OncoImmunology, Volume 5, Issue 1 (2016)

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OncoImmunology, Volume 5, Issue 1 (2016)

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Author's View

Opinion
Activation of cytomegalovirus-specific CD8+ T-cell response by antibody-mediated peptide-major histocompatibility class I complexes
Martina Schmittnaegel, Christian Klein, Victor Levitsky & Hendrik Knoetgen
Article: e1052930
Published online: 27 Oct 2015
AbstractforActivation of cytomegalovirus-specific CD8+ T-cell response by antibody-mediated peptide-major histocompatibility class I complexes | Full Text | References | PDF (148.5 KB)
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Opinion
Radiotherapy supports tumor-specific immunity by acute inflammation
Laura Surace, Nicole Angelika Scheifinger, Anurag Gupta & Maries van den Broek
Article: e1060391
Published online: 22 Oct 2015
AbstractforRadiotherapy supports tumor-specific immunity by acute inflammation | Full Text | References | PDF (52.7 KB)
  • 800 Views
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Opinion
Hyperthermic intra-peritoneal chemotherapy and anticancer immune response
Barbara Zunino & Jean-Ehrland Ricci
Article: e1060392
Published online: 22 Oct 2015
AbstractforHyperthermic intra-peritoneal chemotherapy and anticancer immune response | Full Text | References | PDF (158.8 KB)
  • 803 Views
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Opinion
Cancer cell associated glycans as targets for immunotherapy
Mireille Vankemmelbeke, Jia Xin Chua & Lindy G. Durrant
Article: e1061177
Published online: 22 Oct 2015
AbstractforCancer cell associated glycans as targets for immunotherapy | Full Text | References | PDF (123.3 KB)
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Opinion
Cytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors
Michele Ardolino & David H Raulet
Article: e1002725
Published online: 08 Jan 2016
AbstractforCytokine therapy restores antitumor responses of NK cells rendered anergic in MHC I-deficient tumors | Full Text | References | PDF (53.1 KB)
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Opinion
B7-H4 is a positive regulator of antitumor immunity
Ramtin Rahbar & Pamela S Ohashi
Article: e1050575
Published online: 04 Jan 2016
AbstractforB7-H4 is a positive regulator of antitumor immunity | Full Text | References | PDF (51.2 KB)
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Opinion
The role of NF-kB in modulating antitumor immunity
Ann Richmond & Jinming Yang
Article: e1005522
Published online: 04 Jan 2016
AbstractforThe role of NF-kB in modulating antitumor immunity | Full Text | References | PDF (166.9 KB)
  • 1124 Views
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Opinion
Reviving virus based cancer vaccines by using cytomegalovirus vectors expressing modified tumor antigens
Zhijuan Qiu, Jeremy M Grenier & Kamal M Khanna
Article: e1056974
Published online: 30 Nov 2015
AbstractforReviving virus based cancer vaccines by using cytomegalovirus vectors expressing modified tumor antigens | Full Text | References | PDF (171.5 KB)
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Opinion
All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy
Derek R Clements, Youra Kim, Shashi A Gujar & Patrick WK Lee
Article: e1057674
Published online: 08 Jan 2016
AbstractforAll that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy | Full Text | References | PDF (272.2 KB)
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Opinion
The thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity
V.A. Alamino, M.M. Montesinos, G.A. Rabinovich & C.G. Pellizas
Article: e1064579
Published online: 14 Dec 2015
AbstractforThe thyroid hormone triiodothyronine reinvigorates dendritic cells and potentiates anti-tumor immunity | Full Text | References | PDF (332.8 KB)
  • 787 Views
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Opinion
SA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer
Abhishek K. Srivastava, Esma S. Yolcu, Gunes Dinc, Rajesh K. Sharma & Haval Shirwan
Article: e1064580
Published online: 25 Jan 2016
AbstractforSA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer | Full Text | References | PDF (419.7 KB)
  • 768 Views
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Opinion
Targeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma?
Florie Bertrand, Julia Rochotte, Céline Colacios, Anne Montfort, Nathalie Andrieu-Abadie, Thierry Levade, Hervé Benoist & Bruno Ségui
Article: e1068495
Published online: 08 Jan 2016
AbstractforTargeting TNF alpha as a novel strategy to enhance CD8+ T cell-dependent immune response in melanoma? | Full Text | References | PDF (350.8 KB)
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Opinion
The extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity
Kristian Michael Hargadon
Article: e1069462
Published online: 30 Dec 2015
AbstractforThe extent to which melanoma alters tissue-resident dendritic cell function correlates with tumorigenicity | Full Text | References | PDF (383.6 KB)
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Opinion
Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment—Evidence to turn on the LIGHT
Ajay V. Maker
Article: e1069937
Published online: 01 Feb 2016
AbstractforPrecise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment—Evidence to turn on the LIGHT | Full Text | References | PDF (287.1 KB)
  • 786 Views
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Brief Report

