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Journal of Oral Microbiology Volume 11, 2019 - Issue 1
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Original Article

Antimicrobial peptide GH12 targets Streptococcus mutans to arrest caries development in rats

Yufei WangState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, China;Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaORCID Iconhttps://orcid.org/0000-0002-2661-5113View further author information
ORCID Icon,
Yuhao ZengState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, ChinaView further author information
,
Yuanjing WangState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, ChinaView further author information
,
Haoran LiState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, China;Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaView further author information
,
Sihan YuState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, ChinaView further author information
,
Wentao JiangState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, China;Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaView further author information
,
Yingxue LiState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, China;Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaView further author information
&
Linglin ZhangState Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Disease, Sichuan University, Chengdu, China;Department of Cariology and Endodontics West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-5003-5864View further author information
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Article: 1549921 | Received 14 Jun 2018, Accepted 08 Nov 2018, Published online: 30 Nov 2018

Citations (25)

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Ran Mu, Hanyi Zhang, Zhiyuan Zhang, Xinyue Li, Jiaxuan Ji, Xinyue Wang, Yu Gu & Xiaofei Qin. (2023) Trans-cinnamaldehyde loaded chitosan based nanocapsules display antibacterial and antibiofilm effects against cavity-causing Streptococcus mutans. Journal of Oral Microbiology 15:1.
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Junyuan Luo, Zening Feng, Wentao Jiang, Xuelian Jiang, Yue Chen, Xiaohui Lv & Linglin Zhang. (2021) Novel lactotransferrin-derived synthetic peptides suppress cariogenic bacteria in vitro and arrest dental caries in vivo. Journal of Oral Microbiology 13:1.
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Ravichellam Sangavi, Sankar Muthumanickam, Nambiraman Malligarjunan, Ravi Jothi, Pandi Boomi, Seenichamy Arivudainambi, Muthusamy Raman, Chaitanya G. Joshi, Shunmugiah Karutha Pandian & Shanmugaraj Gowrishankar. In silico analysis unravels the promising anticariogenic efficacy of fatty acids against dental caries causing Streptococcus mutans. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-16.
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Articles from other publishers (22)

