3,001
Views
45
CrossRef citations to date
0
Altmetric
Original Research

Regulatory T cells that co-express RORγt and FOXP3 are pro-inflammatory and immunosuppressive and expand in human pancreatic cancer

, , , , , , & show all
Article: e1102828 | Received 24 Aug 2015, Accepted 26 Sep 2015, Published online: 08 Apr 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Wenqing Yu, Ningfei Ji, Chengjing Gu, Juan Yao, Mingdong Ding, Daming Zhou, Mao Huang & Mingshun Zhang. (2021) IRF4 is Correlated with the Conversion to a Th17-Like Phenotype in Regulatory T Cells from the Malignant Pleural Effusion. International Journal of General Medicine 14, pages 6009-6019.
Read now
Yuanyuan Yu, Kathleen Schuck, Helmut Friess & Bo Kong. (2021) Targeting Aggressive Fibroblasts to Enhance the Treatment of Pancreatic Cancer. Expert Opinion on Therapeutic Targets 25:1, pages 5-13.
Read now
Ezekiel Maloney, Tanya Khokhlova, Venu G. Pillarisetty, George R. Schade, Elizabeth A. Repasky, Yak-Nam Wang, Lorenzo Giuliani, Matteo Primavera & Joo Ha Hwang. (2017) Focused ultrasound for immuno-adjuvant treatment of pancreatic cancer: An emerging clinical paradigm in the era of personalized oncotherapy. International Reviews of Immunology 36:6, pages 338-351.
Read now

Articles from other publishers (41)

Matthew H G Katz, Gina R Petroni, Todd Bauer, Matthew J Reilley, Brian M Wolpin, Chee-Chee Stucky, Tanios S Bekaii-Saab, Rawad Elias, Nipun Merchant, Andressa Dias Costa, Patrick Lenehan, Victoire Cardot-Ruffino, Scott Rodig, Kathleen Pfaff, Stephanie K Dougan, Jonathan Andrew Nowak, Gauri R Varadhachary, Craig L Slingluff & Osama Rahma. (2023) Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma. Journal for ImmunoTherapy of Cancer 11:12, pages e007586.
Crossref
Lei Zhu, Dong Tu, Ruixue Li, Lin Li, Wenjie Zhang, Wenxiang Jin, Tiehan Li & Hong Zhu. (2023) The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study. Frontiers in Genetics 14.
Crossref
Qing Chen, Siqian Ren, Songping Cui, Jincan Huang, Di Wang, Binglin Li, Qiang He & Ren Lang. (2023) Prognostic and recurrent significance of SII in patients with pancreatic head cancer undergoing pancreaticoduodenectomy. Frontiers in Oncology 13.
Crossref
Yan Du, Lin Zhu, Xin Li, Huaqing Shi, Wenkai Jiang & Wence Zhou. (2023) Immunocyte Infiltration Analysis and Immunohistochemistry Identify EVL as a Potential Prognostic Biomarker for Pancreatic Cancer. Journal of Personalized Medicine 13:3, pages 433.
Crossref
Phei Er Saw & Erwei Song. 2023. Tumor Ecosystem. Tumor Ecosystem 443 468 .
Pooya Farhangnia, Shamim Mollazadeh Ghomi, Shabnam Mollazadehghomi & Ali-Akbar Delbandi. 2023.
Tha Luong, Yuvasri Golivi, Ganji Purnachandra Nagaraju & Bassel F. El-Rayes. (2022) Fibroblast heterogeneity in pancreatic ductal adenocarcinoma: Perspectives in immunotherapy. Cytokine & Growth Factor Reviews 68, pages 107-115.
Crossref
Catherine Davidson, David Taggart, Andrew H. Sims, David W. Lonergan, Marta Canel & Alan Serrels. (2022) FAK promotes stromal PD-L2 expression associated with poor survival in pancreatic cancer. British Journal of Cancer 127:10, pages 1893-1905.
Crossref
Chunping Liu, Dongyue He, Longmei Li, Shihui Zhang, Lei Wang, Zhijin Fan & Yichao Wang. (2022) Extracellular vesicles in pancreatic cancer immune escape: Emerging roles and mechanisms. Pharmacological Research 183, pages 106364.
Crossref
Rui Zhang, Jinlin Miao, Kui Zhang, Bei Zhang, Xing Luo, Haoyang Sun, Zhaohui Zheng & Ping Zhu. (2022) Th1-Like Treg Cells Are Increased But Deficient in Function in Rheumatoid Arthritis. Frontiers in Immunology 13.
Crossref
Zhifeng Liu, Yi Jiao, Tianyuan Yu, Hourong Wang, Yingqi Zhang, Di Liu, Yajing Xu, Qian Guan & Mengqian Lu. (2022) A Review on the Immunomodulatory Mechanism of Acupuncture in the Treatment of Inflammatory Bowel Disease. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-9.
