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OncoImmunology Volume 5, 2016 - Issue 5
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Editorial

STAT3 inhibition for cancer therapy: Cell-autonomous effects only?

Guido KroemerEquipe 11 labellisée Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France;INSERM, U1138, Paris, France;Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France;Université Pierre et Marie Curie/Paris VI, Paris, France;Metabolomics and Cell Biology Platforms, GustaveRoussy Comprehensive Cancer Center, Villejuif, France;Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France;Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, SwedenCorrespondence[email protected]
,
Lorenzo GalluzziEquipe 11 labellisée Ligue Nationale contre le Cancer, Center de Recherche des Cordeliers, Paris, France;INSERM, U1138, Paris, France;Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France;Université Pierre et Marie Curie/Paris VI, Paris, France;Gustave Roussy Comprehensive Cancer Center, Villejuif, France
&
Laurence ZitvogelGustave Roussy Comprehensive Cancer Center, Villejuif, France;INSERM, U1015, Equipe labellisé e Ligue Nationale Contre le Cancer, Villejuif, France;University of Paris Sud/Paris XI, Le Kremlin-Bicêtre, France;Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, Villejuif, France
Article: e1126063 | Received 22 Nov 2015, Accepted 24 Nov 2015, Published online: 11 May 2016

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Chunwan Lu, Asif Talukder, Natasha M. Savage, Nagendra Singh & Kebin Liu. (2017) JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer. OncoImmunology 6:3.
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Articles from other publishers (10)

Rongruo Zeng, Lulu Wang, Yuxu Zhang, Ye Yang, Jie Yang & Yan Qin. (2023) Exploring the immunological role and prognostic potential of PPM1M in pan-cancer. Medicine 102:12, pages e32758.
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Jamie V. Shiah, Jennifer R. Grandis & Daniel E. Johnson. (2021) Targeting STAT3 with Proteolysis Targeting Chimeras and Next-Generation Antisense Oligonucleotides. Molecular Cancer Therapeutics 20:2, pages 219-228.
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Dayson Moreira, Sagus Sampath, Haejung Won, Seok Voon White, Yu-Lin Su, Marice Alcantara, Chongkai Wang, Peter Lee, Ellie Maghami, Erminia Massarelli & Marcin Kortylewski. (2021) Myeloid cell–targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell–mediated immunity. Journal of Clinical Investigation 131:2.
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Ying Fan, Shu Li, Xiaoyan Ding, Jian Yue, Jun Jiang, Hong Zhao, Rui Hao, Weiliang Qiu, Kezhen Liu, Ying Li, Shengdian Wang, Limin Zheng, Bin Ye, Kun Meng & Binghe Xu. (2019) First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers. BMC Cancer 19:1.
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Yue-Ting K. Lau, Malini Ramaiyer, Daniel E. Johnson & Jennifer R. Grandis. (2019) Targeting STAT3 in Cancer with Nucleotide Therapeutics. Cancers 11:11, pages 1681.
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Granato, Gilardini Montani, Zompetta, Santarelli, Gonnella, Romeo, D’Orazi, Faggioni & Cirone. (2019) Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization. Biomolecules 9:9, pages 482.
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Jennifer Huynh, Ashwini Chand, Daniel Gough & Matthias Ernst. (2018) Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map. Nature Reviews Cancer 19:2, pages 82-96.
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Dayson Moreira, Tomasz Adamus, Xingli Zhao, Yu-Lin Su, Zhuoran Zhang, Seok Voon White, Piotr Swiderski, Xin Lu, Ronald A. DePinho, Sumanta K. Pal & Marcin Kortylewski. (2018) STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers. Clinical Cancer Research 24:23, pages 5948-5962.
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Olga S. Blomberg, Lorenzo Spagnuolo & Karin E. de Visser. (2018) Immune regulation of metastasis: mechanistic insights and therapeutic opportunities. Disease Models & Mechanisms 11:10.
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Joaquim Bosch-Barrera, Elia Sais, Noemí Cañete, Jordi Marruecos, Elisabet Cuyàs, Angel Izquierdo, Rut Porta, Manel Haro, Joan Brunet, Salvador Pedraza & Javier A. Menendez. (2016) Response of brain metastasis from lung cancer patients to an oral nutraceutical product containing silibinin. Oncotarget 7:22, pages 32006-32014.
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