3,328
Views
60
CrossRef citations to date
0
Altmetric
Research Paper

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines

, , , , &
Pages 879-894 | Received 23 Aug 2017, Accepted 28 Feb 2018, Published online: 04 May 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Mihret Tilahun, Alemu Gedefie, Chernet Belayhun, Zenawork Sahle & Admasu Abera. (2022) Helicobacter pylori Pathogenicity Islands and Giardia lamblia Cysteine Proteases in Role of Coinfection and Pathogenesis. Infection and Drug Resistance 15, pages 21-34.
Read now

Articles from other publishers (58)

Yankai Chang, Junqiang Li & Longxian Zhang. (2023) Genetic diversity and molecular diagnosis of Giardia. Infection, Genetics and Evolution 113, pages 105482.
Crossref
Affan Siddiq, George Dong, Balu Balan, Luke G. Harrison, Aaron Jex, Martin Olivier, Thibault Allain & Andre G. Buret. (2023) A thermo‐resistant and RNase‐sensitive cargo from Giardia duodenalis extracellular vesicles modifies the behaviour of enterobacteria . Journal of Extracellular Biology 2:9.
Crossref
Raúl Argüello-García, Julio César Carrero & M. Guadalupe Ortega-Pierres. (2023) Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens—Factors Linked to Virulence and Pathogenicity. International Journal of Molecular Sciences 24:16, pages 12850.
Crossref
Yuanting Zheng, Neil D. Young, Jiangning Song & Robin B. Gasser. (2023) Genome-Wide Analysis of Haemonchus contortus Proteases and Protease Inhibitors Using Advanced Informatics Provides Insights into Parasite Biology and Host–Parasite Interactions. International Journal of Molecular Sciences 24:15, pages 12320.
Crossref
Brett A. McGregor, Elham Razmjou, Hossein Hooshyar, Drew R. Seeger, Svetlana A. Golovko, Mikhail Y. Golovko, Steven M. Singer, Junguk Hur & Shahram Solaymani-Mohammadi. (2023) A shotgun metagenomic analysis of the fecal microbiome in humans infected with Giardia duodenalis. Parasites & Vectors 16:1.
Crossref
Emily DeMichele, Olivia Sosnowski, Andre G. Buret & Thibault Allain. (2023) Regulatory Functions of Hypoxia in Host–Parasite Interactions: A Focus on Enteric, Tissue, and Blood Protozoa. Microorganisms 11:6, pages 1598.
Crossref
Jana Grüttner, Jorik M. van Rijn, Petra Geiser, Alexandra Florbrant, Dominic-Luc Webb, Per M. Hellström, Magnus Sundbom, Mikael E. Sellin & Staffan G. Svärd. (2023) Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection. PLOS Pathogens 19:5, pages e1011372.
Crossref
Jingxue Wu, Yongwu Yang, Lin Liu, Weining Zhu, Min Liu, Xiran Yu & Wei Li. (2023) ROS-AMPK/mTOR-dependent enterocyte autophagy is involved in the regulation of Giardia infection-related tight junction protein and nitric oxide levels. Frontiers in Immunology 14.
Crossref
Min Liu, Yongwu Yang, Weining Zhu, Jingxue Wu, Xiran Yu & Wei Li. (2023) Specific TLR-mediated HSP70 activation plays a potential role in host defense against the intestinal parasite Giardia duodenalis. Frontiers in Microbiology 14.
Crossref
Bárbara Ferreira, Ágata Lourenço & Maria do Céu Sousa. (2022) Protozoa-Derived Extracellular Vesicles on Intercellular Communication with Special Emphasis on Giardia lamblia. Microorganisms 10:12, pages 2422.
Crossref
Javad Mahdavi, Seyedmousa Motavallihaghi & Reza Ghasemikhah. (2022) Evaluation of clinical and paraclinical findings in patients with reactive arthritis caused by giardiasis: A systematic review. Seminars in Arthritis and Rheumatism 57, pages 152094.
