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Review article

PE_PGRS proteins of Mycobacterium tuberculosis: A specialized molecular task force at the forefront of host–pathogen interaction

ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 898-915 | Received 18 Jan 2020, Accepted 17 Jun 2020, Published online: 25 Jul 2020

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Medha, Priyanka, Sadhna Sharma & Monika Sharma. (2023) PE_PGRS45 (Rv2615c) protein of Mycobacterium tuberculosis perturbs mitochondria of macrophages . Immunology & Cell Biology.
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Andrea Monserrat Negrete-Paz, Gerardo Vázquez-Marrufo, Ana Gutiérrez-Moraga & Ma. Soledad Vázquez-Garcidueñas. (2023) Pangenome Reconstruction of Mycobacterium tuberculosis as a Guide to Reveal Genomic Features Associated with Strain Clinical Phenotype. Microorganisms 11:6, pages 1495.
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Eliza Kramarska, Flavio De Maio, Giovanni Delogu & Rita Berisio. (2023) Structural Basis of PE_PGRS Polymorphism, a Tool for Functional Modulation. Biomolecules 13:5, pages 812.
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V. V. Slizen, L. K. Surkova & G. L. Gurevich. (2023) Variability assessment of PE_PGRS genes and DNA repair, replication, and recombination genes in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of Belarus, Medical series 20:1, pages 42-57.
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Vien Q. T. Ho, Mark K. Rong, Eva Habjan, Samantha D. Bommer, Thang V. Pham, Sander R. Piersma, Wilbert Bitter, Eelco Ruijter & Alexander Speer. (2023) Dysregulation of Mycobacterium marinum ESX-5 Secretion by Novel 1,2,4-oxadiazoles. Biomolecules 13:2, pages 211.
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Norbert S. Hill & Matthew D. Welch. (2022) A glycine-rich PE_PGRS protein governs mycobacterial actin-based motility. Nature Communications 13:1.
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Irina V. Belyaeva, Anna N. Kosova & Andrei G. Vasiliev. (2022) Tuberculosis and Autoimmunity. Pathophysiology 29:2, pages 298-318.
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Jae-Sung Kim, Hyo Keun Kim, Euni Cho, Seok-Jun Mun, Sein Jang, Jichan Jang & Chul-Su Yang. (2022) PE_PGRS38 Interaction With HAUSP Downregulates Antimycobacterial Host Defense via TRAF6. Frontiers in Immunology 13.
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Rahul Gupta, Manitosh Pandey, Amit Kumar Pandey, Pramod Kumar Tiwari & Rabbind Singh Amrathlal. (2022) Novel genetic polymorphisms identified in the clinical isolates of Mycobacterium tuberculosis PE_PGRS33 gene modulate cytokines expression and promotes survival in macrophages. Journal of Infection and Public Health 15:2, pages 245-254.
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Fuyi Li, Xudong Guo, Dongxu Xiang, Miranda E. Pitt, Arnold Bainomugisa & Lachlan J.M. Coin. (2022) Computational analysis and prediction of PE_PGRS proteins using machine learning. Computational and Structural Biotechnology Journal 20, pages 662-674.
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Tao Xu, Minying Li, Chutong Wang, Meili Yuan, Xianyou Chang, Zhongqing Qian, Baiqing Li, Meiqun Sun & Hongtao Wang. (2021) Codon Optimization, Soluble Expression and Purification of PE_PGRS45 Gene from Mycobacterium tuberculosis and Preparation of Its Polyclonal Antibody Protein . Journal of Microbiology and Biotechnology 31:11, pages 1583-1590.
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Darius Riziki Martin, Nicole Remaliah Sibuyi, Phumuzile Dube, Adewale Oluwaseun Fadaka, Ruben Cloete, Martin Onani, Abram Madimabe Madiehe & Mervin Meyer. (2021) Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care. Diagnostics 11:8, pages 1352.
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Nguyen Thi Le Hang, Minako Hijikata, Shinji Maeda, Akiko Miyabayashi, Keiko Wakabayashi, Shintaro Seto, Nguyen Thi Kieu Diem, Nguyen Thi Thanh Yen, Le Van Duc, Pham Huu Thuong, Hoang Van Huan, Nguyen Phuong Hoang, Satoshi Mitarai, Naoto Keicho & Seiya Kato. (2021) Phenotypic and genotypic features of the Mycobacterium tuberculosis lineage 1 subgroup in central Vietnam. Scientific Reports 11:1.
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Aquib Ehtram, Mohd Shariq, Sabeeha Ali, Neha Quadir, Javaid A. Sheikh, Faraz Ahmad, Tarina Sharma, Nasreen Z. Ehtesham & Seyed E. Hasnain. (2021) Teleological cooption of Mycobacterium tuberculosis PE/PPE proteins as porins: Role in molecular immigration and emigration. International Journal of Medical Microbiology 311:3, pages 151495.
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Yan Xie, Yidan Zhou, Sheng Liu & Xiao‐Lian Zhang. (2020) PE_PGRS: Vital proteins in promoting mycobacterial survival and modulating host immunity and metabolism. Cellular Microbiology 23:3.
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Eliza Kramarska, Flavia Squeglia, Flavio De Maio, Giovanni Delogu & Rita Berisio. (2021) PE_PGRS33, an Important Virulence Factor of Mycobacterium tuberculosis and Potential Target of Host Humoral Immune Response. Cells 10:1, pages 161.
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Jacques Augenstreich & Volker Briken. (2020) Host Cell Targets of Released Lipid and Secreted Protein Effectors of Mycobacterium tuberculosis. Frontiers in Cellular and Infection Microbiology 10.
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