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Virulence Volume 9, 2018 - Issue 1
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Research Paper

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors

Jie Gaoa State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, China;b College of Life Sciences, Hebei Normal University, Shijiazhuang, ChinaView further author information
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Wenwen Xina State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Jing Huanga State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, China;b College of Life Sciences, Hebei Normal University, Shijiazhuang, ChinaView further author information
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Bin Jia State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Shan Gaoa State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Liang Chena State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Lin Kanga State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Hao Yanga State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Xin Shena State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Baohua Zhaob College of Life Sciences, Hebei Normal University, Shijiazhuang, ChinaCorrespondence[email protected] [email protected]
View further author information
&
Jinglin Wanga State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, AMMS, Beijing, ChinaView further author information
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Pages 1601-1614 | Received 24 Apr 2018, Accepted 19 Sep 2018, Published online: 15 Oct 2018

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Mokarameh Pudineh Moarref, Mojtaba Alimolaei, Tara Emami & Mohammad Kazem Koohi. (2023) Development and evaluation of cell membrane-based biomimetic nanoparticles loaded by Clostridium perfringens epsilon toxin: a novel vaccine delivery platform for Clostridial-associated diseases. Nanotoxicology 17:5, pages 420-431.
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Articles from other publishers (16)

Richard W Titball, Nicholas Lewis & Richard Nicholas. (2023) Is Clostridium perfringens epsilon toxin associated with multiple sclerosis? . Multiple Sclerosis Journal 29:9, pages 1057-1063.
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Bin Ji, Jianxiang Huang, Kexuan Zou, Meijun Liu, Yufeng Pei, Jing Huang, Yong Wang, Jinglin Wang, Ruhong Zhou, Wenwen Xin & Jie Song. (2023) Direct Visualization of the Dynamic Process of Epsilon Toxin on Hemolysis. Small Methods 7:7.
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Jinglin Xu, Dongxue Li, Lin Kang, Tingting Liu, Jing Huang, Jiaxin Li, Jing Lv, Jing Wang, Shan Gao, Yanwei Li, Bing Yuan, Baohua Zhao, Jinglin Wang & Wenwen Xin. (2023) Systematic evaluation of membrane-camouflaged nanoparticles in neutralizing Clostridium perfringens ε-toxin. Journal of Nanobiotechnology 21:1.
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Jing Huang, Baohua Zhao, Tingting Liu, Lin Kang, Jiaxin Li, Zishuo Guo, Ming Chen, Shan Gao, Jing Wang, Yanwei Li, Jinglin Wang & Wenwen Xin. (2023) Statins as Potential Preventative Treatment of ETX and Multiple Pore-Forming Toxin-Induced Diseases. International Journal of Molecular Sciences 24:6, pages 5414.
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Skye Marshall, Beth McGill, Helen Morcrette, C. Peter Winlove, Catalin Chimerel, Peter G. Petrov & Monika Bokori-Brown. (2022) Interaction of Clostridium perfringens Epsilon Toxin with the Plasma Membrane: The Role of Amino Acids Y42, Y43 and H162. Toxins 14:11, pages 757.
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Christian Marco Hadi Nugroho, Ryan Septa Kurnia, Simson Tarigan, Otto Sahat Martua Silaen, Silvia Triwidyaningtyas, I. Wayan Teguh Wibawan, Lily Natalia, Andi Khomeini Takdir & Amin Soebandrio. (2022) Screening and purification of NanB sialidase from Pasteurella multocida with activity in hydrolyzing sialic acid Neu5Acα(2–6)Gal and Neu5Acα(2–3)Gal. Scientific Reports 12:1.
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Zhijun Geng, Lin Kang, Jing Huang, Shan Gao, Jing Wang, Yuan Yuan, Yanwei Li, Jinglin Wang & Wenwen Xin. (2021) Epsilon toxin from Clostridium perfringens induces toxic effects on skin tissues and HaCaT and human epidermal keratinocytes. Toxicon 198, pages 102-110.
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Armando Rubio-Ramos, Leticia Labat-de-Hoz, Isabel Correas & Miguel A. Alonso. (2021) The MAL Protein, an Integral Component of Specialized Membranes, in Normal Cells and Cancer. Cells 10:5, pages 1065.
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Alexandra Y. Soare, Tracey L. Freeman, Alice K. Min, Hagerah S. Malik, Elizabeth O. Osota & Talia H. Swartz. (2021) P2RX7 at the Host-Pathogen Interface of Infectious Diseases. Microbiology and Molecular Biology Reviews 85:1.
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Haydee Mesa-Galloso, Lohans Pedrera & Uris Ros. (2021) Pore-forming proteins: From defense factors to endogenous executors of cell death. Chemistry and Physics of Lipids 234, pages 105026.
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Zhijun Geng, Jing Huang, Lin Kang, Shan Gao, Yuan Yuan, Yanwei Li, Jing Wang, Wenwen Xin & Jinglin Wang. (2020) Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure . Journal of Cellular and Molecular Medicine 24:13, pages 7341-7352.
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Prabhakar Babele, Ravi Bhushan Kumar, Sakshi Rajoria, Faraz Rashid, Dipankar Malakar, Sameer Suresh Bhagyawant, Dev Vrat Kamboj & Syed Imteyaz Alam. (2020) Putative serum protein biomarkers for epsilon toxin exposure in mouse model using LC-MS/MS analysis. Anaerobe 63, pages 102209.
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Chongli Xu, Yuhan She, Yimin Lin & Chongbo Xu. (2019) Molecular structure and function of the carboxy‐terminus of the alpha‐toxin from Clostridium perfringens type A . Journal of Animal Physiology and Animal Nutrition 104:2, pages 725-734.
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Chongli Xu, Yuhan She, Fengyang Fu, Yimin Lin & Chongbo Xu. (2019) Study of the Structure and Biological Activity of the Amino-Terminus of the α-Toxin from Clostridium welchii Type A. Current Microbiology 76:10, pages 1175-1185.
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Wenwen Xin & Jinglin Wang. (2019) Clostridium perfringens epsilon toxin: Toxic effects and mechanisms of action. Biosafety and Health 1:2, pages 71-75.
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Helen Morcrette, Monika Bokori-Brown, Stephanie Ong, Leo Bennett, Brendan W. Wren, Nick Lewis & Richard W. Titball. (2019) Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein. npj Vaccines 4:1.
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