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Research Article

The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1α signalling pathway

Xuping Yanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;b Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Qinhui Liuc Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Yanping Lic Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Qin Tanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Tong Wua Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Lei Chena Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Shiyun Pua Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Yingnan Zhaoa Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Guorong Zhanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Cuiyuan Huanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Jinhang Zhanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Zijing Zhanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Ya Huanga Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaView further author information
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Min Zoua Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChinaView further author information
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Xiongjie Shid College of Life Sciences, the Institute for Advanced Studies, Wuhan University, Wuhan, ChinaView further author information
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Wei Jiange Molecular Medicine Research Center, West China Hospital of Sichuan University, Chengdu, ChinaView further author information
,
Rui Wangf Department of Cardiology, Yangpu Hospital, Tongji University, Shanghai, ChinaCorrespondence[email protected]
View further author information
&
Jinhan Hea Department of Pharmacy, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University. ChengduChina;c Laboratory of Clinical Pharmacy and Adverse Drug Reaction, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, ChengduChinaCorrespondence[email protected]
View further author information
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Pages 484-494 | Received 25 Feb 2020, Accepted 22 Jul 2020, Published online: 23 Aug 2020

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Hongbiao Ran, Qiuya He, Yuting Han, Jikun Wang, Haibo Wang, Binglin Yue, Ming Zhang, Zhixin Chai, Xin Cai, Jincheng Zhong & Hui Wang. (2023) Functional study and epigenetic targets analyses of SIRT1 in intramuscular preadipocytes via ChIP-seq and mRNA-seq. Epigenetics 18:1.
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Tuo Han, Yajie Fan, Jie Gao, Mahreen Fatima, Yali Zhang, Yiming Ding, Liang Bai & Congxia Wang. (2021) Sodium glucose cotransporter 2 inhibitor dapagliflozin depressed adiposity and ameliorated hepatic steatosis in high-fat diet induced obese mice. Adipocyte 10:1, pages 446-455.
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