Crossref
Wen-Juan Pan, Lu-Lu Shi, Yu-Ru Ren, Cheng-Ying Yao, Yong-Ming Lu & Yan Chen. (2022) Polysaccharide ORP-1 isolated from Oudemansiella raphanipes ameliorates age-associated intestinal epithelial barrier dysfunction in Caco-2 cells monolayer. Food Research International 162, pages 112038.
Crossref
Ahmad Fudail Eiyad Aziz, Norhamizah Roshidi, Nurulhasanah Othman, Khayriyyah Mohd Hanafiah & Norsyahida Arifin. (2022) Application of Proteomics to the Study of the Therapeutics and Pathogenicity of Giardia duodenalis. Diagnostics 12:11, pages 2744.
Crossref
Rodrigo Quezada-Lázaro, Yessica Vázquez-Cobix, Rocío Fonseca-Liñán, Porfirio Nava, Daniel Dimitri Hernández-Cueto, Carlos Cedillo-Peláez, Yolanda López-Vidal, Sara Huerta-Yepez & M. Guadalupe Ortega-Pierres. (2022) The Cysteine Protease Giardipain-1 from Giardia duodenalis Contributes to a Disruption of Intestinal Homeostasis. International Journal of Molecular Sciences 23:21, pages 13649.
Crossref
Elisa Barroeta-Echegaray, Rocío Fonseca-Liñán, Raúl Argüello-García, Rafael Rodríguez-Muñoz, Rosa María Bermúdez-Cruz, Porfirio Nava & M. Guadalupe Ortega-Pierres. (2022) Giardia duodenalis enolase is secreted as monomer during trophozoite-epithelial cell interactions, activates plasminogen and induces necroptotic damage. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Laura Rojas, Jana Grüttner, Showgy Ma’ayeh, Feifei Xu & Staffan G. Svärd. (2022) Dual RNA Sequencing Reveals Key Events When Different Giardia Life Cycle Stages Interact With Human Intestinal Epithelial Cells In Vitro. Frontiers in Cellular and Infection Microbiology 12.
Crossref
Elena Fekete, Thibault Allain, Christina B. Amat, Koichiro Mihara, Mahmoud Saifeddine, Morley D. Hollenberg, Kris Chadee & Andre G. Buret. (2022) Giardia duodenalis cysteine proteases cleave proteinase-activated receptor-2 to regulate intestinal goblet cell mucin gene expression. International Journal for Parasitology 52:5, pages 285-292.
Crossref
Yan Yan Song, Qi Qi Lu, Lu Lu Han, Shu Wei Yan, Xin Zhuo Zhang, Ruo Dan Liu, Shao Rong Long, Jing Cui & Zhong Quan Wang. (2022) Proteases secreted by Trichinella spiralis intestinal infective larvae damage the junctions of the intestinal epithelial cell monolayer and mediate larval invasion. Veterinary Research 53:1.
Crossref
David Holthaus, Martin R. Kraft, Susanne M. Krug, Silver Wolf, Antonia Müller, Estefania Delgado Betancourt, Madeleine Schorr, Gudrun Holland, Felix Knauf, Joerg-Dieter Schulzke, Toni Aebischer & Christian Klotz. (2022) Dissection of Barrier Dysfunction in Organoid-Derived Human Intestinal Epithelia Induced by Giardia duodenalis. Gastroenterology 162:3, pages 844-858.
Crossref
Carlos Francés-Cuesta, Iván Ansari, José Francisco Fernández-Garayzábal, Alicia Gibello & Fernando González-Candelas. (2022) Comparative genomics and evolutionary analysis of Lactococcus garvieae isolated from human endocarditis. Microbial Genomics 8:2.