Saumya Surekha, Ashish Kumar Lamiyan & Varsha Gupta. (2023) Antibiotic Resistant Biofilms and the Quest for Novel Therapeutic Strategies. Indian Journal of Microbiology.
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Menglin Fan, Zilin Zhou, Wanchun Zhu, Meng Li, Yuanyuan Tu, Zhaohan Yu, Jiyao Li, Min Zhang & Kunneng Liang. (2023) Reinforced dentin remineralization via a novel dual-affinity peptide. Dental Materials.
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Yuehong Zhou, Binhan Zhang, Yufei Wang & Rongdang Hu. (2023) Effects of Sulforaphene on the Cariogenic Properties of Streptococcus Mutans In Vitro and Dental Caries Development In Vivo. Antibiotics 12:9, pages 1359.
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Yuhao Zeng, Yu Chen, Chengchen Duan, Xuelian Jiang, Yufei Wang & Linglin Zhang. (2023) A Transcriptional Analysis Showing the Effects of GH12 Combined with Fluoride for Suppressing the Acidogenicity of Streptococcus mutans Biofilms. Microorganisms 11:7, pages 1796.
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Xuelian Jiang, Yufei Wang, Xinwei Li, Zening Feng, Yuhao Zeng, Sili Han, Nobuhiro Takahashi & Linglin Zhang. (2022) Development and evaluation of a chewing gum containing antimicrobial peptide GH12 for caries prevention. European Journal of Oral Sciences 130:5.
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Xinwei Li, Yufei Wang, Xuelian Jiang, Yuhao Zeng, Xinran Zhao, Jumpei Washio, Nobuhiro Takahashi & Linglin Zhang. (2022) Investigation of drug resistance of caries-related streptococci to antimicrobial peptide GH12. Frontiers in Cellular and Infection Microbiology 12.
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Siying Tao, Jiaojiao Yang, Zhifei Su, Fangjie Zhou, Ziyou Wang, Yingming Yang, Lizhong Sun, Yi Deng, Kunneng Liang & Jiyao Li. (2022) A Dentin Biomimetic Remineralization Material with an Ability to Stabilize Collagen. Small 18:38, pages 2203644.
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Yifang Liu, Jiaojiao Yang, Yingming Yang, Meng Li, Hockin H. K. Xu, Michael D. Weir, Xuedong Zhou, Kunneng Liang & Jiyao Li. (2022) Evaluation of the ability of adhesives with antibacterial and remineralization functions to prevent secondary caries in vivo. Clinical Oral Investigations 26:4, pages 3637-3650.
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Yufei Wang, Yuhao Zeng, Zening Feng, Zhongxu Li, Xuelian Jiang, Sili Han, Jumpei Washio, Nobuhiro Takahashi & Linglin Zhang. (2022) Combined Treatment with Fluoride and Antimicrobial Peptide GH12 Efficiently Controls Caries in vitro and in vivo. Caries Research 56:5-6, pages 524-534.
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Shasha Cai, Kai Meng, Peng Liu, Xianting Cao & Guannan Wang. (2021) Suppressive effects of gecko cathelicidin on biofilm formation and cariogenic virulence factors of Streptococcus mutans. Archives of Oral Biology 129, pages 105205.
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Poornima Ramburrun, Nadine A. Pringle, Admire Dube, Razia Z. Adam, Sarah D’Souza & Marique Aucamp. (2021) Recent Advances in the Development of Antimicrobial and Antifouling Biocompatible Materials for Dental Applications. Materials 14:12, pages 3167.
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Gislaine G. O. S. Silveira, Marcelo D. T. Torres, Camila F. A. Ribeiro, Beatriz T. Meneguetti, Cristiano M. E. Carvalho, Cesar de la Fuente-Nunez, Octávio L. Franco & Marlon H. Cardoso. (2021) Antibiofilm Peptides: Relevant Preclinical Animal Infection Models and Translational Potential. ACS Pharmacology & Translational Science 4:1, pages 55-73.
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Ayda Afshar, Esra Yuca, Cate Wisdom, Hussain Alenezi, Jubair Ahmed, Candan Tamerler & Mohan Edirisinghe. (2020) Next‐generation Antimicrobial Peptides (AMPs) incorporated nanofibre wound dressings. MEDICAL DEVICES & SENSORS 4:1.
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Wentao Jiang, Junyuan Luo, Yufei Wang, Xiangshu Chen, Xuelian Jiang, Zening Feng & Linglin Zhang. (2021) The pH-Responsive Property of Antimicrobial Peptide GH12 Enhances Its Anticaries Effects at Acidic pH. Caries Research 55:1, pages 21-31.
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Rizacan Sarikaya, Linyong Song, Esra Yuca, Sheng-Xue Xie, Kyle Boone, Anil Misra, Paulette Spencer & Candan Tamerler. (2021) Bioinspired multifunctional adhesive system for next generation bio-additively designed dental restorations. Journal of the Mechanical Behavior of Biomedical Materials 113, pages 104135.
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Nafiseh Izadi, Masoud Keikha, Kiarash Ghazvini & Mohsen Karbalaei. (2020) Oral antimicrobial peptides and new therapeutic strategies for plaque-mediated diseases. Gene Reports 21, pages 100811.
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Wentao Jiang, Yufei Wang, Junyuan Luo, Xiangshu Chen, Yuhao Zeng, Xinwei Li, Zening Feng & Linglin Zhang. (2020) Antimicrobial Peptide GH12 Prevents Dental Caries by Regulating Dental Plaque Microbiota. Applied and Environmental Microbiology 86:14.
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Y. Li, Y. Wang, X. Chen, W. Jiang, X. Jiang, Y. Zeng, X. Li, Z. Feng, J. Luo & L. Zhang. (2020) Antimicrobial peptide GH12 as root canal irrigant inhibits biofilm and virulence of Enterococcus faecalis . International Endodontic Journal 53:7, pages 948-961.
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Sheng-Xue Xie, Linyong Song, Esra Yuca, Kyle Boone, Rizacan Sarikaya, Sarah Kay VanOosten, Anil Misra, Qiang Ye, Paulette Spencer & Candan Tamerler. (2020) Antimicrobial Peptide–Polymer Conjugates for Dentistry. ACS Applied Polymer Materials 2:3, pages 1134-1144.
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Shima Afrasiabi, Maryam Pourhajibagher, Nasim Chiniforush, Mahdi Aminian & Abbas Bahador. (2020) Anti-biofilm and anti-metabolic effects of antimicrobial photodynamic therapy using chlorophyllin-phycocyanin mixture against Streptococcus mutans in experimental biofilm caries model on enamel slabs. Photodiagnosis and Photodynamic Therapy 29, pages 101620.
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Hengren Zhong, Zhipeng Xie, Hanqi Wei, Shuxia Zhang, Yanting Song, Manchuriga Wang & Yingxia Zhang. (2019) Antibacterial and Antibiofilm Activity of Temporin-GHc and Temporin-GHd Against Cariogenic Bacteria, Streptococcus mutans. Frontiers in Microbiology 10.
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Sheng-Xue Xie, Kyle Boone, Sarah Kay VanOosten, Esra Yuca, Linyong Song, Xueping Ge, Qiang Ye, Paulette Spencer & Candan Tamerler. (2019) Peptide Mediated Antimicrobial Dental Adhesive System. Applied Sciences 9:3, pages 557.
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