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OncoImmunology Volume 5, 2016 - Issue 1
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Original Research

Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30

Christian KellnerDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, GermanyCorrespondence[email protected]
,
Andreas GüntherDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Andreas HumpeDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Roland ReppDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
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Katja KlauszDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Stefanie DererDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Thomas ValeriusDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Matthias Ritgen2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Monika Brüggemann2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Jan GJ van de WinkelGenmab; Utrecht, the Netherlands;Department of Immunology; University Medical Center Utrecht; Utrecht, the Netherlands
,
Paul WHI ParrenGenmab; Utrecht, the Netherlands;Department of Cancer and Inflammation Research; Institute of Molecular Medicine; University of Southern Denmark; Odense, Denmark;Department of Immunohematology and Blood Transfusion; Leiden University Medical Center; Leiden, the Netherlands
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Michael Kneba2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
,
Martin GramatzkiDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
&
Matthias PeippDivision of Stem Cell Transplantation and Immunotherapy, 2nd Department of Medicine; Christian-Albrechts-University Kiel; Kiel, Germany
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Article: e1058459 | Received 09 Feb 2015, Accepted 29 May 2015, Published online: 30 Nov 2015

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Maulik Vyas, Ann-Charlott Schneider, Olga Shatnyeva, Katrin S. Reiners, Samir Tawadros, Stephan Kloess, Ulrike Köhl, Michael Hallek, Hinrich P. Hansen & Elke Pogge von Strandmann. (2016) Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity in vitro and in vivo against chronic lymphocytic leukemia. OncoImmunology 5:9.
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Articles from other publishers (20)