Brief Report
Ibrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells
Gayathri Natarajan, Cesar Terrazas, Steve Oghumu, Sanjay Varikuti, Jason A Dubovsky, John C Byrd & Abhay R Satoskar
Article: e1057385
Published online: 30 Nov 2015
AbstractforIbrutinib enhances IL-17 response by modulating the function of bone marrow derived dendritic cells | Full Text | References | PDF (609.3 KB)
  • 1181 Views
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Editorial

Editorial
Oncolytic immunotherapy: The new clinical outbreak
Jean-François Fonteneau, Carole Achard, Cécile Zaupa, Johann Foloppe & Philippe Erbs
Article: e1066961
Published online: 08 Jan 2016
CitationforOncolytic immunotherapy: The new clinical outbreak | Full Text | References | PDF (192.8 KB)
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Editorial
Doubling the blockade for melanoma immunotherapy
Lorenzo Galluzzi, Alexander Eggermont & Guido Kroemer
Article: e1106127
Published online: 25 Jan 2016
First Page PreviewforDoubling the blockade for melanoma immunotherapy | Full Text | References | PDF (242.5 KB)
  • 1194 Views
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Editorial
First oncolytic virus approved for melanoma immunotherapy
Jonathan Pol, Guido Kroemer & Lorenzo Galluzzi
Article: e1115641
Published online: 17 Feb 2016
AbstractforFirst oncolytic virus approved for melanoma immunotherapy | Full Text | References | PDF (228.9 KB)
  • 8363 Views
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Original Research

