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OncoImmunology Volume 4, 2015 - Issue 9
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Original Research

In vivo potential of recombinant granulysin against human tumors

Sameer Al-WasabyDepartment of Biochemistry and Molecular and Cell Biology; Apoptosis Immunity & Cancer Group; Faculty of Sciences; University of Zaragoza and Aragón Health Research Institute; Zaragoza, Spain
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Diego de MiguelDepartment of Biochemistry and Molecular and Cell Biology; Apoptosis Immunity & Cancer Group; Faculty of Sciences; University of Zaragoza and Aragón Health Research Institute; Zaragoza, Spain
,
Adriana AportaDepartment of Biochemistry and Molecular and Cell Biology; Apoptosis Immunity & Cancer Group; Faculty of Sciences; University of Zaragoza and Aragón Health Research Institute; Zaragoza, Spain
,
Javier NavalDepartment of Biochemistry and Molecular and Cell Biology; Apoptosis Immunity & Cancer Group; Faculty of Sciences; University of Zaragoza and Aragón Health Research Institute; Zaragoza, Spain
,
Blanca CondeDepartment of Human Anatomy and Histology; Faculty of Medicine; University of Zaragoza; Zaragoza, Spain; These authors share senior authorship.
,
Luis Martínez-LostaoDepartment of Biochemistry and Molecular and Cell Biology; Apoptosis Immunity & Cancer Group; Faculty of Sciences; University of Zaragoza and Aragón Health Research Institute; Zaragoza, Spain;Nanoscience Institute of Aragon; Zaragoza, Spain; These authors share senior authorship.
&
Alberto AnelDepartment of Biochemistry and Molecular and Cell Biology; Apoptosis Immunity & Cancer Group; Faculty of Sciences; University of Zaragoza and Aragón Health Research Institute; Zaragoza, Spain; These authors share senior authorship.Correspondence[email protected]
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Article: e1036213 | Received 18 Feb 2015, Accepted 21 Mar 2015, Published online: 27 Jul 2015

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Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Sameer Al-Wasaby, Rocío Navarro, Antonio Tapia-Galisteo, Diego De Miguel, Oscar Gonzalo, Blanca Conde, Luis Martínez-Lostao, Ramón Hurtado-Guerrero, Laura Sanz & Alberto Anel. (2019) Anti-tumoral potential of a human granulysin-based, CEA-targeted cytolytic immunotoxin . OncoImmunology 8:11.
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Articles from other publishers (14)

Ruth Soler-Agesta, Patricia Guerrero-Ochoa, Joaquín Marco-Brualla, Raquel Ibáñez-Pérez, Isabel Marzo, Luis Martínez-Lostao & Alberto Anel. (2022) Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity. International Journal of Molecular Sciences 23:15, pages 8705.
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Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero & Alberto Anel. (2022) Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment. Biomedicines 10:6, pages 1223.
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Valerio Rasi, Owais Abdul Hameed, Patricia Matthey, Sibes Bera, Duane P. Grandgenett, Stefan Salentinig, Michael Walch & Daniel F. Hoft. (2022) Improved Purification of Human Granzyme A/B and Granulysin Using a Mammalian Expression System. Frontiers in Immunology 13.
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Laura Sanz, Raquel Ibáñez-Pérez, Patricia Guerrero-Ochoa, Javier Lacadena & Alberto Anel. (2021) Antibody-Based Immunotoxins for Colorectal Cancer Therapy. Biomedicines 9:11, pages 1729.
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Gráinne Jameson & Mark W. Robinson. (2021) Insights Into Human Intrahepatic NK Cell Function From Single Cell RNA Sequencing Datasets. Frontiers in Immunology 12.
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Sameer Al-Wasaby, Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Ruth Soler, Blanca Conde, Luis Martínez-Lostao & Alberto Anel. (2021) In vivo potential of recombinant granulysin against human melanoma. Cancer Treatment and Research Communications 27, pages 100355.
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Patricia Guerrero-Ochoa, Diederich Aguilar-Machado, Raquel Ibáñez-Pérez, Javier Macías-León, Ramón Hurtado-Guerrero, Javier Raso & Alberto Anel. (2020) Production of a Granulysin-Based, Tn-Targeted Cytolytic Immunotoxin Using Pulsed Electric Field Technology. International Journal of Molecular Sciences 21:17, pages 6165.
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Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Ángel R. Payer, Segundo Gonzalez & Alejandro López-Soto. (2020) Mechanisms of Apoptosis Resistance to NK Cell-Mediated Cytotoxicity in Cancer. International Journal of Molecular Sciences 21:10, pages 3726.
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E. Sparrow & M.D. Bodman-Smith. (2020) Granulysin: The attractive side of a natural born killer. Immunology Letters 217, pages 126-132.
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Isabel Prager & Carsten Watzl. (2019) Mechanisms of natural killer cell-mediated cellular cytotoxicity. Journal of Leukocyte Biology 105:6, pages 1319-1329.
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Marcus Lettau, Michelle Dietz, Katharina Dohmen, Matthias Leippe, Dieter Kabelitz & Ottmar Janssen. (2019) Granulysin species segregate to different lysosome-related effector vesicles (LREV) and get mobilized by either classical or non-classical degranulation. Molecular Immunology 107, pages 44-53.
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Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Michael Dallas, Dawson Knoblock, Jean D. Boyer, Jian Yan, Russell Vang, Amir S. Khan, Laurent Humeau, Niranjan Y. Sardesai, J. Joseph Kim, Stanley Plotkin, David B. Weiner, Cornelia L. Trimble & Mark L. Bagarazzi. (2018) Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy. Clinical Cancer Research 24:2, pages 276-294.
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Ya-Wen Hsiao, Tsung-Ching Lai, Yu-Hsiang Lin, Chia-Yi Su, Jih-Jong Lee, Albert Taiching Liao, Yuan-Feng Lin, Shu-Chen Hsieh, Alexander T.H. Wu & Michael Hsiao. (2016) Granulysin expressed in a humanized mouse model induces apoptotic cell death and suppresses tumorigenicity. Oncotarget 8:48, pages 83495-83508.
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Xianghong Xu, Tao Qu, Ling Fan, Xiaomei Chen, Men Gao, Junping Zhang & Tiankang Guo. (2016) Preparation of pH- and magnetism-responsive sodium alginate/Fe 3 O 4 @HNTs nanocomposite beads for controlled release of granulysin . RSC Advances 6:113, pages 111747-111753.
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