea Cristina Paula-Lima & Jaime Díaz-Zúñiga. (2021) Oral-Gut-Brain Axis in Experimental Models of Periodontitis: Associating Gut Dysbiosis With Neurodegenerative Diseases. Frontiers in Aging 2.
Crossref
Kian Chung Chok, Khuen Yen Ng, Rhun Yian Koh & Soi Moi Chye. (2021) Role of the gut microbiome in Alzheimer’s disease. Reviews in the Neurosciences 32:7, pages 767-789.
Crossref
Wenlei Yu, Linjie Lu, Xintong Ji, Qiwei Qian, Xiaohan Lin & Huanhuan Wang. (2021) Recent Advances on Possible Association Between the Periodontal Infection of Porphyromonas gingivalis and Central Nervous System Injury. Journal of Alzheimer's Disease 84:1, pages 51-59.
Crossref
Peter L. Nara, Daniel Sindelar, Marc S. Penn, Jan Potempa & W. Sue T. Griffin. (2021) Porphyromonas gingivalis Outer Membrane Vesicles as the Major Driver of and Explanation for Neuropathogenesis, the Cholinergic Hypothesis, Iron Dyshomeostasis, and Salivary Lactoferrin in Alzheimer’s Disease. Journal of Alzheimer's Disease 82:4, pages 1417-1450.
Crossref
Che Qiu, Zhen Yuan, Zhiyan He, Huiwen Chen, Yue Liao, Shiliang Li, Wei Zhou & Zhongchen Song. (2021) Lipopolysaccharide Preparation Derived From Porphyromonas gingivalis Induces a Weaker Immuno-Inflammatory Response in BV-2 Microglial Cells Than Escherichia coli by Differentially Activating TLR2/4-Mediated NF-κB/STAT3 Signaling Pathways. Frontiers in Cellular and Infection Microbiology 11.
Crossref
Vittorio Dibello, Madia Lozupone, Daniele Manfredini, Antonio Dibello, Roberta Zupo, Rodolfo Sardone, Antonio Daniele, Frank Lobbezoo & Francesco Panza. (2021) Oral frailty and neurodegeneration in Alzheimer’s disease. Neural Regeneration Research 16:11, pages 2149.
Crossref
Shalini Kanagasingam, Sasanka S. Chukkapalli, Richard Welbury & Sim K. Singhrao. (2020) Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer’s Disease. Journal of Alzheimer's Disease Reports 4:1, pages 501-511.
Crossref
Hannah R. Bulgart, Evan W. Neczypor, Loren E. Wold & Amy R. Mackos. (2020) Microbial involvement in Alzheimer disease development and progression. Molecular Neurodegeneration 15:1.
Crossref
M. Victoria Moreno-Arribas, Begoña Bartolomé, José L. Peñalvo, Patricia Pérez-Matute & Maria José Motilva. (2020) Relationship between Wine Consumption, Diet and Microbiome Modulation in Alzheimer’s Disease. Nutrients 12:10, pages 3082.
Crossref
Shiro Aoki, Naohisa Hosomi, Hiromi Nishi, Masahiro Nakamori, Tomohisa Nezu, Yuji Shiga, Naoto Kinoshita, Hiroki Ueno, Kenichi Ishikawa, Eiji Imamura, Tomoaki Shintani, Hiroki Ohge, Hiroyuki Kawaguchi, Hidemi Kurihara & Hirofumi Maruyama. (2020) Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients. PLOS ONE 15:8, pages e0237185.
Crossref
Daniela Liccardo, Federica Marzano, Federica Carraturo, Marco Guida, Grazia Daniela Femminella, Leonardo Bencivenga, Jacopo Agrimi, Armida Addonizio, Imma Melino, Alessandra Valletta, Carlo Rengo, Nicola Ferrara, Giuseppe Rengo & Alessandro Cannavo. (2020) Potential Bidirectional Relationship Between Periodontitis and Alzheimer’s Disease. Frontiers in Physiology 11.
Crossref
Angela R. Kamer, Ronald G. Craig, Richard Niederman, Juan Fortea & Mony J. de Leon. (2020) Periodontal disease as a possible cause for Alzheimer's disease. Periodontology 2000 83:1, pages 242-271.