Crossref
Marco Lalle & Simone M. Cacciò. 2022. Zoonoses: Infections Affecting Humans and Animals. Zoonoses: Infections Affecting Humans and Animals 1 28 .
Rodney D. Adam. (2021) Giardia duodenalis: Biology and Pathogenesis. Clinical Microbiology Reviews 34:4.
Crossref
Lin Liu, Yongwu Yang, Rui Fang, Weining Zhu, Jingxue Wu, Xiaoyun Li, Jay V. Patankar & Wei Li. (2021) Giardia duodenalis and Its Secreted PPIB Trigger Inflammasome Activation and Pyroptosis in Macrophages through TLR4-Induced ROS Signaling and A20-Mediated NLRP3 Deubiquitination. Cells 10:12, pages 3425.
Crossref
Raúl Argüello-García & M. Guadalupe Ortega-Pierres. (2021) Giardia duodenalis Virulence — “To Be, or Not To Be”. Current Tropical Medicine Reports 8:4, pages 246-256.
Crossref
Thibault Allain, Elena Fekete, Olivia Sosnowski, Dimitri Desmonts de Lamache, Jean-Paul Motta, Dezirae Leger, Troy Feener, Raylene A. Reimer & André G. Buret. (2021) High-fat diet increases the severity of Giardia infection in association with low-grade inflammation and gut microbiota dysbiosis. Scientific Reports 11:1.
Crossref
Renata Rosito Tonelli, Juliana Bizarri Souza, Katherine Tsantarlis, Elisandra Renata Montoia & Iasmin Ferraz. (2021) Giardia-Host Interactions In Vitro: 2015–2020 Review. Current Tropical Medicine Reports 8:3, pages 149-159.
Crossref
Zhiqiang Li, Dimitra Peirasmaki, Staffan Svärd & Magnus Åbrink. (2021) Serglycin-Deficiency Causes Reduced Weight Gain and Changed Intestinal Cytokine Responses in Mice Infected With Giardia intestinalis. Frontiers in Immunology 12.
Crossref
Zoltán Füssy, Martina Vinopalová, Sebastian Cristian Treitli, Tomáš Pánek, Pavla Smejkalová, Ivan Čepička, Pavel Doležal & Vladimír Hampl. (2021) Retortamonads from vertebrate hosts share features of anaerobic metabolism and pre-adaptations to parasitism with diplomonads. Parasitology International 82, pages 102308.
Crossref
Maria Cristina Angelici, Julia Walochnik, Adriana Calderaro, Lynora Saxinger & Joel B. Dacks. (2021) Free-living amoebae and other neglected protistan pathogens: Health emergency signals?. European Journal of Protistology 77, pages 125760.
Crossref
Elena Fekete, Thibault Allain, Affan Siddiq, Olivia Sosnowski & Andre G. Buret. (2021) Giardia spp. and the Gut Microbiota: Dangerous Liaisons. Frontiers in Microbiology 11.
Crossref
Bruno Gavinho, Bruna Sabatke, Veronica Feijoli, Izadora Volpato Rossi, Janaina Macedo da Silva, Ingrid Evans-Osses, Giuseppe Palmisano, Sigrun Lange & Marcel Ivan Ramirez. (2020) Peptidylarginine Deiminase Inhibition Abolishes the Production of Large Extracellular Vesicles From Giardia intestinalis, Affecting Host-Pathogen Interactions by Hindering Adhesion to Host Cells. Frontiers in Cellular and Infection Microbiology 10.
Crossref
Lin Liu, Rui Fang, Ziyan Wei, Jingxue Wu, Xiaoyun Li & Wei Li. (2020) Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway In Vitro. Pathogens 9:9, pages 693.
Crossref
Dimitra Peirasmaki, Showgy Y. Ma’ayeh, Feifei Xu, Marcela Ferella, Sara Campos, Jingyi Liu & Staffan G. Svärd. (2020) High Cysteine Membrane Proteins (HCMPs) Are Up-Regulated During Giardia-Host Cell Interactions. Frontiers in Genetics 11.
