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Virulence Volume 10, 2019 - Issue 1
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Research Paper

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

S. SharbaDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0003-0531-2137View further author information
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N. NavabiDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0002-2791-3526View further author information
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M. PadraDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenView further author information
,
J. A. PerssonDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenView further author information
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M. P. Quintana-HayashiDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenView further author information
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J. K. GustafssonDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0001-7213-4065View further author information
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L. SzeponikDepartment of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0002-8627-6969View further author information
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V. VenkatakrishnanDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenView further author information
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Å. SjölingDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SwedenView further author information
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S. NilssonDepartment of Pathology & Genetics, Sahlgrenska Academy, University of Gothenburg, Sweden;Department of Mathematical Sciences, Chalmer University of Technology, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0003-4748-0446View further author information
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M. Quiding-JärbrinkDepartment of Microbiology and Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenView further author information
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M. E. V. JohanssonDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenORCID Iconhttps://orcid.org/0000-0002-4237-6677View further author information
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S. K. LindenDepartment of Medical Biochemistry and Cell Biology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenCorrespondence[email protected]
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Pages 97-117 | Received 19 Oct 2018, Accepted 14 Jan 2019, Published online: 03 Feb 2019

Citations (24)

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Songwei Yang & Min Yu. (2021) Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity. Journal of Inflammation Research 14, pages 3171-3183.
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Zulkar Nain, Faruq Abdulla, M. Mizanur Rahman, Mohammad Minnatul Karim, Md. Shakil Ahmed Khan, Sifat Bin Sayed, Shafi Mahmud, S. M. Raihan Rahman, Md. Moinuddin Sheam, Zahurul Haque & Utpal Kumar Adhikari. (2020) Proteome-wide screening for designing a multi-epitope vaccine against emerging pathogen Elizabethkingia anophelis using immunoinformatic approaches. Journal of Biomolecular Structure and Dynamics 38:16, pages 4850-4867.
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S. Sharba, V. Venkatakrishnan, M. Padra, M. Winther, M. Gabl, M. Sundqvist, J. Wang, H. Forsman & S. K. Linden. (2019) Formyl peptide receptor 2 orchestrates mucosal protection against Citrobacter rodentium infection. Virulence 10:1, pages 610-624.
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Articles from other publishers (21)

