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OncoImmunology Volume 5, 2016 - Issue 7
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Original Research

Myeloid PTEN deficiency impairs tumor-immune surveillance via immune-checkpoint inhibition

M. KuttkeInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
E. SahinInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
J. PisoniInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
S. PercigInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
A. VogelInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
D. KraemmerInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
L. HanzlInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
J. S. BrunnerInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
H. PaarInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, Austria
,
K. SoukupSt. Anna Children's Cancer Research Institute, Vienna, Austria
,
A. HalfmannSt. Anna Children's Cancer Research Institute, Vienna, Austria
,
A. M. DohnalSt. Anna Children's Cancer Research Institute, Vienna, Austria
,
C. W. SteinerDepartment of RheumatologyInternal Medicine III, Medical University of Vienna, Vienna, Austria
,
S. BlümlDepartment of RheumatologyInternal Medicine III, Medical University of Vienna, Vienna, Austria
,
J. BasilioInstitute for Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology Medical University of Vienna, Vienna, Austria
,
B. HochreiterInstitute for Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology Medical University of Vienna, Vienna, Austria
,
M. SalzmannInstitute for Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology Medical University of Vienna, Vienna, Austria
,
B. HoeselInstitute for Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology Medical University of Vienna, Vienna, Austria
,
G. LametschwandtnerApeiron Biologics AG, Vienna, Austria
,
R. EferlInstitute of Cancer Research, Internal Medicine I, Medical University of Vienna, Vienna, Austria
,
J. A. SchmidInstitute for Vascular Biology and Thrombosis Research, Center for Physiology and Pharmacology Medical University of Vienna, Vienna, Austria
&
G. SchabbauerInstitute for Physiology, Center for Physiology and Pharmacology, Medical University of ViennaVienna, AustriaCorrespondence[email protected]
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Article: e1164918 | Received 30 Oct 2015, Accepted 08 Mar 2016, Published online: 28 Mar 2016

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Isaure Vanmeerbeek, Jenny Sprooten, Dirk De Ruysscher, Sabine Tejpar, Peter Vandenberghe, Jitka Fucikova, Radek Spisek, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi & Abhishek D. Garg. (2020) Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology. OncoImmunology 9:1.
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Abhishek D. Garg, Sanket More, Nicole Rufo, Odeta Mece, Maria Livia Sassano, Patrizia Agostinis, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2017) Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics. OncoImmunology 6:12.
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Articles from other publishers (11)

Dae Young Lee, Eunji Im, Dahye Yoon, Young-Seob Lee, Geum-Soog Kim, Donghwi Kim & Sung-Hoon Kim. (2022) Pivotal role of PD-1/PD-L1 immune checkpoints in immune escape and cancer progression: Their interplay with platelets and FOXP3+Tregs related molecules, clinical implications and combinational potential with phytochemicals. Seminars in Cancer Biology 86, pages 1033-1057.
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Rong Qiu, Wenxi Wang, Juan Li & Yuxiang Wang. (2022) Roles of PTEN inactivation and PD-1/PD-L1 activation in esophageal squamous cell carcinoma. Molecular Biology Reports 49:7, pages 6633-6645.
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Zixuan Wang, Xinyuan Wei, Caili Ji, Wenhua Yu, Chuanwang Song & Caizhi Wang. (2022) PGE2 inhibits neutrophil phagocytosis through the EP2R–cAMP–PTEN pathway. Immunity, Inflammation and Disease 10:7.
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Mario Kuttke, Dominika Hromadová, Ceren Yildirim, Julia S. Brunner, Andrea Vogel, Hannah Paar, Sophie Peters, Maria Weber, Melanie Hofmann, Martina Kerndl, Markus Kieler, Hannes Datler, Laszlo Musiejovsky, Manuel Salzmann, Michaela Lang, Klara Soukup, Angela Halfmann, Omar Sharif & Gernot Schabbauer. (2022) PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis. Frontiers in Immunology 13.
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Antonella Papa & Pier Paolo Pandolfi. 2022. PI3K and AKT Isoforms in Immunity. PI3K and AKT Isoforms in Immunity 95 115 .
Yi Huang, Huanyu Wang, Yize Hao, Hualong Lin, Menghao Dong, Jin Ye, Lei Song, Yunzhi Wang, Qingqing Li, Benjie Shan, Yizhou Jiang, Hongqi Li, Zhiming Shao, Guido Kroemer, Huafeng Zhang, Li Bai, Tengchuan Jin, Chao Wang, Yuting Ma, Yongping Cai, Chen Ding, Suling Liu, Yueyin Pan, Wei Jiang & Rongbin Zhou. (2020) Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nature Cell Biology 22:6, pages 716-727.
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Ye Tao & Bin Liang. (2020) PTEN mutation: A potential prognostic factor associated with immune infiltration in endometrial carcinoma. Pathology - Research and Practice 216:6, pages 152943.
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Henry Taylor, Arian D. J. Laurence & Holm H. Uhlig. (2019) The Role of PTEN in Innate and Adaptive Immunity. Cold Spring Harbor Perspectives in Medicine 9:12, pages a036996.
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Sebastian Meltzer, Tonje Bjørnetrø, Lars Gustav Lyckander, Kjersti Flatmark, Svein Dueland, Rampradeep Samiappan, Christin Johansen, Erta Kalanxhi, Anne Hansen Ree & Kathrine Røe Redalen. (2019) Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer. Translational Oncology 12:8, pages 1038-1044.
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Marc Eissing, Lise Ripken, Gerty Schreibelt, Harm Westdorp, Marjolijn Ligtenberg, Romana Netea-Maier, Mihai G. Netea, I. Jolanda M. de Vries & Nicoline Hoogerbrugge. (2019) PTEN Hamartoma Tumor Syndrome and Immune Dysregulation. Translational Oncology 12:2, pages 361-367.
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Wenli Yuan, Deyao Deng, Hongchao Jiang, Changling Tu, Xueqin Shang, Hongchun He, Ruize Niu & Jian Dong. (2018) Hyperresponsiveness to interferon gamma exposure as a response mechanism to anti-PD-1 therapy in microsatellite instability colorectal cancer. Cancer Immunology, Immunotherapy 68:2, pages 257-268.
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