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Virulence Volume 7, 2016 - Issue 5
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Research Paper

Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens

El-Sayed M. AbdelwhabInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, GermanyCorrespondence[email protected]; [email protected]
,
Jutta VeitsInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
,
Angele BreithauptDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
,
Sandra GohrbandtInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
,
Mario ZillerBiomathematics Working Group, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
,
Jens P. TeifkeDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
,
Jürgen StechInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
&
Thomas C. MettenleiterInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald, Germany
 show all
Pages 546-557 | Received 07 Oct 2015, Accepted 23 Feb 2016, Published online: 21 Apr 2016

Citations (14)

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Claudia Blaurock, Ulrike Blohm, Christine Luttermann, Julia Holzerland, David Scheibner, Alexander Schäfer, Allison Groseth, Thomas C. Mettenleiter & Elsayed M. Abdelwhab. (2021) The C-terminus of non-structural protein 1 (NS1) in H5N8 clade 2.3.4.4 avian influenza virus affects virus fitness in human cells and virulence in mice. Emerging Microbes & Infections 10:1, pages 1760-1776.
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Daniel Marc. (2016) Stop-codon variations in non-structural protein NS1 of avian influenza viruses. Virulence 7:5, pages 498-501.
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Articles from other publishers (12)

Anja C. M. de Bruin, Mathis Funk, Monique I. Spronken, Alexander P. Gultyaev, Ron A. M. Fouchier & Mathilde Richard. (2022) Hemagglutinin Subtype Specificity and Mechanisms of Highly Pathogenic Avian Influenza Virus Genesis. Viruses 14:7, pages 1566.
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João Trigueiro-Louro, Luís A. Santos, Filipe Almeida, Vanessa Correia, Rui M.M. Brito & Helena Rebelo-de-Andrade. (2022) NS1 protein as a novel anti-influenza target: Map-and-mutate antiviral rationale reveals new putative druggable hot spots with an important role on viral replication. Virology 565, pages 106-116.
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Claudia Blaurock, Angele Breithaupt, David Scheibner, Ola Bagato, Axel Karger, Thomas C. Mettenleiter & Elsayed M. Abdelwhab. (2021) Preferential Selection and Contribution of Non-Structural Protein 1 (NS1) to the Efficient Transmission of Panzootic Avian Influenza H5N8 Virus Clades 2.3.4.4A and B in Chickens and Ducks. Journal of Virology 95:18.
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Maria Landmann, David Scheibner, Annika Graaf, Marcel Gischke, Susanne Koethe, Olanrewaju Fatola, Barbara Raddatz, Thomas Mettenleiter, Martin Beer, Christian Grund, Timm Harder, Elsayed Abdelwhab & Reiner Ulrich. (2021) A Semiquantitative Scoring System for Histopathological and Immunohistochemical Assessment of Lesions and Tissue Tropism in Avian Influenza. Viruses 13:5, pages 868.
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Jacqueline King, Timm Harder, Franz J. Conraths, Martin Beer & Anne Pohlmann. (2020) The genetics of highly pathogenic avian influenza viruses of subtype H5 in Germany, 2006–2020. Transboundary and Emerging Diseases 68:3, pages 1136-1150.
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Ahmed Mostafa, Claudia Blaurock, David Scheibner, Christin Müller, Ulrike Blohm, Alexander Schäfer, Marcel Gischke, Ahmed H Salaheldin, Hanaa Z Nooh, Mohamed A Ali, Angele Breithaupt, Thomas C Mettenleiter, Stephan Pleschka & Elsayed M Abdelwhab. (2020) Genetic incompatibilities and reduced transmission in chickens may limit the evolution of reassortants between H9N2 and panzootic H5N8 clade 2.3.4.4 avian influenza virus showing high virulence for mammals. Virus Evolution 6:2.
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Annika Suttie, Yi-Mo Deng, Andrew R. Greenhill, Philippe Dussart, Paul F. Horwood & Erik A. Karlsson. (2019) Inventory of molecular markers affecting biological characteristics of avian influenza A viruses. Virus Genes 55:6, pages 739-768.
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David Scheibner, Reiner Ulrich, Olanrewaju I. Fatola, Annika Graaf, Marcel Gischke, Ahmed H. Salaheldin, Timm C. Harder, Jutta Veits, Thomas C. Mettenleiter & Elsayed M. Abdelwhab. (2019) Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks. Scientific Reports 9:1.
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Edyta Świętoń & Krzysztof Śmietanka. (2018) Phylogenetic and molecular analysis of highly pathogenic avian influenza H5N8 and H5N5 viruses detected in Poland in 2016-2017. Transboundary and Emerging Diseases 65:6, pages 1664-1670.
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Ute Wessels, Elsayed M. Abdelwhab, Jutta Veits, Donata Hoffmann, Svenja Mamerow, Olga Stech, Jan Hellert, Martin Beer, Thomas C. Mettenleiter & Jürgen Stech. (2018) A Dual Motif in the Hemagglutinin of H5N1 Goose/Guangdong-Like Highly Pathogenic Avian Influenza Virus Strains Is Conserved from Their Early Evolution and Increases both Membrane Fusion pH and Virulence. Journal of Virology 92:17.
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Wei Qian, Xiaoqin Wei, Kelei Guo, Yongtao Li, Xian Lin, Zhong Zou, Hongbo Zhou & Meilin Jin. (2017) The C-Terminal Effector Domain of Non-Structural Protein 1 of Influenza A Virus Blocks IFN-β Production by Targeting TNF Receptor-Associated Factor 3. Frontiers in Immunology 8.
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Timm Harder, Jürgen Stech, El-Sayed M Abdelwhab, Jutta Veits, Franz J Conraths, Martin Beer & Thomas C Mettenleiter. (2016) A pallid rainbow: toward improved understanding of avian influenza biology. Future Virology 11:6, pages 429-437.
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