Hisashi Nagase, Masaya Takamoto & Nancy Noben-Trauth. (2023) Genetic deficiencies of both IL-4 receptor alpha chain and IL-10 trigger early onset of severe colitis in mice. Cellular Immunology 393-394, pages 104779.
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Rain Inaba, Sara Vujakovic & Kirk Bergstrom. (2023) The gut mucus network: A dynamic liaison between microbes and the immune system. Seminars in Immunology 69, pages 101807.
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Chengwei He, Han Gao, Shuzi Xin, Rongxuan Hua, Xueran Guo, Yimin Han, Hongwei Shang & Jingdong Xu. (2023) View from the Biological Property: Insight into the Functional Diversity and Complexity of the Gut Mucus. International Journal of Molecular Sciences 24:4, pages 4227.
Crossref
Kristina A. Thomsson, John Benktander, Macarena P. Quintana-Hayashi, Sinan Sharba & Sara K. Lindén. (2022) Mucin O-glycosylation and pathogen binding ability differ between rainbow trout epithelial sites. Fish & Shellfish Immunology 131, pages 349-357.
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Hsin-Mei Chen, Pei-Yu Hung, Chih-Hung Chen, Yu-Jhen Yu, Ming-Shan Syu & Meng-Chun Hu. (2022) HSD3B1 Expression Is Upregulated by Interleukin 4 in HT-29 Colon Cancer Cells via Multiple Signaling Pathways. International Journal of Molecular Sciences 23:21, pages 13572.
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Sinan Sharba, Henrik Sundh, Kristina Sundell, John Benktander, Licinia Santos, George Birchenough & Sara K. Lindén. (2022) Rainbow trout gastrointestinal mucus, mucin production, mucin glycosylation and response to lipopolysaccharide. Fish & Shellfish Immunology 122, pages 181-190.
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Benthe van der Lugt, Maartje C.P. Vos, Mechteld Grootte Bromhaar, Noortje Ijssennagger, Frank Vrieling, Jocelijn Meijerink & Wilma T. Steegenga. (2022) The effects of sulfated secondary bile acids on intestinal barrier function and immune response in an inflammatory in vitro human intestinal model. Heliyon 8:2, pages e08883.
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Natalia Di Tommaso, Antonio Gasbarrini & Francesca Romana Ponziani. (2021) Intestinal Barrier in Human Health and Disease. International Journal of Environmental Research and Public Health 18:23, pages 12836.
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Valerie Cortez & Stacey Schultz‐Cherry. (2021) The role of goblet cells in viral pathogenesis. The FEBS Journal 288:24, pages 7060-7072.
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Juan Wu, Yushuang Yin, Mingzhe Qin, Kun Li, Fang Liu, Xiang Zhou, Xiaoyang Song & Bixi Li. (2021) Vagus Nerve Stimulation Protects Enterocyte Glycocalyx After Hemorrhagic Shock Via the Cholinergic Anti-Inflammatory Pathway. Shock 56:5, pages 832-839.
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Yeganeh Yousefi, Sabah Haq, Suhrid Banskota, Yun Han Kwon & Waliul I. Khan. (2021) Trichuris muris Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense. Pathogens 10:8, pages 925.
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Dingwu Qu, Gang Wang, Leilei Yu, Fengwei Tian, Wei Chen & Qixiao Zhai. (2021) The effects of diet and gut microbiota on the regulation of intestinal mucin glycosylation. Carbohydrate Polymers 258, pages 117651.
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Dewi Masyithah Darlan, Muhammad Fakhrur Rozi & Hemma Yulfi. (2021) Overview of Immunological Responses and Immunomodulation Properties of Trichuris sp.: Prospects for Better Understanding Human Trichuriasis. Life 11:3, pages 188.
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John Benktander, Henrik Sundh, Kristina Sundell, Abarna V. M. Murugan, Vignesh Venkatakrishnan, János Tamás Padra, Jelena Kolarevic, Bendik Fyhn Terjesen, Marnix Gorissen & Sara K. Lindén. (2021) Stress Impairs Skin Barrier Function and Induces α2-3 Linked N-Acetylneuraminic Acid and Core 1 O-Glycans on Skin Mucins in Atlantic Salmon, Salmo salar. International Journal of Molecular Sciences 22:3, pages 1488.
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Yu-Song Yuan, Fei Yu, Ya-Jun Zhang, Su-Ping Niu, Hai-Lin Xu & Yu-Hui Kou. (2021) Changes in proteins related to early nerve repair in a rat model of sciatic nerve injury. Neural Regeneration Research 16:8, pages 1622.
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Mukulika Bose, Bhaskar Mitra & Pinku Mukherjee. (2020) Mucin signature as a potential tool to predict susceptibility to COVID‐19. Physiological Reports 9:1.
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John Benktander, János T. Padra, Ben Maynard, George Birchenough, Natasha A. Botwright, Russel McCulloch, James W. Wynne, Sinan Sharba, Kristina Sundell, Henrik Sundh & Sara K. Lindén. (2020) Gill Mucus and Gill Mucin O-glycosylation in Healthy and Amebic Gill Disease-Affected Atlantic Salmon. Microorganisms 8:12, pages 1871.
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Jensine A. Grondin, Yun Han Kwon, Parsa Mehraban Far, Sabah Haq & Waliul I. Khan. (2020) Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies. Frontiers in Immunology 11.
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Médea Padra, Anders Andersson, Bettina Levänen, Pushpa Premaratne, Helga Asgeirsdottir, Sara Tengvall, Karin Christenson, Marit Stockfelt, Steven Bozinovski, Shigemi Yoshihara, Ann-Sofie Lantz, Lena Palmberg, Barbro Dahlén, Kjell Larsson, Ingemar Qvarfordt, Sara K. Lindén & Anders Lindén. (2020) Increased MUC1 plus a larger quantity and complex size for MUC5AC in the peripheral airway lumen of long-term tobacco smokers. Clinical Science 134:10, pages 1107-1125.
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Valerie Cortez, David F. Boyd, Jeremy Chase Crawford, Bridgett Sharp, Brandi Livingston, Hannah M. Rowe, Amy Davis, Ramzi Alsallaq, Camenzind G. Robinson, Peter Vogel, Jason W. Rosch, Elisa Margolis, Paul G. Thomas & Stacey Schultz-Cherry. (2020) Astrovirus infects actively secreting goblet cells and alters the gut mucus barrier. Nature Communications 11:1.
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Benthe van der Lugt, Maartje C.P. Vos, Mechteld Grootte Bromhaar, Noortje Ijssennagger, Frank Vrieling, Jocelijn Meijerink & Wilma T. Steegenga. (2021) The Effects of Sulfated Secondary Bile Acids on Intestinal Barrier Function and Immune Response in an Inflammatory <i> in vitro</i> Human Intestinal Model. SSRN Electronic Journal.
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