Massimo Fantini, Philip Martin Arlen & Kwong Yok Tsang. (2023) Potentiation of natural killer cells to overcome cancer resistance to NK cell-based therapy and to enhance antibody-based immunotherapy. Frontiers in Immunology 14.
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Sebastian Lutz, Katja Klausz, Anca-Maria Albici, Lea Ebinger, Lea Sellmer, Hannah Teipel, André Frenzel, Anna Langner, Dorothee Winterberg, Steffen Krohn, Michael Hust, Thomas Schirrmann, Stefan Dübel, Regina Scherließ, Andreas Humpe, Martin Gramatzki, Christian Kellner & Matthias Peipp. (2023) Novel NKG2D-directed bispecific antibodies enhance antibody-mediated killing of malignant B cells by NK cells and T cells. Frontiers in Immunology 14.
Crossref
Katja Klausz, Lukas Pekar, Ammelie Svea Boje, Carina Lynn Gehlert, Steffen Krohn, Tushar Gupta, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Britta Lipinski, Lars Toleikis, Sven Poetzsch, Brian Rabinovich, Matthias Peipp & Stefan Zielonka. (2022) Multifunctional NK Cell–Engaging Antibodies Targeting EGFR and NKp30 Elicit Efficient Tumor Cell Killing and Proinflammatory Cytokine Release. The Journal of Immunology 209:9, pages 1724-1735.
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Ammelie Svea Boje, Katja Klausz, Lukas Pekar, Christian Kellner, Stefan Zielonka & Matthias Peipp. (2022) Rekrutierung von Natürlichen Killerzellen durch optimierte Immunliganden. BIOspektrum 28:6, pages 601-604.
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Matthias Peipp, Katja Klausz, Ammelie Svea Boje, Tobias Zeller, Stefan Zielonka & Christian Kellner. (2022) Immunotherapeutic targeting of activating natural killer cell receptors and their ligands in cancer. Clinical and Experimental Immunology 209:1, pages 22-32.
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Christian Kellner, Sebastian Lutz, Hans-Heinrich Oberg, Daniela Wesch, Anna Otte, Katarina J. Diemer, Hauke Wilcken, Dirk Bauerschlag, Claus-Christian Glüer, Christian Wichmann, Dieter Kabelitz, Jeanette H. W. Leusen, Katja Klausz, Andreas Humpe, Martin Gramatzki & Matthias Peipp. (2022) Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen. Biological Chemistry 403:5-6, pages 545-556.
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Ondřej Vaněk, Barbora Kalousková, Celeste Abreu, Shiva Nejadebrahim & Ondřej Skořepa. 2022. Immunotherapeutics. Immunotherapeutics 91 133 .
Barbora Kalousková, Ondřej Skořepa, Denis Cmunt, Celeste Abreu, Kateřina Krejčová, Jan Bláha, Irena Sieglová, Vlastimil Král, Milan Fábry, Robert Pola, Michal Pechar & Ondřej Vaněk. (2021) Tumor Marker B7-H6 Bound to the Coiled Coil Peptide-Polymer Conjugate Enables Targeted Therapy by Activating Human Natural Killer Cells. Biomedicines 9:11, pages 1597.
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Cristina Capuano, Chiara Pighi, Simone Battella, Davide De Federicis, Ricciarda Galandrini & Gabriella Palmieri. (2021) Harnessing CD16-Mediated NK Cell Functions to Enhance Therapeutic Efficacy of Tumor-Targeting mAbs. Cancers 13:10, pages 2500.
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Wei Zhang, Yu Qiu, Xiaoli Xie, Yao Fu, Lijuan Wang & Zhen Cai. (2021) B7 Family Members in Lymphoma: Promising Novel Targets for Tumor Immunotherapy?. Frontiers in Oncology 11.
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Lukas Pekar, Katja Klausz, Michael Busch, Bernhard Valldorf, Harald Kolmar, Daniela Wesch, Hans-Heinrich Oberg, Steffen Krohn, Ammelie Svea Boje, Carina Lynn Gehlert, Lars Toleikis, Simon Krah, Tushar Gupta, Brian Rabinovich, Stefan Zielonka & Matthias Peipp. (2021) Affinity Maturation of B7-H6 Translates into Enhanced NK Cell–Mediated Tumor Cell Lysis and Improved Proinflammatory Cytokine Release of Bispecific Immunoligands via NKp30 Engagement. The Journal of Immunology 206:1, pages 225-236.
Crossref
Ondřej Skořepa, Samuel Pazicky, Barbora Kalousková, Jan Bláha, Celeste Abreu, Tomáš Ječmen, Michal Rosůlek, Alexander Fish, Arthur Sedivy, Karl Harlos, Jan Dohnálek, Tereza Skálová & Ondřej Vaněk. (2020) Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N-Glycosylation. Cancers 12:7, pages 1998.
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Hanqing Chen, Yundi Guo, Jing Sun, Jun Dong, Qinghua Bao, Xueguang Zhang & Fengqing Fu. (2020) Preferential Expression of B7-H6 in Glioma Stem-Like Cells Enhances Tumor Cell Proliferation via the c-Myc/RNMT Axis. Journal of Immunology Research 2020, pages 1-12.
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Luyao Wang, Mei Dou, Qingxia Ma, Ruixue Yao & Jia Liu. (2019) Chimeric antigen receptor (CAR)-modified NK cells against cancer: Opportunities and challenges. International Immunopharmacology 74, pages 105695.
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Alexander David Barrow, Claudia Jane Martin & Marco Colonna. (2019) The Natural Cytotoxicity Receptors in Health and Disease. Frontiers in Immunology 10.
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Yizhou Zou, Weiguang Luo, Jing Guo, Qizhi Luo, Mi Deng, Zhigang Lu, Yi Fang & Cheng Cheng Zhang. (2018) NK cell-mediated anti-leukemia cytotoxicity is enhanced using a NKG2D ligand MICA and anti-CD20 scfv chimeric protein. European Journal of Immunology 48:10, pages 1750-1763.
Crossref
Tong Wang, Fumou Sun, Yang Wang, Jiahao Jiang, Mingzhu Pan, Minne Yuan, Hang Zhang, Xiaodian Du, Kamal Hezam, Kai Song, Min Wang & Juan Zhang. (2018) NKG2D Immunoligand rG7S-MICA Enhances NK Cell-mediated Immunosurveillance in Colorectal Carcinoma. Journal of Immunotherapy 41:3, pages 109-117.
Crossref
M. Peipp, D. Wesch, H.-H. Oberg, S. Lutz, A. Muskulus, J. G. J. van de Winkel, P. W. H. I. Parren, R. Burger, A. Humpe, D. Kabelitz, M. Gramatzki & C. Kellner. (2017) CD20-Specific Immunoligands Engaging NKG2D Enhance γδ T Cell-Mediated Lysis of Lymphoma Cells. Scandinavian Journal of Immunology 86:4, pages 196-206.
Crossref
Fang Fang, Weihua Xiao & Zhigang Tian. (2017) NK cell-based immunotherapy for cancer. Seminars in Immunology 31, pages 37-54.
Crossref
S S Hoseini & N K Cheung. (2017) Acute myeloid leukemia targets for bispecific antibodies. Blood Cancer Journal 7:2, pages e522-e522.
Crossref

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