Article
Interferon gamma modulates sensitivity of CML cells to tyrosine kinase inhibitors
Stefanie Andrea Erika Held, Annkristin Heine, Anne Ruth Kesper, Kathrin Schönberg, Anika Beckers, Dominik Wolf & Peter Brossart
Article: e1065368
Published online: 25 Jan 2016
AbstractforInterferon gamma modulates sensitivity of CML cells to tyrosine kinase inhibitors | Full Text | References | PDF (1.1 MB)
  • 1160 Views
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Article
Non-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis
Emilia Andersson, Isabel Poschke, Lisa Villabona, Joseph W Carlson, Andreas Lundqvist, Rolf Kiessling, Barbara Seliger & Giuseppe V Masucci
Article: e1052213
Published online: 04 Jan 2016
AbstractforNon-classical HLA-class I expression in serous ovarian carcinoma: Correlation with the HLA-genotype, tumor infiltrating immune cells and prognosis | Full Text | References | PDF (653.3 KB) | Supplemental
  • 1707 Views
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Open Access
Article
Effective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells
Jonathan P H Fisher, Barry Flutter, Florian Wesemann, Jennifer Frosch, Claudia Rossig, Kenth Gustafsson & John Anderson
Article: e1025194
Published online: 04 Jan 2016
AbstractforEffective combination treatment of GD2-expressing neuroblastoma and Ewing's sarcoma using anti-GD2 ch14.18/CHO antibody with Vγ9Vδ2+ γδT cells | Full Text | References | PDF (532.8 KB) | Supplemental
  • 2280 Views
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Article
Mucin 1-specific B cell immune responses and their impact on overall survival in breast cancer patients
Carlo Fremd, Stefan Stefanovic, Philipp Beckhove, Maria Pritsch, Hendry Lim, Markus Wallwiener, Joerg Heil, Michael Golatta, Joachim Rom, Christof Sohn, Andreas Schneeweiss, Florian Schuetz & Christoph Domschke
Article: e1057387
Published online: 27 Oct 2015
AbstractforMucin 1-specific B cell immune responses and their impact on overall survival in breast cancer patients | Full Text | References | PDF (249.8 KB)
  • 1246 Views
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Article
Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases
Anna S Berghoff, Elisabeth Fuchs, Gerda Ricken, Bernhard Mlecnik, Gabriela Bindea, Thomas Spanberger, Monika Hackl, Georg Widhalm, Karin Dieckmann, Daniela Prayer, Amelie Bilocq, Harald Heinzl, Christoph Zielinski, Rupert Bartsch, Peter Birner, Jerome Galon & Matthias Preusser
Article: e1057388
Published online: 22 Oct 2015
AbstractforDensity of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases | Full Text | References | PDF (527.6 KB) | Supplemental
  • 4056 Views
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Article
CD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis
Yuhong Liu, Claire E. O'Leary, Liang-Chuan S. Wang, Tricia R. Bhatti, Ning Dai, Veena Kapoor, Peihui Liu, Junjie Mei, Lei Guo, Paula M. Oliver, Steven M. Albelda & G. Scott Worthen
Article: e1061175
Published online: 22 Oct 2015
AbstractforCD11b+Ly6G+ cells inhibit tumor growth by suppressing IL-17 production at early stages of tumorigenesis | Full Text | References | PDF (915.1 KB)
  • 3067 Views
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Article
Identification of glypican-3-derived long peptides activating both CD8+ and CD4+ T cells; prolonged overall survival in cancer patients with Th cell response
Mohammad A. Sayem, Yusuke Tomita, Akira Yuno, Masatoshi Hirayama, Atsushi Irie, Hirotake Tsukamoto, Satoru Senju, Eiji Yuba, Toshiaki Yoshikawa, Kenji Kono, Tetsuya Nakatsura & Yasuharu Nishimura
Article: e1062209
Published online: 22 Oct 2015
AbstractforIdentification of glypican-3-derived long peptides activating both CD8+ and CD4+ T cells; prolonged overall survival in cancer patients with Th cell response | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1974 Views
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Article
Role of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia
Anna Martner, Anna Rydström, Rebecca E Riise, Johan Aurelius, Harald Anderson, Mats Brune, Robin Foà, Kristoffer Hellstrand, Fredrik B Thorén & for the Re:Mission Study Group
Article: e1041701
Published online: 10 Dec 2015
AbstractforRole of natural killer cell subsets and natural cytotoxicity receptors for the outcome of immunotherapy in acute myeloid leukemia | Full Text | References | PDF (1 MB) | Supplemental
  • 1869 Views
  • 29 CrossRef citations
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Article
Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells
Ole Audun Werner Haabeth, Kristina Berg Lorvik, Hideo Yagita, Bjarne Bogen & Alexandre Corthay
Article: e1039763
Published online: 04 Jan 2016
AbstractforInterleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells | Full Text | References | PDF (577.7 KB) | Supplemental
  • 3214 Views
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Article
Cryoablation and Meriva have strong therapeutic effect on triple-negative breast cancer
Dinesh Chandra, Arthee Jahangir, Francois Cornelis, Klara Rombauts, Lydie Meheus, Cheryl L Jorcyk & Claudia Gravekamp
Article: e1049802
Published online: 04 Jan 2016
AbstractforCryoablation and Meriva have strong therapeutic effect on triple-negative breast cancer | Full Text | References | PDF (695.7 KB) | Supplemental
  • 1499 Views
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Article
Biological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis
H Bonsang-Kitzis, B Sadacca, AS Hamy-Petit, M Moarii, A Pinheiro, C Laurent & F Reyal
Article: e1061176
Published online: 12 Jan 2016
AbstractforBiological network-driven gene selection identifies a stromal immune module as a key determinant of triple-negative breast carcinoma prognosis | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1372 Views
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Article
Enhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30
Christian Kellner, Andreas Günther, Andreas Humpe, Roland Repp, Katja Klausz, Stefanie Derer, Thomas Valerius, Matthias Ritgen, Monika Brüggemann, Jan GJ van de Winkel, Paul WHI Parren, Michael Kneba, Martin Gramatzki & Matthias Peipp
Article: e1058459
Published online: 30 Nov 2015
AbstractforEnhancing natural killer cell-mediated lysis of lymphoma cells by combining therapeutic antibodies with CD20-specific immunoligands engaging NKG2D or NKp30 | Full Text | References | PDF (949 KB) | Supplemental
  • 1616 Views
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Article
Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism
Sara Labiano, Asis Palazón, Elixabet Bolaños, Arantza Azpilikueta, Alfonso R. Sánchez-Paulete, Aizea Morales-Kastresana, Jose I. Quetglas, José L. Perez-Gracia, Alfonso Gúrpide, Maria Rodriguez-Ruiz, M. Angela Aznar, Maria Jure-Kunkel, Pedro Berraondo & Ignacio Melero
Article: e1062967
Published online: 25 Jan 2016
AbstractforHypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2168 Views