Crossref
Conor O'Boyle, Michael J Haley, Eloise Lemarchand, Craig J Smith, Stuart M Allan, Joanne E Konkel & Catherine B Lawrence. (2019) Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice. International Journal of Stroke 15:2, pages 175-187.
Crossref
Endang Winiati Bachtiar, Citra F. Putri, Retno D. Soejoedono & Boy M. Bachtiar. (2021) Expression of TNF, IL1B, and iNOS2 in the neural cell after induced by Porphyromonas gingivalis with and without coating antibody anti-Porphyromonas gingivalis. F1000Research 9, pages 1499.
Crossref
Endang Winiati Bachtiar, Citra F. Putri, Retno D. Soejoedono & Boy M. Bachtiar. (2021) Expression of TNF, IL1B, and NOS2 in the neural cell after induced by Porphyromonas gingivalis with and without coating antibody anti-Porphyromonas gingivalis. F1000Research 9, pages 1499.
Crossref
Endang Winiati Bachtiar, Citra F. Putri, Retno D. Soejoedono & Boy M. Bachtiar. (2020) Expression of TNF, IL1B, and NOS2 in the neural cell after induced by Porphyromonas gingivalis with and without coating antibody anti-Porphyromonas gingivalis. F1000Research 9, pages 1499.
Crossref
Francesco Panza, Madia Lozupone, Vincenzo Solfrizzi, Mark Watling & Bruno P Imbimbo. (2019) Time to test antibacterial therapy in Alzheimer’s disease. Brain.
Crossref
Joanne E. Konkel, Conor O'Boyle & Siddharth Krishnan. (2019) Distal Consequences of Oral Inflammation. Frontiers in Immunology 10.
Crossref
Ingar Olsen & Sim K. Singhrao. (2019) Poor Oral Health and Its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction. Current Oral Health Reports 6:2, pages 120-129.
Crossref
Kristin L. Patrick, Samantha L. Bell, Chi G. Weindel & Robert O. Watson. (2019) Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat. Frontiers in Cellular and Infection Microbiology 9.
Crossref
Sim K. Singhrao & Ingar Olsen. (2018) Are Porphyromonas gingivalis Outer Membrane Vesicles Microbullets for Sporadic Alzheimer’s Disease Manifestation?. Journal of Alzheimer's Disease Reports 2:1, pages 219-228.
Crossref
Vladimir Ilievski, Paulina K. Zuchowska, Stefan J. Green, Peter T. Toth, Michael E. Ragozzino, Khuong Le, Haider W. Aljewari, Neil M. O’Brien-Simpson, Eric C. Reynolds & Keiko Watanabe. (2018) Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. PLOS ONE 13:10, pages e0204941.
Crossref
Chris J. Carter, James France, StJohn Crean & Sim K. Singhrao. (2017) The Porphyromonas gingivalis/Host Interactome Shows Enrichment in GWASdb Genes Related to Alzheimer's Disease, Diabetes and Cardiovascular Diseases. Frontiers in Aging Neuroscience 9.
Crossref
Alice Harding, Ulrike Gonder, Sarita J. Robinson, StJohn Crean & Sim K. Singhrao. (2017) Exploring the Association between Alzheimer’s Disease, Oral Health, Microbial Endocrinology and Nutrition. Frontiers in Aging Neuroscience 9.
Crossref
Anna B. Pritchard, StJohn Crean, Ingar Olsen & Sim K. Singhrao. (2017) Periodontitis, Microbiomes and their Role in Alzheimer’s Disease. Frontiers in Aging Neuroscience 9.
Crossref
Chris J. Carter. (2017) Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer’s Disease. Journal of Alzheimer's Disease Reports 1:1, pages 125-157.
Crossref
Farheen Rokad, Ryan Moseley, Rowan S. Hardy, Sasanka Chukkapalli, StJohn Crean, Lakshmyya Kesavalu & Sim K. Singhrao. (2017) Cerebral Oxidative Stress and Microvasculature Defects in TNF-α Expressing Transgenic and Porphyromonas gingivalis-Infected ApoE–/– Mice. Journal of Alzheimer's Disease 60:2, pages 359-369.
Crossref
Alice Harding, Sarita Robinson, StJohn Crean & Sim K. Singhrao. (2017) Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease?. Journal of Alzheimer's Disease 58:2, pages 337-348.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.