Crossref
Feifei Xu, Alejandro Jiménez-González, Elin Einarsson, Ásgeir Ástvaldsson, Dimitra Peirasmaki, Lars Eckmann, Jan O. Andersson, Staffan G. Svärd & Jon Jerlström-Hultqvist. (2020) The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites. Microbial Genomics 6:8.
Crossref
Clarissa Perez Faria, Bruno Miguel Neves, Ágata Lourenço, Maria Teresa Cruz, João D. Martins, Ana Silva, Sónia Pereira & Maria do Céu Sousa. (2020) Giardia lamblia Decreases NF-κB p65RelA Protein Levels and Modulates LPS-Induced Pro-Inflammatory Response in Macrophages. Scientific Reports 10:1.
Crossref
Zhiqiang Li, Dimitra Peirasmaki, Staffan Svärd & Magnus Åbrink. (2020) The Chymase Mouse Mast Cell Protease-4 Regulates Intestinal Cytokine Expression in Mature Adult Mice Infected with Giardia intestinalis. Cells 9:4, pages 925.
Crossref
Anna Manko-Prykhoda, Thibault Allain, Jean-Paul Motta, James A. Cotton, Troy Feener, Ayodele Oyeyemi, Sunint Bindra, Bruce A. Vallance, John L. Wallace, Paul Beck & Andre G. Buret. (2020) Giardia spp. promote the production of antimicrobial peptides and attenuate disease severity induced by attaching and effacing enteropathogens via the induction of the NLRP3 inflammasome. International Journal for Parasitology 50:4, pages 263-275.
Crossref
André G. Buret. (2020) Acceptance of the 2019 Stoll-Stunkard Memorial Lectureship Award: The Study of Host-Parasite Interactions to Better Understand Fundamental Host Physiology: The Model of Giardiasis. Journal of Parasitology 105:6, pages 955.
Crossref
André G. Buret, Simone M. Cacciò, Loïc Favennec & Staffan Svärd. (2020) Update on Giardia : Highlights from the seventh International Giardia and Cryptosporidium Conference . Parasite 27, pages 49.
Crossref
Thibault Allain & André G. Buret. 2020. Giardia and Giardiasis, Part B. Giardia and Giardiasis, Part B 173 199 .
Raúl Argüello-García, David Leitsch, Tina Skinner-Adams & M. Guadalupe Ortega-Pierres. 2020. Giardia and Giardiasis, Part B. Giardia and Giardiasis, Part B 201 282 .
Samantha J. Emery-Corbin, Jana Grüttner & Staffan Svärd. 2020. Giardia and Giardiasis, Part B. Giardia and Giardiasis, Part B 139 171 .
Tiara Cascais-Figueiredo, Phelipe Austriaco-Teixeira, Maria Fantinatti, Maria Luciana Silva-Freitas, Joanna Reis Santos-Oliveira, Camila H. Coelho, Steven M. Singer & Alda Maria Da-Cruz. (2019) Giardiasis Alters Intestinal Fatty Acid Binding Protein (I-FABP) and Plasma Cytokines Levels in Children in Brazil. Pathogens 9:1, pages 7.
Crossref
Sofía Moyano, Juliana Musso, Constanza Feliziani, Nahuel Zamponi, Lorena Soledad Frontera, Andrea Silvana Ropolo, Adriana Lanfredi-Rangel, Marco Lalle & María C. Touz. (2019) Exosome Biogenesis in the Protozoa Parasite Giardia lamblia: A Model of Reduced Interorganellar Crosstalk. Cells 8:12, pages 1600.
Crossref
Wei-Chen Lin, Chia-Yun Tsai, Jian-Ming Huang, Shang-Rung Wu, Lichieh Julie Chu & Kuo-Yang Huang. (2019) Quantitative proteomic analysis and functional characterization of Acanthamoeba castellanii exosome-like vesicles. Parasites & Vectors 12:1.