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Article
Interleukin 33 in tumor microenvironment is crucial for the accumulation and function of myeloid-derived suppressor cells
Peng Xiao, Xiaopeng Wan, Bijun Cui, Yang Liu, Chenyang Qiu, Jiabing Rong, Mingzhu Zheng, Yinjing Song, Luoquan Chen, Jia He, Qinchun Tan, Xiaojia Wang, Xiying Shao, Yuhua Liu, Xuetao Cao & Qingqing Wang
Article: e1063772
Published online: 14 Dec 2015
AbstractforInterleukin 33 in tumor microenvironment is crucial for the accumulation and function of myeloid-derived suppressor cells | Full Text | References | PDF (1.7 MB) | Supplemental
  • 2853 Views
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Article
Comparison of naïve and central memory derived CD8+ effector cell engraftment fitness and function following adoptive transfer
Xiuli Wang, ChingLam W. Wong, Ryan Urak, Ellie Taus, Brenda Aguilar, Wen-Chung Chang, Armen Mardiros, Lihua E. Budde, Christine E. Brown, Carolina Berger, Stephen J. Forman & Michael C. Jensen
Article: e1072671
Published online: 17 Feb 2016
AbstractforComparison of naïve and central memory derived CD8+ effector cell engraftment fitness and function following adoptive transfer | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1939 Views
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Article
T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma
Nathan Singh, Irina Kulikovskaya, David M. Barrett, Gwendolyn Binder-Scholl, Bent Jakobsen, Daniel Martinez, Bruce Pawel, Carl H. June, Michael D. Kalos & Stephan A. Grupp
Article: e1040216
Published online: 04 Jan 2016
AbstractforT cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma | Full Text | References | PDF (1,010.4 KB) | Supplemental
  • 3201 Views
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Article
Favorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination
Kalijn F Bol, Erik H J G Aarntzen, Florentien E M in 't Hout, Gerty Schreibelt, Jeroen H A Creemers, W Joost Lesterhuis, Winald R Gerritsen, Dirk J Grunhagen, Cornelis Verhoef, Cornelis J A Punt, Johannes J Bonenkamp, Johannes H W de Wilt, Carl G Figdor & I Jolanda M de Vries
Article: e1057673
Published online: 04 Jan 2016
AbstractforFavorable overall survival in stage III melanoma patients after adjuvant dendritic cell vaccination | Full Text | References | PDF (249.6 KB) | Supplemental
  • 1207 Views
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Article
Human ectonucleotidase-expressing CD25high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions
Marion Thibaudin, Marie Chaix, Romain Boidot, Frédérique Végran, Valentin Derangère, Emeric Limagne, Hélène Berger, Sylvain Ladoire, Lionel Apetoh & François Ghiringhelli
Article: e1055444
Published online: 23 Dec 2015
AbstractforHuman ectonucleotidase-expressing CD25high Th17 cells accumulate in breast cancer tumors and exert immunosuppressive functions | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1485 Views
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Article
PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance
Alessandra Dondero, Fabio Pastorino, Mariella Della Chiesa, Maria Valeria Corrias, Fabio Morandi, Vito Pistoia, Daniel Olive, Francesca Bellora, Franco Locatelli, Aurora Castellano, Lorenzo Moretta, Alessandro Moretta, Cristina Bottino & Roberta Castriconi
Article: e1064578
Published online: 08 Jan 2016
AbstractforPD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance | Full Text | References | PDF (885.3 KB) | Supplemental
  • 2421 Views
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Article
The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
Kirsten D. Mertz, Lukas F. Mager, Marie-Hélène Wasmer, Thore Thiesler, Viktor H. Koelzer, Giulia Ruzzante, Stefanie Joller, Jenna R. Murdoch, Thomas Brümmendorf, Vera Genitsch, Alessandro Lugli, Gieri Cathomas, Holger Moch, Achim Weber, Inti Zlobec, Tobias Junt & Philippe Krebs
Article: e1062966
Published online: 04 Jan 2016
AbstractforThe IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2763 Views
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Article
Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype
Sanjeeb Shrestha, Jae Myoung Noh, Shin-Yeong Kim, Hwa-Yong Ham, Yeon-Ja Kim, Young-Jin Yun, Min-Ju Kim, Min-Soo Kwon, Dong-Keun Song & Chang-Won Hong
Article: e1067744
Published online: 08 Jan 2016
AbstractforAngiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1660 Views
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Article
Long-lasting multifunctional CD8+ T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination
Florian Wimmers, Erik H. J. G. Aarntzen, Tjitske Duiveman-deBoer, Carl G. Figdor, Joannes F. M. Jacobs, Jurjen Tel & I. Jolanda M. de Vries
Article: e1067745
Published online: 08 Jan 2016
AbstractforLong-lasting multifunctional CD8+ T cell responses in end-stage melanoma patients can be induced by dendritic cell vaccination | Full Text | References | PDF (1.5 MB) | Supplemental
  • 1628 Views
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Article
Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses
Yusuf Dölen, Martin Kreutz, Uzi Gileadi, Jurjen Tel, Angela Vasaturo, Eric A. W. van Dinther, Maaike A. van Hout-Kuijer, Vincenzo Cerundolo & Carl G. Figdor
Article: e1068493
Published online: 08 Jan 2016
AbstractforCo-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses | Full Text | References | PDF (941.8 KB) | Supplemental
  • 3157 Views
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Article
Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models
Marine M Leblond, Aurélie N Gérault, Aurélien Corroyer-Dulmont, Eric T MacKenzie, Edwige Petit, Myriam Bernaudin & Samuel Valable
Article: e1056442
Published online: 17 Dec 2015
AbstractforHypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models | Full Text | References | PDF (1.2 MB) | Supplemental
  • 3441 Views
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Article
Failure recovery of circulating NKG2D+CD56dimNK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence
Jian Gao, Zhaojun Duan, Ling Zhang, Xiangbo Huang, Lu Long, Jing Tu, Hua Liang, Yu Zhang, Tao Shen & Fengmin Lu
Article: e1048061
Published online: 17 Feb 2016
AbstractforFailure recovery of circulating NKG2D+CD56dimNK cells in HBV-associated hepatocellular carcinoma after hepatectomy predicts early recurrence | Full Text | References | PDF (952.8 KB) | Supplemental
  • 1115 Views
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Article
PD-1 expression conditions T cell avidity within an antigen-specific repertoire
Sylvain Simon, Virginie Vignard, Laetitia Florenceau, B. Dreno, A. Khammari, F. Lang & N. Labarriere
Article: e1104448
Published online: 17 Feb 2016
AbstractforPD-1 expression conditions T cell avidity within an antigen-specific repertoire | Full Text | References | PDF (1.1 MB) | Supplemental
  • 2808 Views
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View Point