Crossref
Yuchao Fei, Yifan Cao, Yun Gu, Hanji Fang, Yifan Chen, Jieti Wang, Xin Liu, Kunpeng Lv, Xudong He, Chao Lin, Hao Liu, He Li, Hongyong He, Ruochen Li, Heng Zhang & Weijuan Zhang. (2021) Intratumoral Foxp3+RORγt+ T cell infiltration determines poor prognosis and immunoevasive contexture in gastric cancer patients. Cancer Immunology, Immunotherapy 71:1, pages 1-11.
Crossref
Kushi Kushekhar, Stalin Chellappa, Einar M. Aandahl & Kjetil Taskén. 2022. Biomarkers of the Tumor Microenvironment. Biomarkers of the Tumor Microenvironment 159 182 .
Masakazu Hashimoto, John David Konda, Stephanie Perrino, Maria Celia Fernandez, Andrew M. Lowy & Pnina Brodt. (2021) Targeting the IGF-Axis Potentiates Immunotherapy for Pancreatic Ductal Adenocarcinoma Liver Metastases by Altering the Immunosuppressive Microenvironment. Molecular Cancer Therapeutics 20:12, pages 2469-2482.
Crossref
Lenka Rossmeislová, Jan Gojda & Katarína Smolková. (2021) Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?. Cancer and Metastasis Reviews 40:4, pages 1115-1139.
Crossref
Lorena Ostios-Garcia, Julia Villamayor, Esther Garcia-Lorenzo, David Vinal & Jaime Feliu. (2021) Understanding the immune response and the current landscape of immunotherapy in pancreatic cancer. World Journal of Gastroenterology 27:40, pages 6775-6793.
Crossref
Linh-Huyen Truong & Siim Pauklin. (2021) Pancreatic Cancer Microenvironment and Cellular Composition: Current Understandings and Therapeutic Approaches. Cancers 13:19, pages 5028.
Crossref
Lucie Bernard-Raichon, André Colom, Sarah C. Monard, Amine Namouchi, Margaux Cescato, Hugo Garnier, Stephen A. Leon-Icaza, Arnaud Métais, Alexia Dumas, Dan Corral, Natsinet Ghebrendrias, Pauline Guilloton, Christel Vérollet, Denis Hudrisier, Aude Remot, Philippe Langella, Muriel Thomas, Céline Cougoule, Olivier Neyrolles & Geanncarlo Lugo-Villarino. (2021) A Pulmonary Lactobacillus murinus Strain Induces Th17 and RORγt+ Regulatory T Cells and Reduces Lung Inflammation in Tuberculosis . The Journal of Immunology 207:7, pages 1857-1870.
Crossref
Aneesha Kulkarni & Laura W. Bowers. (2021) The role of immune dysfunction in obesity-associated cancer risk, progression, and metastasis. Cellular and Molecular Life Sciences 78:7, pages 3423-3442.
Crossref
Magdalena Huber, Corinna U. Brehm, Thomas M. Gress, Malte Buchholz, Bilal Alashkar Alhamwe, Elke von Strandmann, Emily P. Slater, Jörg W. Bartsch, Christian Bauer & Matthias Lauth. (2020) The Immune Microenvironment in Pancreatic Cancer. International Journal of Molecular Sciences 21:19, pages 7307.
Crossref
M.A. Alobaid, S.-J. Richards, M.R. Alexander, M.I. Gibson & A.M. Ghaemmaghami. (2020) Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties. Materials Today Bio 8, pages 100080.
Crossref
Yinhsuan Michely Chen, Shu Qi, Stephanie Perrino, Masakazu Hashimoto & Pnina Brodt. (2020) Targeting the IGF-Axis for Cancer Therapy: Development and Validation of an IGF-Trap as a Potential Drug. Cells 9:5, pages 1098.
Crossref
Runze Qiu, Liyu Zhou, Yuanjing Ma, Lingling Zhou, Tao Liang, Le Shi, Jun Long & Dongping Yuan. (2018) Regulatory T Cell Plasticity and Stability and Autoimmune Diseases. Clinical Reviews in Allergy & Immunology 58:1, pages 52-70.
Crossref
J. G. Anderson, A. Kol, P. Bizikova, B. P. Stapelton, K. Ford, A. Villarreal, R. J. Jimenez, D Vasilatis & B. G. Murphy. (2020) Immunopathogenesis of canine chronic ulcerative stomatitis. PLOS ONE 15:1, pages e0227386.
