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Virulence Volume 9, 2018 - Issue 1
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Research Paper

Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents

Antonia Efstathioua Molecular Parasitology Lab, Dpt of Microbiology, Hellenic Pasteur Institute, Athens, GreeceView further author information
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Cássio Santana Meirab Laboratory of Tissue Engineering and Immunopharmacology, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, BA, Brazil;c Center of Biotechnology and Cell Therapy, Hospital São Rafael, Salvador, BA, BrazilView further author information
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Nicolas Gaboriaud-Kolard Pharmacognosy and Pharmaceutical Chemistry Lab, Dpt of Pharmacy, Panepistimiopolis Zografou, University of Athens, Athens, GreeceView further author information
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Tanira Matutino Bastosb Laboratory of Tissue Engineering and Immunopharmacology, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, BA, Brazil;c Center of Biotechnology and Cell Therapy, Hospital São Rafael, Salvador, BA, BrazilORCID Iconhttps://orcid.org/0000-0001-5961-7572View further author information
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Vinícius Pinto Costa Rochab Laboratory of Tissue Engineering and Immunopharmacology, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, BA, Brazil;c Center of Biotechnology and Cell Therapy, Hospital São Rafael, Salvador, BA, BrazilORCID Iconhttps://orcid.org/0000-0002-5309-5950View further author information
ORCID Icon,
Konstantina Vougogiannopouloud Pharmacognosy and Pharmaceutical Chemistry Lab, Dpt of Pharmacy, Panepistimiopolis Zografou, University of Athens, Athens, GreeceView further author information
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Alexios-Leandros Skaltsounisd Pharmacognosy and Pharmaceutical Chemistry Lab, Dpt of Pharmacy, Panepistimiopolis Zografou, University of Athens, Athens, GreeceView further author information
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Despina Smirlisa Molecular Parasitology Lab, Dpt of Microbiology, Hellenic Pasteur Institute, Athens, GreeceORCID Iconhttps://orcid.org/0000-0003-4996-2879View further author information
ORCID Icon &
Milena Botelho Pereira Soaresb Laboratory of Tissue Engineering and Immunopharmacology, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, BA, Brazil;c Center of Biotechnology and Cell Therapy, Hospital São Rafael, Salvador, BA, BrazilCorrespondence[email protected] [email protected]
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Pages 1658-1668 | Received 25 May 2018, Accepted 21 Sep 2018, Published online: 02 Nov 2018

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Kandasamy Saravanan, Govindasamy Hunday & Poomani Kumaradhas. (2020) Binding and stability of indirubin-3-monoxime in the GSK3β enzyme: a molecular dynamics simulation and binding free energy study. Journal of Biomolecular Structure and Dynamics 38:4, pages 957-974.
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Articles from other publishers (8)

Carlos S. M. B. Filho, Ramon R. P. P. B. de Menezes, Emanuel P. Magalhães, Yunierkis P. Castillo, Alice M. C. Martins & Damião P. de Sousa. (2023) Piplartine-Inspired 3,4,5-Trimethoxycinnamates: Trypanocidal, Mechanism of Action, and In Silico Evaluation. Molecules 28:11, pages 4512.
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Hermann AM Mucke. (2021) Patent highlights June–July 2021. Pharmaceutical Patent Analyst 10:6, pages 237-244.
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Aline A. Zuma & Wanderley de Souza. (2021) Chagas Disease Chemotherapy: What Do We Know So Far?. Current Pharmaceutical Design 27:38, pages 3963-3995.
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Antonia Efstathiou & Despina Smirlis. (2021) Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis. Microorganisms 9:4, pages 691.
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Bin Sun, Jiahao Wang, Luohua Liu, Longfei Mao, Lizeng Peng & Yuwei Wang. (2020) Synthesis and activity of novel indirubin derivatives. Chemical Biology & Drug Design 97:3, pages 565-571.
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Rafael da Rosa, Eloir Paulo Schenkel & Lílian Sibelle Campos Bernardes. (2020) Semisynthetic and newly designed derivatives based on natural chemical scaffolds: moving beyond natural products to fight Trypanosoma cruzi. Phytochemistry Reviews 19:1, pages 105-122.
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Antonia Efstathiou, Nicolas Gaboriaud-Kolar, Vassilios Myrianthopoulos, Konstantina Vougogiannopoulou, Ines Subota, Stephanie Aicher, Emmanuel Mikros, Philippe Bastin, Alexios-Leandros Skaltsounis, Ketty Soteriadou & Despina Smirlis. (2019) Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth . Antimicrobial Agents and Chemotherapy 63:6.
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Panagiota-Efstathia Nikolaou, Kerstin Boengler, Panagiotis Efentakis, Konstantina Vouvogiannopoulou, Anastasia Zoga, Nicholas Gaboriaud-Kolar, Vassilios Myrianthopoulos, Pavlos Alexakos, Nikolaos Kostomitsopoulos, Ioannis Rerras, Anna Tsantili-Kakoulidou, Alexios Leandros Skaltsounis, Andreas Papapetropoulos, Efstathios K Iliodromitis, Rainer Schulz & Ioanna Andreadou. (2019) Investigating and re-evaluating the role of glycogen synthase kinase 3 beta kinase as a molecular target for cardioprotection by using novel pharmacological inhibitors. Cardiovascular Research 115:7, pages 1228-1243.
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