Opinion
(Compl)Ex-Th17–Treg cell inter-relationship
Nataša Obermajer & Marc H Dahlke
Article: e1040217
Published online: 23 Dec 2015
Abstractfor(Compl)Ex-Th17–Treg cell inter-relationship | Full Text | References | PDF (311.6 KB)
  • 1002 Views
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Review

Review
T cell receptor mimic antibodies for cancer therapy
Leonid Dubrovsky, Tao Dao, Ron S Gejman, Elliott J Brea, Aaron Y Chang, Claire Y Oh, Emily Casey, Dmitry Pankov & David A Scheinberg
Article: e1049803
Published online: 04 Jan 2016
AbstractforT cell receptor mimic antibodies for cancer therapy | Full Text | References | PDF (374.9 KB)
  • 2424 Views
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Review
Enhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors
José Yélamos, Miguel Galindo, Judith Navarro, Joan Albanell, Ana Rovira, Federico Rojo & Javier Oliver
Article: e1065370
Published online: 08 Jan 2016
AbstractforEnhancing tumor-targeting monoclonal antibodies therapy by PARP inhibitors | Full Text | References | PDF (825 KB)
  • 1045 Views
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Corrigendum

Correction
Corrigendum
Article: e1104009
Published online: 17 Feb 2016
CitationforCorrigendum | Full Text | PDF (82.7 KB)
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