Crossref
Courtney W. Stairs, Anna Kokla, Ásgeir Ástvaldsson, Jon Jerlström-Hultqvist, Staffan Svärd & Thijs J. G. Ettema. (2019) Oxygen induces the expression of invasion and stress response genes in the anaerobic salmon parasite Spironucleus salmonicida. BMC Biology 17:1.
Crossref
Frans N. J. Kooyman, Jaap A. Wagenaar & Aldert Zomer. (2019) Whole-genome sequencing of dog-specific assemblages C and D of Giardia duodenalis from single and pooled cysts indicates host-associated genes. Microbial Genomics 5:12.
Crossref
Hanieh Mohammad Rahimi, Mohammad Amin Pourhosseingholi, Abbas Yadegar, Hamed Mirjalali & Mohammad Reza Zali. (2019) High-resolution melt curve analysis: A real-time based multipurpose approach for diagnosis and epidemiological investigations of parasitic infections. Comparative Immunology, Microbiology and Infectious Diseases 67, pages 101364.
Crossref
Zhiqiang Li, Dimitra Peirasmaki, Staffan Svärd & Magnus Åbrink. (2019) Giardia excretory-secretory proteins modulate the enzymatic activities of mast cell chymase and tryptase. Molecular Immunology 114, pages 535-544.
Crossref
Cherif Chetouhi, Mohammed Laabir, Estelle Masseret & Natacha Jean. (2019) In silico prediction of the secretome from the invasive neurotoxic marine dinoflagellate Alexandrium catenella . Environmental Microbiology Reports 11:4, pages 571-580.
Crossref
Thibault Allain, Elena Fekete & Andre G. Buret. (2019) Giardia Cysteine Proteases: The Teeth behind the Smile. Trends in Parasitology 35:8, pages 636-648.
Crossref
Jingyi Liu, Staffan G. Svärd & Christian Klotz. (2019) Giardia intestinalis cystatin is a potent inhibitor of papain, parasite cysteine proteases and, to a lesser extent, human cathepsin B . FEBS Letters 593:12, pages 1313-1325.
Crossref
Liudmila B. Masnavieva & I. V. Kudaeva. (2019) THE RESPONSE OF THE ORGANISM OF ADOLESCENTS TO THE INHALATION CHEMICAL LOAD AND INFESTATION WITH GIARDIA. Hygiene and sanitation 98:1, pages 28-32.
Crossref
José Ignacio de la Mora-de la Mora, Sergio Enríquez-Flores, Cynthia Fernández-Lainez, Pedro Gutiérrez-Castrellón, Alfonso Olivos-García, Augusto González-Canto, Roberto Hernández, Hugo D. Luján, Itzhel García-Torres & Gabriel López-Velázquez. (2019) Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences. Molecular and Biochemical Parasitology 228, pages 16-26.
Crossref
Jingyi Liu, Zhirong Fu, Lars Hellman & Staffan G. Svärd. (2019) Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins. Molecular and Biochemical Parasitology 227, pages 29-38.
Crossref
Steven M. Singer, Marc Y. Fink & Vanessa V. Angelova. 2019. Giardia and Giardiasis, Part A. Giardia and Giardiasis, Part A 171 208 .
M. Guadalupe Ortega-Pierres & Raúl Argüello-García. 2019. Giardia and Giardiasis, Part A. Giardia and Giardiasis, Part A 129 169 .
Showgy Y. Ma'ayeh, Livia Knörr, Karin Sköld, Alexandra Garnham, Brendan R. E. Ansell, Aaron R. Jex & Staffan G. Svärd. (2018) Responses of the Differentiated Intestinal Epithelial Cell Line Caco-2 to Infection With the Giardia intestinalis GS Isolate. Frontiers in Cellular and Infection Microbiology 8.
Crossref