Crossref
Aleksei Titov, Aygul Valiullina, Ekaterina Zmievskaya, Ekaterina Zaikova, Alexey Petukhov, Regina Miftakhova, Emil Bulatov & Albert Rizvanov. (2020) Advancing CAR T-Cell Therapy for Solid Tumors: Lessons Learned from Lymphoma Treatment. Cancers 12:1, pages 125.
Crossref
Xiaomeng Liu, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Qingcai Meng, Jie Hua, Xianjun Yu & Si Shi. (2019) The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications. Molecular Cancer 18:1.
Crossref
Rika Kato, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Shinichiro Nakachi, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Kanae Kubo, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto & Keishi Fujio. (2019) CD4+CD25+LAG3+ T Cells With a Feature of Th17 Cells Associated With Systemic Lupus Erythematosus Disease Activity. Frontiers in Immunology 10.
Crossref
Michael D. Powell, Kaitlin A. Read, Bharath K. Sreekumar & Kenneth J. Oestreich. (2019) Ikaros Zinc Finger Transcription Factors: Regulators of Cytokine Signaling Pathways and CD4+ T Helper Cell Differentiation. Frontiers in Immunology 10.
Crossref
Dounia Chraa, Asmaa Naim, Daniel Olive & Abdallah Badou. (2019) T lymphocyte subsets in cancer immunity: Friends or foes. Journal of Leukocyte Biology 105:2, pages 243-255.
Crossref
Kelly A. Remedios, Bahar ZirakPriscila Munoz SandovalMargaret M. LoweDevi Boda, Evan HenleyShrishti BhattraiTiffany C. ScharschmidtWilson LiaoHaley B. NaikMichael D. Rosenblum. (2018) The TNFRSF members CD27 and OX40 coordinately limit T H 17 differentiation in regulatory T cells . Science Immunology 3:30.
Crossref
Juhao Yang, Mangge Zou, Joern Pezoldt, Xuyu Zhou & Jochen Huehn. (2018) Thymus-derived Foxp3+ regulatory T cells upregulate RORγt expression under inflammatory conditions. Journal of Molecular Medicine 96:12, pages 1387-1394.
Crossref
Kun Fan, Chao Yang, Zhiyao Fan, Qiuyi Huang, Yiyin Zhang, He Cheng, Kaizhou Jin, Yu Lu, Zhengshi Wang, Guopei Luo, Xianjun Yu & Chen Liu. (2018) MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer. Cancer Letters 418, pages 167-175.
Crossref
Reiner K. W. Mailer. (2018) Alternative Splicing of FOXP3—Virtue and Vice. Frontiers in Immunology 9.
Crossref
Jinhua Wang, Wan Li, Ying Zhao, De Kang, Weiqi Fu, Xiangjin Zheng, Xiaocong Pang & Guanhua Du. (2018) Members of FOX family could be drug targets of cancers. Pharmacology & Therapeutics 181, pages 183-196.
Crossref
Isaac Rosado-Sánchez, Inés Herrero-Fernández, Laura Tarancon-Diez, Santiago Moreno, Jose Antonio Iribarren, David Dalmau, Francisco Vera-Méndez, Manuel Leal & Yolanda María Pacheco. (2018) Increased frequencies of Th17 cells and IL17a-producing regulatory T-cells preceding the immunodiscordant response to antiretroviral treatment. Journal of Infection 76:1, pages 86-92.
Crossref
Joern Pezoldt, Juhao Yang, Mangge Zou & Jochen Huehn. 2018. The Gut Microbiome in Health and Disease. The Gut Microbiome in Health and Disease 119 140 .
I.H. Sahin, G. Askan, Z.I. Hu & E.M. O’Reilly. (2017) Immunotherapy in pancreatic ductal adenocarcinoma: an emerging entity?. Annals of Oncology 28:12, pages 2950-2961.
Crossref
Juan-juan Dai, Ming-jie Jiang, Xing-Peng Wang & Ling Tian. (2017) Inflammation-Related Pancreatic Carcinogenesis. Pancreas 46:8, pages 973-985.
Crossref
Kirsten A Ward‐Hartstonge & Roslyn A Kemp. (2017) Regulatory T‐cell heterogeneity and the cancer immune response. Clinical & Translational Immunology 6:9.
Crossref
Chen Liu, He Cheng, Guopei Luo, Yu Lu, Kaizhou Jin, Meng Guo, Quanxing Ni & Xianjun Yu. (2017) Circulating regulatory T cell subsets predict overall survival of patients with unresectable pancreatic cancer. International Journal of Oncology 51:2, pages 686-694.
Crossref
Stalin Chellappa, Einar M. Aandahl & Kjetil Taskén. 2017. Biomarkers of the Tumor Microenvironment. Biomarkers of the Tumor Microenvironment 195 220 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.